Enligt forskning är ständiga förbättringar ett väsentligt element i olika kvalitetsledningssystem, medan arbete med ständiga förbättringar i organisationer har undersökts vara ofta för begränsat i omfattning och svårt att hålla igång. Därmed var syftet med denna studie att bidra med kunskap om hur organisationer kan arbeta för att hålla ständiga förbättringar igång. Det empiriska materialet samlades in med kvalitativa, halvstrukturerade intervjuer av sju ledare som representerar till-verkande företag antingen i Sverige eller i Finland. Dessa företag har tagit i bruk Lean management och arbetar med ständiga förbättringar framgångsrikt. Resultatet visade att de studerade organisationerna har sina unika sätt att arbeta med och hålla igång ständiga förbättringar, även om det finns likheter. Enligt de studerade organisationerna gällde de mest viktiga faktorer som möjliggör att hålla igång ständiga förbättringar ledarskap, ledaregenskaper och strategisk planering; processer, arbetssätt och verktyg; samt arbetsmiljö och kultur. Kritiskt för att hålla igång ständiga förbättringar är att ledare prioriterar ständiga förbättringar och visar sig prioriteten på flera olika sätt, visade resultatet. Engagemang för ständiga förbättringar på lång sikt är nödvändigt och kan tränas upp. Medan viktigt för ständiga förbättringar är att alla arbetar med gemensamma praktiker, viktigt för att hålla igång ständiga förbättringar är att engagera medarbetare i att använda sina kompetenser till att utveckla dessa praktiker. Det finns olikheter i hur de studerade organisationerna ser att deras arbete med ständiga förbättringar skulle se ut om de hade de bästa möjligheterna att arbeta med ständiga förbättringar. Här hittades det också dock några liknande teman. I studien drogs slutsatsen att ständiga förbättringar har anpassats efter behoven och omständigheterna i organisationerna. Att utveckla praktiker själv är ett medel för att överföra principer som stödjer ständiga förbättringar i handling och att utveckla kulturen gentemot dessa värderingar och principer. För ett framgångsrikt arbete med att hålla igång ständiga förbättringar är det viktigt att utforma och utveckla strukturer och praktiker i anslutning till organisationens strategiska objektiv så att man beaktar organisationens kontext. / According to research, continuous improvement is an essential element of different quality management systems, while work with continuous improvement in organizations has been studied to be frequently too limited in scope and difficult to sustain. Therefore, the purpose of this study was to contribute with knowledge on how organizations can work to sustain continuous improvement.   The empirical data was collected through qualitative, semi-structured interviews of seven leaders representing manufacturing companies either in Sweden or in Finland. The companies have adopted Lean management and work with continuous improvement successfully.   The results showed that the studied organizations have their unique ways of working with and sustaining continuous improvement, even though there are similarities. According to the studied organizations, the most important factors that enable sustaining continuous improvement were related to leadership, leadership attributes, and strategic planning; processes, techniques, and tools; as well as working environment and culture. The results showed that critical for sustaining continuous improvement are leaders prioritizing continuous improvement and manifesting the priority through several ways. Commitment to continuous improvement in the long term is vital and can be trained. While everyone working along with shared practices is important for continuous improvement, involving employees to use their capabilities to develop these practices supports sustaining continuous improvement. The studied organizations have differences in how they see that their work with continuous improvement would look like if they had the best opportunities to work with continuous improvement, even though some similar themes were found. The study concluded that continuous improvement has been adapted to the needs and situations of the organizations. Self-developed practices are means of putting the principles supporting continuous improvement into practice and developing the culture towards the values and principles. For a successful work with sustaining continuous improvement, it is important to build and form structures and practices in alignment with the strategic objectives of the organization, taking into account the organizational context. / <p>2018-06-27</p>

L'Agence Nationale de la Recherche, créée en 2005, contribue à rapprocher le système de recherche français du modèle anglo-saxon, dans lequel les agences de financement jouent un rôle déterminant dans la conduite des politiques scientifiques. À partir d'une enquête sur l'agence et de l’étude des programmes de financement en génomique végétale et en chimie durable, cette thèse analyse le rôle de l'ANR dans la transformation du mode d'allocation des financements. Elle s’appuie sur des données issues d'entretiens auprès de chercheurs, d’un traitement statistique des projets déposés et de l'analyse de sources primaires et secondaires sur l’activité de l'ANR. Nous montrons notamment que l'ANR constitue une organisation intermédiaire partiellement autonome dont le métier a considérablement évolué depuis sa création en 2005. La carrière de l'agence témoigne des luttes de définition dont elle fait l'objet. Le gouvernement par projet pratiqué par l'ANR a contribué à généraliser la pratique des appels à projets compétitifs en France, qui favorise la différenciation des situations locales, la fragmentation des communautés de recherche et le changement du rapport des chercheurs aux financements. Plus généralement, nous montrons que la multiplication des appels à projets compétitifs conduit à établir ce que nous qualifions une économie de la recherche sur projets. Dans une telle économie, l'enjeu central pour les chercheurs devient le contrôle de la traduction des activités de recherche locales sous la forme générique de « projet » afin de mener leur activité. / The National Research Agency (ANR) created in 2005 brings the French research system closer to Anglo-saxon ones, where funding agencies play an important part in research policies. Based on an investigation of the ANR and two funding programs in plant genomics and green chemistry, this dissertation shows the significant role played by the ANR in the transformation of funding allocation in France. It contributes both to sociology of science policies and to sociology of organisations. We use data from interviews with researchers, statistical analysis of submitted projects and various reports and media contents. We show that the ANR is an intermediate and semi-autonomous organisation whose aims have significantly evolved since its creation in 2005. The definition of its missions has been a continuous object of struggles which can be seen in the « career » of the agency. Because the ANR mainly « governs through projects », its activities led to the multiplication of competitive calls for projects in France. Some of the consequences are the singularisation of local situations, the scattering of research communities and a change in how researchers behave regarding fundings. More broadly, we show that the multiplication of competitive project funding opportunities leads to an « economy of projectified research ». In this type of economy, the main issue for researchers is to control the way their research is converted into « project » in order to be funded.

The rapid growth of universities in the Least Developing Countries (LDCs) is aimed at enhancing access to tertiary education, which has resulted in a sharp increase in the enrolment rate. However, the quantitative increase has been marred with a correspondingly continuous decline in the quality of education. This is attributed to a wide range of limiting factors mainly classified as institutional problems. Some of these problems include a shortage of resources, limited skills and incompetent human capital, lack of ICT infrastructure, and the ineffective use of existing ICT resources. These problems and others have adversely affected how national education and research network can improve research output and quality of education. In this study, a survey, in the form of an exploratory quantitative research design is used. A descriptive non-experimental quantitative approach was also chosen, and a questionnaire was administered to approximately one hundred and seventy-two (172) participants drawn from twenty-nine (29) Ethiopian Public Universities. The results of the analysis show that the study variables namely NREN service for education, EthERNet, electronic device and research output have a significant and positive impact on the Quality of Education (QE) to differing degrees. Also, the study variables such as NREN service for research, high-performance computing, and remote computing facilities indicated that they had a significant and positive impact on Research Output (RO) to differing degrees. The study explored the impact of EthERNet in improving the quality of education and research output by examining the existing network infrastructure and NREN services. The study employed the use of the Actor-Network Theory (ANT) to assess the existing network infrastructure and NREN services to determine that a reliable network can improve the quality of education and research output. Besides, Structural Equation Model (SEM) was used to identify the positive and negative factors that impact on the roles, relationships, and formation of quality of education and research output. Furthermore, a three-step design science approach was applied to propose and justify the theoretical framework, which is used as a base to develop a service portfolio and roadmap conceived to design the required NREN service for EthERNet. This research contributed to the body of knowledge by finding the missing link between the quality of education and research outputs. From a theoretical perspective, the research contributed a theoretical framework by developing the construct and their measures that can be used in assessing the adoption and usage of technology. Furthermore, the study contributes to the literature by demonstrating an analytical process which could be used as a guide for future NREN service requirement to improve the quality of education and research output with the existing findings being used as a reference point. / School of Computing / Ph. D. (Computer Science)

>Magister Scientiae - MSc / Electrochemiluminescence (EeL) is applied for industrial applications that have considerable potential, such as clinical diagnostic, analytical chemistry, and light-emitting devices, due to selectivity, sensitivity for detection and quantification of molecules through generation of fluorescence light when electric current is applied on the materials. In EeL the electrochemical reaction allows for precise control over the time and position of the light emitting reaction. The control over time allows one to synchronise the luminescence and the biochemical reaction under study and control over position not only improves sensitivity of the instrument by increasing the signal to noise ratio, but also allows multiple analytical reactions in the same sample to be analyzed using an electrode array. The EeL generation fluorescent materials are based on inorganic semiconductor materials for light-emitting devices. Further progress in this EeL field mainly depends on discovery of new advanced materials, interfacial films and nanoparticle coatings, advances in microfluidics leading to total increase in EeL properties. There has been extensive use of polymers for enhancement of EeL properties. Electrochemiluminescent conjugated polymers constitute a new class of fluorescent polymers that emit light when excited by the flow of an electric current. These new generation fluorescent materials may now challenge the domination by inorganic semiconductor materials for the commercial market of light-emitting devices such as lightemitting diodes and polymer laser devices (PLDs).

Philosophiae Doctor - PhD / This chapter outlines basic gene structure and how gene structure is related to promoter structure in both prokaryotes and eukaryotes and their transcription machinery. An in-depth discussion is given on variations types of the promoters among both prokaryotes and eukaryotes and as well as among three prokaryotic organisms namely, E.coli, B.subtilis and Mycobacteria with emphasis on Mituberculosis. The simplest definition that can be given for a promoter is: It is a segment of Deoxyribonucleic Acid (DNA) sequence located upstream of the 5' end of the gene where the RNA Polymerase enzyme binds prior to transcription (synthesis of RNA chain representative of one strand of the duplex DNA). However, promoters are more complex than defined above. For example, not all sequences upstream of genes can function as promoters even though they may have features similar to some known promoters (from section 1.2). Promoters are therefore specific sections of DNA sequences that are also recognized by specific proteins and therefore differ from other sections of DNA sequences that are transcribed or translated. The information for directing RNA polymerase to the promoter has to be in section of DNA sequence defining the promoter region. Transcription in prokaryotes is initiated when the enzyme RNA polymerase forms a complex with sigma factors at the promoter site. Before transcription, RNA polymerase must form a tight complex with the sigma/transcription factor(s) (figure 1.1). The 'tight complex' is then converted into an 'open complex' by melting of a short region of DNA within the sequence involved in the complex formation. The final step in transcription initiation involves joining of first two nucleotides in a phosphodiester linkage (nascent RNA) followed by the release of sigma/transcription factors. RNA polymerase then continues with the transcription by making a transition from initiation to elongation of the nascent transcript.

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The Institute of Medicine (IOM) and National Research Council (NRC) established guidelines for weight gain during pregnancy to maximize positive health outcomes for mothers and their offspring. However, in the US, about half of all pregnant women exceed these recommendations. Excessive weight gain during pregnancy is associated with various negative outcome for mothers and their children. Research in recent years has begun to explore the relationship between both diet quality and ultra-processed food (UPF) intake during pregnancy with gestational weight gain (GWG). However, research is scarce, especially pertaining to UPF intake and GWG. Additionally, there is no research which explores these relationships among Latina women living within the US. The purpose of this study is to explore the relationships between prenatal diet quality, measured with the Healthy Eating Index-2020 (HEI), and intake of UPF, based on the Nova classification system, with the adequacy of GWG among a predominantly Latina sample of adult pregnant women living within the US. Additionally, the association between social determinants of health with diet quality and with UPF intake were also explored. The study is a secondary-data analysis of data from a longitudinal study. The sample analyzed includes 118 pregnant women between the ages of 18-45 years old (mean = 29.9, SD = 6.1). Mean pre-pregnancy body mass index (pBMI) for the total sample was 25.8 kg/m2 (overweight). 67% of the sample identified as Hispanic/Latina. Overall, 22% of the sample were classified with inadequate GWG; 17% with adequate GWG; and 61% with excessive GWG. The mean total HEI score for the sample was 54.1 out of 100, where higher scores reflect higher diet quality and adherence to the Dietary Guidelines for Americans. There was a statistically significant difference across GWG groups (inadequate/adequate/excessive) in mean total HEI scores (p < .05). The adequate GWG group had the highest total HEI scores and the excessive GWG group had the lowest total HEI scores. Variables that were found to be univariately associated with excessive gestational weight gain included: average total HEI score, pBMI, ethnicity; education; and income (p < .05). A 1-point increase in mean total HEI scores was associated with a 5% lower chance of excessive GWG (p = .02). However, after adjustment for covariates (maternal age; pBMI; income; education; race and ethnicity), the association between average total HEI score and excessive gestational weight gain was attenuated and no longer statistically significant. There was a statistically significant difference across GWG groups (inadequate, adequate, or excessive) in their scores of two HEI components: Greens and Beans (p < .01); and Seafood and Plant Proteins (p < .01). The adequate GWG group had the highest scores and the excessive GWG group had the lowest scores in these HEI components. In simple logistic regressions of excessive GWG versus adequate GWG on HEI components, the Greens and Beans scores and the Seafood and Plant Protein scores were significantly associated with excessive GWG. After adjustment, the Greens and Beans scores and Seafood and Plant Proteins scores indicated strong estimated negative associations with excessive GWG, OR = 0.61, 〖 χ〗_1^2= 8.07, p < 0.01 and OR = 0.60, 〖 χ〗_1^2= 7.84, p < 0.01, respectively. A higher score on these components was associated with a lower risk of excessive GWG. The mean percentage of energy intake from ultra-processed foods (PEI-UPF) was 51.2%. There was no statistically significant difference in the PEI-UPF across GWG groups (inadequate, adequate, or excessive) and the PEI-UPF was not associated with odds of excessive GWG. However, the adequate GWG group had the lowest intake of PEI-UPF (49.2%) and the excessive GWG group had the highest intake of PEI-UPF (52.1%). Social determinants of health were not associated with the mean PEI-UPF, but results suggested a positive relationship between social support and total HEI scores (p = .08). Deeper analysis of the social support measure revealed a statistically significant relationship between the appraisal subscale of social support and HEI scores, Β = 0.13, F(1, 102) = 7.11 (p = 0.009). Overall, dietary intake during pregnancy may influence the adequacy of gestational weight gain. Achieving recommended intake of greens and beans, as well as seafood and plant proteins, may play a particularly important role in reducing the risk for excessive gestational weight gain. In addition, greater levels of social support, particularly access to another person who can offer advice and guidance with personal problems, may enhance diet quality during pregnancy.

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Student: Terezie Poláková Supervisor of master thesis: PharmDr. Miroslav Kovařík, Ph.D. Title of master thesis: Assessment of energy metabolism in patients with chronic obstructive pulmonary disease. Chronic obstructive pulmonary disease (COPD) is the name for lung disease with systemic consequences. Besides the respiratory symptoms there are also described changes in body metabolism, which could lead to the development of serious metabolic syndrome called cachexia. The main aim of this study was to compare the resting energy expenditure (REE) and nutrition substrate utilization in 12 patients with advanced form of COPD from the Czech Multicentre Research Database of COPD (5 females and 7 males, mean age 68 ± 6 years) and in 9 patients of control group without respiratory impairment (5 females and 4 males, 62 ± 4 years). Assessment of body metabolism was determined by method of indirect calorimetry. Measured REE was then compared with prediction based on Harris-Benedict equation. The utilization of main nutrition substrates was determined from the respiratory quotient and urea nitrogen loss in urine. We found that measured REE in COPD patients was about 20 % higher than in control group....

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Student: Magdaléna Doleželová Supervisor of master thesis: PharmDr. Miroslav Kovařík, Ph.D. Title of master thesis: Body composition parameters in dependence on the metabolism degrese in patiens with COPD Chronic Obstructive Pulmonary Disease (COPD) is a very serious illness characterized by incompletely reversible airflow obstruction and lung emphysema. Contributes to its overall severity are extrapulmonary manifestations, especially cachexia and loss of lean tissue mass. Chronic inflammation of the respiratory airways and increased respiratory effort cause the hypermetabolic state to some patients with COPD. This thesis investigates the impact of increased metabolism on body composition in patients with COPD. Our study included 50 COPD patients (38 men, 12 women) who were examined by bioelectrical impedance. In this study, we compared the parameters of body composition of men with resting energy expenditure REE > 130% (hereinafter Men over 130%) (n = 9) and the group of men with REE < 130 % (hereinafter Men below 130 %) (n = 29). In the group of Men over 130 % we found a lower average value of body weight by 18 % compared to Men below 130 %. Total body and intracellular water were 12 %...

The Great Recession that followed the financial crisis of 2008 had a devastating impact on workers, leading to high levels of unemployment and underemployment, increased job insecurity and stagnant or declining wages. While the legitimation crisis of neoliberalism could be viewed as a turning point for labour internationally, the immediate response by political parties across the spectrum was one of austerity measures and cuts to welfare. As the largest collective representatives of workers, trade unions are at the forefront of mobilisations attempting to challenge this consensus. Simultaneously, they are engaging in new activities to enhance public awareness and understanding of the crucial role that trade unions play in the labour market. Thus, the 21st century crisis is creating both challenges and opportunities. Each trade union movement’s response depends on the different forms of power they possess and choose to deploy, their strategies and allegiances, and the specific socio-economic and political context in which they are situated. Questions concerning what constitutes union power and the ways in which it is being exercised and revitalized therefore represent fascinating lines of enquiry to explore. To do so, however, requires a new perspective on trade union power that recognises the significance of the media which has been overlooked in industrial relations theory. Drawing on insights from industrial relations, the sociology of media and social movement studies, this thesis proposes the concept of communicative power to trace how trade unions produce and circulate discourse through the media (either union-owned or corporate) to a mass audience. Methodologically, it uses the tripartite approach which focuses our attention onto three key communication processes involved in trade union attempts to exercise communicative power: the production of union discourse, the circulation of union discourse, and the reception of union discourse. This is applied to four cases involving seven union organisations in the UK and Denmark over a five-year period 2010-2015. Data was gathered using 40 semi-structured interviews with union officials and activists, content analysis of newspapers, union media outlets and social media, and secondary survey data. In sum, this thesis argues that the media is, and always has been, central to how trade unions exercise and revitalize power in society. And within the context of accelerating digital capitalism, it looks set to becoming an increasingly important determinant of their future trajectory.