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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
41

Enhancing anti-melanoma immune responses

Harries, Mark January 2000 (has links)
No description available.
42

Human melanoma invasion and the antiinvasive and immunomodulatory role of α-melanocyte stimulating hormone (α-MSH)

Eves, Paula Clare January 2001 (has links)
No description available.
43

Comparative aspects of tyrosinase activity : purification of human tyrosinase from IGR1 cells and comparison of properties with tyrosinase from Agaricus bisporus

Weinel, Allison Clare January 1994 (has links)
No description available.
44

In vitro and in silico characterisation of a novel immunoglobulin

Waters, Patrick J. January 1999 (has links)
No description available.
45

The master-regulators of EMT and E-cadherin constitute a novel pathway in malignant melanoma

Hill, Louise Anne January 2013 (has links)
The master-regulators of an epithelial-mesenchymal transition (MR-EMT) have a pivotal role in the regulation of carcinoma development, promoting transformation and generating a migratory and invasive phenotype. Within epithelial cells, the ZEB proteins are co-regulated, jointly repressed by the miR-200 family of microRNAs. However, here it is demonstrated that the expression and regulation of the MR-EMT in malignant melanoma cell lines appears to be fundamentally different, with a hierarchical organisation identified. ZEB2 and SNAIL2 were found to be expressed in melanocytes, whilst ZEB1 and TWIST1 expression was acquired by a sub-set of malignant melanoma cell lines. Melanoma-initiating mutations within B-RAF and NRAS were shown to reversibly promote expression of ZEB1 and TWIST1 at the expense of ZEB2 and SNAIL2. Additionally, ZEB2 and SNAIL2 were identified up-stream of ZEB1 and TWIST1 within the MAPK signalling cascade, with ZEB2 functioning as a repressor of ZEB1. Furthermore, ZEB2 and SNAIL2 were found to positively regulate expression of MITF, a marker of melanocyte differentiation. In contrast, ZEB1 repressed expression of MITF and was the primary transcriptional repressor of E-cadherin, an adhesion molecule vital for the interaction between differentiated melanocytes and keratinocytes. Previously, within epithelial cell lines, all the MR-EMT have been identified as transcriptional repressors of E-cadherin. However, ZEB2 and SNAIL2 were co-expressed with E-cadherin within melanocytes and melanoma cell lines and, along with TWIST1, were not able to independently induce E-cadherin re-activation following repression. Surprisingly, ZEB2 became a repressor of E-cadherin in conjunction with ZEB1. Finally, E-cadherin expression was also shown to be controlled in a ZEB1-dependent manner by the transcriptional co-repressor BRG1, the ATPase subunit of the SWI/SNF chromatin remodelling complex, and by the presence of DNA methylation at the E-cadherin promoter. Indeed, DNA methylation was identified as a possible factor controlling the success rate of metastatic colonisation in melanoma cells, allowing for the dynamic re-expression of E-cadherin at the secondary site. These data demonstrate that in malignant melanoma the expression and regulation of the MREMT is fundamentally different to that of epithelial tumours, with the MR-EMT structured hierarchically, with opposing regulatory functions.
46

Association Between Melanoma And Glioma: An Observaitonal Study In A Random Sample Of The Taiwanese Populaiton

Chu, Yeong Ruey, Il'yasova, Dora, Luo, Ruiyan, Ho, Wen Chao 06 January 2017 (has links)
Background: In a previous study, it was shown that melanoma patients have a greater incidence of glioma as compared to the general population in United States. Because glioma and melanoma do not have common environmental risk factors, this observation suggests a common genetic predisposition shared by glioma and melanoma that maybe used to lead future research of the specific genes and drug targets for both malignancies. However, this observation has to be confirmed in other populations. The aim of this study was to investigate the association between melanoma and glioma in Taiwanese population. Methods: We used claim data of Taiwan’s National Health Insurance Research Database (NHIRD) from year 1998 to 2010. The study population included 1,000,000 randomly selected men and women ages 20 and older from the NHIRD database. Glioma was defined by ICD-9-CM codes 191, 192.0-192.3, 192.8, 192.9, 225 and 237.5. Melanoma was defined by ICD-9-CM codes 172, 173, 190.0, 190.9, 192.1, 216.X (X=0, 3-7, 9), 224, 223.2, 235.1, 235.2, 237.6, 238.2, 238.3, 238.8. We excluded participants under ages 20 at 1998 and unknown gender (n=324,879). Cox's proportional hazard regression analysis was conducted to estimate the association between the history of melanoma on glioma risk. Main results: The hazard ratio of developing glioma was significantly higher in patients with melanoma than in those without melanoma (hazard ratio (HR) = 6.18; 95% confidence interval (CI) = 5.57-6.85). The hazard ratio for developing glioma was lower in male patients than in female patients, with the hazard ratio of 0.77 (95% CI = 0.71-0.84), adjusted for melanoma and age. The hazard ratio increased with age peaking at age group age from 60 to 69 and decrease after 70 years and older. Conclusion: The present study showed that Taiwanese patients with melanoma are at a higher risk of developing glioma. The exact underlying etiologies require further investigation.
47

Melanoma maligno acral en el Hospital Guillermo Almenara Irigoyen : un estudio clínico epidemiológico - años 1995-2000

Huamán Muñante, José Gonzalo January 2003 (has links)
El Melanoma Maligno Acral (MMA) lentiginoso es una de las 4 variedades clínicas del melanoma maligno. Ocurre en 2-8% de pacientes blancos y es el tipo predominante en afro caribeños y orientales (35-60%). El tumor se encuentra particularmente en los dedos y sitios que soportan peso. La variante subungueal afecta mas comúnmente el primer dedo del pie y la mano, constituyendo el 2% de todos los melanomas cutáneos. Un factor que dificulta el diagnóstico correcto de la variedad clínica del melanoma es el tiempo de enfermedad, ya que los casos localmente avanzados no permiten distinguir claramente su historia natural. El MM es una de las patologías que tiene el mayor retardo en el diagnóstico y en la mayoría de los casos esto sería atribuible al retraso en la búsqueda de atención médica por el paciente, por lo cual es importante reconocer signos y síntomas que advertidos oportunamente nos lleven a realizar un diagnóstico y tratamiento precoz. Planteamos así la presente revisión de los casos presentados en el hospital en los últimos 5 años. Nuestros resultados muestran que el MMA constituye alrededor del 50% del total de MM cutáneos primarios, con 22 de 53 casos registrados. El grupo etáreo afectado con mayor frecuencia está entre 60-70 años, habiéndose encontrado un predominio en varones (60%). El tiempo transcurrido desde el inicio de enfermedad y diagnóstico fue entre 6 y 12 meses en la mayoría de casos. El dolor fue el motivo principal de consulta 99 casos), entre otros, así como sangrado, crecimiento de la lesión, cambio de color y ulceración. La lesión previa mas frecuentemente reportada fue la mancha o lunar en 13 casos. La totalidad de los melanomas se ubicó en los pies: 03 casos se localizaron en la uña. Respecto al tamaño, en el 60% de los casos la lesión medía de 2-3 cms. En lo referente al estadiaje 19 casos (85%) correspondían a estadíos avanzados: Clark IV y V, 10 con Breslow mayor de 1.5 mm y 09 con más de 4 mm. Adicionalmente hubo 03 casos asociados a vitíligo acrofacial. Concluimos que el MMA es el más frecuente de los melanomas cutáneos primarios en nuestros pacientes, la información de las historias clínicas en algunos casos es insuficiente para precisar la variedad, finalmente nuestros resultados concuerdan en su mayoría con lo reportado en la literatura.
48

What is the impact of brain and extremity inclusion in the imaging of malignant melanoma with F-18 FDG PET/CT

Mbakaza, Olwethu Natash January 2016 (has links)
A Research report submitted to the Faculty of Health Sciences, University of the Witwatersrand in fulfillment of the requirements for the degree of Master of Medicine in the branch of Nuclear Medicine / Objectives: This study aimed to ascertain if there is any clinical value in including brain and extremities in the 18 F-FDG PET/CT imaging of patients with malignant melanoma. Methods: This was a retrospective study done at Charlotte Maxeke Johannesburg Academic Hospital(CMJAH), Johannesburg. All consecutive 18F-PET/CT reports for patients referred to the CMJAH department of Nuclear Medicine for an 18-F-FDG PET/CT study, spanning form 01 January 2008 to 31 December 2013, who have histologically proven malignant melanoma were included in the study. The prevalence of brain and extremity lesions of 18F-FDG PET/CT reports was documented. Hospital records were viewed to see if clinical and histological correlation was done for lesions that were likely malignant; and to also review the impact of 18F-FDG PET/CT findings on patient management. Results: One hundred and fifty nine 18F-FDG PET/CT studies in 121 patients were included for assessment. The median patient age was 54 years (ranging from 16-84 years). Eighteen patients (12%) had lesions in the brain, eight (5.33%) of which were classified as likely benign, five (3.33%) of which were classified as indeterminate. However, nine (5.7%) patients in the whole group did not have brain acquisition and were excluded from the assessment. None of the patients were likely malignant or indeterminate brain lesions underwent further investigation such as radiological correlation with MRI or a pathological correlation. Three patients had change in management as a result of finding of brain lesions on 18F-FDG PET/CT. One patient had radiotherapy of the brain with steroids, in addition to their chemotherapy regimen; another had whole brain palliative radiotherapy, in addition to their chemotherapy regimen to a different regimen. Thirty six patients (37%) had lesions in the extremities, three (8%) of the 36 were classified as likely benign, six (17%) of which were classified as likely malignant, and two (6%) of which were classified as indeterminate. The remaining twenty five (69%) had their primary tumour in the extremities. However , 61 (38%) patients in the whole group did not have acquisition of the extremities. Ninety eight patients had extremity scans. None of the patients with extremity lesions underwent further radiological and or pathological correlation, and none had a change in stage or change in clinical management Conclusion: Our study showed that although there was no change in the clinical staging resulting from the acquisition of extra brain and extremity views on 18F-FDG PET/CT, there was a change in the clinical management of those with brain lesions. There was no change in clinical management of those patients with extremity lesions. The suggested protocol is acquisition of brain views only in patients with additional metastatic lesions after the acquisition of the whole body view(base of skull to mid-thigh). The protocol, however needs validation with a more comprehensive, prospective study / MT2017
49

Evaluation of in vitro antitumor activity of triazole / azide synthetic chalcones / Avaliação de atividade antitumoral in vitro de triazol/azida chalconas sintéticas

Evangelista, Fernanda Cristina Gontijo 01 October 2018 (has links)
Submitted by Repositorio Tarefa (tarefarepositorio@gmail.com) on 2018-10-22T15:15:33Z No. of bitstreams: 2 Avaliação de atividade antitumoral in vitroELIDA.PDF: 334912 bytes, checksum: 7e3630670b1d8ca55012362260918128 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2018-10-22T15:15:33Z (GMT). No. of bitstreams: 2 Avaliação de atividade antitumoral in vitroELIDA.PDF: 334912 bytes, checksum: 7e3630670b1d8ca55012362260918128 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2018-10-01 / Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP / Many compounds isolated from lichens exhibit biological activity, and a number of them are proven sources of antitumor drugs. Even simple structural changes to these bioactive compounds can lead to potentiation of their activity. The purposes of this study were to evaluate the antiproliferative activity and selectivity of the following compounds isolated from lichens: atranorin; diffractaic, divaricatic, perlatolic, psoromic, norstitic, protocetraric, and fumarprotocetraric acids; and alkyl derivatives. Cytotoxicity tests based on the sulforhodamine B dye were performed on seven lines of neoplastic cells and one line of normal cells (3T3) / Muitas substâncias isoladas de liquens apresentam atividades biológicas, e algumas demonstraram ser fontes promissoras de drogas antitumorais. Modificações estruturais simples a partir dessas substâncias bioativas podem levar a potencialização da atividade apresentada. Os objetivos deste estudo foram avaliar a atividade antiproliferativa e seletividade dos seguintes compostos isolados de liquens: atranorina, ácidos difractaico, divaricático, perlatólico, psorômico, norstítico, protocetrárico e fumarprotocetrárico e derivados alquílicos. O ensaio de citotoxicidade foi realizado com corante sulforrodamina B em sete linhagens de células neoplásicas e uma linhagem de células normais (3T3)
50

Mechanisms of Resistance to BRAF and MEK inhibitors in BRAF-mutant melanoma

Patel, Hima Milan 23 August 2022 (has links)
No description available.

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