In this thesis, we study the existence of stationary solutions for two cases. One is for random difference equations. For this, we prove the existence and uniqueness of the stationary solutions in a finite-dimensional Euclidean space Rd by applying the coupling method. The other one is for semi linear stochastic evolution equations. For this case, we follows Mohammed, Zhang and Zhao [25]'s work. In an infinite-dimensional Hilbert space H, we release the Lipschitz constant restriction by using Arzela-Ascoli compactness argument. And we also weaken the globally bounded condition for F by applying forward and backward Gronwall inequality and coupling method.

Capillary electrochromatography (CEC) is a major capillary electrophoresis (CE) mode that have been interfaced to mass spectrometry (MS) for sensitive and selective analysis of chiral compounds. This research expands CEC applications in cancer biomarker and chiral CE analysis. Chapter 1 is a review of liquid chromatography-mass spectrometry (LC/MS), gas chromatography-mass spectrometry (GC/MS), and capillary electrophoresis mass spectrometry (CE/MS) for analysis of metabolites in prostate cancer diagnostics and therapies. In this chapter, a literature survey was performed within the databases PubMed, 4 Caplus/Webline and Web of Sciences. A total 17 studies reporting on various analytical platforms for metabolite identification in prostate cancer research, which often include case-control comparison were identified and reviewed. Chapter 2 described the analysis of metabolite biomarkers in prostate cancer tissues by capillary electrochromatography mass spectrometry. In this chapter, a capillary CEC–MS/MS method was developed for the simultaneous determination and separation of eight proofs of concept (POC) metabolites (betaine, malate, proline, N-acetyl aspartate, N-acetylglucosamine, uracil, xanthine, and alanine) as potential prostate cancer diagnostic markers. A polymeric monolith column with a hydrophilic crosslinker and strong anion-exchange mixed-mode has been fabricated by an in situ copolymerization of vinyl benzyl trimethylammonium chloride, and bisphenol A glycerolate dimethacrylate (BisGMA) in the presence of methanol and dodecyl alcohol as porogens and AIBN as initiator. After CEC separation, samples were analyzed by a triple–quadrupole mass spectrometer operated in positive ion mode. After optimization, the data showed that the CEC-MS/MS method using monolithic column achieved a much better chromatographic selectivity compared to coated columns and increased sensitivity than bare fused silica column The effect of mobile phase pH, ACN percentage and additive were studies. Under the optimum mobile phase conditions, this method was carried out to separate and detect eight metabolites in the biopsy sample. The LOD for the metabolites is between 50nM-100nM. This method has successfully used to examine patients’ prostate cancer with an accuracy of 95%. Chapter 3 demonstrates Insights into Chiral Recognition Mechanisms in CEC using linear salvation energy relationship. By varying the linker (amide and carbamate), head group (alanine, leucine, and valine) and chain length (C8, C10 and C12) of the amino acid bound surfactants; monolithic column was made to ultimately understand the factors governing chiral stationary solid phase. Through the comparison of system parameters, we can see that surfactant head group, linker and chain length affect the separation of achiral and chiral compounds. Also, with the same type surfactant, data was presented to show how the trend of LSER parameters and how it affects separation between in CEC. This study showed the predictive capability of LSER to understand the aforementioned intermolecular processes controlling retention and by doing so, be able to quantitatively predict the experimental conditions to achieve an acceptable chiral separation.

In this thesis, first we study the unique classical solution of quasi-linear second order parabolic partial differential equations (PDEs). For this, we study the existence and uniqueness of the $L^2_{\rho}( \mathbb{R}^{d}; \mathbb{R}^{d}) \otimes L^2_{\rho}( \mathbb{R}^{d}; \mathbb{R}^{k})\otimes L^2_{\rho}( \mathbb{R}^{d}; \mathbb{R}^{k\times d})$ valued solution of forward backward stochastic differential equations (FBSDEs) with finite horizon, the regularity property of the solution of FBSDEs and the connection between the solution of FBSDEs and the solution of quasi-linear parabolic PDEs. Then we establish their connection in the Sobolev weak sense, in order to give the weak solution of the quasi-linear parabolic PDEs. Finally, we study the unique weak solution of quasi-linear second order elliptic PDEs through the stationary solution of the FBSDEs with infinite horizon.

La présence de dépendance spatiale des prix immobiliers impose aux méthodes d’estimation de prendre en compte cet élément. Les deux approches de la statistique spatiale sont l’économétrie spatiale et la géostatistique. La géostatistique estime directement la matrice de variance-covariance en supposant que la covariance entre les observations dépend inversement de la distance séparant leur localisation. L’économétrie spatiale définit et intègre la matrice d’interaction spatiale dans un modèle de régression hédonique. Si ces deux méthodes sont possibles pour étudier la dépendance spatiale des prix immobiliers dans des contextes variés, il n’existe cependant pas de règles très claires quant au choix de la méthode à sélectionner. Cette thèse procède à un examen détaillé de ces deux approches afin de pouvoir en distinguer les ressemblances et les différences, les avantages et les inconvénients. Des exemples d’application de chaque approche dans une étude immobilière sont présentés. La géostatistique est utilisée pour analyser la stationnarité du variogramme, ainsi que la sensibilité du variogramme aux paramètres de l’estimation hédonique. Le modèle d’économétrie spatiale est utilisé pour tenter d’identifier économétriquement le quartier dominant du marché immobilier d’une ville / Geostatistics and spatial econometrics are two spatial statistical approaches used to deal with spatial dependence. Geostatistics estimates directly the variance-covariance matrix by assuming that the covariance among observations depends inversely on the distance between their locations, called the covariogram. Spatial econometrics defines and integrates the spatial interaction matrix in a hedonic regression model. In real estate, price estimation should take into account these spatial characteristics because property prices are correlated. Hence, these two approaches are commonly used to study the spatial dependence of the real estate prices in many contexts. However, a definite rule in selection these statistic approaches has not been established. This thesis examined these two approaches in order to distinguish the similarities, differences, advantages, and disadvantages of each methodology. Some examples of their applications in a real estate study. The geostatistics is used to analyze the stationarity of the variogram and its sensitivity depending on the parameters added in hedonic estimation. The spatial econometric is used to define econometrically the real estate market dominant area

On étudie les fonctions multivaluées vers un espace de Hilbert. Après avoir introduit unebonne notion de p énergie, on donne une définition possible d’espace de Sobolev et on prouveun théorème d’existence des p minimiseurs. Puis on considère les fonctions bivaluées de deuxvariables, stationnaires pour les déformations au départ et à l’arrivée. On démontre qu’ellessont localement lipschitziennes et on utilise cette régularité pour montrer la convergence fortedans W1,2 vers leur unique éclatement en un point. L’ensemble de branchement d’une tellefonction est la réunion localement finie de courbes analytiques qui se rencontrent en faisantdes angles égaux. Nous donnons aussi un exemple de fonction discontinue et stationnaireseulement pour les déformations au départ.Dans un deuxième temps, on prouve qu’il n’existe pas de rétraction uniformément continuede l’espace des champs vectoriels continus vers le sous-espace de ceux dont la divergence estnulle en un sens distributionnel. On généralise ce résultat en toute codimension en utilisant lanotion de m charge et à tout ensemble X ⊂ Rn vérifiant une hypothèse géométrique mineure. / We study multiple valued functions with values in a Hilbert space. We introduce a possibledefinition of Sobolev spaces and the rightful notion of p energy. We prove the existence of pminimizers. Then we consider two-valued real functions of two variables which are stationarywith respect to both domain and range transformations. We prove their local Lipschitzcontinuity and use it to establish strong convergence in W1,2 to their unique blow-up at anypoint. We claim that the branch set of any such function consists of finitely many real analyticcurves meeting at nod points with equal angles. We also provide an example showing thatstationarity with respect to domain transformations only does not imply continuity.In a second part, we prove that there does not exist a uniformly continuous retractionfrom the space of continuous vector fields onto the subspace of vector fields whose divergencevanishes in the distributional sense. We then generalise this result using the concept of mcharges on any subset X _ Rn satisfying a mild geometric condition, there is no uniformlycontinuous representation operator for mcharges in X.

The objective of this thesis is to design the appropriate parking management for downtown of Jindrichuv Hradec. The theoretical part is focused on the traffic problem and its negative effects on environment of cities in relation to increase in private car transport in recent years. In the next chapter, parking management and its specific strategies are described as instruments solving problems with urban transport including its static and dynamic part. Practical part includes description of current traffic conditions and accessibility of the town centre of Jindrichuv Hradec. The description results from information obtained by personal mapping of location and measuring of parking occupancy. The proposed solution of certain parking policies that result in more efficient use of parking resources with minimized traffic impacts on historical centre of town follows.

Des stratégies d'approvisionnement pérennes sont nécessaires pour les gestionnaires de la chaîne d'approvisionnement afin de faire face aux incertitudes d’approvisionnement et de demande. La diminution des niveaux de service et l'augmentation simultanée des coûts de stockage sont les impacts les plus importants de ces incertitudes. Les perturbations peuvent être causées par des discontinuités de l’approvisionnement, de l'instabilité politique, des catastrophes naturelles et des grèves des employés. Elles pourraient avoir un effet important sur la performance de la chaîne d'approvisionnement. Pour faire face à de telles perturbations, les modèles d'optimisation des stocks doivent être adaptés pour couvrir une structure de réseau multi-échelons et envisager des stratégies d'approvisionnement alternatives telles que le transport latéral (lateral transshipment) et plusieurs sources d’approvisionnement. Dans ce travail, une approche de modélisation basée sur des scénarios est proposée pour résoudre un problème d'optimisation multi-échelons des stocks. En prenant en compte la demande stochastique et les incertitudes sur les capacités de production, le modèle minimise le coût opérationnel total (coûts de stockage, de transport et de retard) tout en optimisant la gestion des stocks et les flux des marchandises. Afin de faire face aux incertitudes, plusieurs échantillons de scénarios sont générés par Monte Carlo et les exemples correspondants d'approximation (SAA) des programmes sont résolus pour obtenir une politique de réponse adéquate au système d'inventaire en cas de perturbations. De nombreuses expériences numériques sont menées et les résultats permettent d'acquérir des connaissances sur l'impact des perturbations sur le coût total du réseau et le niveau de service. / Supply Chain Management (SCM) is an important part of most companies and applying the appropriate strategy is essential for managers in competitive industries and markets. In this context, Inventory Management plays a crucial role. Different inventory systems are widely used in practice. However, it is fundamentally difficult to optimize, especially in multi-echelon networks. A key challenge in managing inventory is dealing with uncertainties in supply and demand. The simultaneous decrease of customer service and increase of inventory-related costs are the most significant effects of such uncertainties. To deal with this pattern, supply chain managers need to establish more effective and more flexible sourcing and distribution strategies. In this thesis, a “framework to optimize inventory decisions in multi-echelon distribution networks under supply and demand uncertainty” is proposed. In the first part of the research work, multi-echelon distribution systems, subject to demand uncertainty, are studied. Such distribution systems are one of the most challenging inventory network topologies to analyze. The optimal inventory and sourcing policies for these systems are not yet unknown. We consider a basic type of distribution network with a single family product through a periodic review setting. Based on this property, a two-stage mixed integer programming approach is proposed to find the optimal inventory-related decisions considering the non-stationary demand pattern. The model, which is based on a Distribution Requirements Planning (DRP) approach, minimizes the expected total cost composed of the fixed allocation, inventory holding, procurement, transportation, and back-ordering costs. Alternative inventory optimization models, including the lateral transshipment strategy and multiple sourcing, are thus built, and the corresponding stochastic programs are solved using the sample average approximation method. Several problem instances are generated to validate the applicability of the model and to evaluate the benefit of lateral transshipments and multiple sourcing in reducing the expected total costs of the distribution network. An empirical investigation is also conducted to validate the numerical findings by using the case of a major French retailer’s distribution network. The second part of the research work is focused on the structure of the optimal inventory policy which is investigated under supply disruptions. A two-stage stochastic model is proposed to solve a capacitated multi-echelon inventory optimization problem considering a stochastic demand as well as uncertain throughput capacity and possible inventory losses, due to disruptions. The model minimizes the total cost, composed of fixed allocation cost, inventory holding, transportation and backordering costs by optimizing inventory policy and flow decisions. The inventory is controlled according to a reorder point order-up-to-level (s, S) policy. In order to deal with the uncertainties, several scenario samples are generated by Monte Carlo method. Corresponding sample average approximations programs are solved to obtain the adequate response policy to the inventory system under disruptions. In addition, extensive numerical experiments are conducted. The results enable insights to be gained into the impact of disruptions on the network total cost and service level. In both parts of the research, insights are offered which could be valuable for practitioners. Further research possibilities are also provided.

Neste trabalho, é apresentado um modelo aperfeiçoado para gerar carregamentos dinâmicos pseudo-aleatórios para modelos estruturais sob excitação sísmica e de vento. Este é baseado no modelo de vento sintético proposto por Franco, diferindo pelo fato que usa a transformada de wavelet harmônica ao invés da série de Fourier, pois tem como objetivo descrever um comportamento não estacionário com a ajuda de uma função temporal. Para testar a qualidade do sinal desenvolvido neste trabalho, este foi comparado com sinais verdadeiro, das acelerações de sismos ocorrido na cidade de Hachinohe, no Japão e em El-centro, na Califórnia, e com um sinal gerado pelo modelo do sismo sintético de Corbani, este também baseado no modelo de vento sintético, com o uso de séries de Fourier. Em todas as análises feitas, foi mostrando que embora a geração de carregamentos com transformadas de wavelet harmônica seja mais complexa, esta possui um bom potencial para gerar carregamentos mais próximos da realidade do que métodos usuais baseados em carregamentos estacionários. / In this work is intruduced a improve model to create random loads to use in structural models under sismic and wind disturbance. The model is based on synthetic wind model intends by Franco, differing by the fact that applies harmonic wavelet transform instead of Fourier series, because it has the goal to describe a non stationary behavior with temporal function support. To test the quality from the signal developed in this work, it has been analyzed against true seismic acceleration signal that occurs from Hachinohe city in Japan and El-centro city in California, and with the synthetic seismic model developed by Corbani, that one descending on synthetic wind model, with Fourier series application. In all analysis, although loading creation with harmonic wavelet transform have been more sophisticated, that one has a great potencial to creat loading closer to the fact than usual methods based in stationary loading.

O problema de controle de estoques com demanda não estacionária e lead-time positivo tem se tornado cada vez mais relevante em virtude da crescente tendência de redução do ciclo de vida dos produtos e internacionalização das cadeias de suprimentos. Embora haja uma solução exata para a minimização do custo esperado da política de estoques para este cenário, baseado no método de programação dinâmica, o custo computacional deste método ainda é considerado elevado. Este trabalho detalha e avalia através de simulação o método exato e duas aproximações para a minimização do custo esperado da política de estoques, em termos do desempenho em custo e eficiência computacional. Os resultados experimentais permitem a análise dos métodos disponíveis. Enquanto a abordagem heurística de Bollapragada e Morton, que utiliza o nivelamento da demanda não estacionária, perde desempenho de custo com o aumento do lead-time, a nova heurística proposta, que aproxima os parâmetros da política ótima por valores limitantes, produz resultados sucessivamente melhores com o aumento do lead-time. / The inventory control problem with nonstationary demand and positive lead-time has become increasingly important due to the growing trend of reduction in product life cycle and internationalization of the supply chain. Although there is an exact solution to the minimization of the expected cost of inventory policy on this environment, through the method of dynamic programming, the computational cost of this method is still considered high. This work details and evaluates through simulation the exact method and two heuristic solutions for the minimization of expected cost of inventory policy, in terms of cost performance and computational efficiency. The experimental results allow the analysis of the available methods. While the Bollapragada and Morton heuristic approach, which levels the non-stationary demand, decreases the cost performance when lead-time is increased, the new heuristic proposed, that approximates the optimal policy parameters by limiting values, successively produces better results with increasing lead-times.

Dans cette thèse, on s'intéresse à la notion de temps fort de stationnarité et à celle, étroitement liée, de dual de stationnarité forte. Ces outils permettent d'étu- dier la convergence de processus ergodiques, en déterminant un instant aléatoire où l'équilibre est atteint. Les espaces d'état des processus considérés ici sont des graphes continus ou discrets. Dans la première partie, on considère le cas discret, et on dégage une condition nécessaire et suffisante à l'existence, pour n'importe quelle loi initiale, d'un temps fort de stationnarité fini. Pour cela, on construit explicitement un dual de station- narité forte, à valeurs dans l'ensemble des parties connexes du graphe, qui évolue à chaque étape en ajoutant ou en enlevant des points de sa frontière. Lorsque cette opération sépare l'ensemble dual en plusieurs parties, afin de ne pas le déconnecter, une de ces parties est choisie au hasard, avec une probabilité proportionnelle à son poids par la mesure invariante. On s'intéresse également au comportement général d'un processus dual, et on donne quelques exemples différents de celui construit précédemment. Dans la deuxième partie, on traite le cas continu, et le processus étudié est alors une diffusion. On caractérise notamment sa mesure invariante, et on explicite un générateur infinitésimal qui devrait être celui d'un processus dual. Néanmoins, ce cas s'avère plus compliqué que le cas discret. Le processus dual n'est donc construit que pour un mouvement brownien sur un graphe particulier, comme l'unique so- lution d'un problème de martingale. Des pistes sont présentées pour traiter des diffusions sur des graphes plus généraux, notamment en utilisant la convergence d'une suite de processus de saut tels que ceux présentés dans la première partie. / In this thesis, we are interested in the notion of strong stationary time, and in that, strongly connected, of strong stationary dual. These tools allow to study the convergence of ergodic processes, by determining a random time when the equilibrium is reached. The state space of the considered processes are discrete or continuous graphs. In the first part, we consider the discrete case, and we explicit a necessary and sufficient condition to the existence, for any initial distribution, of a finite strong stationary time. To do so, we construct explicitly a strong stationary dual, with values in the set of connected subsets of the graph, which evolves at each step by adding or removing some points at its border. Whenever this operation separates the dual set in several parts, in order not to disconnect it, one of these parts is chosen randomly, with a probability proportionnal to its weight relative to the invariant distribution. We also study the general behaviour of any dual process,2 and we give some other examples. In the second part, we deal with the continuous case, and the studied process is then a diffuion. We caracterize its invariant distribution, and we explicit an infinitesimal generator, which is expected to be that of a dual process. Nevertheless, this case turns out to be a little more involved that the discrete one. The dual process is thus constructed only for a brownian motion on a particular graph, as the unique solution of a martingale problem. Some leads are given to solve the case of diffusions on more general graphs, especially by using the convergence of a sequence of jump processes such as those presented in the first part.