Urban settings are described in scholarly literature as areas beset with high concentrations of poverty, high incidences of crime and violence, and are typically occupied by high percentages of people of color (McKinney, Flenner, Frazier, & Abrams, 2006; Mitcham, Portman, & Dean, 2009; Vera, 2011). For many children who live in low-income urban school districts, our educational system is failing them (McKinney, Flenner, Frazier, & Abrams, 2006). Swanson-Gehrke (2005) reported that at least two-thirds of these children fail to reach basic levels of achievement in reading. Such dismal achievement results may be attributed to a myriad of issues faced by students living in high poverty that may impede the learning process. Improving the school achievement of these students requires comprehensive knowledge, unshakable convictions, and high-level pedagogical skills (Gay, 2010). The identification of effective instructional practices used to address the academic and social needs of these students has appeared to be an elusive task. The current study focused on this reality by investigating a school that has been able to create systems that result in improved academic and social outcomes of their students. Specifically, the study examined the instructional practices and beliefs of teachers of students of color with disabilities or at-risk of identification of disability at a high-performing high-poverty school.

Although university supervisors have a responsibility to prepare apprentice teachers to become culturally responsive special educators, supervisors themselves may not be qualified or have the requisite experience and training to do so (Jacobs, 2006). Additionally, little is known about how to effectively mentor preservice teachers to engage in critically reflective practice and how to foster culturally and linguistically responsive pedagogy (CLRP) to meet the needs of all learners (Athanases et al. 2008; Grant & Zozakiewicz, 1995). Specifically, there is a lack of teacher education research about the specific nature and quality of supervisory conversations that foster critical reflection among special educators who serve exceptional students from diverse cultural and linguistic backgrounds. This study was designed to (a) understand how supervisors engage in supervisory conferences to promote student teachers' critical reflection about CLRP and (b) identify contextual factors that appear to influence the nature and quality of discussions about CLRP in these conversations. Three university supervisors and their five special education student teachers were the participants for this research. Using an interpretivist, qualitative approach, several layers of inductive analysis were applied to multiple data sources: Content analysis was used to examine lesson plans, observation notes, and supervisory conversations for evidence of understanding and application of CLRP. Discourse analysis methods allowed for examination of supervisory conferences: interactional sociolinguistics to understand which participants initiated discussions about CLRP, how these discussions evolved, and tensions around these topics; and pragmatics to understand what types of prompts, statements and questions generated or scaffolded critical thinking in preservice teachers. Instrumental case study methodology was then applied to supervisor-student teacher dyads to identify emergent themes. Findings revealed that discussions about CLRP emerged between each supervisor -- student teacher pair, perhaps due to the presence of a supervisory conference guide. Supervisors used a variety of prompts to engage student teachers in technical, descriptive and dialogic levels; however, critical reflection was not demonstrated in this study. Supervisors seemed underprepared in the skills required to foster a stance of critical reflection in their student teachers. Implications for the preparation of university supervisors and special education teacher education research are presented. / text

Many important therapeutic agents are associated with significant undesired side effects which often limit treatment duration and dosing. Specifically, most major classes of antitumor chemotherapeutics have deleterious effects on cell division and DNA synthesis throughout the body due to systemic biodistribution. Engineering systems for controlled drug delivery allows for improved quality of life during treatment; as well as higher localized therapeutic concentrations by isolating toxic drugs used in many diseases to specific physiological compartments. An important drug delivery strategy for controlled release of therapeutics is based on responsive polymer matrices, which undergo swelling transitions in response to environmental stimuli. Biologically relevant factors which may trigger the release of therapeutics from responsive polymers include pH, ionic strength, and temperature. Temperature responsive polymers integrated into a composite system with metal nanoparticles allow for on demand drug release via an externally-applied optical or magnetic energy source. The intent of this work was to develop a temperature-responsive drug delivery platform for controlled therapeutic release, as well to expand the toolbox for rational design of responsive hydrogel nanoparticles intended for therapeutic delivery. Temperature-responsive hydrogels were synthesized and examined in the form of nanoparticles and bulk polymer networks. These materials are based on interpenetrating polymer networks (IPNs) of polyacrylamide (PAAm) and poly(acrylic acid) (PAA), which exhibit a positive volume swelling response with respect to temperature. Since this system responds to pH, ionic strength, and temperature, these IPNs were characterized over a wide range of solution conditions. Critical synthesis parameters needed to optimize thermal responses for specific solution conditions were identified, as were the specific effects of pH and ionic strength on network swelling and stability. The reverse emulsion process used to synthesize IPN nanoparticles was characterized to determine how particle growth proceeds during preparation. To enhance biocompatibility, IPN nanoparticles were surface-modified with a corona of poly(ethylene glycol) to reduce protein adsorption, a common strategy to improve in vivo performance. Due to the large amounts of surfactants employed in the preparation of IPN nanoparticles, purification methods needed to improve safety of IPN nanoparticles were optimized, and studied in vitro to ensure cellular compatibility. / text

Localized drug delivery is emerging as an effective technique due to its ability to administer therapeutic concentrations and controlled release of drugs to cancer sites in the body. It also prevents the contact of harsh chemotherapy drugs to healthy regions in the body that otherwise would become exposed to current treatments. This study reports on a model chemotherapy drug delivery system comprising non-ionic surfactant vesicles (niosomes) packaged within a temperature-sensitive chitosan network. This smart packaging, or package-within-a package system, provides two distinct advantages. First, the gel prevents circulation of the niosomes and maintains delivery in the vicinity of a tumor. Secondly, the chitosan network protects the niosomes against fluctuations in tonicity, which affects delivery rates. Tonicity is the sum of the concentrations of the solutes which have the capacity to exert an osmotic force across the membrane. Release rates were monitored from both bare niosomes alone and niosome-embedded, chitosan networks. It was observed that chitosan networks prolonged delivery from 100 hours to 55 days in low ionic strength environment and pH conditions similar to a tumor site. The primary effect of chitosan is to add control on release time and dosage, and stabilize the niosomes through a high ionic strength surrounding that prevents uncontrolled bursting of the niosomes. Secondary factors include cross-link density of the chitosan network, molecular weight of the individual chitosan polymers, dye concentration within the niosomes, and the number density of niosomes packaged within the chitosan network. Each of these factors can be altered to fine-tune release rates. Release rate experiments were conducted with 5,6-carboxyfluorescein, a fluorescent dye and chemotherapeutics paclitaxel and carboplatin. In vitro studies showed a preferential affinity of the smart packaged system to ovarian carcinoma cell line OV2008 as compared to normal epithelial cell lines of Ilow and MCC3. Further, feasibility of the drug delivery system was evaluated in vivo. Toxicity studies revealed that the system was non-toxic and feasible in vivo. The final outcome of this study includes tuning of the variables mentioned above that will contribute to the development of low cost and improved methods for drug delivery with application to intracavitary ovarian cancer treatment and other types of cancer

In the dominant management discourse, managers and consultants are credited with the ability to move their organisation in a planned, controlled way towards an idealised future. The assumptions underpinning this discourse include the following: organisations are thought of as systems that can be designed and steered in an intended direction; culture is seen as a control system to align employees’ conduct in support of the organisation’s strategy; consultants are viewed as experts in designing and implementing effective and efficient interventions, being on top of the process. These assumptions are grounded in the natural sciences of certainty, in which rational, formative and linear causality are presumed. I argue in this thesis, through a reflexive enquiry of my own practice, that these assumptions do not sufficiently resonate with my experience as an internal consultant on leadership and culture change. I am offering a critique of the dominant way of understanding organisations, culture and control, with the implication of coming to reappraise the involvement of a consultant in processes of culture change. In understanding organisations to be self-organising patterns of human interaction, culture is a social phenomenon, as it continually emerges as social control in the day-to-day local interactions of people making sense of experience. Using webs of significance, present in one’s personal history and in society, people interpret and give order to their life as they negotiate and evaluate their engagements together. In their engagement, participants will negotiate how to functionalise general values in particular situations that involve differences and can cause anxiety or even conflict. In this process of negotiation and evaluation, they are forming and being formed by each other. In this interaction no one is in control, determining in a predictable way what will happen. The participants have an influence that impacts on potential next steps in their interaction. An internal consultant’s involvement is in facilitating these processes of local interaction, enabling participants to have the conversations they tend not to have themselves, perhaps due to the anxiety of the interaction being unpredictable and predictable at the same time while no one is in control of the process or the outcome. A consultant is, as fellow participant, involved in the interaction while forming and being formed by it. He is at the same time detached: by inviting participants to work with and reflect on their experience of engaging, he enables reflexive awareness of what they are involved in together. The internal consultant, through temporary leadership, facilitates the conversation by focusing on the present, and working with differences, allowing the potential for novelty and change to occur. This temporary leadership is not a designated role or the authority of being the expert, but emerges in social interaction, through recognition and acceptance of participants acknowledging the consultant as leader in having a stronger influence than others. I propose that this alternative perspective does not offer a set of techniques, a causal framework to improve organisations in an intended and controlled way, as supposed in the dominant discourse. Rather, the perspective of complex responsive processes of relating enables a better understanding of human interaction processes; of culture emerging as social control and consulting as a social process, within the paradoxes of predictability and unpredictability, of being and not being in control, and of stability and change at the same time. It requires an internal consultant to assume a form of temporary leadership by enabling participants, through reflexive understanding of their experience, to be responsible in a critically aware manner of the ways in which they influence the next steps of engaging.

Research over the last three decades has documented that teacher efficacy has an effect on student achievement (Armor et al., 1976; Bandura, 1997). The literature on culturally responsive teaching (CRT) recognizes teacher efficacy as one of the attributes of successful teachers of students from culturally and linguistically diverse (CLD) backgrounds (Gay, 2000; Ladson-Billings, 1994). Researchers (e.g., Goddard & Goddard, 2001) have also found that collective teacher efficacy (CTE) beliefs can affect teachers’ goal setting, motivation, and persistence with challenging tasks or situations; specifically, the CTE construct not only explains school-level effects on achievement, but also explains effects on individual teachers’ self-efficacy. When CLD students require special education services, their instruction must be equally responsive to their cultural and linguistic characteristics in addition to their educational needs based on the disability (García & Ortiz, 2004; McCray & García, 2002). Consequently, CRT practices are central to improve these students’ learning outcomes (Gay, 2000). The purpose of this descriptive, correlational survey research study was to investigate (a) the relationship between special education teachers’ collective teacher efficacy beliefs and CRT efficacy for teaching CLD students in special education; and (b) the influences of personal and professional background variables on participating teachers’ CRT efficacy beliefs. The survey was sent to 855 special education teachers of CLD students with disabilities in three urban school districts in Texas; 344 complete responses were received, yielding a 44% response rate. The survey consisted of four sections: Background Information, Collective Teacher Efficacy (CTE), Culturally Responsive Teaching Self-Efficacy Scale (CRTSE), and Culturally Responsive Teaching Outcome-Expectancy Scale (CRTOE). Data were analyzed using descriptive statistics, factor analysis, analysis of variance, and multiple regression. The results revealed statistically significant relationships (a) between CRTSE and CRTOE beliefs, with a positive and moderate association; and (b) between CTE and CRT efficacy beliefs (CRTSE as well as CRTOE), but the associations were positive and weak. Teachers’ language characteristics, instructional setting, certification in bilingual education/English as a second language, and their perceptions of the quality of their professional preparation emerged as significant influences on their CRTSE and CRTOE beliefs. Implications for teacher education and future research are presented. / text

Advances in medical treatment are leading away from generalized care towards intelligent systems or devices which can sense and respond to their environment. With these devices, the burden of monitoring and dosing for treatment can be removed from the doctor (or the patient) and be placed on the device itself. Implicit closed-loop control systems will allow the device to respond to its environment and release therapeutic agent in response to a specific stimulus. Environmentally responsive hydrogels show great promise in being incorporated in such an intelligent device, such as pH-responsive hydrogels which can swell and deswell in response to changes in the pH of the media. Thus, pH changes can be exploited for controlled and intelligent drug delivery when used in combination with these pH-responsive hydrogels. In this work, heterogeneous, thermal-redox initiated free-radical polymerizations were developed to synthesize novel pH-responsive hydrogels, microparticles, and nanogels. The specific disease of interest was type I diabetes, which requires daily doses of insulin both at a basal amount and either a postprandial or preprandial bolus in order to maintain blood glucose levels within safe limits. To allow pH-responsive hydrogels to be sensitive to glucose, glucose oxidase was incorporated which oxidizes glucose to gluconic acid. A novel inverse-emulsion polymerization method was developed for the synthesis of poly[2-(diethylaminoethyl methacrylate)-grafted-polyethylene glycol monoethyl ether monomethacrylate] (P(DEAEM-g-PEGMMA)) nanogels (100-400 nm) for intelligent insulin delivery. The new polymerization method allowed the incorporation of hydrophilic components, such as glucose oxidase and catalase, as well as PEG surface tethers of lengths 400 Da up to 2000 Da. Surface tethers successfully decreased the surface charge of the nanogels. Insulin loading and release was determined for microparticles which were able to imbibe substantial amounts of insulin from solution when swollen, entrap the insulin when collapsed, and then release the insulin in response to either a pH or glucose stimulus. / text

Polymeric biomaterials have become ubiquitous in modern medical devices. ‘Smart’ materials, materials that respond to external stimuli, have been of particular interest for biomedical applications such as drug delivery. Poly(n-isopropylacrylamide) (pNIPAAm) is the best studied thermally responsive, biocompatible, ‘smart’ polymer and has been integrated into many potential drug delivery devices; however, the architectural design of the polymer in these devices is often overlooked. My research focus was the exploration of pNIPAAm architecture for biological applications. Two new biomaterials were synthesized as a result. Architectural modification of linear pNIPAAm was used to synthesize a well-defined homopolymer pNIPAAm with a sharp transition slightly above normal body temperature under isotonic conditions. This polymer required a combination of polymerization and control techniques including controlled radical polymerization, hydrogen bond induced tacticity, and end-group manipulation. The synthesis of this polymer opened up a variety of biomedical possibilities, one of which is the use of these polymers in a novel hydrogel system. Through the use of the controlled linear pNIPAAm synthesized through chain architectural modification, hydrogels with physiological transition temperatures were also synthesized. These hydrogels showed greater shrinking properties than traditional hydrogels synthesized in the same manner and showed physiological mechanical properties. Highly branched pNIPAAm was also optimized for biological applications. In this case, the branching reduced the efficacy of end-groups in transition temperature modification but increased the efficacy of certain copolymers. The resulting biomaterial was incorporated into a nanoparticle drug delivery system. By combining gold nanoparticles with highly branched pNIPAAm, which was designed to entrap small molecule drugs, a hybrid system was synthesized where heating of the nanoparticle through surface plasmon resonance can trigger drug release from the pNIPAAm. This system proved to be easy to synthesize, effective in loading, and controlled in release. As shown from the applications, architectural control of pNIPAAm can open up new possibilities with this polymer for biomedical applications. Small structural changes can lead to significant changes in the bulk properties of the polymer and should be considered in future pNIPAAm based medical devices.

This study explored the racial identity development of White corporate trainers who deliver training in racially diverse organizations. The purpose of this study was to acquire an understanding about the various factors that affect the racial identity development of White trainers as well as to distinguish ways in which racially diverse organizations support the creation of culturally responsive training. The study sought to identify aspects that affect White trainers’ identity and the role of the organizations in defining, or impacting, competencies related to culturally responsive training. A basic qualitative design guided the study and data was collected through two face-to-face interviews and a written reflection in response to their own completed interview transcripts. The participants included six White females and one male and were employed in organizations in the areas of oil and gas, real estate, retail, and consulting. The participants were identified by their connection to Texas A&M University students and faculty, the Academy of Human Resource Development, or the American Society for Training and Development. The findings of the study indicated that White corporate trainers develop their racial identity through a variety of experiences in their personal and professional environments. The White trainers’ perceptions of racial identity were impacted through environmental influences and their construction of Whiteness. Their racial consciousness was further developed through their work within racially diverse organizations and cultural diversity within the training environment exposed the trainers to their weaknesses and areas for growth. The process of becoming more culturally responsive trainers was a constant evolution that took place through self-reflection and the acknowledgment of race as an important component related to identity and their work.

In my study, I have chosen to examine how the user interface and content must conform to design guidelines for responsive design makes it suitable for diverse desktop environment and for varied mobile platforms. The purpose of this study is to examine the extent recommended design guidelines based on scientific research has a positive impact on user performance and perception when using this study delivered hi-fi prototype. The goal of this study is to provide a Hi-Fi prototype with high usability that will introduce and inform the public about BrasilCine according specifications. Study findings from user testing and supplementary questionnaires show that the implemented technologies as design guidelines for responsive design and design features have a positive impact on user performance and perception. The study results are therefore relevant for further prototype development.