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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

Conception et synthèse d'inhibiteurs de l'Aminopeptidase membranaire N ([EC. 3.4.11.2], APN ou CD13) / Conception and synthesis of inhibitors of Aminopeptidase membranar N ([EC. 3.4.11.2], APN or CD13)

Roux, Lionel 25 November 2010 (has links)
La lutte contre le cancer est l'un des défis majeurs du XXème siècle. Pour que les tumeurs puissent se développer dans l'organisme, elles ont besoin d'un apport en nutriment par le biais de vaisseaux sanguins pour se faire, elles vont avoir recours au processus angiogénique. Lors de ce processus, les cellules endothéliales qui tapissent la paroi des vaisseaux sanguins vont se multiplier et créer de nouveaux vaisseaux sanguins qui vont permettre la vascularisation des tumeurs. L'angiogenèse constitue donc aujourd'hui un axe de recherche pour la lutte contre la progression tumorale et donc contre le cancer. Lors de ce développement tumoral, une enzyme, l'aminopeptidase neutre APN est surexprimée sur les parois des cellules endothéliales. Différentes études ont été menées et montrent que l'inhibition de cette enzyme bloque la progression tumorale. Mon travail au sein de l'équipe du Pr Céline Tarnus consistait en la conception et la synthèse d'inhibiteurs de l'APN. Une relation structure activité de nos composés vis-à-vis de l'APN a tout d'abord été effectuée. Le développement de synthèse du composé le plus actif ont été faite, puis la synthèse d'inhibiteurs d'APN ayant pour objectif l'utilisation de la BNCT a été abordée. / The fight against the cancer is one of the most important struggles of this century. For the development of the tumors inside the body, they need to receive nutriments by the blood vessels and they use the angiogenic process. During this process, the endothelial cells being shown on the wall of the blood vessel will multiply and design new blood vessel, which will allow the tumor's vascularisation. Today, the angiogenesis is an axis of research for the fight against the cancer. During the tumoral development, the aminopeptidase N (APN) is overexpressed on the wall of endothelial cells. Various studies have shown that the inhibition of this enzyme stops the tumoral progression. My work in the Pr. Céline Tarnus Team consists in the conception and the synthesis of APN's inhibitors. In a first time, a structure activity relationship has been realized. Syntheses of a subnamolar compound have been developed, and then the synthesis of APN's inhibitors with the use of BNCT has been got onto.
22

Platinum(II) complexes containing 1,2- and 1,7-carborane ligands for boron neutron capture therapy

Todd, Jean Ann. January 2001 (has links) (PDF)
Bibliography: leaves 178-195.
23

Platinum(II) complexes containing 1,2- and 1,7-carborane ligands for boron neutron capture therapy / by Jean Ann Todd.

Todd, Jean Ann January 2001 (has links)
Bibliography: leaves 178-195. / xiv, 195 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 2001
24

Multinuclear platinum (II) complexes containing carboranes for potential use in boron neutron capture therapy / by Susan Louise Woodhouse.

Woodhouse, Susan Louise January 2004 (has links)
"January 2004" / Bibliography: leaves 163-184. / v, 184 leaves : ill. (some col.), photos ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, School of Chemistry and Physics, Discipline of Chemistry, 2004
25

Optimized accelerator based epithermal neutron beams for boron neutron capture therapy /

Kudchadker, Rajat, January 1996 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 1996. / Typescript. Vita. Includes bibliographical references (leaves 146-151). Also available on the Internet.
26

Optimized accelerator based epithermal neutron beams for boron neutron capture therapy

Kudchadker, Rajat, January 1996 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 1996. / Typescript. Vita. Includes bibliographical references (leaves 146-151). Also available on the Internet.
27

Pharmacokinetics and biodistribution of boron compounds foundations for boron neutron capture theory /

Ceberg, Crister. January 1994 (has links)
Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.
28

Pharmacokinetics and biodistribution of boron compounds foundations for boron neutron capture theory /

Ceberg, Crister. January 1994 (has links)
Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.
29

Targeting CD37 and folate receptor for cancer therapy strategies based on engineered protein and liposomes /

Zhao, Xiaobin. January 2007 (has links)
Thesis (Ph. D.)--Ohio State University, 2007. / Full text release at OhioLINK's ETD Center delayed at author's request
30

Avaliacao dosimetrica da solucao fricke gel usando a tecnica de espectrofotometria para aplicacao na dosimetria de eletrons e neutrons / Dosimetric evaluation of the fricke gel dosimeter using the spectrophotometric technique for application in electron and neutron dosimetry

MANGUEIRA, THYAGO F. 09 October 2014 (has links)
Made available in DSpace on 2014-10-09T12:26:53Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:00:05Z (GMT). No. of bitstreams: 0 / Dissertacao (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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