Background: Type 2 diabetes affects approximately 8% of the world’s population. Individuals of South Asian ancestry tend to develop metabolic abnormalities, leading to diabetes, at lower measures of absolute obesity and approximately 10 years earlier than white Caucasians. Current literature is unclear on the source of this ethnic heterogeneity; the variation in risk cannot be explained by lifestyle factors alone. The overarching aim of this thesis is to explore the role of genetic variants and epigenetic differences to explain the greater risk for type 2 diabetes among South Asians. Methods: We first conducted a systematic review of the literature to ascertain the genetic risk from known single nucleotide polymorphisms (SNPs) among South Asians. We then compared these risk estimates to those from white Caucasians in a cohort of 69,033 individuals. Second, using the EpiDREAM prospective cohort study of individuals at high-risk for diabetes, we assessed the impact of genetic burden for impaired pancreatic beta-cell function alone and together with abdominal obesity on glucose traits. Ethnic heterogeneity in this interaction was also studied. Lastly, using data from two Canadian birth cohorts of South Asian and white Caucasian ancestry, we investigated ethnic differences in the epigenetic architecture for genes known to be implicated birth weight and length, as both are associated with the future risk of adult diabetes. Results: The systematic review identified 15 SNPs robustly associated with type 2 diabetes in both South Asians and white Caucasians. The magnitude of risk and allele frequency of these genetic variants did not differ between the ethnic groups. Additionally, we identified 8 novel polymorphisms implicated in diabetes only among South Asians. Second, using data from the EpiDREAM study, we identified an interaction between cumulative genetic burden of beta-cell impairment, measured using an un-weighted genotype score, and abdominal obesity on glucose traits in South Asians, but not white Caucasians. Third, our investigation of differential DNA methylation between the ethnic groups revealed seven CpG sites for which changes in methylation corresponded to alterations in birth weight among white Caucasians, but not South Asians. An independent agnostic genome-wide search identified methylation levels at three CpG sites that appear to uniquely modulate birth weight in South Asians. Conclusions: Overall, our results indicate that the greater risk for metabolic traits in South Asians likely does not result from common genetic variants shared by both South Asians and white Caucasians. Rather, differences in risk may be additionally influenced by unique risk variants in South Asians. Furthermore, it appears that the risk from a genetic impairment in South Asians may be magnified by abdominal obesity. / Thesis / Doctor of Philosophy (PhD)

Background: Folate and vitamin B12 have interdependent metabolic functions that are essential for neonate growth outcomes (i.e. birth weight) based on studies from India. The objective of this research was to evaluate the association of maternal folate and vitamin B12 concentrations with neonate birth weight in South Asian (SA) and white European (WE) populations. Methods: In this cross-sectional analysis of prospective cohort studies, maternal and neonatal data were collected during the second trimester from 3758 mother-child dyads living in Canada. Maternal diet and supplement use were assessed using a validated food frequency questionnaire. Biochemical indicators were analyzed in a subset of SA mothers. Birth weight was measured within 72 hours of delivery. All regression analyses were performed unadjusted and with adjustment for identified covariates. Results: Maternal folate and vitamin B12 (dietary, supplemental and total) were not associated with neonate birth weight in SA and WE pregnant women. Higher consumption of milk products by SA women was associated with higher birth weight (β=0.06; p=0.01), whereas higher consumption of egg by WE women was associated with lower birth weight (β=-0.19; p<0.01). Folate and vitamin B12 deficiency in the SA subgroup was 13.7% and 17.8%, respectively. Maternal serum vitamin B12 status was inversely associated with birth weight (β=-0.16; p=0.03). Conclusions: Folate and vitamin B12 may be proxies for poor nutritional status. Therefore, folate and vitamin B12 may have an association with neonate birth weight in a less developed area (i.e. India) rather than in a highly developed area (i.e. Canada). Highly developed countries have an adequate intake of folate and vitamin B12 and thus a higher nutritional baseline status. These findings complement current research on folate and vitamin B12 concentrations with birth weight in well-nourished populations. / Thesis / Master of Science (MSc) / Infant birth weight is an indicator of health and disease risk in adult life. The mother’s vitamin intake can influence the weight of the infant. This research aimed to study whether the mother’s folate and vitamin B12 status is related to infant birth weight. Dietary and supplemental data along with blood samples from South Asian and white European pregnant women living in Canada were collected during the second trimester. The mother’s dietary, supplemental and total folate and vitamin B12 intakes were not related to infant birth weight. In South Asian mothers, higher milk intake was related to higher birth weight and in white Europeans, higher egg intake was related to lower infant birth weight. Higher vitamin B12 in the blood was related to lower infant birth weight in South Asians. More research is needed to determine the relationship between folate and vitamin B12 with infant birth weight.

No / Germany in 1945 was crammed with millions of people displaced by war, deportation, Nazi slave labour, and flight before the advance of the Red Army. Many of them, including Poles and the Baltic peoples of Estonia, Latvia and Lithuania, refused to return to their communist-controlled homelands. Simultaneously in Italy, the Middle East and Britain, there were more than 100,000 Polish military personnel under British command, along with their dependants. Most of these were survivors of the one and a half million Poles deported to Siberia by the Soviet security police. Based on official documents and the words of the survivors and their children, this book describes the brutal uprooting of these people, their subsequent terrible experiences in the Soviet and Nazi forced labour camps and prisons, and their ultimate settlement in Britain. Here the newcomers created communities, integrated into British life while attempting to preserve their cultures and identities, and experienced how ethnic minorities relate to the host society. 'This book is a fascinating history of the Polish and Baltic communities who arrived in the United Kingdom shortly after the Second World War. The author relies on interviews with elderly members of these communities and on documents from the Public Record Office. It was perhaps the last opportunity to obtain these important oral histories and Lane is the first British researcher to do so.' - International Affairs 'Its originality lies in the author's ability to weave personal stories into the otherwise dry facts concerning population movements. In this respect, the book becomes an inspiring social history.'

Thesis (Ph. D.)--University of Hawaii at Manoa, 1991. / Includes bibliographical references (leaves 473-513) / Microfiche. / ix, 513 leaves, bound 29 cm

Title: Czechs and Slovaks in the first season of the second century of NHL Abstract The theme od the thesis are Czechs and Slovaks in the first season of the second century of NHL. The main aim of my work is to analyze the course of the season 2017-2018. In my work I will focus on the Czech and Slovak players and their comparison with players from the other European countries and with USA and Canada ice hockey superpowers. The comparison will be focused on the number of players, Canadian points, players' productivity in the 2017 NHL Entry Draft, their average age, and the players' age versus productivity. I will also focus on the team statistics (representation of Czechs, Slovaks and Europeans in each team). Key words Ice hockey, NHL, ice hockey players, Czechs, Slovaks, Europeans, goals, points

Since the political climate in the former Soviet bloc has shifted, there is an influx of East Europeans to the United States. As these refugees enter the U.S. educational system in greater numbers, teachers must adapt to the special needs of this population. The intent of this study is to focus on the composing skills of a Polish student who enrolled in an English for Non-Native Residents (ENNR) program at an urban university. The investigation examines the contextual framework that supports the subject's literacy experiences by means of a longitudinal case study format Several ethnographic and experimental techniques are used to explore three areas of interest: cultural context, the learning situation, and the composing processes. Multiple sources of data are used to investigate culture and learning, and a single elicitation technique is applied to the study of the writing process. Study of the cultural context suggests that the subject's early education and literacy experiences in Poland strongly influenced her development as a writer of English. Investigation of the classroom context at the university revealed both her preferences and frustrations with teaching and learning experiences. The primary focus of this study is exploration of writing process by means of a think-aloud protocol. The subject was asked to speak aloud while composing an essay on a narrative topic. She was instructed to say everything that came to mind while writing, and the session was videotaped for later analysis. A coding system was developed to help identify various components of the writing process, such as planning, commenting, rereading and pauses. Writing strategies, repetitions, fillers, revisions, verbal rehearsing, and quantity of words were identified according to frequency and location within the protocol. The results of the protocol analysis suggest that composing is not a neat and tidy process, but a complex configuration of multiple strategies. In the early stages simple patterns such as comments, planning, and fillers help the subject get started. A cycle of patterns, which seem automatic and deeply embedded, occurs throughout. These patterns emerge as Writing-Rehearsing-Pausing events. Each of these categories contains within a multitude of behaviors, such as pausing to think, rereading, and trying out new ideas. The data reveal numerous efforts at surface editing, yet the final product contains an average of 2.8 errors per sentence. The findings suggest that a writer's strategies and goals may shift during a controlled writing situation, and that initial steps may differ from those needed to attain closure. They suggest that attempts at surface revisions may not, in fact, improve the final product.

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