The purpose of this study is to provide an inclusive portrait of the experience of female spouses living with traumatized male Canadian soldiers healing from Post-Traumatic Stress Disorder (PTSD). By facilitating the articulation of the spouses' stories this research gives a voice to and fosters appreciation for this neglected population. As well, this study helps clarify the needs and possible therapeutic interventions for spouses of soldiers in psychotherapy for PTSD. Although recently there has been an increased focus on addressing PTSD in soldiers, there has been comparatively little research and clinical attention given to the soldiers' families. For this study, in-depth interviews were conducted with six spouses of former peacekeeping Canadian soldiers who received group therapy for PTSD. Using the Life Story interview method, a spontaneous picture of the spouses' experiences was elicited as part of a comprehensive relationship narrative. This provided the opportunity for understanding the experience of living with a soldier in treatment for PTSD within a couple relationship and larger social context. Narrative summaries were created from the interviews and follow-up was conducted with each participant to gain feedback on these narratives. Participants were also given the opportunity to read each other's narratives and discuss their impressions. The narrative summaries are presented along with thematic results. The participants' stories revealed instances of aggression, primary trauma and problems related to their husbands' periods of alcohol abuse, so Figley's model of Secondary Traumatic Stress was not the best conceptual fit to explain the experiences of these women. Limited support was found, however, for Hobfoll's (1998)model of a loss spiral to help describe the descent into chronic disability associated with combat-related PTSD as well as the difficulties soldiers experience in their transition from military service. This study's implications for practice include recommendations for groups for military spouses; the need to address the iatrogenic suffering of soldiers and their spouses; treatment recommendations for soldiers with PTSD. Future research also needs to include delivery and evaluation of a group-based counselling intervention for the spouses of traumatized soldiers. / Education, Faculty of / Educational and Counselling Psychology, and Special Education (ECPS), Department of / Graduate

South Africa as a country is known for its high crime rate which produces an ongoing traumatising environment for its multicultural nation. Posttraumatic stress disorder in the general South African population is thought to be more prevalent than most international norms which make this topic both relevant and important. Cultural diversity is seen to play a role in the experience of PTSD which means that it has become important to gain an understanding of the potential effect of the individual’s cultural background on the processing of a traumatic experience and the symptoms related to the experience. The proposed research focused on appraisals of the traumatic event and symptoms (in schematic and cultural terms). An interpretive (with current cognitive conceptions of the disorder as guiding theory) phenomenological approach was used. The sample consisted of eight isiXhosa-speaking adults that qualified for a diagnosis of PTSD with no prior psychiatric diagnosis. Data was gathered using a semi-structured interview and analysed using the Interpretive Phenomenological Analysis. Results indicated that participants understood their PTSD symptoms in a functional manner but struggled to make sense of their traumatic event. Not understanding their traumatic event was the variable that maintained their PTSD diagnosis. Most of the interpretations made by these participants were fairly universal and there were very few links to content that can directly be attributed to a traditional African worldview. Practitioners may not need to completely reinvent the wheel as far as treatment strategies for PTSD for isiXhosa-speaking individuals in an urban setting go.

Background: This study identified, addressed and validated risk factors that can be measured in the peri-traumatic period which may eventually be used in predicting the development of traumatic stress. Many people in South Africa possibly suffer from Posttraumatic Stress Disorder (PTSD) if we consider the extent of trauma exposures that is apparent within the South African population. Traumatised individuals are at risk but may remain undiagnosed and untreated. It makes sense for first line and primary health care practitioners (i.e., not highly qualified psychological practitioners) to screen for risk since they have the initial contact with trauma individuals. A relatively easy screening instrument that can be administered time efficiently would be useful in this regard. The principles of this instrument are that it needs to be objectively measurable, quick and easy to administer. No consistent measure geared towards identifying risk factors in such a manner immediately post trauma currently exists in South Africa. Objectives: The overall aim was to start a process of designing a psychometric instrument that is valid in predicting the development of traumatic stress. Since this is the initial stage of constructing a new measure, content validity was of utmost importance. It became imperative to ensure that items were not only relevant and appropriate, but also accurate and capable in identifying at-risk individuals. The proposed end goal is to develop effective identification strategies in South Africa geared towards helping victims of traumatic events. Method: A pilot psychometric questionnaire was compiled using three major international reviews, South African research on known risk factors, and literature on PTSD risk assessment considerations. This preliminary assembled item pool was used as a departure point and evaluated quantitatively as well as qualitatively by expert reviewers who have research and/or clinical experience with PTSD in a South African context. Their feedback resulted in either the omission or the modification of certain items; for some items, further exploration was recommended. The questionnaire was further scrutinised and modified accordingly after qualitative interviews with and critical feedback from the intended administrators or primary health care professionals, namely Registered Counsellors (RCs) and/or nursing staff from a participating general government hospital and a non-government organisation. Findings: Expert reviewers did not agree consistently across all the items. At times they rated certain items as relevant according to the necessity of the information rather than with regards to the relevance of the content of the item – in terms of prediction of PTSD. It was also observed that intended administrators did not always agree with expert reviewers.

Background: Chronic traumatic encephalopathy (CTE) is an enigma that has become synonymous with combat sports over the past few decades. Mixed martial arts (MMA) is a combat sport that is growing in popularity world-wide. The objective of this study is to determine the factors associated with head trauma among MMA athletes. Methods: Logistic regression analyses using SPSS 20 was employed to model putative covariates against the dichotomous outcomes of unconsciousness (for the full dataset) and diagnosed concussion (for the enriched subset of fighters who were rendered unconscious). Results: Increasing age, black or African-American ethnicity, shorter rest periods between fights, increasing numbers of significant clinch strikes landed, significant distance body strikes landed and power strikes landed to the body at distance are all factors associated with being diagnosed with a concussion among the fighters rendered unconscious. Conclusion: If bolstered by confirming laboratory and clinical evidence, policies should be developed for implementation by MMA governing bodies to help reduce incidences of head trauma and concussion, built around fighters’ demographic and behavioural characteristics. In particular, enforcing a mandatory rest period between fights and placing an upper limit on fighters’ age are ideas worth exploring.

Background: Recent Canadian Armed Forces operations involved multiple deployments and exposure to traumatic events that are associated with post-traumatic stress disorder, depression and substance abuse. Despite efforts to facilitate mental health care, some soldiers do not get the help they need. Objective: To understand soldiers’ experiences and explore barriers and facilitators they encountered accessing mental health care. Results: Qualitative descriptive interviews with 11 Canadian Armed Forces members revealed six major categories that provide insights into their experiences accessing mental health care. Participants’ revealed significant barriers to care including fear of damaging their career or being released, stigma beliefs and actions from peers and leaders, and physical and organizational barriers to care. Social support from family, military co-workers, and unit leaders facilitated care. Conclusions: Notwithstanding efforts to facilitate access to mental health care, some soldiers still perceive significant barriers to care.

Traumatic brain injury is a substantial cause of disability worldwide; recovery is a long-term, intensive process. Patients with traumatic brain injury are admitted to inpatient rehabilitation with the goal of preventing disability and the need for long-term care as well as promoting patient independence. Acknowledging that traumatic brain injury also affects the family, much of the literature focuses on the well-being of families and their needs, bringing attention to family functioning, resilience, and psychosocial well-being. Recognizing the important role of families in health care, Canadian healthcare institutions espouse family-centred philosophy. Not to mention, the resulting impairments from traumatic brain injury and the complex nature of inpatient rehabilitation can also lead to the involvement of families in this process. However, we do not yet fully understand how families are involved in adult inpatient traumatic brain injury rehabilitation. Given the adoption of a family-centred philosophy as well as the potential benefits of family-centred care for patient and family outcomes, it is important to understand this involvement to guide the provision of family-centred health and rehabilitation services. This study is the first step in a program of research that is devoted to understanding family involvement in adult inpatient traumatic brain injury rehabilitation. I used an interpretive qualitative approach with a two-phased sequential design to elucidate how families were involved in the inpatient rehabilitation process. I conducted one-on-one semi-structured interviews with six patients with TBI, four family members, and 10 healthcare professionals followed by observations on the inpatient Acquired Brain Injury ward at a Canadian adult rehabilitation centre. In Phase 1 interviews, both the patients and family members described family involvement as family members being with and supporting the patients, informing other family members as well as the healthcare professionals and keeping themselves informed, helping the patients to make decisions, and participating in care and therapy. The healthcare professionals similarly described family members being with and supporting the patients; however, they conversely illustrated family members’ involvement as providing information to and receiving information from the healthcare professionals as well as making decisions when required or deemed necessary by them, and learning care and therapy. While the observation findings supported the patients’, family members’, and healthcare professionals’ perceptions that family members support the patients by being present and spending time with them, they highlighted the healthcare professional-led nature of the rehabilitation process in the inpatient setting in relation to information sharing, decision making, and care and therapy. They also illuminated the potential impact of the ward environment on family involvement. This study was the first to explore family involvement with this adult patient population in the inpatient rehabilitation setting from the perspectives of patients, family members, and healthcare professionals as well as through direct observation. It revealed that patients and family members had different understandings than healthcare professionals of the ways in which families were involved. Given the adoption of a family-centred philosophy, we need to understand how to operationalize it in this type of adult setting and close the gap between theory and practice.

Considerable research has demonstrated a link between thoughts of revenge, or vengeful rumination, and the development of posttraumatic stress disorder (PTSD) symptoms, particularly in situations involving interpersonal trauma. Personality factors have been related to both vengefulness and PTSD. No study to date has simultaneously examined the unique contributions of vengefulness and personality factors in the development of PTSD symptoms. Therefore, the present study addressed these questions in an inpatient sample by comparing contributions of the Big Five personality factors and vengeful rumination to the development of PTSD symptoms through correlation, hierarchical regression, and omnibus regression analyses. Results showed that Neuroticism predicted PTSD symptoms better than other personality factors, that Neuroticism and Agreeableness predicted vengeful rumination in opposite directions, and that personality factors and vengeful rumination each added unique variance in the prediction of PTSD symptoms. Future directions and implications are discussed.

Le traumatisme cranio-cérébral (TCC) est l'une des plus grandes causes de mortalité et de morbidité de ce siècle. Les études menées ces dernières années sur ce sujet, ont montré que l'hypopituitarisme est une des conséquences les plus fréquentes et les plus durables consécutives à un TCC. L'hypopituitarisme se traduit par une ou des déficience(s) hormonale(s) et notamment une diminution de la sécrétion de l'hormone de croissance (GH). Mes travaux de thèse ont consisté à mettre en place un model murin pour étudier le déficit en GH après un TCC ; et ainsi rechercher à quel niveau l'axe somatotrope est-il touché. J'ai tout d'abord participé à des études qui m'ont permis de mettre en place des pré-requis expérimentaux à l'étude du TCC sur des souris (J. Endoc. 2009 ; PNAS, 2010). Dans ce modèle animal, 10% à 20% de ces souris traumatisées présentent un défaut de sécrétion de la GH trente jours après avoir subi un TCC au niveau du cortex pariétal droit, ont un défaut de sécrétion de la GH, alors que les animaux opérés mais non traumatisés (sham) ne présentent pas ce défaut. Les souris déficientes pour la sécrétion de GH ne présentent pas de dérégulation de l'architecture vasculaire hypophysaire ou hypothalamique. Au niveau moléculaire, la transcription des ARNm de l'hormone de croissance et de la neurohormone hypothalamique GHRH (qui stimule la sécrétion de GH) ne semble pas affectée par les effets du traumatisme. En revanche, très rapidement après un traumatisme localisé au niveau du cortex, on observe l'apparition d'une cicatrice gliale. Cette cicatrice astrocytaire apparait non seulement dans la région du traumatisme, mais également au niveau de l'éminence médiane. Cette réponse inflammatoire, associée à un défaut des tanycytes bordant le 3ème ventricule, pourrait expliquer, au moins en partie, ce déficit en GH post-TCC. En résumé, cette étude nous a permis de reproduire sur le modèle murin (avec un même fond génétique) les déficits en GH que l'on observe chez des patients traumatisés. / Traumatic Brain Injury (TBI) is a major cause of mortality and morbidity. Studies on this subject in recent years have revealed that hypopituitarism is one of the most common sequelae to TBI. Since the pituitary is an endocrine tissue, hypopituitarism results in marked hormonal deficiency, including decreased serum levels of growth hormone. As such, the work contained within this thesis has focused on developing a mouse model of TBI-induced GH deficiency, with the principal aim of discovering where the deficit lies in the somatotropic axis (i.e. hypothalamaic releasing hormone vs. pituitary cell activity). By subjecting mice to a controlled impact to the right parietal cortex, we observed a GH secretory defect in 10% to 20% of cases. These defects where apparent thirty days following trauma and were not detected in animals subjected to surgery, but not TBI (sham). Mice suffering hypopituitarism secondary to TBI did not show any obvious changes to pituitary or hypothalamic vascular architecture, and at the molecular level, GH and GHRH (the major GH-secretagogue) mRNA levels were normal. However, in the acute phase following TBI, a large glial scar developed which extended to the level of the median eminence (ME). This inflammatory response could explain, at least in part, GH deficiency post-TBI if associated with dysfunction of third ventricle tanycytes known to be involved in hypothalamic neuron output. In summary, by using an isogenic, age-matched mouse model of TBI, this study has provided insights into the causes of GH deficiency, a common consequence of cranial trauma in humans.

abstract: Traumatic brain injury (TBI) affects an estimated 1.7 million people in the United States each year and is a leading cause of death and disability for children and young adults in industrialized countries. Unfortunately, the molecular and cellular mechanisms of injury progression have yet to be fully elucidated. Consequently, this complexity impacts the development of accurate diagnosis and treatment options. Biomarkers, objective signatures of injury, can inform and facilitate development of sensitive and specific theranostic devices. Discovery techniques that take advantage of mining the temporal complexity of TBI are critical for the identification of high specificity biomarkers. Domain antibody fragment (dAb) phage display, a powerful screening technique to uncover protein-protein interactions, has been applied to biomarker discovery in various cancers and more recently, neurological conditions such as Alzheimer’s Disease and stroke. The small size of dAbs (12-15 kDa) and ability to screen against brain vasculature make them ideal for interacting with the neural milieu in vivo. Despite these characteristics, implementation of dAb phage display to elucidate temporal mechanisms of TBI has yet to reach its full potential. My dissertation employs a unique target identification pipeline that entails in vivo dAb phage display and next generation sequencing (NGS) analysis to screen for temporal biomarkers of TBI. Using a mouse model of controlled cortical impact (CCI) injury, targeting motifs were designed based on the heavy complementarity determining region (HCDR3) structure of dAbs with preferential binding to acute (1 day) and subacute (7 days) post-injury timepoints. Bioreactivity for these two constructs was validated via immunohistochemistry. Further, immunoprecipitation-mass spectrometry analysis identified temporally distinct candidate biological targets in brain tissue lysate. The pipeline of phage display followed by NGS analysis demonstrated a unique approach to discover motifs that are sensitive to the heterogeneous and diverse pathology caused by neural injury. This strategy successfully achieves 1) target motif identification for TBI at distinct timepoints and 2) characterization of their spatiotemporal specificity. / Dissertation/Thesis / Doctoral Dissertation Neuroscience 2020

Magister Psychologiae - MPsych / It is commonly known that South African society is characterised by high rates of exposure to violence and traumatic events. However, there is a convincing body of knowledge that indicates that a significant proportion of young adults exposed to traumatic events do not develop negative, trauma-related symptoms, but rather adapt in a positive manner