Made available in DSpace on 2014-10-09T12:50:15Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:01:54Z (GMT). No. of bitstreams: 1 10826.pdf: 3720317 bytes, checksum: 26d9f64b9d44684f557ae44f37e86002 (MD5) / Dissertação (Mestrado Profissionalizante em Lasers em Odontologia) / IPEN/D-MPLO / Intituto de Pesquisas Energeticas e Nucleares, IPEN/CNEN-SP; Faculdade de Odontologia, Universidade de Sao Paulo

Made available in DSpace on 2014-10-09T12:54:51Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:06:57Z (GMT). No. of bitstreams: 1 12794.pdf: 2065231 bytes, checksum: 5d277cd94726f9af455400aea420ffe2 (MD5) / Dissertacao (Mestrado Profissionalizante em Lasers em Odontologia) / IPEN/D-MPLO / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP; Faculdade de Odontologia, Universidade de Sao Paulo, Sao Paulo

Made available in DSpace on 2014-10-09T12:54:53Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:06:54Z (GMT). No. of bitstreams: 1 12796.pdf: 440348 bytes, checksum: 5d7b85c92d4b0bf453b89e0590595d61 (MD5) / Dissertacao (Mestrado Profissionalizante em Lasers em Odontologia) / IPEN/D-MPLO / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP; Faculdade de Odontologia, Universidade de Sao Paulo, Sao Paulo

Yes / There are many human oral antimicrobial peptides responsible for playing important roles including maintenance, repairing of oral tissues (hard or soft) and defense against oral microbes. In this review we have highlighted the biochemistry, physiology and proteomics of human oral histatin peptides, secreted from parotid and submandibular salivary glands in human. The significance of these peptides includes capability for ionic binding that can kill fungal Candida albicans. They have histidine rich amino acid sequences (7–12 family members; corresponding to residues 12–24, 13–24, 12–25, 13–25, 5–11, and 5–12, respectively) for Histatin-3. However, Histatin-3 can be synthesized proteolytically from histatin 5 or 6. Due to their fungicidal response and high biocompatibility (little or no toxicity), these peptides can be considered as therapeutic agents with most probable applications for example, artificial saliva for denture wearers and salivary gland dysfunction conditions. The objectives of current article are to explore the human histatin peptides for its types, chemical and biological aspects. In addition, the potential for therapeutic bio-dental applications has been elaborated. / King Saud University

O carcinoma epidermoide de cavidade oral (CECO) é um dos tumores mais comuns em câncer de cabeça e pescoço, com aproximadamente 300.000 novos casos e 145.000 mortes em todo o mundo. Apesar da intensa pesquisa e dos avanços recentes no diagnóstico e terapia, a taxa de sobrevivência dos pacientes ainda é baixa. Os estudos da metabolômica levaram a uma melhor compreensão do metabolismo do câncer, no seu desenvolvimento e progressão. Essas descobertas possibilitaram a identificação de biomarcadores metabólicos que podem auxiliar na identificação de doenças e tratamentos. O presente estudo buscou três objetivos: (1) Identificar e quantificar os metabólitos plasmáticos em portadores de CECO e em controles, utilizando técnicas de ressonância magnética nuclear (RMN); (2) Comparar a concentração plasmática de metabólitos de pacientes com CECO com a de seus controles estratificados por variáveis clínicas, patológicas, sociodemográficas e características de estilo de vida; (3) Avaliar se as concentrações de metabólitos estão relacionadas com a presença da doença (CECO), ajustadas pelas variáveis epidemiológicas e características de estilo de vida. Para a análise dos metabólitos, amostras de plasma sanguíneo de 47 casos e de 49 controles foram identificadas, quantificadas e comparadas com variáveis clínicas, patológicas, sociodemográficas e características de estilo de vida por meio de análises estatísticas. Os resultados mostram que todos os indivíduos portadores de CECO estiveram expostos em algum momento da vida aos fatores de risco (álcool, tabaco e má higiene bucal). Além disso, as variáveis mostraram interferir na concentração dos metabólitos, estes que apresentaram-se alterados, principalmente os que possuem relação com as vias metabólicas de obtenção de energia, sugerindo que o metabolismo de pacientes com CECO difere dos indivíduos sem a doença (controles) / Squamous cell carcinoma of the oral cavity (SCCOC) is one of the most common tumors in head and neck cancer, with approximately 300,000 new cases and 145,000 deaths worldwide each year. Despite intense research and recent advances in diagnosis and therapy, the patient\'s survival rate is still low. Metabolism studies have led to a better understanding of the metabolism of cancer in its development and progression. Theses findings allowed the identification of metabolic biomarkers that may aid to identificate diseases and treatments. This current study aimed at three objectives: (1) To identify and quantify plasma metabolites in SCCOC patients and controls using nuclear magnetic resonance (NMR) techniques; (2) To compare plasma concentration of metabolites of patients with SCCOC and its stratified controls by clinical, pathological, sociodemographics, and lifestyle characteristics; (3) To evaluate whether the metabolic concentrations are related to the presence of SCCOC, adjusted by epidemiological variables and lifestyle characteristics. In order to analyze the metabolites, blood plasma samples from 47 cases and 49 controls were identified, quantified and compared with clinical, pathological, sociodemographic, and lifestyle variables by means of statistical analysis. The results show that all subjects with SCCOC were exposed eventually to risk factors (alcohol consumption, smoking and bad oral hygiene). Furthermore, the variables showed to interfere in the concentration of metabolites, which have been altered, especially those that are related to metabolic pathways of obtaining energy, suggesting that the metabolism of patients with SCCOC differs from the individuals without the disease (controls)

Making researches, specific “based on patients self rating” are created. Oscular cavity health researches subjective health rating measures may be used creating public healing strategy, more considering patients requirements. Using these measures, resources may be more effectively used, to get maximum effect. Will to improve general health condition and oscular cavity condition, are strongly motivating factors, reaching for odontological healing. Topicality characterizes on identifying health knowledge and skills, after using research creating prophylactic study programs, mouth illnesses prophylactic projects. Object: health of oscular cavity and hygiene in health keeping and strengthening process. Aim: identify oral cavity health and hygienic skills of oral cavity in health keeping and strengthening process of students, sustaining on research made. Tasks: 1. valuate health and oral cavity condition of respondents; 2. explore student‘s hygienic skills of oral cavity; 3. posit factors, determing respondent‘s knowledge about oral cavity health; 4. sort out respondents knowledge about importance of care of prosthesis. By data of research made, health and oral cavity condition of most respondents is well. Most respondents have enough knowledge about factors, determing oral cavity health. Third year students have more knowledge about oral cavity health than first year students.

Made available in DSpace on 2014-10-09T12:49:26Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:02:35Z (GMT). No. of bitstreams: 1 10197.pdf: 3419296 bytes, checksum: e271656d34b0cc65fff142154edf6b74 (MD5) / Dissertacao (Mestrado Profissionalizante em Lasers em Odontologia) / IPEN/D-MPLO / Instituto de Pesquisas Energeticas e Nucleares, IPEN/CNEN-SP; Faculdade de Odontologia, Universidade de Sao Paulo

Made available in DSpace on 2014-10-09T12:28:56Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:02:37Z (GMT). No. of bitstreams: 1 17897.pdf: 1027757 bytes, checksum: d6b5ec3afbc6b4a705c60af963b604a7 (MD5) / Dissertacao (Mestrado Profissionalizante em Lasers em Odontologia) / IPEN/D-MPLO / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP; Faculdade de Odontologia, Universidade de São Paulo, São Paulo

Made available in DSpace on 2014-10-09T12:54:52Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:06:55Z (GMT). No. of bitstreams: 1 12795.pdf: 1101502 bytes, checksum: 1295efa0e9e5019cc340a0e287b85edb (MD5) / Dissertação (Mestrado Profissionalizante em Lasers em Odontologia) / IPEN/D-MPLO / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP; Faculdade de Odontologia, Universidade de Sao Paulo, Sao Paulo

Made available in DSpace on 2014-10-09T12:54:12Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:09:28Z (GMT). No. of bitstreams: 1 12696.pdf: 380416 bytes, checksum: b41e65f3de160c24632b1af1ee4ac0ee (MD5) / Dissertacao (Mestrado Profissionalizante em Lasers em Odontologia) / IPEN/D-MPLO / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP; Faculdade de Odontologia, Universidade de São Paulo , São Paulo