Orientadores: Ana Maria Frattini Fileti, João Alexandre Ferreira da Rocha Pereira / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica / Resumo: Não Informado / Made available in DSpace on 2018-08-04T07:25:30Z (GMT). No. of bitstreams: 1 Antunes_ArnaldoJoseBannwart_D.pdf: 3655663 bytes, checksum: adb0d2c9c8215b5c4205125f25e9342c (MD5) Previous issue date: 2005 / Abstract: The present work is concerned with the design and experimental testing of control system with a fuzzy algorithm for temperature control of a methyl methacrylate (MMA) batch polymerization. Ethyl acetate is used as solvent and benzoyl peroxide is the reaction initiator. According to the literature, this reaction is complex and highly nonlinear, therefore there is some dificulty choosing the most appropriate controller. To verify the system complexity and the influence of the fuzzy control algorithm it is compared to a conventional PID (velocity form) controller. The controller tuning parameters were obtained via open-Ioop experiments. For the conventional PID, the Cohen-Coon method was applied followed by stability analysis. For the fuzzy controller, the open loop results helped to shape the knowledge base, with the determination of the membership functions. This work shows the several alternatives for tuning a fuzzy controller. It can be achieved by modifying the knowledge base or scaling factors. Besides, a digital temperature filter was succesfully used in order to prevent the oscillatory behaviour of the reaction temperature. According to experimental results, the PID-fuzzy was considered more suitable and reliable for this polymerization process control since it outperformed PID velocity form algorithm / Doutorado / Sistemas de Processos Quimicos e Informatica / Doutor em Engenharia Química

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Orientador: Leila Peres / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Química / Made available in DSpace on 2018-08-26T22:00:36Z (GMT). No. of bitstreams: 1 Lucente_AnaGlauciaBogalhos_D.pdf: 2114033 bytes, checksum: ddc1d7f9bcfcce3f7ddfd258b22465d3 (MD5) Previous issue date: 2015 / Resumo: A falta de um material que viabilize a confecção de uma prótese dentária em um menor número de etapas, economizando tempo e facilitando a vida dos pacientes foi a maior motivação para o desenvolvimento desta tese que se baseia na patente BR n. PI 0602107-7 A: Conjuntos de arcos dentais pré-fabricados, flexíveis e com dentes ajustáveis obtida pelo grupo de pesquisa onde se insere este trabalho, em que se propõe o uso do arco dental flexível pré-fabricado na confecção da prótese, que poderá ser produzida em um menor tempo, com um menor custo. O material usado para o arco dental flexível pré-fabricado por energia de micro ondas, bem como para a prótese dental final deverá conter uma base polimérica que permitirá a flexibilidade inicial do arco, que após receber ajustes na posição dos dentes, adequados a cada paciente, será incorporado à prótese final, sendo o conjunto reticulado de forma simultânea. Para tanto, foi investigada a viabilidade do uso do copolímero de metacrilato de metila-n-metacrilato de butila (PMMA-co-PBMA), sintetizado via técnica de miniemulsão, como a matriz polimérica base para a confecção de arcos dentais pré-fabricados, flexíveis e com dentes ajustáveis e da prótese final. Na síntese do copolímero pretendido, foram estudadas as características dos iniciadores, surfactante, estabilizador e temperatura de reação sobre a distribuição volumétrica (Dv) e populacional (DSD) de tamanhos de partícula, conversão global, temperatura de transição vítrea (Tg), massa molar média ponderal (Mw), massa molar média numérica (Mn) e polidispersividade (Mw/Mn). Verificou-se a influência da solubilidade dos iniciadores em baixas temperaturas na conversão global, Dv e DSD, fator que não interfere em altas temperaturas. Além das análises de Tg, Mw e Mw/Mn dos copolímeros e homopolímeros obtidos por mecanismo de adição. Realizaram-se também análises de Ressonância Magnética Nuclear (RMN) e Espectroscopia no Infravermelho com Transformada de Fourrier (FT-IR) indicando que o copolímero foi formado na configuração alternada ou aleatória. A resina formulada a partir do copolímero sintetizado para uso no arco dental pré-fabricado foi caracterizado, a partir de ensaios de resistência à flexão, microdureza, módulo de elasticidade, coeficiente de Poisson, da Tg do material e monômero residual. Os resultados mostram um material compatível com resinas comerciais em relação à microdureza e módulo de elasticidade / Abstract: The lack of a material that enables the production of a dental prosthesis in fewer steps, saving time and making life easier for the patients was the major motivation for developing this thesis is based on the patent BR n. PI 0602107-7 A: Sets of prefabricated dental arches, flexible and adjustable teeth obtained by the research group which includes this work, it is proposed the use of prefabricated flexible dental arch in the making of the prosthesis, which can be produced in less time, with less cost. The material used for the flexible prefabricated dental arch by microwave energy and for the final dental prosthesis should contain a polymer base which will allow the initial flexibility of the arch, after receiving adjustments to the position of the teeth, adequate to each patient will be incorporated into the final prosthesis being crosslinked together simultaneously. Therefore, it was investigated the feasibility of using n-butyl methyl methacrylate-methacrylate copolymer (PMMA-co-PBMA) synthesized via miniemulsion technique as the base polymer matrix for the manufacture of prefabricated dental arches, flexible and adjustable teeth and the final prosthesis. In the synthesis of the desired copolymer characteristics of primers were studied, surfactant, stabilizer and reaction temperature on the size distribution (Dv) and population (DSD) particle size, overall conversion, glass transition temperature (Tg), mass-average molecular weight (Mw), number-average molecular weight (Mn) and polydispersity (Mw/Mn). It has been found to influence the solubility of the initiators at low temperatures in the overall conversion, Dv and DSD factor that does not interfere at high temperatures. In addition to the analyzes Tg, Mw and Mw / Mn of the copolymers and homopolymers obtained by adding mechanism. Nuclear Magnetic Resonance analysis (NMR) spectroscopy and Fourier transform infrared (FT-IR) were also performed indicating that the copolymer was formed in alternating or random configuration. The resin made from copolymer synthesized for use in prefabricated dental arch was characterized as bending strength tests, hardness, modulus of elasticity, Poisson's ratio, the Tg of the material and residual monomer. The results show a material similar to commercial resins with regard to hardness and modulus of elasticity / Doutorado / Ciencia e Tecnologia de Materiais / Doutora em Engenharia Quimica

Asymmetric polymeric materials can be formed by either top-down or bottom-up methods. Bottom-up methods involve assembling the atoms and molecules to form small nanostructures by carefully controlled synthesis, which results in a reduction of some of the top-down limitations. In this dissertation, thermal, tribological and antireflective properties of polymeric materials have been enhanced by introducing structural asymmetry. The overall performance of commercial polymeric coatings, e.g. epoxy and polyvinyl chloride, has been improved by conducting the blending methods, specifically, chemical modification (α,ω-dihydroxydimethyl(methyl-vinyl)oligoorganosiloxane), cross-linking (triallyl isocyanurate), and antioxidant (tris(nonylphenyl) phosphite) incorporation. The nonequilibrium polymeric structures (moth-eye and square array) have been developed for the ultrahigh molecular weight block copolymers via the short-term solvent vapor annealing self-assembly. The large domain size of the moth eye structure allows for improvement of the light transmittance particularly in the visible and near infrared ranges, while the square arrangement of the block copolymer opens the possibility of magnetic data storage application by the large magnetic nanoparticles' embedment or masking of the superconductors.

This thesis is an experimental investigation of the phase behavior, volumetric properties, and viscosity of poly (methyl methacrylate) (PMMA), poly (ε-caprolactone) (PCL) and their blends. Homopolymerization and copolymerizations of methyl methacrylate (MMA) and 2-methylene-1,3-dioxepane (MDO) in mixtures of acetone + CO2 have also been explored. The viscosities and densities of acetone + CO2 mixtures were measured in the temperature range 323-398 K at pressures up to 35 MPa. This is the first study in which viscosity of acetone + CO2 mixtures have been measured and the mixtures have been evaluated as solvents for PCL. It is shown that PCL can be readily dissolved in these fluid mixtures at modest pressures even at high carbon dioxide levels. Investigations have been conducted over a temperature range from 323 to 398 K at pressures up to 50 MPa for polymer concentrations up to 20 wt %, and CO2 concentrations up to 60 wt %. It is shown that in these mixtures PCL is dissolved at pressures that are much lower than the pressures reported for miscibility in the mixtures of carbon dioxide with other organic solvents. It is shown that PMMA also readily dissolves at modest pressures. Blends of PMMA and PCL require higher pressures than for the individual polymers for complete miscibility. Free-radical polymerizations of MMA in acetone at 343 K were followed using in-situ measurements of viscosity and density at different pressures from 7- 42 MPa. This is the first time viscosity has been used as a real-time probe of high pressure polymerizations. Two distinct kinetic regimes were identified. Homopolymerizations of MDO were conducted in carbon dioxide at 323 and 343 K at pressures up to 42 MPa. For the first time it is shown that high molecular weight PCL can be produced from MDO in high pressure CO2. Ring-opening free-radical copolymerizations of MDO with MMA, styrene and acrylonitrile were conducted for the first time in carbon dioxide and have been shown to lead to polymers with high molecular weights. / Ph. D.

Dynamic modelling and optimization of three different processes namely (a) bulk polymerization of styrene, (b) solution polymerization of methyl methacrylate (MMA) and (c) emulsion copolymerization of Styrene and MMA in batch and semi-batch reactors are the focus of this work. In this work, models are presented as sets of differential-algebraic equations describing the process. Different optimization problems such as (a) maximum conversion (Xn), (b) maximum number average molecular weight (Mn) and (c) minimum time to achieve the desired polymer molecular properties (defined as pre-specified values of monomer conversion and number average molecular weight) are formulated. Reactor temperature, jacket temperature, initial initiator concentration, monomer feed rate, initiator feed rate and surfactant feed rate are used as optimization variables in the optimization formulations. The dynamic optimization problems were converted into nonlinear programming problem using the CVP techniques which were solved using efficient SQP (Successive Quadratic Programming) method available within the gPROMS (general PROcess Modelling System) software. The process model used for bulk polystyrene polymerization in batch reactors, using 2, 2 azobisisobutyronitrile catalyst (AIBN) as initiator was improved by including the gel and glass effects. The results obtained from this work when compared with the previous study by other researcher which disregarded the gel and glass effect in their study which show that the batch time operation are significantly reduced while the amount of the initial initiator concentration required increases. Also, the termination rate constant decreases as the concentration of the mixture increases, resulting rapid monomer conversion. The process model used for solution polymerization of methyl methacrylate (MMA) in batch reactors, using AIBN as the initiator and Toluene as the solvent was improved by including the free volume theory to calculate the initiator efficiency, f. The effects of different f was examined and compared with previous work which used a constant value of f 0.53. The results of these studies show that initiator efficiency, f is not constant but decreases with the increase of monomer conversion along the process. The determination of optimal control trajectories for emulsion copolymerization of Styrene and MMA with the objective of maximizing the number average molecular weight (Mn) and overall conversion (Xn) were carried out in batch and semi-batch reactors. The initiator used in this work is Persulfate K2S2O8 and the surfactant is Sodium Dodecyl Sulfate (SDS). Reduction of the pre-batch time increases the Mn but decreases the conversion (Xn). The sooner the addition of monomer into the reactor, the earlier the growth of the polymer chain leading to higher Mn. Besides that, Mn also can be increased by decreasing the initial initiator concentration (Ci0). Less oligomeric radicals will be produced with low Ci0, leading to reduced polymerization loci thus lowering the overall conversion. On the other hand, increases of reaction temperature (Tr) will decrease the Mn since transfer coefficient is increased at higher Tr leading to increase of the monomeric radicals resulting in an increase in termination reaction.

Palladium complexes of bis(di-tert-butylphosphinomethyl)benzene (DTBPMB) show remarkably high activity as alkene methoxycarbonylation catalysts, in addition to numerous other catalytic conversions, and are currently being commercialised by Lucite in ethene methoxycarbonylation to methyl propanoate. Any large-scale exploitation of this catalyst system for heavier products, however, is likely to be hindered by catalyst-product separation problems common to homogeneous catalysts; hence modification of this catalyst system to allow facile product separation was investigated. Tethering of DTBPMB residues onto polystyrene via Suzuki-type coupling of suitable precursors onto bromopolystyrene and boronic acid functionalised polystyrene resins was investigated and the phosphine was successfully immobilised. Phosphination of the resins was not complete however and as such there is concern that other phosphine residues may be present which do not exhibit a bidentate binding motif. The synthesis of a potassium sulfonate derivative of DTBPMB (KBPMBS) was successful and immobilisation of this onto ion exchange resins was also investigated. Some preliminary results from studies into 1-octene methoxycarbonylation using palladium complexes of these resins were obtained. Supporting of this diphosphine onto silica via a sol-gel co-condensation methodology was also investigated; the synthesis of a suitably functionalised precursor containing a sulfonamide linkage was successful via protection of the diphosphine using borane. Although formation of the silica support was successful, attempts to deprotect the phosphine-borane resulted in cleavage of the ligand from the support. An alternative route to this supported ligand was attempted and others discussed. Synthesis of a suitable sol-gel precursor via alkene hydrosilation was also attempted and is discussed. Supporting of the sulfonated phosphine, KBPMBS onto silica functionalised with imidazolium tethered residues was also investigated, although complete leaching of the phosphine from the support by methanol washing was observed. Immobilisation of the synthesised KBPMBS ligand in an ionic liquid (IL) phase was investigated. Complex formation and catalytic activity were demonstrated and a positive effect on conversion was observed upon addition of carbon dioxide to the system; possibly due to the increased CO solubility within the IL phase. Efficient product separation from the IL-immobilised catalyst system was demonstrated, both by organic extraction and using supercritical carbon dioxide flow. However, poor catalyst stability under these conditions appears to present a barrier to recycling this system, with loss of conversion observed on catalyst recycling. Other attempts to immobilise the DTBPMB ligand are discussed and reduction of the sulfide derivative of DTBPMB was demonstrated using hexachlorodisilane, which could be used as a general synthetic strategy for protecting highly electron rich phosphines. It is possible that increasing the bulk of the DTBPMB ligand may increase catalyst stability and result in catalyst systems with higher turnover numbers. Therefore syntheses of bulky ligands based on the DTBPMB backbone were investigated. 1,2,4,5-tetrakis(di(tert-butyl)phosphinomethyl)benzene was successfully synthesised although palladium complexes of this showed no activity in catalytic methoxycarbonylation. Attempts to synthesise a related biphenyl-based tetraphosphine is also discussed, although isolation of this in a pure form was not achieved. Routes toward tetraphenyl and dimethyl-diphenyl functionalised derivatives of DTBPMB have also been explored, although only a monophosphine was isolated due to difficulties in obtaining an intermediate di(chloromethyl) precursor in both synthetic pathways, although this now appears to have been overcome.

L'objectif de ces travaux était de mettre au point des vecteurs de diffusion efficaces du thymol pour lutter contre un acarien parasite des abeilles. Le choix s'est porté sur la formation de nano-objets par émulsification spontanée pouvant libérer efficacement du thymol grâce à leur grande surface spécifique. L'émulsification spontanée par « effet Ouzo » a été choisie en raison de (i) la simplicité du procédé nécessaire pour son application par les apiculteurs et de (ii) la possibilité de former une grande diversité de nano-objets. L'émulsification spontanée par effet Ouzo a tout d'abord été étudiée fondamentalement avec un polymère (nanoprécipitation), le polyméthacrylate de méthyle (PMMA), pour s'affranchir des phénomènes déstabilisants typiques des émulsions tels que le mûrissement d'Ostwald et la coalescence. Cette étude a permis de définir clairement les compositions du système PMMA/solvant/eau pour lesquelles la nanoprécipitation du PMMA induit la formation exclusive de nanoparticules de distribution de taille étroite (zone Ouzo) ou la formation de nanoparticules additionnées de macroparticules (zone non-Ouzo), séparées par la limite Ouzo. Deux mécanismes de formation des nanoparticules ont été déduits suivant la sursaturation du PMMA (nucléation et croissance ou nucléation et agrégation). L'influence des stabilisants a montré l'importance de l'adsorption des ions OH- sur la taille des nanoparticules et sur le déplacement de la limite Ouzo alors que seule la stabilité colloïdale est améliorée avec l'ajout de tensioactifs. Cette étude fondamentale a servi de base pour la formation des nanogouttelettes de thymol et des nanocapsules thymol-PVA réticulé et thymol-PMMA par effet Ouzo. Des nanoparticules thymol-PVP ont également été formées par complexation de la poly(N-vinyl-2-pyrrolidone) en milieu aqueux. Ces nano-objets de thymol ont été testés sur des ruches infestées pour déterminer leur efficacité d'éradication de l'acarien Varroa Destructor. / The objective of this work dealt with setting up efficient thymol diffusion vectors to fight against a bee mite, the Varroa Destructor. The formation of nano-objects by spontaneous emulsification was investigated because they provide large specific area to enhance thymol evaporation. Spontaneous emulsification by so-called Ouzo effect was chosen because of (i) the simplicity of the process necessary for the transfer to beekeepers and (ii) the great diversity of nano-objects morphologies which can be designed. Spontaneous emulsification by Ouzo effect was first studied fundamentally with a polymer (nanoprecipitation), the poly(methyl methacrylate) (PMMA), in order to avoid typical emulsion destabilizing phenomena such as Ostwald ripening and coalescence. This study enabled to clearly define the PMMA/solvent/water system compositions for which PMMA nanoprecipitation induces only formation of nanoparticles with a narrow size distribution (Ouzo domain) or formation of microparticles besides nanoparticles (non-Ouzo domain), separated by the Ouzo boundary. Two nanoparticles formation mechanisms were deduced with respect to the supersaturation of PMMA (nucleation and growth or nucleation and aggregation). Stabilizers influence set off the importance of OH- ions adsorption on nanoparticles size and on Ouzo boundary shifting whereas only colloidal stability is improved through surfactant addition. This fundamental study laid down basis for thymol nanodroplets and for thymol-cross linked PVA and thymol-PMMA nanocapsules formation by Ouzo effect. Thymol-PVP nanoparticles were also prepared by poly(N-vinyl-2-pyrrolidone) complexation in aqueous medium. These thymol nano-objects were tested on infested beehives to determine their efficiency to eradicate the Varroa Destructor mite.

L’objectif de cette thèse est de proposer une stratégie simplifiée et précise pour caractériser et modéliser le comportement mécanique des polymères amorphes de l'état quasi-fluide à l'état solide.L'étude a été réalisée sur des PMMA de masses molaires et de degré de réticulations différentes.D’abord, le comportement mécanique dans le domaine viscoélastique linéaire est étudié à l'aide de tests DMTA et rhéologiques. Il ressort de l’étude que l'augmentation de la masse molaire et du degré de réticulation augmentait les modules de stockage et de perte en tant que la transition α. En parallèle, l'utilisation du principe de superposition temps-température a permis de déterminer «des vitesses de déformation équivalentes à la température de référence».Ensuite, le comportement mécanique à grande déformation est étudié par essais cycliques en traction uni-axial et de cisaillement à haute température et couplés à la DIC. De plus, les effets de la vitesse de déformation et de la température ont été couplés grâce à "vitesse de déformation équivalent à la température de référence" extrait des observations dans le domaine linéaire. Les résultats ont montré que cibler la même vitesse de déformation équivalente conduira aux mêmes courbes contrainte-déformation, c'est-à-dire la même réponse mécanique. Ceci permet de réduire le nombre de tests expérimentaux nécessaires pour caractériser le comportement mécanique des polymères amorphes.Enfin, un modèle basée dans un cadre thermodynamique a été utilisée pour reproduire la réponse mécanique des PMMAs à grande déformation. Le modèle présentait un bon accord avec les données expérimentales, étant capable de reproduire des comportements visco-élasto-plastiques, viscoélastiques, hyperélastiques et visco-hyperelastiques pour la traction cyclique. / The present PhD thesis proposes a simplified and accurate strategy for characterising and modelling the mechanical behaviour of amorphous polymers from the quasi-fluid state up to the solid state.The study was carried out on PMMAs with different molar masses and crosslinking degree.First, we addressed the mechanical behaviour in the linear viscoelastic domain using DMTA and rheological tests. Results showed that increasing the molar mas and crosslinking degree increased the elastic and loss moduli as the α-transition. In parallel, using the time-temperature superposition principle allowed determining “equivalent strain rates at reference temperature”.Then, we performed uniaxial tensile and shear uploading-unloading tests at high temperature and coupled with DIC, to characterise the mechanical behaviour at large strain. Additionally, strain rate and temperature effects were coupled by means of the “equivalent strain rate at reference temperature” extracted from observations in the linear domain. Results showed that targeting the same equivalent strain rate lead to the same stress-strain curves, i.e. same mechanical response. This allows reducing the number of experimental tests needed to characterise the mechanical behaviour of amorphous polymers.Finally, a constitutive modelling based in a thermodynamics framework, was used to reproduce the mechanical response of the PMMAs at large deformation. The model presented a good agreement with the experimental data, being able to reproduce viscoelastoplastic, viscoelastic, hyperelastic and viscohyperelastic behaviours for cyclic loading tensile.

Foram desenvolvidos e manufaturados compósitos porosos com estrutura de gradiente funcional em Poli (metacrilato de metila) (PMMA) e Hidroxiapatita (HAp) aplicáveis como implantes ósseos. O PMMA é largamente utilizável e aceito como material de implante tem boas propriedades mecânicas, baixo custo, fácil manufatura, porém é considerado bioinerte. A HAp é uma cerâmica comprovadamente bioativa, porém de baixas propriedades mecânicas, alto custo e de difícil manufatura. O PMMA com estrutura funcional e HAp apresentou valores próximos a 50 MPa, mas com potencial de melhoria. O objetivo deste desenvolvimento é produzir um implante com a sua superfície porosa e bioativa, para que este possa ser osteointegrado em um tempo menor ao tecido hospedeiro, melhorando a relação: material implantado/leito receptor. O conceito é baseado em uma estrutura de núcleo denso em PMMA e camada superficial porosa com superfície bioativa. A camada de PMMA porosa foi desenvolvida utilizando-se o carboximetilcelulose (CMC) como agente porogênico e HAp como agente bioativador da matriz polimérica. Foram elaboradas análises de bicompatibilidade, resistência mecânica, macro e microestrutura. Para testar a biocompatibilidade foram realizados inicialmente testes in vitro com cultura de células VERO, visando investigar a toxicidade dos materiais constituintes, a influência do novo biomaterial em atividades celulares e o comportamento destes em condições próximas daquelas a serem encontradas no ambiente de implantação. Em seguida, os testes in vivo realizados em coelhos averiguaram a interação tecido-material (bioatividade), a biocompatibilidade do material, e a potencialidade do uso do material em aplicação à superfícies (osteointegração). Foi realizada análise histológica dos tecidos explantados, onde os resultados basearam-se na análise da morfologia geral dos componentes teciduais encontrados junto ao implante. A caracterização da superfície foi realizada por testes de rugosidade, por microscopia ótica e eletrônica de varredura. Foram realizados ensaios mecânicos de compressão para analisar a resistência mecânica do biomaterial. Os resultados in vitro mostraram que os materiais utilizados não apresentaram qualquer indício de toxicidade. Através das imagens realizadas em MEV (Microscopia Eletrônica de Varredura) pode se observar o crescimento de células VERO na superfície do material e em direção aos poros da matriz. A análise macroestrutural dos poros também obtida por MEV demonstrou em uma caracterização inicial do material que este apresentou características biomiméticas como poros em formato oblongo e interconectados. A média obtida do tamanho dos poros foi de aproximadamente 250 \'mü\'m. Os resultados dos ensaios mecânicos de compressão mostraram que o PMMA denso é o que mais se aproximou do tecido ósseo cortical com 101 MPa. Por fim, os resultados histológicos apontam para a biocompatibilidade do compósito, tornando-o assim aplicável como camada superficial de implantes. / Were developed and manufactured porous composite with functional gradient structure in Polymethylmethacrylate (PMMA) and hydroxyapatite (HAp) applicable as bone implants. PMMA is widely used and accepted as implant material, has good mechanical properties, low cost, easy manufacturing and considered a bioinert biomaterial, the Hap is a demonstrably bioactive ceramic with poor mechanical properties, high cost and difficult to manufacture. The PMMA functional structure and HAp had values close to 50 MPa, but with potential for improvement. The objective of this development was produced an implant with a porous surface and bioactive to be osteointegrated in a less time, improving the relationship: implanted material/receiver bed. The concept is based on a dense structure core of PMMA and a porous bioactive surface layer. The porous PMMA was developed using the carboxymethylcellulose (CMC) as a porogenic agent and hap to bioactive the PMMA matrix. Biocompatibility tests, mechanical strength tests and macro and microstructure analisys were carried out. To evaluated the biocompatibility of this material were made primarily in vitro tests, the VERO cells were used in vitro analysis aimed investigate the toxicity of the constituent materials, the influence of the new biomaterial in cellular activities and behavior in these conditions close to those to be found in the environment of deployment. Then, in vivo tests conducted in rabbits evaluated the interaction with tissue-material (bioactivity), the biocompatibility of the material, and the potential use of the material in the application areas (osseointegration). Were performed histological analysis of tissues, where the results were based on the analysis of the general morphology of the tissue components found near the implant. The surface characterization was performed by roughness tests, optical microscopy and SEM. Mechanical tests were conducted to examine the compressive strength of biomaterial. Results in vitro showed that the materials did not present any evidence of toxicity. The samples were analyzed by SEM where the growth of cells can be observed in the surface of the material and towards to the pores. The macrostructural analysis also obtained by SEM showed in an initial characterization of the material that presented bone biomimetics characteristics with oblong pores with interconnected. The average pore size obtained was approximately 250 \'mü\'m. The results of mechanical tests showed that the compression of PMMA is the densest approached the cortical bone tissue near 101 MPa. Finally, the histological results point to the biocompatibility of the composite, thus making it applicable to the surface layers of implants.