Peer tutoring has become well-established in higher education and, with growing interest in peer learning, has started to gain popularity at school level with evident success in a range of settings and subject areas. Specific implementations such as PALS have become commercial successes based on offering attainment gains and social outcomes while reducing teacher workload. However, the impact on children with special educational needs is variable and there remains a lack of consensus on how PALS can affect performance for such students. Similarly, while there are some studies in the Middle East, the supporting literature for peer-tutoring and PALS is highly Western-centric and relies on adoption of constructivist principles in the wider classroom. Such values are uncommon in the Middle East, with the dominance of traditional values presenting a significant barrier to pedagogical innovation in Saudi Arabia. This study is therefore a timely exploration of how peer-tutoring can integrate with a group’s existing traditional pedagogical beliefs, engaging them in more active learning. The study used a mixed methods design to look at three main aspects of the PALS provision: the effectiveness of teacher training as preparation for leading peer tutoring, how fully was the Maths PALS programme implemented, and the impact on students with special educational needs in terms of a range of mathematics attainment and social outcomes. A 3-month intervention model is used to generate comparisons between an intervention and control pupils, helping to locate this study in the context of other quantitative research from Western countries. This is supported by qualitative data looking at the experiences of staff and students to better understand the specific experience of trying such a novel approach in a Saudi Arabian context. It is argued that attainment progress was satisfactory when considered alongside the substantial social progress, suggesting that peer tutoring has the potential to be a long-term learning strategy and, perhaps more importantly, can open the door to Saudi Arabia developing more purposeful and collaborative learning environments. The age grouping common in Saudi Arabia, spanning a much greater age range than is common in other countries, also offers insight into what makes cross-age peer tutoring effective and suggests that measuring progress in such situations requires more advanced statistical techniques. It is also shown that trainee teachers can be efficiently trained in using PALS and highly rate its impact, indicating that teacher training could be a valuable launchpad for pedagogical innovation in Saudi Arabia.

<p>A few aspects of aircraft noise were evaluated. These were (i) methods of subjective evaluations, (ii) effects of equalization and (iii) the effects of cognitive aspects.</p><p>In the first paper, sorting algorithms were used instead of conventional paired comparison method in order to reduce the number of pairs in the evaluation of subjective judgments. The quick sorting algorithm method revealed more than 99% correlation coefficient with paired comparison method although the method used N*log(N) evaluations instead of N(N-1)/2.</p><p>In the second paper, equalization effects on perception were evaluated in two steps, first with stationary aircraft sounds and second with non-stationary aircraft sounds.</p><p>The first experiment examined the effects of stationary sound segments respect to three different angle positions of the aircrafts relative to the observer (78.7°, 90° & 101.3°), two different SNR conditions (sounds having original broadband plus tonal components versus control broadband sounds having no tonal components) and two different flight conditions (arrival and take-off). Subjects were asked to scale five perceptual attributes (loudness, annoyance, hardness, power and pitch) using Borg CR100 scale. The angle condition showed highly significant effects on annoyance and hardness. Maximal effects were found at an angle of 78.7°. The SNR revealed a significant impact on loudness, power and pitch.</p><p>The second experiment analyzed the effects of tonal components and the problem of appropriate equalization. The spectrum of the signals was modified in two steps (buzz-saw, isolated BPF tone). Further EPNL-equalization, A-, B-, C-, D- and spectral broadband equalizations were applied to the synthesized sounds. Annoyance, loudness, hardness and pitch in the isolated tone conditions showed significantly stronger effects than the buzz-conditions on the perceived judgments. The EPNL-equalization led to a lower degree of differentiation between the spectral conditions compared to B- and C-level equalization.</p><p>In the third paper, the effects of aircraft sounds on children’s cognitive performance were investigated. Impact of aircraft noise on children cognition was found significantly higher in reading comprehensions than in basic mathematics and problem solving tests. It seems children are very sensitive to the modifications in the aircraft noise but further studies are necessary to compliment such a finding.</p>

No description available.

Depuis au moins 540 Ma deux grands systèmes de subduction coexistent sur Terre : d'une part, les systèmes de subduction-collision (chaînes Hercynienne, Himalayenne ou Alpine) et d'autre part, les systèmes de subduction de type péri-pacifique. Pour ces derniers, l'avant-arc constitue une zone clef pour retracer l'évolution de la subduction au cours du temps. En effet ces zones au contact avec le slab peuvent enregistrer des événements tectoniques et/ou des conditions métamorphiques variées (e.g. formation de « paired metamorphic belts »), qui sont autant d'indicateurs du contexte géodynamique. Le massif métamorphique de El Oro en Equateur est un exemple exeptionnel où une section complète et basculée de l'avant-arc Triasique est préservée. L'ensemble est constitué d'une série métasédimentaire de bas à haut grade métamorphique intrudée par des granitoïdes de type S, juxtaposé avec un laccolithe gabbroïque et des schistes bleus. Ce travail de thèse s'est concentré sur l'étude du métamorphisme de haute-température basse-pression et ses relations les schistes bleu. Afin de contraindre l'événement tectono-métamorphique affectant l'avant-arc Equatorien au Trias et la formation d'une "paired metamorphic belt", nous avons utilisé des outils structuraux, métamorphiques, géochimiques, géochronologiques et de modélisation thermique. Nos résultats montrent que durant cette période l'avant-arc Equatorien connait un intense épisode de fusion partielle en régime extensif. La base de la croûte est migmatisée sur une épaisseur de 10km. Les estimations Pression-Température indiquent que les conditions de fusion partielle varient de 4.5 kbar et 650°C pour la partie supérieure métaxitique et jusqu'à 7.5 kbar et 720°C pour la partie inférieure diatexitique. La gradient géothermique inféré est divisé en deux segments : un segment supérieur caractérisé par un gradient de 40°C/km et un segment inférieur caractérisé par un gradient quasi-isothermique. L'absence de paragénèse de ultra-haute température est attribuée à la grande fertilité du protolithe métasédimentaire. Les résultats géochimiques montrent que les plutons granodioritiques sont issus d'un mélange entre : (1) les liquides de fusion partielle produit par la réaction de deshydration de la muscovite des métasédiments et (2) un magma basique. Les âges U-Pb sur zircons et monazites révèlent que l'événement anatectique fût bref entre 229 et 225 Ma. La source de chaleur à l'origine de l'événement thermique est attribuée à la mise en place d'un pluton gabbroïque à ~ 230 Ma en base de croûte. Successivement, se sous-plaque les schistes-bleu refroidissant rapidement l'avant-arc. L'événement anatectique observé dans le massif de El Oro au Trias s'insrit à plus grande échelle au sein d'une large anomalie thermique affectant l'ensemble du continent sud Américain entre 260 et 220 Ma. Durant cette période la marge est un soumise à un régime extensif accompagné d'un important magmatisme d'origine crustal, principalement en position d'arc et d'avant-arc. Nous attribuons cette anomalie thermique d'ampleur continental à une "avalanche mantellique". A la lumière du contexte géodynamique globale nous inteprétons la formation de la paired metamorphic belt de El Oro à la rupture du slab. / Since about 540 Ma, two subductions systems co-exist on Earth: the subduction-collision systems (Hercynian, Himalayan or Alpin belts) and the circum-pacific subduction system. For the last the forearc region constitutes a key zone to understand the dynamic of the subduction. Indeed the forearc region in contact with the slab may records various tectonics events and/or metamorphic conditions (e.g. formation of paired metamorphic belt). Theses geological records are direct evidences of the linked geodynamical context. The El Oro metamorphic complex in Ecuador is a unique example where a whole Triassic forearc section is tilted and well preserved. The complex is made of low to high grade metasedimentary rocks intruded by S-type granitoids, juxtaposed with gabbroic rocks and blueschists. This study is focused on the high-temperature metamorphism and its retionaships with the high-pressure metamorphism. In order to constrain the tectono-metamorphic affecting the forearc region and the formation of a paired metamorphic belt we used strutural, metamorphic, geochemical, geochronological and themal modeling studies. Our results show that during Triassic times the Ecuadorian forearc underwent a strong episode of partial melting in extentional context. The migmatized part of crust is 10 km thick. Pressure-Temperature estimates indicate that partial melting started at 4.5 kbar and 650°C for the upper metatexitic part until 7.5 kbar and 720 °C for the lower diatexitic part. The resulting geothermal gradient exhibits two parts: an upper part caracteristed by a thermal gradient of 40°C/km and a lower part caractérized by a near-adiabatic gradient. The absence of ultra-high tempetature paragenesis is attributed to the high fertility of the metasedimentary protolith. Geochemical results show that granodiorite made of a miwing between: (1) the melt extacted under muscovite dehydration melting and (2) a basic magma. U-Pb ages on zircon and monazite reveal that the anatectic event was short, between 229 and 225 Ma. The origin of the thermal anomaly is attributed to the emplacement of the gabbroic plutonic unit at ~230 at root level. Successively, the blueschites are underplating triggering a strong coolng of the forearc region. The anatectic recorded in the El Oro metamorphic complex at Triassic times is part of a larger thermal anomaly affecting the whole south american margin between 260 and 220 Ma. During this period the margin is under extentional conditions and exhibit a strong S-type magmatic activity. This magmatism is mainly located in arc and forearc position. We attribute this large-scale thermal anomaly to slab fall in the lower mantle. In the light of the geodynamical context, we suggest that the formation of the El Oro paired metamorphic belt is related to slab breakoff.

Automated tissue image analysis aims to develop algorithms for a variety of histological applications. This has important implications in the diagnostic grading of cancer such as in breast and prostate tissue, as well as in the quantification of prognostic and predictive biomarkers that may help assess the risk of recurrence and the responsiveness of tumors to endocrine therapy. In this thesis, we use pattern recognition and image analysis techniques to solve several problems relating to histopathology and immunohistochemistry applications. In particular, we present a new method for the detection and localization of tissue microarray cores in an automated manner and compare it against conventional approaches. We also present an unsupervised method for color decomposition based on modeling the image formation process while taking into account acquisition noise. The method is unsupervised and is able to overcome the limitation of specifying absorption spectra for the stains that require separation. This is done by estimating reference colors through fitting a Gaussian mixture model trained using expectation-maximization. Another important factor in histopathology is the choice of stain, though it often goes unnoticed. Stain color combinations determine the extent of overlap between chromaticity clusters in color space, and this intrinsic overlap sets a main limitation on the performance of classification methods, regardless of their nature or complexity. In this thesis, we present a framework for optimizing the selection of histological stains in a manner that is aligned with the final objective of automation, rather than visual analysis. Immunohistochemistry can facilitate the quantification of biomarkers such as estrogen, progesterone, and the human epidermal growth factor 2 receptors, in addition to Ki-67 proteins that are associated with cell growth and proliferation. As an application, we propose a method for the identification of paired antibodies based on correlating probability maps of immunostaining patterns across adjacent tissue sections. Finally, we present a new feature descriptor for characterizing glandular structure and tissue architecture, which form an important component of Gleason and tubule-based Elston grading. The method is based on defining shape-preserving, neighborhood annuli around lumen regions and gathering quantitative and spatial data concerning the various tissue-types.

published_or_final_version / Psychology / Doctoral / Doctor of Philosophy

Diencephalic amnesia is thought to be the result of damage to a single thalamic structure that is responsible for the memory impairment. However, an alternative view is that different thalamic structures contribute to the memory impairment in subtly different ways. Paired-associate learning is one important measure of learning and memory that is highly sensitive to disruption in people with amnesia or dementia. The current study will investigate the influence of lesions to two thalamic subregions, the anterior thalamic nuclei (AT) and the lateral thalamic nuclei (LT) in an object-odour paired associate learning task. Each of these subregions has been suggested by the literature as critical for amnesia after thalamus injury. The current study does not involve a place/ space component. Both AT and LT lesions caused impairments in the object-odour paired associate task, but not in the simple discrimination tasks. The results of this study provide new evidence to suggest that the anterior thalamic region may be responsible for more than spatial memory processing. This result is inconsistent with those of Aggleton & Brown (1999) that consider the AT to be part of an 'extended hippocampal system'. The deficits observed from LT lesions in this study provide new insight into the lateral thalamic region's role in pattern processing.

Paired receptor families, consisting of multiple genetically and structurally similar but functionally opposite activating and inhibitory cell surface receptors, are among the fine tuners of the immune regulation. Recent studies on the evolutionary origin of these receptor families have suggested links to pathogen driven diversification, according to which activating receptors continuously evolve in order to counterbalance pathogens that try to subvert the immune response by stimulating the inhibitory receptor through their virulence factors. This thesis is about the CD200R paired receptor family. This family consists of an inhibitory receptor CD200R which is expressed on various leukocytes and delivers inhibitory signals upon engagement with its ligand CD200. In this study, the possibility that the activating members of the family evolved under pathogen pressure was investigated. Genomic DNA from twenty two different mice strains was screened for the presence of members of CD200R family. The number of activating receptors varied, CD200RLe and CD200RLc were found to be mutually exclusive and three strains possessed previously unknown members of CD200R family. In addition, the possibility that CD200R family members and other paired receptors interacted directly with bacteria was tested with a new assay but only the interaction of PIR-A1 with <em)S. aureus was found as previously reported. The rabbit CD200R family has been characterized and ligand receptor interaction between rabbit CD200 and rabbit CD200R has been demonstrated. However, no interaction between rabbit CD200R and a candidate viral CD200 homologue, the M141R protein of myxoma viruses, could be shown. This finding suggested a CD200R independent role for M141R molecule and possibly other homologues in pox viruses. Finally, two novel antibodies (OX131 and OX132) were characterized together with formerly generated antibodies against mouse CD200R family. The binding specificities and their effects on the CD200-CD200R interaction have been shown. This will help usage of these antibodies in various studies on the functionality and distribution of these receptors.

The present study sought to investigate the combined influences of degree of first-list learning, stimulus order, emphasis, and meaningfulness on the selection strategies of college subjects.

This study examined the comparative effectiveness of learning of cognitive skills when instruction is presented through computer-based instruction using student-to-computer ratios of one-to-one and two-to-one. Effectiveness was gauged through scores on posttests administered subsequent to completion of each of nine computer-based lessons and on a single composite test score.