When examining objects using tactile senses, individuals often incorporate multiple sources of haptic sensory information to estimate the object’s properties. How do our brains integrate various cues to form a single percept of the object? Previous research has indicated that integration from cues across sensory modalities is optimally achieved by weighting each cue according to its variance, such that more reliable cues have more weight in determining the percept. To explore this question in the context of a within-modality haptic setting, we assessed participants’ perception of edges that cross the index, middle, and ring fingers of the right hand. We used a 2-interval forced choice (2IFC) task to measure the acuity of each digit individually, as well as the acuity of all three digits working together, by asking participants to distinguish the locations of two closely spaced plastic edges. In examining the data, we considered three perceptual models, an optimal (Bayesian) model, an unweighted average model, and a winner-take-all model. The results indicate that participants perceived sub-optimally, such that the acuity of the three digits together did not exceed that of the best individual digit. We further investigated our question by having participants unknowingly undergo a 2IFC cue conflict condition, where they thought they were touching a straight edge which was actually staggered and thus gave each digit a different positional cue. Our analyses indicate that participants did not undertake optimal cue combination but are inconclusive with respect to which suboptimal strategy they employed. / Thesis / Master of Science (MSc) / This thesis investigates the neural mechanisms behind tactile perception, specifically how the brain combines multiple sensory cues to construct a unified percept when interacting with objects through touch. Typically, optimal sensory integration involves assigning more weight to more reliable cues. Our research focused on tactile integration by examining participants’ ability to perceive the positions of edges crossing their index, middle, and ring fingers simultaneously. The results indicated that, contrary to predictions, participants exhibited various sub-optimal cue integration strategies. Their ability to perceive the combined positions of all three fingers was not superior to that of the best-performing individual finger. We also explored cue conflict situations, where the locations of the tactile cues were no longer from a straight edge, unbeknown to participants, and the results here reinforced the finding that participants did not consistently employ optimal cue combination strategies. This research offers valuable insights into how the brain processes tactile information.

<p>Measurement of human tactile spatial acuity – the ability to perceive the</p> <p>fine spatial structure of surfaces contacting our fingertips – provides a valuable</p> <p>tool for probing both the peripheral and central nervous system. However,</p> <p>measures of tactile spatial acuity have long been plagued by a prodigious amount</p> <p>of variability present between individuals in their sense of touch. Previously</p> <p>proposed sources of variability include sex, and age; here we propose a novel</p> <p>source of variability – fingertip size. Building upon anatomical research, we</p> <p>hypothesize that mechanoreceptors are more sparsely distributed in larger fingers.</p> <p>In this thesis, I provide empirical and theoretical support for the hypothesis</p> <p>that fingertip growth from childhood into adulthood sets up an apparent sex</p> <p>difference in human tactile spatial acuity during young adulthood (Chapter 2), and</p> <p>also predicts changes in acuity more strongly than does age over development</p> <p>(Chapter 3). To further understand how fingertip size could limit an individual's</p> <p>tactile spatial acuity, we develop an ideal observer model using</p> <p>neurophysiological data collected by other labs (Chapter 4).</p> <p>In summary, this research provides support for a novel source of variability</p> <p>in the sense of touch: one that parsimoniously explains an apparent sex difference,</p> <p>and helps clarify the source of changes in tactile spatial acuity occurring with age</p> <p>during childhood.</p> / Doctor of Philosophy (PhD)

In recent years, computational neuroscientists have suggested that human behaviour, including perception, occurs in a manner consistent with Bayesian inference. According to the Bayesian ideal observer model, the observer combines cues from multiple sensory streams as a weighted average based on each cue’s reliability. Most cue-combination research has focused on integration of cues between sensory modalities or within the visual modality. Cue combination within the tactile modality has been relatively rarely studied, and it is still not known whether cues from individual digits combine optimally. In this thesis, we use the ideal observer model to determine whether cues from three different digits are combined optimally. We predicted that cues from multiple digits would be combined according to the optimal cue combination model. To test our hypothesis, we devised a two-interval forced choice (2IFC) task where participants had to discriminate the distal/proximal location of a 1-mm thick edge across the fingerpad(s) of the index (D2), middle (D3), and ring (D4) fingers. We used a Bayesian adaptive method, the ψ method, to compute participants’ psychometric functions for single-digit (D2, D3, and D4) and multiple-digit (D23, D24, D34, and D234) conditions. We determined the stimulus level ∆x, the distance (mm) between the distal and proximal stimuli locations, at 76% correct probability. This distance corresponds to a sensitivity index d'=1 and is the σ value of the participant’s stimulus measurement distribution. We then used the single-digit σ values to predict optimal cue combination for the multiple-digits combinations. We did not observer optimal cue-combination between the digits in this study. We outline potential implications the results of this experimental have on determining how the nervous system combines cues between digits, focusing on theoretical and experimental updates to the experiment that might result in the observation of optimal cue combination between digits. / Thesis / Master of Science (MSc)

No / Vernier acuity depends on the integration of information from multiple photoreceptors. For this reason, vernier acuity thresholds ought to exhibit effects of stimulus size and contrast analogous to those that occur in area summation experiments. In this paper, we consider some area and contrast effects found in vernier acuity experiments, and explain them with a model of detection and discrimination which we call the Noisy Template model. The Noisy Template model assumes that psychophysical tasks are performed (or can be approximated) by cross-correlation of the stimulus with a decision template which is optimal for the task at hand. The Noisy Template model crucially adds the assumption that the template contains noise. This yields inefficiency in the decision process which increases with stimulus size and contrast. Predictions of the Noisy Template model are derived for the case of vernier acuity, and compared with existing experiments.

No / A current, popular, theory of spatial localization holds that the visual system represents the location of simple objects by a single positional tag, the accuracy of which is largely independent of the internal properties of the object. We have already presented evidence of the limitations of such a view (Keeble & Hess (1998). Vision Research, 38, 827-840) in that 3-micropattern alignment performance was found to be dependent on the orientation of the micropatterns. We tested whether this was caused by a local anisotropy in positional coding by conducting 3-micropattern bisection experiments with varying patch orientation. No corresponding effect of patch orientation was found, implying a difference in the mechanisms used for the two tasks. In a further experiment we show that alignment task performance is very similar to the otherwise identical 2-patch orientation discrimination task. We conclude that the 3-micropattern alignment task is mediated by orientational mechanisms. We therefore present a 2nd-order orientation model for 3-patch alignment.

No / In this report, we evaluate the role of visual areas responsive to motion in the human brain in the perception of stimulus speed. We first identified and localized V1, V3A, and V5/MT+ in individual participants on the basis of blood oxygenation level-dependent responses obtained in retinotopic mapping experiments and responses to moving gratings. Repetitive transcranial magnetic stimulation (rTMS) was then used to disrupt the normal functioning of the previously localized visual areas in each participant. During the rTMS application, participants were required to perform delayed discrimination of the speed of drifting or spatial frequency of static gratings. The application of rTMS to areas V5/MT and V3A induced a subjective slowing of visual stimuli and ( often) caused increases in speed discrimination thresholds. Deficits in spatial frequency discrimination were not observed for applications of rTMS to V3A or V5/MT+. The induced deficits in speed perception were also specific to the cortical site of TMS delivery. The application of TMS to regions of the cortex adjacent to V5/MT and V3A, as well as to area V1, produced no deficits in speed perception. These results suggest that, in addition to area V5/MT+, V3A plays an important role in a cortical network that underpins the perception of stimulus speed in the human brain. / BBSRC

Repetitive and forceful exertions have been dentified as an important risk factor for occupational injuries. One method used to determine appropriate exposures to these and other risk factors is psychophysics, which is based on individual perceptions of task demands and/or risk. Effects of work exposure have been indicated as of potential importance, but have not been well studied. Indications from an earlier study related to psychophysical limits for a repetitive manual torquing task were that five days of work conditioning had minimal effects on resulting Maximum Acceptable Repetition Rates (MARR). However, it is unknown whether and how longer work exposure durations might influence MARRs. The current study investigated the effects of work exposure on MARR and adjustment time over 10 working days (two weeks) with two days of rest after five days. Ten participants (five males and five females) performed a manual torquing (45 Nm load) task at mid-chest level in the coronal plane for a one hour test session. Starting repetition rate for each participant was set at single high and low rate on alternate days. Temporal (exposure) effects were determined, where day of exposure was the independent variable, and MARR and adjustment time were the dependent variables. Final MARRs were relatively lower during the first few exposure days (14 - 15 repetitions/min) and increased for days 5 - 7 (16 - 18 repetitions/min). On average participants made four adjustments to reach MARR . Day was not found to significantly affect MARR, though week affected both MARR and adjustment time. Thus, an exposure of two weeks may be needed to obtain stable and valid psychophysical limits for manual torquing and, perhaps, related tasks. / Master of Science

A violência sexual é um problema de saúde pública que afeta boa parte da população mundial. Seu estudo, entretanto, é marcado por dificildades conceptuais, legais, epidemiológicas e metodológicas. Dentre os diversos modos de se entender e examinar a violência sexual, as atitudes são comumente investigadas, sobretudo com o emprego de escalas Likert. Contudo, o escalonamento psicofísico pelos métodos de Thurstone possui características típicas de escalas intervalares que lhe conferem vantagens em relação às escalas ordinais. O principal objetivo da presente pesquisa foi construir uma escala de distâncias psicológicas de descritores sexuais para cada grupo experimental através do Caso V da Lei do Julgamento Comparativo de Thurstone. 132 participantes, divididos em três grupos controle, sobreviventes (mulheres vítimas de violência sexual) e reeducandos (homens agressores sexuais) avaliaram oito termos sexuais (cócegas, cheiro, toque, beijo, nudez, agarrar, esfregar e gemer) pelo método de escolha forçada de julgamento de pares. A cada par de termos sexuais apresentado aleatoriamente, os sujeitos deviam escolher aquele com o maior conteúdo sexual. Resultados indicaram que os descritores toque, cheiro e cócegas foram constantemente julgados com os menores conteúdos sexuais entre os três grupos, enquanto beijo e gemer foram os que mais alteraram de ordem entre os grupos. Literatura sobre aspectos linguísticos dos estímulos utilizados não foi suficiente para explicar a escolha de uma palavra em detrimento de outra, reforçando-se a ideia de que os julgamentos foram diferenciais de acordo com as variáveis e o grupo ao qual os participantes pertenciam. Dessa maneira, homens julgaram os descritores com valores próximos, deixando a escala com menor amplitude, o que indica baixa discriminação e necessidade de menos conteúdo sexual para que as palavras fossem percebidas sexualmente. Reeducandos apresentaram o mesmo padrão de resultados, mas de maneira acentuada. Mulheres, por outro lado, tiveram boa discriminação dos termos sexuais e apresentaram maior amplitude na escala. Para as sobreviventes, o padrão de resultados foi o mesmo das mulheres, com poucas variações. As diferenças encontradas entre grupos podem ser decorrentes de atitudes sexuais e em relação à violência sexual e do modo como mulheres e homens processam informação sexual, sendo atravessadas por questões sociais de gênero / Sexual violence is a public health problem that affects a portion of the world population. Its study, yet, is marked by conceptual, legal, epidemiological, theoretical and methodological difficulties. Among the various ways of understanding and examining sexual violence, attitudes are commonly investigated, mainly by employing Likert scales. However, psychophysical scaling by Thurstones methods possess characteristics typical of interval scales, which gives it advantages over ordinal scales. The major goal of the present research was to build a scale of psychological distances of sexual descriptors for each experimental group through the Case V of Thurstones Law of Comparative Judgment. One hundred and thirty two participants, divided in three groups control, survivors (female victims of sexual violence) and inmates (male sex offenders) evaluated eight sexual words (tickle, smell, touch, kiss, nude, grab, rub, and moan) by the forced choice method of pairwise judgment. To each word pair was presented randomly, subjects were asked to choose the one with the higher sexual content. Results indicated that the descriptor touch, smell, and tickle were constantly judge as having the lowest sexual content amongst the three groups. Literature abou linguistic aspects of the used stimuli was nou sufficient to explain the choice of one word over another, reinforcing the idea that the judgments were differential according to the variables and the group to which the participant belonged. Thus, men judged the descriptors as having similar values, making the scales amplitude smaller, which indicates lower discrimination and the need for less sexual content for the words to be perceived sexually. Inmates showed the same pattern of results, but in a accentuated manner. Women, on the other hand, had good discrimation of the sexual descriptors and exhibited higher scale amplitude. For the survivors, the pattern of results was the same as for the women, with few variations. The found differences between groups may be due to attitudes toward sexuality and sexual violence, and to the way women and men process sexual information, being permeated by gender social issues

Sensory adaptation is an important aspect of perception. A seemingly non-beneficial consequence of adaptation is that it produces perceptual illusions. For instance, following focal adaptation, the perceived separation between stimuli straddling the adapted attribute or region is often exaggerated. This type of illusion, known as perceptual repulsion, is both a consequence of and a clue to the brain’s coding strategies and how they are influenced by recent sensory events. Adaptation-induced perceptual repulsion has been well documented in vision (e.g. the tilt aftereffect) and to a lesser extent in audition, but rarely studied in touch. The present thesis investigated the effects of adaptation on tactile spatial perception using a combination of human psychophysics and computational modeling. In a two-interval forced choice task, participants compared the perceived separation between two point-stimuli applied on the forearms successively. The point of subjective equality was extracted as a measure of perceived two-point distance. We showed that tactile spatial perception is subject to an adaptation-induced repulsion illusion: vibrotactile adaptation focally reduced tactile sensitivity and significantly increased the perceived distance between points straddling the adapted skin site (Chapter 2). This repulsion illusion, however, was not observed when the intervening skin was desensitized with topical anesthesia instead of vibrotactile adaptation, suggesting that peripheral desensitization alone is insufficient to induce the illusion (Chapter 3). With Bayesian perceptual modeling, we showed that the illusion was consistent with the hypothesis that the brain decodes tactile spatial input without awareness of the adaptation state in the nervous system (Chapter 4). Together, the empirical and theoretical work furthers the understanding of dynamic tactile spatial coding as the somatosensory system adapts to the sensory environment. Its main findings are consistent with the adaptation- induced repulsion illusions reported in vision and audition, suggesting that perception in different sensory modalities shares common processing features and computational principles. / Thesis / Doctor of Philosophy (PhD) / Sensory adaptation can shape how we perceive the world. In this thesis, we showed that the perception of space in touch is pliable and subject to the influence of adaptation. Psychophysical testing in human participants showed that vibratory adaptation induced an illusion that expanded the perceived distance between stimuli on the skin. This illusion provides clues into how information about space in touch is normally processed and interpreted by the brain. In addition, we developed a computational model that used a powerful statistical framework – Bayesian inference – to probe touch on a theoretical basis. To the best of our knowledge, the present thesis provides the first combined psychophysical and computational study on the effects of adaptation on tactile spatial perception. Our findings suggest that touch shares some common information processing principles with vision and hearing, and adaptation plays a functionally similar role in mediating this process across the senses.

Following peripheral nerve transection and microsurgical repair (PNIr) most patients retain significant sensorimotor impairments, a proportion of which also develop chronic neuropathic pain. Individual psychological factors may contribute to the development, intensity and duration of chronic pain. Furthermore, a large body of evidence has indentified beneficial and maladaptive cortical plasticity following disease or injury. The general aim of this thesis was to determine the extent of sensory and motor recovery, functional and structural brain changes, and the impact of chronic neuropathic pain on sensorimotor outcomes following upper limb PNIr. Towards this main aim a sensorimotor psychophysical assessment (that included psychological assessments), nerve conduction testing, and an MRI session that examined brain function and structure was performed in patients with peripipheral nerve injury induced neuropathic pain (PNI-P) and those with no neuropathic pain (PNI-NP). Nerve conduction testing demonstrated that all patients had incomplete peripheral nerve regeneration, and that PNI-P patients had worse sensory nerve regeneration. Psychophysical assessment confirmed that all PNIr patients had significant sensorimotor deficits. Additionally, deficits on tests of vibration detection, sensorimotor integration, and fine dexterity were significantly greater in PNI-P patients. Psychological measures clearly distinguished PNI-P from PNI-NP and healthy controls (HC). Vibrotactile stimulation of the deafferented territory in PNI-NP patients results in reduced BOLD activation within the primary and secondary somatosensory cortices. Interestingly, the regions of reduced BOLD corresponded with gray matter thinning which was negatively correlated with behavioural measures of sensory recovery. Structural abnormalities were also identified in the right insula. PNI-P patients had thinning within the right middle insula and a corresponding decrease in white matter pathways projecting into/out of that region. PNI-P patients also had white matter abnormalities in pathways feeding into/out of the contralesional primary somatosensory cortex and thalamus. In conclusion, PNIr is clearly associated with sensorimotor impairments and brain plasticity. Furthermore, neuropathic pain is associated with worse peripheral nerve regeneration, sensorimotor deficits, different psychological profiles, and structural alterations in brain regions involved in pain perception and somatosensation. These results provide insight into peripheral regeneration, the development of chronic pain, brain plasticity and structure-function-behavioural relationships following nerve injury and have important therapeutic implications.