Massive infrastructure networks such as electric power, natural gas, or water systems play a pivotal role in everyday human lives. Development and operation of these networks is extremely capital-intensive. Moreover, security and reliability of these networks is critical. This work identifies and addresses a diverse class of computationally challenging and time-critical problems pertaining to these networks. This dissertation extends the state of the art on three fronts. First, general proofs of uniqueness for network flow problems are presented, thus addressing open problems. Efficient network flow solvers based on energy function minimizations, convex relaxations, and mixed-integer programming are proposed with performance guarantees. Second, a novel approach is developed for sample-efficient training of deep neural networks (DNN) aimed at solving optimal network dispatch problems. The novel feature here is that the DNNs are trained to match not only the minimizers, but also their sensitivities with respect to the optimization problem parameters. Third, control mechanisms are designed that ensure resilient and stable network operation. These novel solutions are bolstered by mathematical guarantees and extensive simulations on benchmark power, water, and natural gas networks. / Doctor of Philosophy / Massive infrastructure networks play a pivotal role in everyday human lives. A minor service disruption occurring locally in electric power, natural gas, or water networks is considered a significant loss. Uncertain demands, equipment failures, regulatory stipulations, and most importantly complicated physical laws render managing these networks an arduous task. Oftentimes, the first principle mathematical models for these networks are well known. Nevertheless, the computations needed in real-time to make spontaneous decisions frequently surpass the available resources. Explicitly identifying such problems, this dissertation extends the state of the art on three fronts: First, efficient models enabling the operators to tractably solve some routinely encountered problems are developed using fundamental and diverse mathematical tools; Second, quickly trainable machine learning based solutions are developed that enable spontaneous decision making while learning offline from sophisticated mathematical programs; and Third, control mechanisms are designed that ensure a safe and autonomous network operation without human intervention. These novel solutions are bolstered by mathematical guarantees and extensive simulations on benchmark power, water, and natural gas networks.

Under the envisioned smart city paradigm, there is an increasing demand for the coordinated operation of our infrastructure networks. In this context, this thesis puts forth a comprehensive toolbox for the optimization of electric power and water distribution networks. On the analytical front, the toolbox consists of novel mixed-integer (non)-linear program (MINLP) formulations; convex relaxations with optimality guarantees; and the powerful technique of McCormick linearization. On the application side, the developed tools support the operation of each of the infrastructure networks independently, but also towards their joint operation. Starting with water distribution networks, the main difficulty in solving any (optimal-) water flow problem stems from a piecewise quadratic pressure drop law. To efficiently handle these constraints, we have first formulated a novel MINLP, and then proposed a relaxation of the pressure drop constraints to yield a mixed-integer second-order cone program. Further, a novel penalty term is appended to the cost that guarantees optimality and exactness under pre-defined network conditions. This contribution can be used to solve the WF problem; the OWF task of minimizing the pumping cost satisfying operational constraints; and the task of scheduling the operation of tanks to maximize the water service time in an area experiencing electric power outage. Regarding electric power systems, a novel MILP formulation for distribution restoration using binary indicator vectors on graph properties alongside exact McCormick linearization is proposed. This can be used to minimize the restoration time of an electric system under critical operational constraints, and to enable a coordinated response with the water utilities during outages. / Master of Science / The advent of smart cities has promoted research towards interdependent operation of utilities such as water and power systems. While power system analysis is significantly developed due to decades of focused research, water networks have been relying on relatively less sophisticated tools. In this context, this thesis develops Advanced efficient computational tools for the analysis and optimization for water distribution networks. Given the consumer demands, an optimal water flow (OWF) problem for minimizing the pump operation cost is formulated. Developing a rigorous analytical framework, the proposed formulation provides significant computational improvements without compromising on the accuracy. Explicit network conditions are provided that guarantee the optimality and feasibility of the obtained OWF solution. The developed formulation is next used to solve two practical problems: the water flow problem, that solves the complex physical equations yielding nodal pressures and pipeline flows given the demands/injections; and an OWF problem that finds the best operational strategy for water utilities during power outages. The latter helps the water utility to maximize their service time during power outages, and helps power utilities better plan their restoration strategy. While the increased instrumentation and automation has enabled power utilities to better manage restoration during outages, finding an optimal strategy remains a difficult problem. The operational and coordination requirements for the upcoming distributed resources and microgrids further complicate the problem. This thesis develops a computationally fast and reasonably accurate power distribution restoration scheme enabling optimal coordination of different generators with optimal islanding. Numerical tests are conducted on benchmark water and power networks to corroborate the claims of the developed formulations.

<p dir="ltr">This thesis presents a comprehensive exploration of advanced optimization strategies for addressing mixed-integer optimal control problems (MIOCPs) in aerospace applications, emphasizing the enhancement of convergence robustness, computational efficiency, and accuracy. The research develops a broad spectrum of optimization methodologies, including multi-phase approaches, parallel computing, reinforcement learning (RL), and distributed algorithms, to tackle complex MIOCPs characterized by highly nonlinear dynamics, intricate constraints, and discrete control variables.</p><p dir="ltr">Through discretization and reformulation, MIOCPs are transformed into general quadratically constrained quadratic programming (QCQP) problems, which are then equivalently converted into rank-one constrained semidefinite programs problems. To address these, iterative algorithms are developed specifically for solving such problems. Initially, two iterative search methods are introduced to achieve convergence: one is a hybrid alternating direction method of multipliers (ADMM) designed for large-scale QCQP problems, and the other is an iterative second-order cone programming (SOCP) algorithm developed to achieve global convergence. Moreover, to facilitate the convergence of these iterative algorithms and to enhance their solution quality, a multi-phase strategy is proposed. This strategy integrates with both the iterative ADMM and SOCP algorithms to optimize the solving of QCQP problems, improving both the convergence rate and the optimality of the solutions. To validate the effectiveness and improved computational performance of the proposed multi-phase iterative algorithms, the proposed algorithms were applied to several aerospace optimization problems, including six-degree-of-freedom (6-DoF) entry trajectory optimization, fuel-optimal powered descent, and multi-point precision landing challenges in a human-Mars mission. Theoretical analyses of convergence properties along with simulation results have been conducted, demonstrating the efficiency, robustness, and enhanced convergence rate of the optimization framework.</p><p dir="ltr">However, the iteration based multi-phase algorithms primarily guarantee only local optima for QCQP problems. This research introduces a novel approach that integrates a distributed framework with stochastic search techniques to overcome this limitation. By leveraging multiple initial guesses for collaborative communication among computation nodes, this method not only accelerates convergence but also enhances the exploration of the solution space in QCQP problems. Additionally, this strategy extends to tackle general nonlinear programming (NLP) problems, effectively steering optimization toward more globally promising directions. Numerical simulations and theoretical proofs validate these improvements, marking significant advancements in solving complex optimization challenges.</p><p dir="ltr">Following the use of multiple agents in QCQP problems, this research expand this advantage to address more general rank-constrained semidefinite programs (RCSPs). This research developed a method that decomposes matrices into smaller submatrices for parallel processing by multiple agents within a distributed framework. This approach significantly enhances computational efficiency and has been validated in applications such as image denoising, showcasing substantial improvements in both efficiency and effectiveness.</p><p dir="ltr">Moreover, to address uncertainties in applications, a learning-based algorithm for QCQPs with dynamic parameters is developed. This method creates high-performing initial guesses to enhance iterative algorithms, specifically applied to the iterative rank minimization (IRM) algorithm. Empirical evaluations show that the RL-guided IRM algorithm outperforms the original, delivering faster convergence and improved optimality, effectively managing the challenges of dynamic parameters.</p><p dir="ltr">In summary, this thesis introduces advanced optimization strategies that significantly enhance the resolution of MIOCPs and extends these methodologies to more general issues like NLP and RCSP. By integrating multi-phase approaches, parallel computing, distributed techniques, and learning methods, it improves computational efficiency, convergence, and solution quality. The effectiveness of these methods has been empirically validated and theoretically confirmed, representing substantial progress in the field of optimization.</p>

This paper explores strategies in portfolio optimization, focusing on integrating mean-variance optimization (MVO) frameworks with cardinality constraints to enhance investment decision-making. Using a combination of quadratic programming and mixed-integer linear programming, the Gurobi optimizer handles complex constraints and achieves computational solutions. The study compares two mathematical formulations of the cardinality constraint: the Complementary Model and the Big M Model. As cardinality increased, risk decreased exponentially, converging at higher cardinalities. This behavior aligns with the theory of risk reduction through diversification. Additionally, despite initial expectations, both models performed similarly in terms of root relaxation risk and execution time due to Gurobi's presolve transformation of the Complementary Model into the Big M Model. Root relaxation risks were identical while execution times varied slightly without a consistent trend, underscoring the Big M Model's versatility and highlighting the limitations of the Complementary Model.

The primary aim of this thesis is to develop effective solution techniques for large-scale maritime inventory routing problems that possess a core substructure common in many real-world applications. We use the term “large-scale” to refer to problems whose standard mixed-integer linear programming (MIP) formulations involve tens of thousands of binary decision variables and tens of thousands of constraints and require days to solve on a personal computer. Although a large body of literature already exists for problems combining vehicle routing and inventory control for road-based applications, relatively little work has been published in the realm of maritime logistics. A major contribution of this research is in the advancement of novel methods for tackling problems orders of magnitude larger than most of those considered in the literature. Coordinating the movement of massive vessels all around the globe to deliver large quantities of high value products is a challenging and important problem within the maritime transportation industry. After introducing a core maritime inventory routing model to aid decision-makers with their coordination efforts, we make three main contributions. First, we present a two-stage algorithm that exploits aggregation and decomposition to produce provably good solutions to complex instances with a 60-period (two-month) planning horizon. Not only is our solution approach different from previous methods discussed in the maritime transportation literature, but computational experience shows that our approach is promising. Second, building on the recent successes of approximate dynamic programming (ADP) for road-based applications, we present an ADP procedure to quickly generate good solutions to maritime inventory routing problems with a long planning horizon of up to 365 periods. For instances with many ports (customers) and many vessels, leading MIP solvers often require hours to produce good solutions even when the planning horizon is limited to 90 periods. Our approach requires minutes. Our algorithm operates by solving many small subproblems and, in so doing, collecting and learning information about how to produce better solutions. Our final research contribution is a polyhedral study of an optimization problem that was motivated by maritime inventory routing, but is applicable to a more general class of problems. Numerous planning models within the chemical, petroleum, and process industries involve coordinating the movement of raw materials in a distribution network so that they can be blended into final products. The uncapacitated fixed-charge transportation problem with blending (FCTPwB) that we study captures a core structure encountered in many of these environments. We model the FCTPwB as a mixed-integer linear program and derive two classes of facets, both exponential in size, for the convex hull of solutions for the problem with a single consumer and show that they can be separated in polynomial time. Finally, a computational study demonstrates that these classes of facets are effective in reducing the integrality gap and solution time for more general instances of the FCTPwB.

In this thesis, we propose novel optimization and spatial queueing models that expand the currently existing methods by allowing multiple servers to be located at the same station and multiple servers to be dispatched to a single call. In particular, a mixed integer linear programming (MILP) model is introduced that determines how to locate and dispatch ambulances such that the coverage level is maximized. The model allows multiple servers to be located at the same station and balances the workload among them while maintaining contiguous first priority response districts. We also propose an extension to the approximate Hypercube queueing model by allowing multi-server dispatches. Computational results suggest that both models are effective in optimizing and analyzing the emergency systems. We also introduce the M[G]/M/s/s queueing model as an extension to the M/M/s/s model which allows for multiple servers to be assigned to a single customer.

Les travaux de cette thèse sont les fruits de collaboration depuis 2008 entre l’ICL et le Centre Ingénierie et Santé (CIS) de l'Ecole des Mines de Saint Etienne. CIS et ICL sont tous deux membres de l'Institut Fédératif de Recherche en Science, Ingénierie et Santé (IFRESIS) et participent tous deux aux travaux du Cancéropôle Lyon Auvergne Rhône-Alpes (CLARA) dont Franck Chauvin animait l'axe IV sur Epidémiologie, SHS, Information du Patient et Organisation des Soins. Cette thèse a été initiée avec la volonté de développer une recherche originale sur l'optimisation de la production de soins en cancérologie.Nous nous intéressons à différentes problématiques de la gestion de soins des patients dans un hôpital de jour en cancérologie. Nous visons à équilibrer au mieux les besoins journaliers en lits tout en prenant en compte l'adhérence aux protocoles de soins, les contraintes des oncologues et les aléas des flux de patients. Pour un hôpital de jour en oncologie, nous avons identifié et étudié les décisions suivantes : I. Le planning médical une fois par an afin de déterminer les périodes de travail des oncologues dans une semaine. Nous avons proposé une formulation originale sous forme d'un modèle de programmation linéaire en nombres mixtes (MIP) et une approche en 3-étapes. II. L’affectation des nouveaux patients qui détermine le jour de la chimiothérapie pour chaque patient entrant. Nous avons présenté trois stratégies de planification et nous avons décrit un algorithme de simulation pour évaluer ces stratégies de planification. Les stratégies de planification proposées exploitent les informations contenues dans les protocoles de soins des patients et utilisent l’optimisation Monte Carlo III. La planification des rendez-vous. Nous avons présenté deux méthodes pour la résolution de ce problème : une approche basée sur la relaxation Lagrangienne et une heuristique basée sur une optimisation par recherche localeIV. La planification des jours fériés : permet de remédier au problème des semaines comportant des jours fériés. Nous avons développé un modèle en programmation linéaire en nombres mixtes permettant de répartir rapidement la charge du jour férié sur les jours en amont et en aval sans trop dégradé l’efficacité du traitement, ni surcharger le travail de l’HDJ. / This research is performed in close collaboration with the cancer center ICL. The « Institut de Cancérologie de la Loire » (Loire Cancer Institute), a.k.a. ICL, is a French public comprehensive cancer center providing oncology.This thesis addresses the problem of determining the work schedule, called medical planning, of oncologists for chemotherapy of oncology patients at ambulatory care units. A mixed integer programming (MIP) model is proposed for medical planning in order to best balance bed capacity requirements under capacity constraints of key resources such as beds and oncologists. The most salient feature of the MIP model is the explicit modeling of specific features of chemotherapy such as treatment protocols. The medical planning problem is proved to be NP-complete. A three-stage approach is proposed for determining good medical planning in reasonable computational time.

Sistemas dutoviários desempenham um papel fundamental na cadeia de suprimento da indústria de petróleo. Este tipo de sistema é responsável pelo transporte da maior parte do volume de petróleo e seus derivados. Sistemas de dutos transportam uma grande quantidade de diferentes tipos de petróleo e seus derivados a custo mais baixo que outros tipos de modais. Dutos interligam campos de produção de petróleo, portos, refinarias, centros de distribuição (ou depósitos), e mercado consumidor. O problema estudado neste trabalho é baseado em um sistema que é composto por uma refinaria que pode transferir vários produtos para um terminal (depósito) através de um único duto. Os produtos são conjuntos de derivados de petróleo que devem ser transferidos da refinaria para o terminal ou do terminal para a refinaria. Ambos, refinaria e terminal estão conectados a outras refinarias, terminais e mercados consumidores e com isto formam uma complexa rede de dutos. Por outro lado há um conjunto de demandas externas e internas. Esta última demanda decorre da necessidade de processamento de produtos intermediários que são misturas compostas de várias correntes intermediárias, tais como diluentes de óleos combustíveis, propano intermediário, e diesel intermediário. Com o objetivo de obter vantagens sobre a estrutura da rede de transporte, torna-se benéfica e mesmo necessária a operação do duto em ambas as direções para atender tanto à demanda externa quanto à interna. O objetivo deste trabalho é desenvolver um modelo matemático para a programação de um sistema de poliduto. A formulação para a programação deve considerar a possibilidade de trocar o sentido do poliduto. Neste contexto, a programação de um poliduto envolve decisões tais como sentido de operação, quantidade, temporização e seqüências de produtos, com objetivo de obter uma solução ótima, considerando todas as restrições de demanda, perfil de produção, estoques e custos. O modelo de programação é baseado em uma representação de tempo discreto e composto da área de tancagem da refinaria, um terminal, e um poliduto. Além disto o duto é dividido em segmentos de volumes iguais como em Rejowski Jr e Pinto (2003). As principais variáveis de decisão são a direção da movimentação do duto (da refinaria para terminal ou do terminal para refinaria) e o que está sendo movimentado a cada intervalo. Estas decisões são formuladas através de uma representação disjuntiva. As disjunções são transformadas em uma formulação baseada em programação matemática mista-inteira, a partir da representação Convex-hull. A função objetivo considera os custos de estocagem, movimentação e interface de produtos. O modelo é aplicado inicialmente a um caso protótipo e posteriormente aplicado a um sistema real composto pelos terminais de São Sebastião e Guararema e o poliduto OSPLAN. Neste caso ao todo quatro famílias de produtos são transportadas: gasolina, querosene, nafta e diesel. A programação é gerada para o período de uma semana. / Pipeline systems play a major role in the supply chain of the petroleum industry. These systems are responsible for the transportation of most of the crude oil and petroleum derivatives. Pipeline systems transfer large amounts of different petroleum types and their products at a lower cost than any other transportation mode. Pipelines interconnect oil fields, ports, refineries, distribution centers (or depots), and consumer markets. The problem addressed is this work is based on a system that is composed by an oil refinery that must transfer multiple products through a single pipeline connected to one depot. The products are a set of petroleum derivatives that must be either transported from the refinery to the depot or from the depot to the refinery. Both depot and refinery also connect other refineries as well as other depots and customers, thus forming a complex transportation network. On the other hand, there are several demands that arise either from external customers or from refineries. The latter demand is due from the need of processing intermediate streams with components mixtures such as diluents, propane and diesel. In order to take advantage of the structure of the transportation network, it becomes beneficial and even necessary to operate the pipeline in both directions so that internal and external demands are satisfied. The objective of this work is to develop a mathematical model for the short term scheduling of a multiproduct pipeline system. The scheduling formulation must account for the bidirectionality of the multiproduct pipeline. In this context, the scheduling a multiproduct pipeline involves the from-to decision, the product amounts, their sequence and timing, in the optimal sense, considering all constrains on demands, production rates, inventories, and costs. The scheduling model is based on a discrete time representation and is composed by one refinery tank farm, one depot and one multiproduct pipeline. Moreover, the pipeline is divided into segments of equal volume, as in Rejowski Jr and Pinto (2003). The main decisions variables are the directions of transfer (refinery to depot or depot to refinery) and the types of products at each time interval. These decisions are formulated with a disjunctive representation. The disjunctions are represented in mixed integer formulation based on the convex-hull approach. The objective function involves inventory, transfer and product interface costs. The model is first applied to a prototype case and after applied to a real-world system that is composed of the São Sebastião and Guararema depot and the OSPLAN pipeline. Overall four families of products are transported: gasoline, kerosene, naphtha and oil diesel. These are scheduled over a period of one week.

Neste trabalho, apresentamos um estudo sobre o problema de dimensionamento de lotes com múltiplas plantas, múltiplos itens e múltiplos períodos. As plantas têm capacidade de produção limitada e a fabricação de cada produto incorre em tempo e custo de preparação de máquina. Nosso objetivo é encontrar um plano de produção que satisfaça a demanda de todos os clientes, considerando que a soma dos custos de produção, de estoque, de transporte e de preparação de máquina seja a menor possível. Este trabalho tem duas contribuições centrais. Primeiramente, propomos a modelagem do problema de dimensionamento de lotes com múltiplas plantas utilizando o conceito de localização de facilidades. Para instâncias de pequena dimensão, os testes computacionais mostraram que a resolução do problema remodelado apresenta, como esperado, resultados melhores que o modelo original. No entanto, seu elevado número de restrições e de variáveis faz com que as instâncias de maiores magnitudes não consigam ser resolvidas. Para trabalhar com instâncias maiores, propomos um método híbrido (math-heurística), que combina o método relax-and-fix, com a restrição de local branching. Testes computacionais mostram que o método proposto apresenta soluções factíveis de boa qualidade para estas instâncias / In this work, we present a study about the multi-plant, multi-item, multi-period lot-sizing problem. The plants have limited capacity, and the production of each item implies in setup times and setup costs. Our objective is to find a production plan which satisfies the demand of every client, considering that the sum of the production, stocking, transport and setup costs is the lowest possible. This work has two main contributions. Firstly, we propose the multi-plant lot-sizing problem modeling using the facility location concept. For small dimension problems, computational tests showed that the remodeled problem resolution presents, as expected, better results than the original model. However, the great number of restrictions and variables make bigger instances to be intractable. To work with the bigger dimension instances, we propose a hybrid method (math-heuristic), which combines the relax-and-fix method and the local branching restriction. Computational tests show that the proposed math-heuristic presents good quality feasible solutions for these instances

A presente pesquisa aborda um problema de roteirização e programação de veículos incorporando uma nova restrição operacional: a requisição simultânea de múltiplos veículos para atendimento da demanda. Trata-se de uma característica encontrada em operações de apoio à exploração de petróleo \"offshore\", em que mais de uma embarcação é requerida para executar tarefas de reboque e lançamento de linhas de ancoragem. Esta imposição, somada às restrições de janela de tempo, precedência entre tarefas, autonomia das embarcações e atendimento integral da demanda, configuram este problema. A programação é orientada pela minimização dos custos variáveis da operação e dos custos associados ao nível de serviço no atendimento. Este problema é uma variação do problema clássico de roteirização e programação de veículos com janela de tempo, de classe NP-Difícil. Nesta pesquisa, propõe-se modelar e resolver o problema em escala real por meio do algoritmo \"branch and cut\" acoplado às heurísticas de busca em vizinhança \"local branching\" e \"variable neighborhood search\". Para gerar as soluções iniciais será empregado o método \"feasibility pump\" e uma heurística construtiva. / This research focuses a fleet scheduling problem with new operational constraints: each task requiring multiple types of vehicles simultaneously. This kind of operation occurs in offshore exploitation and production sites, when more than one vessel is needed to accomplish the tugging and mooring of oil platforms. Other constraints are maintained such as time windows, precedence between tasks, route duration and the demand attendance. The solution schedules are cost oriented, which encompasses the routing variable costs and the customer service costs. This is a variation of the classical fleet routing and scheduling, which is an NP-Hard problem. This research aims to solve the real scale problem through a combined use of branch and cut strategy with local search algorithms such as local branching and variable neighborhood search. An efficient heuristic rule will be used in order to generate initial solutions using the feasibility pump method.