As rates of obesity have increased this disease has become a common problem that physicians are faced with treating. This paper aims to review the different options for patients and determine the best treatments for obesity. Modalities that are considered include dietary treatment, exercise, pharmacologic treatment, and weight loss surgery. This study compares reduced calorie diets, low fat diets, low glycemic index/load diets, the Mediterranean diet, and low carbohydrate diets. The validity of exercise as an effective prescription for obesity is evaluated and debunked. Pharmacologic treatments that are contrasted include those drug therapies that are currently approved by the United States Food and Drug Administration for the long-term treatment of obesity. Those are orlistat, lorcaserin and phentermine/topiramate. The surgical treatments reviewed include vertical banded gastroplasty, adjustable gastric banding, Roux-en Y gastric bypass, biliopancreatic diversion, and biliopancreatic diversion with duodenal switch. After a comprehensive review of the literature the conclusion reached was that treatment for obesity should begin with the least invasive options and those that have the least potential for harm. That is, diet should be a first course of action. Among diets a Mediterranean diet or another culturally adapted low glycemic index/load diet is best. However, more studies are needed to determine how to translate the diets for different cultures and individual tastes. When diets are unable to produce enough weight loss, pharmacologic treatments are considered. Among them, lorcaserin and phentermine/topiramate do not have enough long-term studies to warrant a strong recommendation as of the publishing of this paper. The only other option available, orlistat, comes with many uncomfortable gastrointestinal side effects, so it is also not an ideal option. In addition, orlistat does not produce the amount of weight loss that is seen with surgical procedures. Patients and physicians considering surgical treatment for obesity will find that the best option is laparoscopic adjustable gastric banding.

Background: In Hirschsprung's disease, the trend has been for earlier performance of definitive surgery. In our institution, primary Swenson pull- through has become the preferred procedure. Methods: Retrospective review of the patients treated for Hirschsprung's disease from January 1988 through March 1998 was performed. Sixty-five patients were identified. Median values, analysis of variance and χ2 were used for comparisons. Results: The multiple-stage group (M, n = 47) was similar to the primary group (P, n = 18) for gestational age (40 v 39 weeks), time to meconium passage (37.9 v 35.5 hours), and age at diagnosis (median, M 27 v P 3.5 days). Age (median, M 268 v P 5 days) and weight (mean, M 9.4 v P 3.7 kg; P < .001) at pull-through were lower in the primary group. Length of stay (LOS) was lower in the primary group (mean, M 40,8 v P 20.3 days; P < .05). Operating time for pull- through was decreased in P (mean, M 305.2 v P 272.2 minutes; P = .02). Total complications were lower in the primary group (P = .03), with no differences in mortality or enterocolitis rates. Conclusions: At our institution there were no increases in total complications or enterocolitis in the group undergoing primary Swenson. Primary pull-through is a viable option for the treatment of Hirschsprung's disease.

As doenças perimplantares (DPi) vêm sendo consideradas umas das maiores causas de perdas tardias de implantes dentários e nenhum dos tratamentos já propostos na literatura mostrou ser eficiente a ponto de se tornar a primeira escolha terapêutica. Considerando que a definição correta do tratamento depende invariavelmente do entendimento da etiopatogenia, ocorrências e diagnóstico das DPi, o objetivo da presente tese foi abordar as DPi através de uma ampla revisão dos seus conceitos e da apresentação de dados clínicos preliminares de três meses de um ensaio clínico controlado randomizado comparando os resultados dos tratamentos cirúrgico (C) e não cirúrgico (NC) da perimplantite. Foram incluídos implantes apresentando um ou mais sítios com profundidade de sondagem perimplantar (PSi) ≥ 5mm, com presença de sangramento submucoso (SSi) e/ou supuração e apresentando perda óssea radiográfica (PO) ≥ 3mm. O tratamento não cirúrgico incluiu debridamento mecânico com curetas de teflon e irrigação com solução salina, assim como o tratamento cirúrgico, com acesso por retalho mucoperiostal. Não foram utilizadas técnicas ressectivas e nem implantoplastia. A amostra foi randomizada de maneira estratificada para o hábito de fumar e a presente análise, de 3 meses de acompanhamento após o tratamento, se refere à amostra de 22 indivíduos (29 implantes), sendo 12 (17 implantes) no grupo C e 10 (12 implantes) no NC. No início do estudo não foram observadas diferenças significativas entre os grupos para variáveis demográficas e clínicas, exceto nas condições periodontais de índice de placa visível (IPV) (NC 22,3±14,08 / C 40,2±19,9) e sangramento a sondagem (NC 15,9±10,2 / C 31,8±15,9). Após três meses de tratamento, não houve desistências e, considerando o pior sítio do implante, os dois tratamentos reduziram significativamente as medidas de PSi (NC 5,8±0,27 para 4,3±0,55mm / C 5,9±0,29 para 5,0±0,28mm), os dois grupos apresentaram redução de SSi mas apenas no grupo C foi significativa, diminuindo de 100% para 53%. Não houve diferenças entre os níveis de perda de inserção clínica (PIi). Em uma análise multivariada para identificar os preditores de sucesso dos tratamentos, implantes com PSi basal > 6 mm apresentaram piores reduções de PSi, SSi e PIi, o histórico de periodontite dificultou a redução de PSi enquanto indivíduos com 5 ou mais implantes e reabilitados com próteses cimentadas apresentaram piores reduções de SSi. A taxa de sucesso dos tratamentos foi de 33% no grupo NC e 17% para o grupo C sem diferenças estatísticas. Conclui-se que ambos os tratamentos diminuíram sinais inflamatórios embora sem a demonstração de diferenças entre eles, e que preditores de risco ao sucesso do tratamento devem ser investigados. / Peri-implant diseases (PiD) have been considered the major causes of late loss of dental implants, and none of the proposed treatments in the literature demonstrated to be efficient to become the first therapeutic choice. Considering that the correct definition of treatment depends invariably on the understanding of the etiopathogenesis, occurrence and diagnosis of PiD, the aim of the present theses was to approach PiD through a 9oné99ono f its concepts and presenting preliminary clinical data of 3 months from a randomized controlled 9oné9 comparing surgical (ST) and non-surgical (NST) treatments of peri-implantitis. Implants presenting pocket depth (PD) ≥5mm and bleeding on probing (Bosshardt et al.) with radiographic bone loss ≥3 mm were included in the study. NST included mechanical debridement of the implant with Teflon curets and irrigation with saline solution, whereas ST included the debridement with mucoperiostal flap. Ressective surgery and implantoplasty were not applied. The sample was randomized by stratification according to smoking habit, and the present 3-months analysis after treatment referes to 22 individuals (29 implants), 12 (17 implants) in ST and 10 (12 implants) in the NST group. At basliene, no significant differences were observed between groups for demographic and clinical variables, except for periodontal conditions of teeth in regards to visible plaque (NST 22.3±14.08% and ST 40.2±19.9%) and BOP (NST 15.9±10.2% and ST 31.8±15.9%). After 3 months, there were no drop-outs and, considering the worst site of each implant, the two treatments reduced significantly mean PD (NST 5.8±0.27mm to 4.3±0.55mm and ST 5.9±0.29mm to 5.0±0.28mm. Both groups presented reduction in BOP, but only in the ST the reduction was significant, decreasing from 100% to 53%. There were no significant differences in clinical attachment loss after 3 months in the two groups. In a multivariable analysis to identify predictors of treatment success, implants with baseline PD >6mm presented lower reduction in PD over 3 months, as well as BOP and CAL. Previous history of periodontitis lead to higher PD and individuals with more then 5 implants and rehabilitated with bonded prosthesis had higher BOP over time. It can be concluded that both treatments reduced signs of inflammation although without significant differences between them, and baseline PD, number of implants, history of periodontitis and type of prosthetic fixation may be used as predictors of clinical outcomes of peri-implantitis treatment.

As doenças perimplantares (DPi) vêm sendo consideradas umas das maiores causas de perdas tardias de implantes dentários e nenhum dos tratamentos já propostos na literatura mostrou ser eficiente a ponto de se tornar a primeira escolha terapêutica. Considerando que a definição correta do tratamento depende invariavelmente do entendimento da etiopatogenia, ocorrências e diagnóstico das DPi, o objetivo da presente tese foi abordar as DPi através de uma ampla revisão dos seus conceitos e da apresentação de dados clínicos preliminares de três meses de um ensaio clínico controlado randomizado comparando os resultados dos tratamentos cirúrgico (C) e não cirúrgico (NC) da perimplantite. Foram incluídos implantes apresentando um ou mais sítios com profundidade de sondagem perimplantar (PSi) ≥ 5mm, com presença de sangramento submucoso (SSi) e/ou supuração e apresentando perda óssea radiográfica (PO) ≥ 3mm. O tratamento não cirúrgico incluiu debridamento mecânico com curetas de teflon e irrigação com solução salina, assim como o tratamento cirúrgico, com acesso por retalho mucoperiostal. Não foram utilizadas técnicas ressectivas e nem implantoplastia. A amostra foi randomizada de maneira estratificada para o hábito de fumar e a presente análise, de 3 meses de acompanhamento após o tratamento, se refere à amostra de 22 indivíduos (29 implantes), sendo 12 (17 implantes) no grupo C e 10 (12 implantes) no NC. No início do estudo não foram observadas diferenças significativas entre os grupos para variáveis demográficas e clínicas, exceto nas condições periodontais de índice de placa visível (IPV) (NC 22,3±14,08 / C 40,2±19,9) e sangramento a sondagem (NC 15,9±10,2 / C 31,8±15,9). Após três meses de tratamento, não houve desistências e, considerando o pior sítio do implante, os dois tratamentos reduziram significativamente as medidas de PSi (NC 5,8±0,27 para 4,3±0,55mm / C 5,9±0,29 para 5,0±0,28mm), os dois grupos apresentaram redução de SSi mas apenas no grupo C foi significativa, diminuindo de 100% para 53%. Não houve diferenças entre os níveis de perda de inserção clínica (PIi). Em uma análise multivariada para identificar os preditores de sucesso dos tratamentos, implantes com PSi basal > 6 mm apresentaram piores reduções de PSi, SSi e PIi, o histórico de periodontite dificultou a redução de PSi enquanto indivíduos com 5 ou mais implantes e reabilitados com próteses cimentadas apresentaram piores reduções de SSi. A taxa de sucesso dos tratamentos foi de 33% no grupo NC e 17% para o grupo C sem diferenças estatísticas. Conclui-se que ambos os tratamentos diminuíram sinais inflamatórios embora sem a demonstração de diferenças entre eles, e que preditores de risco ao sucesso do tratamento devem ser investigados. / Peri-implant diseases (PiD) have been considered the major causes of late loss of dental implants, and none of the proposed treatments in the literature demonstrated to be efficient to become the first therapeutic choice. Considering that the correct definition of treatment depends invariably on the understanding of the etiopathogenesis, occurrence and diagnosis of PiD, the aim of the present theses was to approach PiD through a 9oné99ono f its concepts and presenting preliminary clinical data of 3 months from a randomized controlled 9oné9 comparing surgical (ST) and non-surgical (NST) treatments of peri-implantitis. Implants presenting pocket depth (PD) ≥5mm and bleeding on probing (Bosshardt et al.) with radiographic bone loss ≥3 mm were included in the study. NST included mechanical debridement of the implant with Teflon curets and irrigation with saline solution, whereas ST included the debridement with mucoperiostal flap. Ressective surgery and implantoplasty were not applied. The sample was randomized by stratification according to smoking habit, and the present 3-months analysis after treatment referes to 22 individuals (29 implants), 12 (17 implants) in ST and 10 (12 implants) in the NST group. At basliene, no significant differences were observed between groups for demographic and clinical variables, except for periodontal conditions of teeth in regards to visible plaque (NST 22.3±14.08% and ST 40.2±19.9%) and BOP (NST 15.9±10.2% and ST 31.8±15.9%). After 3 months, there were no drop-outs and, considering the worst site of each implant, the two treatments reduced significantly mean PD (NST 5.8±0.27mm to 4.3±0.55mm and ST 5.9±0.29mm to 5.0±0.28mm. Both groups presented reduction in BOP, but only in the ST the reduction was significant, decreasing from 100% to 53%. There were no significant differences in clinical attachment loss after 3 months in the two groups. In a multivariable analysis to identify predictors of treatment success, implants with baseline PD >6mm presented lower reduction in PD over 3 months, as well as BOP and CAL. Previous history of periodontitis lead to higher PD and individuals with more then 5 implants and rehabilitated with bonded prosthesis had higher BOP over time. It can be concluded that both treatments reduced signs of inflammation although without significant differences between them, and baseline PD, number of implants, history of periodontitis and type of prosthetic fixation may be used as predictors of clinical outcomes of peri-implantitis treatment.

As doenças perimplantares (DPi) vêm sendo consideradas umas das maiores causas de perdas tardias de implantes dentários e nenhum dos tratamentos já propostos na literatura mostrou ser eficiente a ponto de se tornar a primeira escolha terapêutica. Considerando que a definição correta do tratamento depende invariavelmente do entendimento da etiopatogenia, ocorrências e diagnóstico das DPi, o objetivo da presente tese foi abordar as DPi através de uma ampla revisão dos seus conceitos e da apresentação de dados clínicos preliminares de três meses de um ensaio clínico controlado randomizado comparando os resultados dos tratamentos cirúrgico (C) e não cirúrgico (NC) da perimplantite. Foram incluídos implantes apresentando um ou mais sítios com profundidade de sondagem perimplantar (PSi) ≥ 5mm, com presença de sangramento submucoso (SSi) e/ou supuração e apresentando perda óssea radiográfica (PO) ≥ 3mm. O tratamento não cirúrgico incluiu debridamento mecânico com curetas de teflon e irrigação com solução salina, assim como o tratamento cirúrgico, com acesso por retalho mucoperiostal. Não foram utilizadas técnicas ressectivas e nem implantoplastia. A amostra foi randomizada de maneira estratificada para o hábito de fumar e a presente análise, de 3 meses de acompanhamento após o tratamento, se refere à amostra de 22 indivíduos (29 implantes), sendo 12 (17 implantes) no grupo C e 10 (12 implantes) no NC. No início do estudo não foram observadas diferenças significativas entre os grupos para variáveis demográficas e clínicas, exceto nas condições periodontais de índice de placa visível (IPV) (NC 22,3±14,08 / C 40,2±19,9) e sangramento a sondagem (NC 15,9±10,2 / C 31,8±15,9). Após três meses de tratamento, não houve desistências e, considerando o pior sítio do implante, os dois tratamentos reduziram significativamente as medidas de PSi (NC 5,8±0,27 para 4,3±0,55mm / C 5,9±0,29 para 5,0±0,28mm), os dois grupos apresentaram redução de SSi mas apenas no grupo C foi significativa, diminuindo de 100% para 53%. Não houve diferenças entre os níveis de perda de inserção clínica (PIi). Em uma análise multivariada para identificar os preditores de sucesso dos tratamentos, implantes com PSi basal > 6 mm apresentaram piores reduções de PSi, SSi e PIi, o histórico de periodontite dificultou a redução de PSi enquanto indivíduos com 5 ou mais implantes e reabilitados com próteses cimentadas apresentaram piores reduções de SSi. A taxa de sucesso dos tratamentos foi de 33% no grupo NC e 17% para o grupo C sem diferenças estatísticas. Conclui-se que ambos os tratamentos diminuíram sinais inflamatórios embora sem a demonstração de diferenças entre eles, e que preditores de risco ao sucesso do tratamento devem ser investigados. / Peri-implant diseases (PiD) have been considered the major causes of late loss of dental implants, and none of the proposed treatments in the literature demonstrated to be efficient to become the first therapeutic choice. Considering that the correct definition of treatment depends invariably on the understanding of the etiopathogenesis, occurrence and diagnosis of PiD, the aim of the present theses was to approach PiD through a 9oné99ono f its concepts and presenting preliminary clinical data of 3 months from a randomized controlled 9oné9 comparing surgical (ST) and non-surgical (NST) treatments of peri-implantitis. Implants presenting pocket depth (PD) ≥5mm and bleeding on probing (Bosshardt et al.) with radiographic bone loss ≥3 mm were included in the study. NST included mechanical debridement of the implant with Teflon curets and irrigation with saline solution, whereas ST included the debridement with mucoperiostal flap. Ressective surgery and implantoplasty were not applied. The sample was randomized by stratification according to smoking habit, and the present 3-months analysis after treatment referes to 22 individuals (29 implants), 12 (17 implants) in ST and 10 (12 implants) in the NST group. At basliene, no significant differences were observed between groups for demographic and clinical variables, except for periodontal conditions of teeth in regards to visible plaque (NST 22.3±14.08% and ST 40.2±19.9%) and BOP (NST 15.9±10.2% and ST 31.8±15.9%). After 3 months, there were no drop-outs and, considering the worst site of each implant, the two treatments reduced significantly mean PD (NST 5.8±0.27mm to 4.3±0.55mm and ST 5.9±0.29mm to 5.0±0.28mm. Both groups presented reduction in BOP, but only in the ST the reduction was significant, decreasing from 100% to 53%. There were no significant differences in clinical attachment loss after 3 months in the two groups. In a multivariable analysis to identify predictors of treatment success, implants with baseline PD >6mm presented lower reduction in PD over 3 months, as well as BOP and CAL. Previous history of periodontitis lead to higher PD and individuals with more then 5 implants and rehabilitated with bonded prosthesis had higher BOP over time. It can be concluded that both treatments reduced signs of inflammation although without significant differences between them, and baseline PD, number of implants, history of periodontitis and type of prosthetic fixation may be used as predictors of clinical outcomes of peri-implantitis treatment.

The aim of this thesis was to evaluate the benefits and complications of surgical treatment of refractory epilepsy. The criterion for the selection of patients was undergoing preoperative long-term monitoring. Information were obtained from six patients after 2-3 years r of surgery using the narrative interview and questionnaire QOLIE 89, which evaluates the quality of life. The interview was analyzed using grounded theory while the information obtained from questionnaire were used only as supplement and comparison of the results. Overall evaluation of questionnaire QOLIE 89 was in standard in five of six patients which is against the results obtained in interviews. Comparing risks and complications with benefits of surgical treatment of refractory epilepsy in the observed group was evaluate as problematic. Patients expected more positive benefit of the treatment and improving the quality of life. Keyword: epilepsy, surgical treatment, nursing care, quality of live

Due to the demographic development osteopoorosis is an increasing serious medical and economical problem today in developed industrial countries including Czech republic. Fractures of the proximal femur in the elderly are one of the manifestations of the illness. Within the context of the pharmacological prevention we must consider carefully its contribution in comparison with costs of the fracture treatment in the hospital. This graduation theses deals with evaluation of expenses on the surgical treatment of these fractures and expenses on the pharmacological prevention using Fosamax. This comparison is made in economic situation in Czech republic in the end of the first decade of 21. century

Objetivo: Comparar os resultados cefalométricos obtidos com tratamentos compensatórios e tratamentos orto-cirúrgicos para pacientes que apresentam Classe III esquelética. Metodologia: Foram selecionadas de forma retrospectiva telerradiografias iniciais e finais de 97 pacientes Classe III esquelética. Os critérios de inclusão foram: dentição permanente completa até primeiros molares, relação molar de Classe III, ausência de extrações dentárias durante o tratamento, ausência de problemas periodontais severos, Wits menor que -2mm, telerradiografia em normalateral iniciais e finais, fotografias intra e extra-bucais iniciais e modelos de gesso iniciais. Os pacientes foram divididos em 3 grupos. Grupo C: pacientes que foram submetidos ao tratamento ortodôntico associado à cirurgia ortognática (uni ou bimaxilar) totalizando 30 pacientes (idade média inicial 25,07 [22,90-25,56]). Grupo R pacientes que foram submetidos ao tratamento ortodôntico compensatório usando a prescrição Roth totalizando 30 pacientes (idade média inicial 16,22 [15,68-23,90]). Grupo B pacientes que foram submetidos ao tratamento ortodôntico compensatório usando a prescrição Biofuncional para Classe III totalizando 37 pacientes (idade média inicial 19,97 [18,53–24,68]). A severidade da Classe III foi determinada pela relação posterior e dividida em ¼, ½, ¾ e completa. Todas as telerradiografias foram digitalizadas e seus traçados foram realizados pelo mesmo examinador no software Dolphin (Dolphin Imaging Versão 11.9). As variáveis estudadas foram divididas em grupos: Alterações Maxilares, Mandibulares, Maxilo-Mandibulares, Convexidade Facial, Padrão Facial, Posição dos dentes superiores, Posição dos dentes inferiores e Perfil Tegumentar. A análise estatística foi realizada utilizando o software SPSS, versão 18.0. [SPSS Inc. lançado 2009. PASW Statistics for Windows, Versão 18.0. Chicago: SPSS Inc.]. As variáveis contínuas simétricas foram expressas como média e erro padrão da média (± SEM) ou mediana e intervalo de confiança de 95% ([IC 95%]), definido pelo teste de Shapiro-Wilk. As variáveis categóricas foram descritas por frequências absolutas (n) e relativas (n%). Para comparação de meios entre grupos independentes, foi aplicada uma Análise de Variância Unidireccional (ANOVA) com teste post hoc de Tukey ou teste de Kruskal-Wallis com teste post hoc Dunn. Além disso, o teste de classificação assinado por Wilcoxon foi usado para dados emparelhados (por exemplo, medições pré e pós-tratamento). Por outro lado, as variáveis categóricas foram comparadas intragrupo pelo teste do Qui-Quadrado com análise residual ajustada padronizada. Todos os dados foram avaliados usando o SPSS, versão 18.0. O nível de significância foi fixado em 5%.Resultados: O grupo C apresentou uma severidade maior do 8 que os demais grupos tendo 73,3% dos pacientes com uma Classe III severa (3/4 e completa). Houve um avanço do ponto A (projeção da maxila) nos Grupos B e C e um recuo do mesmo no Grupo R. Já na mandíbula, apenas o Grupo C apresentou um recuo estatisticamente significativo. Os três grupos apresentaram uma melhora na relação Wits estatisticamente significativa. Contudo, apenas os grupos C e B apresentaram uma melhora significativa nas medidas ANB e NAP, mostrando que nestes grupos houve uma melhora no perfil dos pacientes. Em relação ao posicionamento dentário, o Grupo R apresentou uma vestibuloversão, extrusão e projeção dos incisivos superiores e uma linguoversão, retrusão e extrusão dos incisivos inferiores. Já o grupo Biofuncional apenas apresentou uma extrusão dos incisivos superiores e inferiores, sem alteração em relação à inclinação. O Grupo C apresentou uma descompensação com vestibuloversão dos incisivos inferiores e palatoversão dos incisivos superiores. Nos grupos C e B, os lábios superiores foram posicionados mais para anterior e os lábios inferiores mais para posterior, melhorando o perfil tegumentar. Já no grupo R, o lábio superior foi posicionado mais para posterior, deixando o perfil tegumentar mais côncavo. Conclusões: O grupo C e B apresentaram um avanço da maxila (Ponto A) semelhantes, enquanto que o Grupo R mostrou um recuo da mesma. Alterações mandibulares só ocorreram no grupo C. Houve uma melhora na convexidade facial e pefil tegumentar nos grupos C e B e houve uma piora no grupo R. O Grupo R apresentou maiores características de compensação dentária do que o grupo B, sendo que este último apresentou os melhores resultados quando opta-se pela camuflagem ortodôntica. Quando existe envolvimento de ambas as bases ósseas (maxila e mandíbula), o melhor tratamento é a associação de tratamento ortodôntico e cirurgia ortognática. Quando o envolvimento é apenas da maxila, o tratamento com a prescrição Biofuncional apresenta resultados semelhantes ao tratamento com ortodontia e cirurgia. A prescrição Biofuncional apresenta resultados de camuflagem melhores do que a prescrição Roth em todas as situações. / Objective: To compare cephalometric results obtained with compensatory treatments and ortho-surgical treatments for patients with skeletal Class III. Methods: Initial and final cephalograms of 97 skeletal Class III patients were retrospectively selected. Inclusion criteria were: complete permanent dentition until first molars, Class III molar relationship, absence of dental extractions during treatment, absence of severe periodontal problems, Wits less than -2mm, teleradiography at initial and final, intra and extra photographs and initial gypsum models. Patients were divided into 3 groups. Group C: patients who underwent orthodontic treatment associated with orthognathic surgery (uni or bimaxillary) totaling 30 patients (initial mean age 25,07 [22,90-25,56]). Group R patients who underwent compensatory orthodontic treatment using the Roth prescription totaling 30 patients (initial mean age 16,22 [15,68-23,90]). Group B patients who underwent compensatory orthodontic treatment using the Biofunctional prescription for Class III totaling 37 patients (Initial mean age 19,97 [18,53-24,68]). The severity of Class III was determined by the posterior relationship and divided into ¼, ½, ¾ and complete. All cephalograms were digitized and their tracings were performed by the same examiner in Dolphin software (Dolphin Imaging Version 11.9). The variables studied were divided into groups: Maxillary, Mandibular, Maxillo-Mandibular, Facial Convexity, Facial Pattern, Upper Teeth Position, Lower Teeth Position and Tegumentary Profile. Statistical analysis was performed using SPSS software, version 18.0. [SPSS Inc. released 2009. PASW Statistics for Windows, Version 18.0. Chicago: SPSS Inc.]. The symmetric continuous variables were expressed as mean and standard error of the mean (± SEM) or median and 95% confidence interval ([95% CI]), defined by the Shapiro-Wilk test. Categorical variables were described by absolute (n) and relative (n%) frequencies. For comparison of means between independent groups, a Univirectional Variance Analysis (ANOVA) was applied with Tukey post hoc test or Kruskal-Wallis test with Dunn post hoc test. In addition, the Wilcoxon-signed classification test was used for paired data (for example, pre- and post-treatment measurements). On the other hand, the categorical variables were compared intra-group by the chi-square test with standardized adjusted residual analysis. All data were evaluated using SPSS, version 18.0. The level of significance was set at 5%. Results: Group C had a higher severity than the other groups, with 73,3% of patients with a severe Class III (3/4 and complete). There was a progression of point A (projection of the maxilla) in Groups B and C and a retreat of the same in Group R. In the mandible, only Group C presented a statistically significant 10 decrease. The three groups showed a statistically significant improvement in the Wits ratio. However, only groups C and B showed a significant improvement in ANB and NAP measurements, showing that in these groups there was an improvement in the patients' profile. Regarding tooth positioning, Group R presented vestibuloversion, extrusion and projection of the upper incisors and a linguoversion, retrusion and extrusion of the lower incisors. On the other hand, the Biofunctional group presented only an extrusion of the upper and lower incisors, with no change in relation to the inclination. Group C presented a decompensation with vestibuloversion of the lower incisors and palatoversion of the upper incisors. In groups C and B, the upper lips were positioned more anteriorly and the lower lips more posteriorly, improving the tegumentary profile. In the Roth group, the upper lip was positioned posteriorly, leaving the tegmental profile more concave. Conclusions: Group C and B presented similar maxillary advancement (Point A), while Group R showed a decrease of the same. Mandibular changes occurred only in group C. There was an improvement in facial convexity and tegumentary skin in groups C and B and there was worsening in group R. Group R presented higher tooth compensation characteristics than group B, and the latter presented the best results when opted for orthodontic camouflage. When there is involvement of both bone bases (maxilla and mandible), the best treatment is the association of orthodontic treatment and orthognathic surgery. When the involvement is only of the maxilla, the treatment with the prescription Biofuncional presents results similar to the treatment with orthodontics and surgery. The Biofunctional prescription presents better camouflage results than the Roth prescription in all situations.

Beaucoup de progrès restent à réaliser dans la compréhension de la physiopathologie ainsi que dans la prise en charge thérapeutique de lépilepsie. De nombreux patients restent réfractaires au traitement médical et sont susceptibles dêtre de bons candidats à un traitement chirurgical. Lapport de nouvelles techniques dimagerie est une avancée importante dans la définition des crises et dans la localisation du foyer épileptogène et a permis daméliorer le résultat du traitement chirurgical par une meilleure sélection des candidats. La première partie de notre travail est une introduction générale où sont principalement exposées les techniques actuelles dexploration de lépilepsie ainsi que les résultats à long terme du traitement chirurgical chez 399 patients souffrant dépilepsie réfractaire, de manière à préciser le rôle de la chirurgie ainsi que les facteurs pouvant influencer le résultat postopératoire. La prise en charge des crises dépilepsie réfractaire dont le foyer épileptique se localise au niveau de zone fonctionnelle reste difficile et controversée. Il existe des arguments historiques et physiologiques justifiant une exérèse chirurgicale du foyer au niveau de zones fonctionnelles telles que le cortex sensitivomoteur mais il nexiste pourtant pas dans la littérature moderne de série qui permette dévaluer lefficacité de ce traitement et de le comparer avec dautres techniques chirurgicales comme par exemple les transsections sous- piales multiples. Dans la deuxième partie de ce travail, nous présentons une série de cinq patients provenant de la série des 399 patients exposée dans la première partie de notre travail, qui ont tous bénéficié dune résection corticale au niveau du cortex sensitivomoteur. Nous montrons que la difficulté du traitement de ces patients nest pas tant le geste chirurgical mais la définition et la localisation exacte du foyer épileptogène. Nous démontrons également que la mise au point exhaustive et précise de cette pathologie, en utilisant les méthodes dinvestigation décrites dans la première partie, permet de sélectionner les candidats de manière optimale avec des résultats postopératoires satisfaisants. La physiopathologie des crises dépilepsie est encore mal définie. Le mécanisme le plus souvent évoqué est un déséquilibre synaptique entre les afférences excitatrices et inhibitrices, une anomalie des canaux ioniques membranaires ou encore un trouble du métabolisme neuronal ou glial au niveau dun foyer où les neurones présentent une activité anormale. Une des questions primordiales à éclaircir est de savoir si cest le neurone qui est hyperexcitable, le réseau neuronal présent au sein du foyer ou les deux. Les structures gliales formées par les astrocytes et les oligodendrocytes jouent-elles un rôle accessoire ou primordial dans ce phénomène ? En dehors du rôle que pourraient jouer les connexions synaptiques dans le phénomène épileptique, les jcs semblent être importantes dans le mécanisme physiopatholgique des crises. Elles pourraient favoriser la synchronisation de lactivité épileptique ainsi que la propagation de celle-ci vers les régions cérébrales avoisinantes. La troisième partie de notre travail explore le rôle que pourrait jouer les jcs dans le phénomène épileptique. Les épilepsies mésiotemporales associées à une sclérose hippocampique sont les épilepsies dont le traitement chirurgical est le plus fréquemment proposé lorsque les crises deviennent réfractaires au traitement médical. Lobtention de tissu est dès lors aisée ce qui nous a permis détudier lexpression des jcs au niveau de tissus hippocampiques provenant de patients épileptiques et de la comparer avec celle déterminée au niveau dhippocampes provenant de patients non épileptiques et obtenus postmortem. Notre objectif est de savoir si cette éventuelle contribution au phénomène épileptique est liée à une augmentation de lexpression des jcs au niveau des tissus épileptiques et, si oui au niveau de quels types cellulaires (neurones, astrocytes) et de quelles régions de lhippocampe (gyrus dentelé, CA1 à CA4, subiculum)

Background: Bone metastases occur in most patients with advanced hormone-refractory prostate cancer causing pain, pathologic fractures, and spinal cord compression. Few studies specifically address surgical treatment of metastatic spinal cord compression (MSCC) in prostate cancer. Criteria for identifying patients who may benefit from surgery are poorly defined. Most of the current knowledge regarding tumor biology in prostate cancer is based on studies of primary tumors or soft tissue metastases. The mechanisms regulating growth of bone metastases are not fully established. Aims: a) to evaluate outcome after surgery for MSCC in prostate cancer and to identify prognostic factors for survival and functional recovery; b) to evaluate current practice for referral of prostate cancer patients with MSCC; c) to analyze expression of androgen receptor (AR), cell proliferation, apoptosis, and prostate-specific antigen (PSA) in bone metastases with regard to survival after surgery for complications of bone metastases. Patients and Methods: We retrospectively evaluated the hospital records of 68 consecutive patients operated for metastatic spinal cord compression. Tumor tissue from bone metastases was obtained on spinal surgery (54 patients), fracture surgery (4 patients) and biopsy (2 patients), and analyzed by immunohistochemistry. Results: Study I: Mortality and complication rate after surgery was high. Patients with hormone-naïve disease and those with hormone-refractory disease with good performance status and without visceral metastases had more favorable survival. The ability to walk after surgery was related to better survival. Study II: A new score for prognosis of survival after surgery for spinal cord compression includes: hormone status of prostate cancer, Karnofsky performance status, evidence of visceral metastasis, and preoperative serum PSA. The score is simple, tumor specific, and easy to apply in clinical practice. Study III: Our results suggest that delays in diagnosis and treatment may have negative impact on functional outcome. Pretreatment ability to walk, hormone status of prostate cancer, and time from loss of ambulation influenced neurological recovery after surgery for spinal cord compression. Study IV: High nuclear AR immunostaining in bone metastases and high preoperative serum PSA were associated with a poor outcome after metastasis surgery in patients with hormone-refractory prostate cancer. Short-term effect of castration therapy disclosed that nuclear AR immunostaining was decreased and apoptosis was increased, but cell proliferation remained largely unaffected. Conclusion:  Prostate cancer patients with metastatic spinal cord compression represent a heterogeneous group. We identified prognostic factors for survival and functional outcome, which may help clinicians in making decisions about treatment. Our results also implicate the need for development of local and regional guidelines for treatment of patients with spinal cord compression, as well as the importance of information to patients at risk.