This thesis presents two experimental microelectronic prototypes for neurophysiological applications. Both systems target diagnostics and treatment of neurological disorders, and they are experimentally validated in vivo by online intracranial EEG recording in freely moving rats. The first prototype is a 56-channel chopper-stabilized low-noise neural recording interface IC with programmable mixed-signal DC cancellation feedback, fabricated in a 0.13μm CMOS process. Each recording channel has a low-noise fully-differential amplifier, and a digital integrator and a delta-sigma DAC in the feedback to cancel DC offsets of up to ±50mV. Chopper stabilization technique is used to reduce the amplifier flicker noise. The recorded signals are digitized by 7 column-parallel SAR ADCs. The second prototype is a compact headset for multi-site neuromonitoring and neurostimulation in rodent brain. A stack of 2 mini-PCBs was designed and experimentally validated. It includes a previously fabricated 0.35μm CMOS recording and stimulation IC, a low-power FPGA, and the IC peripherals.

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This thesis is concerned with the use of neural networks for motor control tasks. The main goal of the thesis is to investigate ways in which the biological notions of motor programs and Central Pattern Generators (CPGs) may be implemented in a neural network framework. Biological CPGs can be seen as components within a larger control scheme, which is basically modular in design. In this thesis, these ideas are investigated through the use of modular recurrent networks, which are used in a variety of control tasks. The first experimental chapter deals with learning in recurrent networks, and it is shown that CPGs may be easily implemented using the machinery of backpropagation. The use of these CPGs can aid the learning of pattern generation tasks; they can also mean that the other components in the system can be reduced in complexity, say, to a purely feedforward network. It is also shown that incremental learning, or 'shaping' is an effective method for building CPGs. Genetic algorithms are also used to build CPGs; although computational effort prevents this from being a practical method, it does show that GAs are capable of optimising systems that operate in the context of a larger scheme. One interesting result from the GA is that optimal CPGs tend to have unstable dynamics, which may have implications for building modular neural controllers. The next chapter applies these ideas to some simple control tasks involving a highly redundant simulated robot arm. It was shown that it is relatively straightforward to build CPGs that represent elements of pattern generation, constraint satisfaction. and local feedback. This is indirect control, in which errors are backpropagated through a plant model, as well as the ePG itself, to give errors for the controller. Finally, the third experimental chapter takes an alternative approach, and uses direct control methods, such as reinforcement learning. In reinforcement learning, controller outputs have unmodelled effects; this allows us to build complex control systems, where outputs modulate the couplings between sets of dynamic systems. This was shown for a simple case, involving a system of coupled oscillators. A second set of experiments investigates the use of simplified models of behaviour; this is a reduced form of supervised learning, and the use of such models in control is discussed.

Much experimental evidence indicates that lat perceptual decisions are made by integrating sensory information in cortical areas, until the accumulated evidence fies certain criteria. Recently proposed theories further suggest that the ain performs statistically optimal strategies during decision processes. This thesis extends and develops biologically inspired decision models from different aspects.

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This thesis deals with automatic defect detection. The objective was to develop the techniques required by a small manufacturing business to make cost-efficient use of inspection technology. In our work on inspection techniques we discuss image acquisition and the choice between custom and general-purpose processing hardware. We examine the classes of general-purpose computer available and study popular operating systems in detail. We highlight the advantages of a hybrid system interconnected via a local area network and develop a sophisticated suite of image-processing software based on it. We quantitatively study the performance of elements of the TCP/IP networking protocol suite and comment on appropriate protocol selection for parallel distributed applications. We implement our own distributed application based on these findings. In our work on inspection algorithms we investigate the potential uses of iterated function series and Fourier transform operators when preprocessing images of defects in aluminium plate acquired using a linescan camera. We employ a multi-layer perceptron neural network trained by backpropagation as a classifier. We examine the effect on the training process of the number of nodes in the hidden layer and the ability of the network to identify faults in images of aluminium plate. We investigate techniques for introducing positional independence into the network's behaviour. We analyse the pattern of weights induced in the network after training in order to gain insight into the logic of its internal representation. We conclude that the backpropagation training process is sufficiently computationally intensive so as to present a real barrier to further development in practical neural network techniques and seek ways to achieve a speed-up. Weconsider the training process as a search problem and arrive at a process involving multiple, parallel search "vectors" and aspects of genetic algorithms. We implement the system as the mentioned distributed application and comment on its performance.

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