The aim of this diploma thesis is to find a solution of heating system, a hot water preparation and a subsequent design of the heat source for the apartment building. The project consists of a calculation of heat losses, a design of radiators, a dimensioning of pipes and a design of two options of the heat source for heating and hot water preparation. The first option of the heat source I chose a pellet boiler and the second option is an electric boiler with solar collectors for the preparation of hot water. The introductory part deals with analysis of this object and emission limits of heat source using different fuels.

The doctoral thesis deals with the analysis of the flow in the circular and not circular cross-section pipes by methods using the distribution of the vorticity density. This analysis is particularly focused on the derivation of the new velocity profiles formulas using the above mentioned method. In this work is presented a historical overview of the derived velocity profiles. This overview of already derived velocity profiles will be a fundamental benchmark for newly derived velocity profiles. These new velocity profiles are derived for the circular and not circular cross-section pipes and the derivation is based on the analogy of electromagnetic induction by using Biot-Savart law. It is necessary to apply this analogy at first on solitary vortex filament. By taking this step is possible to get the value of the induced velocity from one solitary vortex filament. Subsequently it is possible to obtain the value of the induced velocity from the vorticity wall and afterwards from the vorticity density distribution over the cross section. This work contains also the results of the experimental measurements of the velocity profiles, and of the CFD simulations. Experimentally measured results are used besides other for the selecting of the most suitable CFD computational model. Selected CFD model will be subsequently declared as a reference model and the valid velocity profiles for this model will serve with the experimentally measured data as a benchmark for the newly derived velocity profiles.

Thesis abstract: Geopolitical Rivalry in Central Asia and Turkmenistan's power as a weak state Charles University, Institute of International Studies, MAS programme 2019 Emma Welsink English Abstract Research on weak states and their position in the international system has been a widely discussed topic for decades, especially in relation to the Cold War bipolar system that revolved around Russia and the United States as great powers. Yet what is lacking is a contemporary analysis that concentrates on the current multipolar system in which the importance of economic alliances and power surpass military power, and how this affects weak states' foreign policy behavior and trade opportunities. This research therefore offers an empirical analysis on great power geopolitical competition between Russia and China over Turkmenistan's economic allegiance, specifically regarding its natural gas export, and seeks to explain how this geopolitical competition has affected Turkmenistan's foreign energy policy behavior as a weak state vis-á-vis these great powers. Additionally, this research seeks to examine how Turkmenistan has even instrumentalized this competition to further its national interest of energy export diversification. More specifically, this research shows that great power competition has played a...

In der vorliegenden Arbeit wurde die Eintretenswahrscheinlichkeit von Tagesbrüchen und das Risikomanagement am Beispiel von Rohrleitungen in tagesbruchgefährdeten Gebieten des Mitteldeutschen Braunkohlenreviers umfassend beleuchtet. Im ersten Schritt wurden die Möglichkeiten und Grenzen der verschiedenen Überwachungs- und Sicherungsmaßnahmen analysiert. Es wird gezeigt, dass kein Überwachungsverfahren in der Lage ist, das unmittelbare Bevorstehen eines Tagesbruchs hinreichend genau zu prognostizieren. Die Verfahren können in der Regel nur Hinweise geben, die dann durch einen Spezialisten zu interpretieren sind. Die vorgestellten Sicherungsverfahren sind zwar teilweise in der Lage, den Tagesbruch oder seine Auswirkungen auf Rohrleitungen auf ein ungefährliches Maß zu senken. Jedoch sind diese Verfahren meist in der flächendeckenden Anwendung viel zu teuer. Um solche Verfahren nur noch punktuell an den größten Gefährdungsschwerpunkten einsetzen zu müssen, ist eine zuverlässige Bewertung der Eintrittswahrscheinlichkeit eines Tagesbruchs notwendig. Mit der Methodik der Spezifischen Bruchwahrscheinlichkeit kann erstmals die Eintrittswahrscheinlichkeit von Tagesbrüchen in einem Grubenfeld quantifiziert werden, worin auch die wesentliche wissenschaftliche Bedeutung der Arbeit liegt. Die Entwicklung von praktischen Zahlenwerten ermöglicht es, das Tagesbruchrisiko objektiv zu quantifizieren und somit die sicherheitstechnische Zulässigkeit der geplanten Oberflächennutzung zu bewerten.:1. Einleitung 2. Vorgehensweise und Abgrenzung 3. Grundlagen 4. Überwachungsmaßnahmen 5. Sicherungsmaßnahmen 6. Modell der Spezifischen Bruchwahrscheinlichkeit und Anwendungsbeispiele 7. Risikomanagement 8. Ansätze zur Weiterentwicklung 9. Zusammenfassung Literatur Anlagen

It has been 15 years since the United Nations Declaration on the Rights of Indigenous Peoples recognized the Free, Prior and Informed consent Principle, yet it has not been able to function to its fullest potential. This Thesis aims to carry out a Qualitative Comparative Analysis of the following three countries of Australia, Canada, and the United States. With the hypothesis, that the underlying factors behind this failure can be attributed to Settler-Colonialism and Global Capitalism. To carry out this study Theoretical Frameworks based on Settler-Colonial studies and a critique of the Stakeholder theory named Critical Stakeholder Analysis (CSA) will be employed. Using the existing body of research in this area of inquiry as a point of departure, this thesis attributes the failure to implement the Free, Prior, and Informed Consent principle to its fullest potential on asymmetrical power dynamics, settler-colonial structures, and profitability.

Rare diseases are estimated to affect 3.75% of the global population, which roughly translates to 300 million affected individuals. A large proportion of patients still do not have their diagnosis and current approaches such as chromosomal microarray (CMA), whole exome sequencing (WES), and whole genome sequencing (WGS) that targets DNA and the exome aims to resolve that very first step. RNA-seq serves as a powerful approach complementing the aforementioned methods that have reached a plateau in the diagnostic yield. RNA-seq can facilitate the finding of aberrant events that appear during transcription e.g., splicing, changes in gene expression and monoallelic expression. In this study, we aimed to establish RNA-seq analysis pipelines and evaluate whether RNA-seq could be utilized to enhance diagnostic yield. A total of 47 clinical samples were analysed along with the publicly controlled GEAUVADIS dataset to evaluate the potential of RNA-seq in a clinical setting. The pilot pipeline used, an RNA-seq analysis wrapper around Detection of RNA Outlier Pipeline (DROP), used detected a highly ranked splicing variant in a positive control control  sample that was hard to identify in a WGS analysis. The remaining two other positive control other two control samples with aberrant expression were also detected by the pipeline. Additionally, the pipeline gave a manageable list of candidate genes per affected sample in the population along with corroborating graphs that can support the decision-making for clinicians. The results of this pipeline proved successful for integrating RNA-seq and thustherefore, we expect anticipate an increase in diagnosis.

The aim of the diploma thesis is to describe and analyse information sources, which are useful for the molecules portfolio selection suitable for the future development of a generic drug. These information sources should be examined on the case study of the portfolio selection in a given therapeutic area. The topic of the diploma thesis is presented in the context of basic principles and functions of the generic farmaceutical industry and its information needs. The introductory chapter characterizes the farmaceutical industry in general and warn on a competitive environment, which the farmaceutical companies can succeed in thanks to the advanced methods of the business intelligence. The second chapter focuses on the differences betwen the generic and original pharmaceutical industry, a drug lifecycle is also introduced there. The next chapter specifies the methods of the business intelligence in the generic pharmaceutical industry on the ground of its information needs. The fourth chapter plays a key role. First of all, it introduces general characteristics of information sources used in the strategic portfolio management. Secondly, the detailed description and analysis of eight main information sources used by the generic companies within business intelligence follows. In the last chapter these...

Diploma thesis deals with problematics of offtake of flue gasses. In experimental part there was measured compound of flue gasses by analyzator of flue gates. Aplication is a project of heating of object of The Academy of Sciences of the Czech Republic in Brno. Project solves design of heating system, flue and of source of heat. Heating area is created by floor convectors,towel rails and radiators. Source of heat is designed in two variants : as a cascade of condensation boilers and as a cascade of low-temperature boilers.

Work deals with design and implementation a tutorial for demonstration deferred shading technique and its possibilities. It explains lighting and shading principles in intuitive and interactive way. Deferred shading is a technique which determines pixel color after the geometry rasterization of the entire scene. In other words the processing of geometry does not interfere with the shading process.

Diploma thesis deals with geothermal foundations. The aim of the thesis is to find optimal way of pipe winding for heat-carrying liquid in foundation piles. The problem is solved by CFD simulations in ANSYS Fluent. Determinative parameters like the pressure loss, heat fluxes and U-value in one pile circuit with two ways of pipe installations – Single coil, where reverse pipe is led in the middle of pile and Duplex Coil with reverse pipe in spiral shape are observed.