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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Tumor recognition by cytotoxic T cells : definition of new tumor antigens and the effect of interleukin-10 on antigen presentation /

Salazar-Onfray, Flavio, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 8 uppsatser.
2

Impulszytophotometrische DNS-Messungen an menschlichen Tumoren Vergleich von Ergebnissen, Aussagefähigkeit und Fehlern verschiedener Methoden /

Roters, Michael, January 1977 (has links)
Thesis (doctoral)--Universität Hamburg, 1977.
3

FISETIN, A FLAVONOID, INDUCES CELL CYCLE ARREST AND APOPTOSIS IN HUMAN BREAST CANCER CELLS

Smith, Matthew Laun 18 August 2011 (has links)
Significant morbidity and mortality continues to be associated with breast cancer and its treatments. Fisetin, a phytochemical that is present in many fruits and vegetables, has demonstrated anticancer activity. My research explores fisetin as a possible novel therapeutic modality for breast cancer. Breast cancer cell lines (MDA-MB-468, MDA- MB-231, MCF-7, T47-D, SKBR-3; mitoxantrone-resistant (MITX) and paclitaxel- resistant (Tx400) cell lines) were exposed to fisetin and cell survival was assessed by MTT, crystal violet, acid phosphatase, and colony-forming assays. Normal cells (human mammary epithelial cells, fibroblasts, human umbilical vein endothelial cells) were used as negative controls. The mechanism of action of fisetin was explored using cell cycle analysis and assays for apoptosis/necrosis, including Annexin V-propidium iodide staining and LDH-release. Apoptosis induction pathways were studied using Western blotting, as well as caspase inhibitors and cell viability assays. Flow cytometry was used to assess mitochondrial membrane stability (DiOC6 staining) and reactive oxygen species (ROS) production (dihydroethidium staining). Fisetin had a dose- and time-dependent cytotoxic effect on breast cancer cell lines (e.g., 100 ?M fisetin decreased MDA-MB-468 cell number by 70% at 72h in both crystal violet and acid phosphatase assays). In contrast, the viability of normal cells was not substantially affected by concentrations of fisetin that killed breast cancer cells. Fisetin-treated breast cancer cells showed cell cycle arrest (MDA-MB-468 cells arrested at G2/M phase; MDA-MB-231 cells arrested in S- phase) and death by apoptosis (e.g., MDA-MB-468 cells showed up to 50% apoptosis and 8% late apoptosis/necrosis by Annexin V-staining; cell cycle analysis and LDH- release assays supported these results). Fisetin-induced apoptosis was associated with mitochondrial membrane permeabilization, as well as activation of the caspase cascade since the pro-apoptotic effect of fisetin was reduced in the presence of a pan-caspase inhibitor. In addition, fisetin did not cause ROS production in MDA-MB-468 or 231 cells, ruling out a role for ROS in fisetin-mediated cytotoxicity. My findings suggest that fisetin may be useful in the treatment of breast cancer.
4

An investigation into the role of p53 and NF-kB in the survival of neuroblastoma cells following cytotoxic treatment

Nelson, Barry January 2003 (has links)
No description available.
5

Predicting local recurrence following breast conserving therapy for early stage breast cancer : the significance of a narrow (less than or equal to 2mm) surgical resection margin

Groot, Gary 25 August 2011
Introduction Controversy continues over the extent of surgical resection margin required to minimize the risk of local recurrence (LR) in breast conserving therapy (BCT) for stage I and II breast cancer. This thesis explores whether or not a narrow (less than or equal to 2 mm) but negative resection margin in BCT for stage I and II breast cancer affects LR. Methodology To address the question, all patients registered at the Saskatoon Cancer Center between January 1, 1991 and December 31, 2000 with a diagnosis of stage I or II invasive duct carcinoma of the breast treated with BCT were examined. All charts and pathology reports were reviewed with a review of the pathology for all cases where the resection margin was unclear in the original report. Other factors know or thought to effect LR (age, radiation boost, grade, extensive duct carcinoma in situ, ER/PR receptor status, tumor size, and systemic adjuvant therapy) were considered in the statistical analysis. Results Amongst the 200 narrow margin cases 19 LR were detected (19/200=9.5%) while 52 LR were detected in the 491 wide margin cases (52/491=10.6%). This difference was not statistically significant. Conclusions A narrow (less than or equal to 2 mm) surgical resection margin does not result in an increase in local recurrence compared to a surgical resection margin greater than 2 mm in breast conserving therapy for early stage duct carcinoma and does not warrant re-excision.
6

Predicting local recurrence following breast conserving therapy for early stage breast cancer : the significance of a narrow (less than or equal to 2mm) surgical resection margin

Groot, Gary 25 August 2011 (has links)
Introduction Controversy continues over the extent of surgical resection margin required to minimize the risk of local recurrence (LR) in breast conserving therapy (BCT) for stage I and II breast cancer. This thesis explores whether or not a narrow (less than or equal to 2 mm) but negative resection margin in BCT for stage I and II breast cancer affects LR. Methodology To address the question, all patients registered at the Saskatoon Cancer Center between January 1, 1991 and December 31, 2000 with a diagnosis of stage I or II invasive duct carcinoma of the breast treated with BCT were examined. All charts and pathology reports were reviewed with a review of the pathology for all cases where the resection margin was unclear in the original report. Other factors know or thought to effect LR (age, radiation boost, grade, extensive duct carcinoma in situ, ER/PR receptor status, tumor size, and systemic adjuvant therapy) were considered in the statistical analysis. Results Amongst the 200 narrow margin cases 19 LR were detected (19/200=9.5%) while 52 LR were detected in the 491 wide margin cases (52/491=10.6%). This difference was not statistically significant. Conclusions A narrow (less than or equal to 2 mm) surgical resection margin does not result in an increase in local recurrence compared to a surgical resection margin greater than 2 mm in breast conserving therapy for early stage duct carcinoma and does not warrant re-excision.
7

Estudo demográfico e aspectos psicológicos de pacientes sob rastreamento de carcinoma prostático / Demographic study and psychological aspects of patients under prostate cancer screening

Naccarato, Angela Maria Elizabeth Piccolotto, 1955- 16 August 2018 (has links)
Orientadores: Fernandes Denardi, Wagner Eduardo Matheus / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-16T00:00:51Z (GMT). No. of bitstreams: 1 Naccarato_AngelaMariaElizabethPiccolotto_M.pdf: 3567933 bytes, checksum: bf53ae2ff5454c30b3dd914c045af6a8 (MD5) Previous issue date: 2010 / Resumo: Introdução: O câncer de próstata (CaP) é a segunda causa de morte em homens, estudos recentes tem confirmado a eficácia do toque retal (TR) e seus benefícios no diagnóstico precoce. Objetivo: Avaliar aspectos demográficos e psicológicos de homens submetidos ao TR durante consulta para rastreamento do CaP. Pacientes e Métodos: Estudo realizado com 345 pacientes submetidos ao TR pela primeira vez entre Fevereiro 2006 a Dezembro 2007, que foram avaliados quanto às impressões sobre o TR. Dados sobre etnia, idade, escolaridade, profissão e as motivações para o rastreamento foram colhidos e a correlação entre variáveis descritivas e aspectos psicológicos dos pacientes foi realizada. Resultados: A média de idade foi de 52.8 anos. Sentiram medo 40.94% (sendo medo do exame 15.94% e medo do diagnóstico 25%), vergonha 26.45% e 48.26% referiram não pensar em nada. A correlação entre faixa etária, nível de escolaridade e reações emocionais não apresentou diferença significativa. 52.35% consideraram o exame melhor do que imaginavam, dos quais 41.81% eram analfabetos/1º grau incompleto, 4.12% uma experiência ruim e 96.8% fariam o teste novamente. O convencimento em se consultar foi em 50.14% por decisão própria, 26,67% encaminhados por médicos, 18,55% pela esposa, 7,83% por familiares ou amigos, 6,67% através da mídia e 24.06% tiveram consulta marcada pelas parceiras. Embora 85,47% soubessem da importância do exame, 80,81% consideram-se mais esclarecidos após a consulta. A falta de informação sobre o exame foi mais freqüente dentre os pacientes de menor escolaridade e 52.38% com decisão própria em se consultar tinham conhecimento prévio à consulta sobre a importância do exame. Conclusão: Medo e vergonha frente ao TR desempenham papel significativo na resistência ao se submeter ao exame, porem a maioria absoluta dos pacientes achou menos desagradável do que imaginava e repetirá o exame futuramente / Abstract: Introduction: Prostate cancer (PCa) is the second leading cause of death in men. Recent studies have confirmed the effectiveness of the digital rectal examination (DRE) in early diagnosis. Aim: To evaluate the psychological and demographic aspects of men who received DRE during the PCa screening in an outpatient clinical setting. Patients and Methods: Patients (345) who underwent DRE for the first time from February 2006 to December 2007 were evaluated for their psychological reactions and feelings after the examination. Data on age, race, education, profession and the motivations for the screening were gathered. Correlation of descriptive and psychological aspects of patients under PCa screening was done. Results: The average age of the patients was 52.8 years; 40.94% had felt fear (examination fear 15.94%, and diagnosis fear 25%), 26.45% shame and 48.26% indicated they were not thinking about anything. There was no correlation between age, educational level and emotional reactions. Most patients (96.8%) would undergo a DRE again and 52.35% had considered it better than they had imagined. Of these patients, 41.81% were illiterate/incomplete elementary school. Only 4.12% described having a negative experience. The factors that persuade the patient to book an appointment were: 50.1% made their own decision, 26.67% were recommended by a physician, 18.55% family/friends and 6.67% were influenced by the media. Wives booked 24.06% of the consultations. Although 85.47% of patients had some previous knowledge about the examination, 80.81% felt they had further clarification afterward. Lower educational level was related to lack of information about DRE, while 52.38% who made their own decision had previous knowledge of the importance of DRE. Emotional aspects and access to information play significant roles in the decision to undergo PCa screening and must be considered in educational campaigns. Conclusion: The majority of the patients found DRE less awkward than what they had imagined it to be and would repeat the examination in the future. Fear and shame before the examination are baseless, but are a barrier to the DRE / Mestrado / Pesquisa Experimental / Mestre em Cirurgia
8

Molecular and functional characterization of a novel ring-H2 finger protein, ANAPC11, the anaphase-promoting complex subunit 11. / CUHK electronic theses & dissertations collection

January 2003 (has links)
by Chan Hei. / "July 2003." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2003. / Includes bibliographical references (p. 235-247). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.
9

The Use of health promotion to increase the uptake of cervical cancer screening program in Nyangabgwe Hospital, Botswana

Okore, Ogbonnaya January 2011 (has links)
Thesis (MPH)--University of Limpopo (Medunsa Campus), 2011. / BACKGROUND: In Botswana, cervical cancer is the most common cancer among women (18), and the Southern Africa regional prevalence rate of cervical cancer is 15.5% (25). In Nyangabgwe Referral Hospital, cervical cancer is the most common malignancy admitted in the gynecology ward, contributing 73% and 78% of all malignancy admissions in 2007 and 2008 respectively. It is estimated that 200,000 to 300,000 women die from cervical cancer every year, mostly in poor countries (1). The study intends to create more awareness on the importance cervical cancer screening in Nyangabgwe Referral Hospital and catchment areas. Purpose: The purpose of the study is to improve the uptake of cervical cancer screening by integrating a health promotion component to the standard program. Methods: The study was an interventional quantitative research. Two populations were selected for the study namely women attending Nyangabgwe Referral Hospital and the clinics in Francistown (the research group) and women attending Princess Marina Hospital (the control group). The population of women attending Nyangabgwe Referral Hospital was exposed to health promotion. The second population of women attending Princess Marina Hospital was unexposed to the health promotion intervention. A pre-test quantitative trend of cervical cancer screening patterns was collected from June to September 2009 in the health facilities before the intervention from October 2009 to January 2010. Intervention was conducted in the study sites and was followed by a post - test quantitative measure of cervical cancer screening trends in both the research group and the control groups. Instruments for the health promotion were; flyers with translations in English and Setswana given to participants, posters which were posted at various strategic positions in the hospital and as well as in female wards. The population of study was all women attending Nyangabgwe Referral Hospital and its catchment clinics (the study site). Interactive health education sessions were provided to the population. Questionnaires which had Setswana translation were administered to respondents who were screened for cervical cancer in the study and control sites. Results: The analysis of finding revealed that the total uptake of Pap smear test was higher during the period of intervention than in the pre-intervention period in all the sites and for all the age groups. Among the health promotion activities, the effect of health education talks in the hospital and clinics was greater (67%), than the effects of flyer or pamphlets (35%) and posters in hospitals and clinics (17%) in escalating uptakes of cervical cancer screening services. Conclusions: The standard cervical cancer screening program alone as designed and executed by health care workers is not enough to stimulate the desired response of increase access to cervical cancer screening services, because many women usually are left out. Recommendations: The study results call for the need of instituting a visible and accountable comprehensive health promotion component to the standard cervical cancer screening program in order to sustain a steady cervical cancer screening uptake that will result in the expected decline in morbidity and mortality due to cervical cancer disease.
10

Early Prevention and Screening of Cervical Cancer in a Developing Country

Carvallo Michelena, Alvaro, Rojas Dominguez, Jorge Luis, Piscoya, Alejandro 27 February 2015 (has links)
Cartas al editor

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