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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
471

FAMILIAL POLYCYTHEMIA LIKELY DUE TO NOVEL HEMOGLOBIN VARIANT- HEMOGLOBIN HYDEN

kolagatla, sandhya, moka, nagabhishek, bailey, samuel 05 April 2018 (has links)
Adult hemoglobin (HbA) is made up of two pairs of globin chains. Some rare mutations of the globin chains can result in high affinity towards hemoglobin molecule thus changing the equilibrium of normal oxygen loading in lungs and the delivery of same to the tissues. Because of change in the affinity to the oxygen these mutations can result in erythrocytosis (polycythemia). Here we discuss a case of Familial Polycythemia likely due to novel hemoglobin variant. 42-year Caucasian male presents to the clinic with high hemoglobin for several years but otherwise denies any symptoms of headache, vision changes, chest pain. He had history of multiple phlebotomies. His past medical history is significant for Polycythemia, PICC line associated clot,Type2 Diabetes, Hypertension, Epidural abscess. Social history is significant for smokeless tobacco but otherwise non-smoker, non-alcoholic, not an IVDA and doesn’t use testosterone. Family history is significant for his sister, her two 14year old daughters and multiple other family members with elevated hemoglobin and undergo phlebotomies, maternal grandfather died of cancer in his 30s. Physical examination is only significant for BMI of 32.46 otherwise no skin discoloration or cyanosis. Laboratory data WBC 9.4 with normal differential, hemoglobin 18.2, hematocrit 55.4, platelet count 180,000, peripheral blood smear was within normal limits, negative for JAK-2, normal erythropoietin, negative for hemochromatosis, Oxygen dissociation p50 of 19 which is low indicating left shifted dissociation curve, hemoglobin electrophoresis HbA: 61.2%, HbA2: 3%, HbF: 0%, Beta variant: 35.8%. In order to further characterize beta variant Bi-directional sequence analysis for Molecular alterations was performed and the following alterations were detected Gene: HBB, DNA change: Codon 39, heterozygous CAG>CCG Protein change: P.G1n39Pro. [glutamine (Q) to proline (P)]. HGVS: c.119A>C, p.Q40P, Classification: Likely deleterious variant. (GenBank accession number NM_000518.4). This is a previously unreported beta chain hemoglobin variant present. This hemoglobin variant is named as Hemoglobin Hyden based on the place where this is found in Hyden, Kentucky. There have been four variants reported at codon 40 of the beta globin gene, which is an external contact site between beta globin and alpha-2 globin. One variant, Hb vassa, is associated with mild hemolytic anemia. The three other variants (Hb Alabama, Hb Tianshui and Hb San Bruno) are not associated with clinical or hematological abnormalities. In our opinion p.Q40P is likely a cause of erythrocytosis. In order to further establish the causality it may be beneficial to test first degree relative to in this family in order to determine whether the p.Q40P alteration tracks with disease and is not present in unaffected individuals. Hemoglobin threshold for phelebotomy to lower the risk of thrombosis and cardiovascular events is yet to be defined.
472

Boletín diario de información científica N° 1

Asociación Peruana de Bibliotecas Académicas ALTAMIRA 16 April 2020 (has links)
La Asociación Peruana de Bibliotecas Académicas ALTAMIRA se une al esfuerzo para la lucha contra el COVID-19 facilitando acceso a la información científica especializada mediante el envío de un boletín diario con las últimas publicaciones académicas sobre el COVID-19. Este Boletin cuenta con secciones: información oficial sobre COVID-19, artículos científicos, artículos preprint, revisiones sistemáticas y otras fuentes de información.
473

Boletín diario de información científica N° 40

Asociación Peruana de Bibliotecas Académicas ALTAMIRA 06 1900 (has links)
Boletín que incluye información científica sobre el COVID-19, incluye artículos científicos y artículos preprint actualizados al 11 de Junio de 2020.
474

Spineless

Johnay Hall (8770229) 01 May 2020 (has links)
<p>This novel began as a short story collection exploring aspects of blackness that dealt with homosexuality, family dynamics, violence, Christianity and societal constructs. The first draft was titled <i>Innerworkings</i>. My goal was to show how the actions or inactions of others can easily affect someone else’s life by focusing on each character individually before their story intertwined without another’s. This current thesis manuscript steams from my experience of talking to family members and peers, each with a different option about how the topics stated should be handled. Most of the conversations left me with more questions and feelings of guilt or questioning what my life looks like vs what it should look like. With the current thesis manuscript, I strive to find a way to bring up a new way to handle discussions where spiritually and unspiritual topics can be handled respectfully. </p> <p> </p> <p>Reading Jesmyn Ward’s <i>Sing, Unburied Sing</i> and <i>Salvage the Bones</i> allowed me to see how a story could play out when each character is given their individual spotlight while also giving the reader insight to how they view the other characters. The work here is also influenced by Tomi Adeyemi’s novel <i>Children of Blood and Bone </i>and Marlon James’s <i>Black Leopard, Red Wolf</i> that showcased how important maps and character charts were in helping the readers understand the world and plot by giving them insight before they cracked open the first chapter. With time, I hope to be able to integrate maps and family tree dynamics into the novel so that The Community can be properly showcased as a character and its changes over time. </p>
475

Boletín diario de información científica N° 34

Asociación Peruana de Bibliotecas Académicas ALTAMIRA 03 June 2020 (has links)
Boletín que incluye información científica sobre el COVID-19, incluye artículos científicos y artículos preprint actualizados al 03 de Junio de 2020.
476

Naissance de l'individu et émergence du roman de formation. La contribution du roman-mémoires des années 1730 / Birth of the individual ans emergence of the novel of formation. The contribution of the memoirs novel of the years 1730

Ibrahim, Laith 03 July 2018 (has links)
Le discours critique sur le roman-mémoires des années 1730 semble souvent hésiter entre deux attitudes antagonistes : soit il y discerne les signes d’une « naissance de l’individu » et y voit l’émergence du roman de formation (Bildungsroman). Soit il considère que ces catégories sont anachroniques : la notion d’« individu », comme être conscient de soi et de son intériorité affective et comme l’élément élémentaire dont se compose la société n’apparaît-elle pas seulement dans la deuxième moitié du XVIIIe siècle en particulier dans la réflexion de Jean-Jacques Rousseau ? et le roman de formation ne trouve-t-il pas son prototype en Allemagne, avec Les Années d’apprentissage de Wilhelm Meister de Goethe ? Mais en réalité, Rousseau et Goethe sont tous deux de grands lecteurs de romans-mémoires et ils s’en sont nettement inspirés dans leurs écrits. La présente thèse souhaite montrer que le roman-mémoires des années 1730 peut être analysé comme un roman de formation, dans la mesure où il décrit les étapes constitutives de l’identité d’un individu et porte une vision du monde sur sa place dans la vie sociale. Mais une telle hypothèse implique de s’interroger sur cette forme romanesque « rebelle à tout ordre » (Henri Coulet, Le Roman jusqu’à la Révolution) : Comment définir cette forme romanesque ? Quel est son rôle dans la cristallisation de la notion d’« individu » ainsi que du roman de formation ? C’est à ces questions que s’efforce de répondre cette thèse en analysant quelques œuvres emblématiques de cette nouvelle forme romanesque, ainsi que leurs enjeux, leurs dimensions philosophiques, esthétiques, politiques et anthropologiques et leurs contributions à l’avènement de l’individu et à l’émergence du roman de formation (Bildungsroman). / The critical discourse on the memoir novel of the years 1730 often seems to hesitate between two antagonistic attitudes : either it discerns in it the signs of a "birth of the individual" and sees in it the emergence of the novel of formation (Bildungsroman). Or it considers these categories as anachronistic : did not the notion of the "individual" as a being conscious of itself and of its emotional interiority and as the basic element of which society is composed only appear in the second half of eighteenth century, most notably in the reflections of Jean-Jacques Rousseau ? And did not the novel of formation find its prototype in Germany, with Goethe’s Wilhelm Meister’s Apprenticeship ? But in reality, Rousseau and Goethe were both great readers of memoir novels and were clearly inspired by them in their writings. The present thesis hopes to show that the memoir novel of the years 1730 can be analyzed as a novel of formation, insofar as it describes the constituent steps of individual identity and carries a worldview regarding its place in social life. However, such a hypothesis implies asking some questions about this novelistic form, considered as "rebellious to any order" (Henri Coulet, Le Roman jusqu’à la Révolution) : How can this novelistic form be defined ? What was its role in the crystallization of the notion of the "individual", as well as that of the novel of formation ? These are the questions that this thesis attempts to answer by analyzing some emblematic works of this then new novelistic form, as well as their importance, their philosophical, aesthetic, political and anthropological dimensions and their contributions to the advent of the individual and the emergence of the novel of formation (Bildungsroman).
477

Missing Story: contingency and narrative in modern fiction and film

Dabashi, Pardis 12 November 2019 (has links)
The first study to examine the status of plot in the modernist novel and the integral role that commercial narrative film played in shaping it, Missing Story reads the modernist novel in conjunction with the evolution of cinematic narrative. It argues that an exemplary subset of modern novelists detected in narrative cinema of the early twentieth century an attempt to co-opt realist storytelling, and to ignore the social, political, economic, and philosophical reasons why modernist authors sought to displace realism. Plot has been considered anathema to a modernist narrative difficulty meant to challenge the ideology of Enlightenment progress and bourgeois values for which realist plot was assumed an aesthetic proxy. Missing Story, however, reveals that far from expunging realist plot, the modernist novel attempted to recuperate it in complex ways, and that cinema’s increased reliance on realist storytelling played a hitherto un-recognized role in this aesthetic crisis. Narrative film forced modern novelists to acknowledge the affordances of realist plot—its ability, in the nineteenth-century realist tradition, to generate coherent selfhood over time, to lend narrative shape to the changing tides of history, and to secure social belonging. My project shows how the novel’s relinquishment of realist plot thus generated a surge of contradictory textual dynamics and affective intensities in modernist narrative form and its characters. Demonstrating that modernist novelists were drawn to film’s powers of storytelling rather than abstraction, my project also revises recent scholarship on modernism and the new media. Even though media histories of modernism have broadened their purview to include a diversity of mass cultural—rather than solely avant-garde—texts, they still tend to focus on the breakdown of form and the ways that modernist literature sees itself in popular culture’s fissures and lapses. Through readings of works by Nella Larsen, William Faulkner, Djuna Barnes, Tod Browning, and Max Ophuls, I argue that it was commercial film’s ability to suture stories together—not to break them apart— that generated a formal and ideological crisis in the modern novel. That crisis, I contend, resulted from an intense ambivalence toward plot, ambivalence fueled by critique and colored by longing. / 2021-11-12T00:00:00Z
478

Boletín diario de información científica N° 48

Asociación Peruana de Bibliotecas Académicas ALTAMIRA 23 June 2020 (has links)
Boletín que incluye información científica sobre el COVID-19, incluye artículos científicos y artículos preprint actualizados al 23 de Junio de 2020.
479

Boletín diario de información científica N° 49

Asociación Peruana de Bibliotecas Académicas ALTAMIRA 24 June 2020 (has links)
Boletín que incluye información científica sobre el COVID-19, incluye artículos científicos y artículos preprint actualizados al 24 de Junio de 2020.
480

Boletín diario de información científica N° 50

Asociación Peruana de Bibliotecas Académicas ALTAMIRA 25 June 2020 (has links)
Boletín que incluye información científica sobre el COVID-19, incluye artículos científicos y artículos preprint actualizados al 25 de Junio de 2020. Tipo

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