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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

Nutritional aspects of bone health and muscle performance in the elderly in the UK

Safarian, Mohammad January 2003 (has links)
No description available.
22

Studies on the regulation of marrow fibroblast colony formation and differentiation

Davies, Paul Andrew January 1994 (has links)
No description available.
23

Effect of age on bone mineral density, bone turnover and calcium homoeostasis in men

Fatayerji, Diana January 1998 (has links)
No description available.
24

The effects of exercise on bone mineral density

Welsh, Linda Jane January 1996 (has links)
No description available.
25

Molecular genetics and biochemistry of vitamin D binding proteins in metabolic bone disease

Kanan, Raed Mohammad January 1999 (has links)
No description available.
26

Bone mineral density in women : effects of exercise and changes in body mass

Ramsdale, Sally Jean January 1995 (has links)
No description available.
27

Extent of use and compliance to biophosphonates in the medical management of osteoporosis: an observational pilot study in a managed care organization

Maluleke, Tirhani Lineth January 2013 (has links)
Research report presented to the department Pharmacy and Pharmacology of the University of the Witwatersrand in partial fulfillment of the requirements of the Masters of Science in Pharmaceutical Affairs, University of the Witwatersrand, 20 February 2013 / The current study was a retrospective observational pilot study designed to assess compliance to bisphosphonates treatment by patients diagnosed with osteoporosis (between 01 January 2010 and 17 August 2011). In this study, the cost of pharmacological agents used in the chronic medical management of osteoporosis was also estimated. The total number of patients whose records were eligible for analysis was 286, with the mean age of 66.7 years. The majority of patient's records (91%) were for females
28

Investigation on the correlation between methylglyoxal and diabetic complications : neurodegeneration and Osteoporosis

Lee, Kwanming 02 November 2018 (has links)
Diabetes Mellitus is a chronic disease characterized by uncontrollable chronic high blood glucose (hyperglycemia) and complications, leading to serious damage to different tissues. In clinical studies, diabetic patients are found to have a higher risk of developing neurodegeneration and osteoporosis, and hyperglycemia-induced formation of advanced glycation endproducts (AGEs) may contribute towards the pathogenesis of diabetes-induced neurodegeneration and osteoporosis. Therefore the aim of this project is to investigate the role of hyperglycemia-induced methylglyoxal (MG) on neurodegeneration, neuroinflammation and osteoporosis.;Firstly, the role of MG on neurodegeneration of neuronal astrocytes, a kind of major glia in the brain, was studied. Astrocyte plays roles in the structural and functional support of the brain neurons and maintains normal brain physiology. In the present study, MG disturbed insulin signaling and led to apoptosis in rat primary astrocytes. Furthermore, the protective effects of ginsenosides were studied. From the results, impairment of insulin signaling was found in astrocyte culture under MG treatment. Moreover, cleavage of caspase and Poly ADP ribose polymerase (PARP) was observed together with insulin signaling disruption, showing the neurotoxic effects of MG towards astrocytes. The effects of ginsenosides in MG-treated astrocytes were also investigated. The ginsenosides Rd and R-Rh2 were shown to ameliorate the cell viability of MG-treated astrocytes and improve insulin signaling and inhibit apoptosis, indicating that Rd, R-Rh2, and related compounds may have therapeutic potential in treating diabetes-induced neurodegeneration.;Secondly, the role of MG on neuroinflammation was studied. The effects of MG in astrocytic cultures and hippocampi of experimental animals were compared. The astrocyte DITNC1 and C57BL/6 mice were treated with MG solution and hippocampi were harvested. MG induced astrogliosis in DITNC1 astrocytic cultures and C57BL/6 mice. Also, activation of the proinflammatory JNK signaling pathway was observed. Furthermore, increased gene expression of pro-inflammatory cytokines and astrocytic markers were observed. In addition, inhibition of JNK activities resulted in down-regulation of TNF- in MG-treated astrocytes. Our results suggest that MG may contribute to the progression of diabetes-related neurodegeneration through JNK pathway activation in astrocytes and the subsequent neuroinflammatory responses in the central nervous system.;Thirdly, the role of MG on osteoporosis and osteoclasts were studied. The osteoclasts are bone cells having catabolic action in the bone remodeling cycle. The effects of MG on osteoporosis in both animal and cell models were investigated. SD rats were treated with either MG or streptozotocin and the macrophage RAW264.7 was treated with MG. MG was shown to induce osteoclastogenesis by increased gene expression of osteoclast bone biomarkers CTSK, OSCAR and TRACP5. The results of MG-treated rats were similar to type 1 diabetic model. Furthermore, in MG-treated macrophages activation of the JNK was observed, and inhibition of JNK activities resulted in down-regulation of osteoclast biomarkers. Our results, suggested that MG may contribute to the progression of diabetes-related osteoporosis and the imbalanced bone remodeling through the JNK pathway in osteoclasts.;To conclude, MG causes different diabetic complications in multiple organs. It may be a potential therapeutic target to reduce and delay the development of neurodegeneration, neuroinflammation, and osteoporosis in diabetes.
29

An educational intervention with fourth grade students to determine osteoporosis knowledge and milk comsumption behavior

Spadafora, Amy M. January 2001 (has links)
Thesis (M.A.)--Marshall University, 2001. / Title from document title page. Document formatted into pages; contains vi, 48 p. Includes bibliographical references (p. 24-26).
30

Health Related Quality of Life in Children with Osteoporosis: Utility of the DOCC scale and the PODCI

Mackulin, COLLEEN 20 November 2008 (has links)
Purpose Clinical care providers today are more aware and have a better understanding of how osteoporosis affects a child’s quality of life and their ability to function. Fractures result in pain and suffering for children with this chronic illness and there is often a further reduction in mobility, independence, hospitalization, time out of school, and considerable stress upon the family (Caulton, Ward, Alsop, Dunn, Adams, & Mughal, 2004). No published data could be found on the health related quality of life (HRQoL) for children who have been diagnosed or are receiving treatment for osteoporosis. The purpose of this study was to report on the HRQoL of children with osteoporosis using two validated questionnaires. Methods An exploratory cohort study was conducted with a small convenience sample of 31 children with secondary osteoporosis receiving medical care from the Children’s Hospital of Eastern Ontario (CHEO) participated. Data were collected using a generic questionnaire, the Dimension of Childhood Chronicity (DOCC) scale, and a disease specific questionnaire, the Pediatric Outcome Data Collection Instrument (PODCI), both of which measure HRQoL. Results The total score for the DOCC scale was a mean of 59 out of a total possible score of 92. This result was not statistically different when compared with mean of children with disabilities. On the PODCI questionnaire, participants scored the lowest, with scores less than 68, in the areas of sports and physical functioning, pain and comfort, and happiness. Their overall Global Functioning score was 75. These results were statistically significant when compared to a healthy population. Based on the HBSC study question, 70% of study participants rated their health as good or excellent. Conclusions Despite low study numbers, it is evident that their disease has a substantial effect on the day to day life. However, parents do not view their child as unhealthy as they are seeing improvements in their physical functioning and their children are happy and enjoying life. / Thesis (Master, Nursing) -- Queen's University, 2008-11-20 12:49:49.4

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