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This thesis will revisit the debate between moral particularists and moral generalists in the field of meta-ethics. The general aim of this project will be to come to a better understanding of the status and role of moral principles in a reasons-holistic moral landscape. The specific aim will be to develop a viable position within the particularism-generalism debate that will combine elements from both theories. My central argument will be threefold: (a) I will argue that, in a reasons-holistic moral landscape, exceptionless moral principles are not sufficient to ground the possibility of moral thought and judgement; (b) that the possibility of moral thought and judgement depends in part on a determinate set of exceptionless moral principles and an indeterminate set of defeasible moral principles; and (c) that moral principles are insufficient to codify all or most moral truths in finite and manageable terms. My position therefore is a modified version of Principled Particularism. In this thesis, despite defending a version of particularism, I will not shy away from employing generalist terminology or from accepting certain generalist assumptions. Furthermore, unlike some particularists, I will stress the necessity and utility of moral principles. This thesis will also incorporate research about moral thought and judgement from the fields of moral psychology, cognitive science, and neuroscience.