Abstract Purpose: To compare the frequency specific Cortical Auditory Evoked Potential (CAEP) and the chirp-evoked 40 Hz Auditory Steady State Response (ASSR) with equivalent residual noise levels for behavioural threshold prediction in adults with normal hearing and with SNHL. Method: The study tested 23 adults with normal hearing and 20 adults with SNHL. The participants were aged between 18–65 years. A repeated measures within- participant descriptive design was used to collect the quantitative data. The participants underwent behavioural pure tone, CAEP and ASSR testing on the same day. Results: Similar CAEP difference scores across frequencies for the participants with normal hearing (mean=12.32-14.40 dB) and with SNHL (mean=10.00-16.47 dB) were measured. However, for the ASSR difference scores across frequencies slightly smaller difference scores were measured for the participants with SNHL (mean=10.17-17.30 dB) than for the participants with normal hearing (mean=11.74- 17.14 dB). CAEP thresholds were significantly closer to the behavioural pure tone thresholds at 500 (p=0.028; mean absolute difference 14.40 dB) and 2000 (p=0.016; mean absolute difference 12.56 dB) Hz for participants with normal hearing. In participants with sensorineural hearing loss, CAEP and ASSR thresholds were measured at similar sensation levels and were not statistically different (p>0.05). Conclusion: For the purpose of threshold estimation, representing the auditory function to the level of the auditory cortex the CAEP was closer to the behavioural hearing thresholds than the 40 Hz ASSR at all frequencies except at 4000 Hz, regardless of the hearing sensitivity. Keywords: Auditory steady state response (ASSR), Cortical auditory evoked potential (CAEP), Auditory evoked potential (AEP), Residual noise, Signal to noise ratio (SNR), objective threshold estimation, awake adults. / Dissertation (MA (Audiology))--University of Pretoria, 2019. / Speech-Language Pathology and Audiology / MA Audiology / Unrestricted

京都大学 / 0048 / 新制・論文博士 / 博士(医学) / 乙第13133号 / 論医博第2137号 / 新制||医||1024(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 溝脇 尚志, 教授 妹尾 浩, 教授 鈴木 実 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

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When monitoring a binary process proportion p, it is usually assumed that the binary observations are independent. However, it is very common that the observations are correlated with p being the correlation between two successive observations. The first part of this research investigates the problem of monitoring p when the binary observations follow a first-order two-state Markov chain model with p remaining unchanged. A Markov Binary GLR (MBGLR) chart with an upper bound on the estimate of p is proposed to monitor a continuous stream of autocorrelated binary observations treating each observation as a sample of size n=1. The MBGLR chart with a large upper bound has good overall performance over a wide range of shifts. The MBGLR chart is optimized using the extra number of defectives (END) over a range of upper bounds for the MLE of p. The numerical results show that the optimized MBGLR chart has a smaller END than the optimized Markov binary CUSUM. The second part of this research develops a CUSUM-pp chart and a GLR-pp chart to monitor p and p simultaneously. The CUSUM-pp with two tuning parameters is designed to detect shifts in p and p when the shifted values are known. We apply two CUSUM-pp charts as a chart combination to detect increases in p and increases or decreases in p. The GLR-pp chart with an upper bound on the estimate of p, and an upper bound and a lower bound on the estimate of p works well when the shifts are unknown. We find that the GLR-pp chart has better overall performance. The last part of this research investigates the problem of monitoring p with p remains at the target value when the correlated binary observations are aggregated into samples with n>1. We assume that samples are independent and there is correlation between the observations in a sample. We proposed some GLR and CUSUM charts to monitor p and the performance of the charts are compared. The simulation results show MBNGLR has overall better performance than the other charts. / Ph. D.

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