Thesis (M.S.)--University of Wisconsin--Madison, 1984. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (MSc) Stllenbosch University, 2001. / ENGLISH ABSTRACT: A prospective study was conducted in 1999 to establish the incidence and nature of acute poisonings in the Cape Town / Western Cape region. This study was based on an analysis of Poison Centre queries and acute poisoning admissions to Tygerberg Hospital over a period of 1 year (1999). Summary of findings for Hospital admissions (1010 cases): Acute poisonings were more common in adults (83%) than in children (17%) and drug overdose was by far the most common clinical entity in adult Hospital admissions (89% of cases). Most overdoses in adults were intentional (97%). Seventy five percent of these cases were female, predominantly in the 20-40 year age group. The incidence of non-drug chemical exposures in adults was relatively low (11%). In children, on the other hand, there was much less of a discrepancy between drug and non-drug chemical exposures (41% and 59% respectively). Paracetamol was the drug most commonly used in overdose in both adults and children. In adults ethanol featured in 17% of cases. Ingestion of paraffin and related volatile hydrocarbons were the most important cause of acute poisoning in children. Acute poisoning admissions due to drugs of abuse, excluding ethanol, were minimal in both age groups (1%). Toxic exposures to non-drug chemicals in the agricultural and industrial settings were low (3%). The number of exposures to biological toxins was also minimal (2%). Summary of findings for Poison Centre inqueries (3744 consultations): In 1999 the Tygerberg Poison Information Centre received 3744 calls, of which 2690 were related to acute human exposures to poisonous substances. The remainder of the calls (1054) was either about drug therapy, or general non-patient related toxicological matters. There were more calls regarding poisoning in adults (61%) than in children (39%). Most of the paediatric poisonings were accidental (97%), whereas in adults 55% were deliberate and 45% accidental. Forty four percent of the children and 52% of adults were female. In children, inqueries about exposures to potentially harmful non-drug household chemical products comprised 56% of poison calls, while drug overdose was 28% and exposures to biological toxins 16%. In adults 44% of inqueries were with regard to household products, 40% about drugs and 16% biological toxins. A comparison of Hospital admissions versus Poison Centre consultations: In order to make a valid comparison between Hospital admissions and Poison Centre consultations, acute poisoning cases originating from the same area were compared. Eight hundred and thirty four (90%) of patients admitted to Tygerberg Hospital and 592 (25%) of Poison Centre consultations originated from the same region, the Tygerberg catchment area. Several differences were noted when comparing poisoning cases reported to the Poison Centre and Hospital admissions. Six hundred and eighty eight (83%) adults and 145 (17%) children were admitted to Hospital in contrast to Poison Centre inqueries, where 322 (54%) were adults and 270 (46%) children. In adults, 99% of Hospital admissions versus 59% of Poison Centre consultations were regarded as self-inflicted. Ninety three percent of adults admitted to Hospital were drug overdoses, whereas only 48% of adult Poison Centre consultations involved ingestion of medicines. In adult overdoses with paracetamol and other analgesics, tricyclic antidepressants, antiepileptics, theophylline and ethanol were significantly higher in Hospital admissions than in Poison Centre consultations. In contrast, exposures to pesticides e.g. pyrethroids, misuse of recreational drugs e.g. cannabis and biological toxin exposures e.g. spider bites, were significantly higher in Poison Centre consultations than in Hospital admissions. In children, poisoning exposures to volatile hydrocarbons, especially paraffin, were significantly higher in Hospital admissions compared to Poison Centre enqueries. As is evident from the disparity in the results above, inqueries to the Tygerberg Poison Information Centre cannot be regarded as a reflection of the true incidence of acute poisonings in the community. Poison Information Centre statistics are distorted because of two factors: 1. Under-reporting to the Poison Information Centre. Healthcare providers are familiar with how to manage drugs commonly used in overdose (e.g. paracetamol) and certain household non-drug chemicals (e.g. paraffin), and often do not consult the Poison Centre for poison cases involving these substances. The number of inqueries received by the Poison Information Centre regarding these substances is, therefore, an under representation of actual incidence. 2. Over-reporting to the Poison Information Centre. The Tygerberg Poison Information Centre is well known for its expertise in biological toxins (e.g. spider and snake bites, scorpion stings, plant and mushroom ingestions, and marine toxins). Therefore, the number of inqueries received by the Centre with regard to these exposures is far higher than actual incidence of exposures. It is clear from this study that one cannot use data derived from a poison centre alone as an indicator of true incidence of poisoning in the community. A more accurate estimate of incidence of acute poisoning could be obtained by including data from hospital admissions, as well as those from primary health care facilities. Another prominent finding in this study was the high incidence of self-inflicted drug overdose in adult females, with paracetamol being the drug of choice. Poison prevention should therefore not be limited to children. Adult prevention programs need urgent attention. / AFRIKAANSE OPSOMMING: ‘n Prospektiewe studie om die insidensie en aard van akute vergigtigings in die Wes-Kaap vas te stel, is gedurende 1999 in Tygerberg Hospitaal uitgevoer. Die studie is gebaseer op ‘n analise van oproepe wat deur die Tygerbergse Vergifinligtingsentrum ontvang is en pasiente wat gedurende dieselfde tydperk met ‘n diagnose van akute vergiftiging by die Hospitaal toegelaat is. Qpsomming van Hospitaal toelatinqs (1010 qevalle): Toelatings van akute vergiftigings was meer algemeen by volwassenes (83%) as by kinders (17%). Die meeste hospitaal toelatings (83%) by volwassenes is a.g.v. geneesmiddeloordoseing. By 97% van volwassenes was gifstowwe doelbewus ingeneem, met vroue in die meerderheid (75%). Die insidensie van vergiftigings met nie-geneesmiddel verwante gifstowwe by volwassenes was laag (11%). By kinders was daar egter ‘n meer eweredige verspreiding tussen geneesmiddel (41%) en nie-geneesmiddel verwante (59%) gifstowwe. By beide volwassenes en kinders, was parasetamol die middel wat by die meeste oordoserings betrokke was. Alkohol was by 17% van vergiftigings by volwassenes betrokke. Paraffien en verwante vlugtige substanse was die belangrikste gifstowwe betrokke by akute vergiftigings by kinders. Akute vergiftigings as gevolg van die gebruik van dwelmmiddels was laag in alle ouderdomsgroepe (1%). Vergiftigings in die landbou en industriele sektore was laag (3%). Dit was ook die geval ten opsigte van blootstelling aan biologiese toksienes (2%). Opsomminq van Tyqerberq Verqifinliqtinqsentrum konsultasies (3744 qevalle): Gedurende 1999 het die Tygerberg Vergifinligtingsentrum 3744 oproepe ontvang waarvan 2690 as gevolg van akute vergiftigings was. Die ander 1054 oproepe het gehandel oor geneesmiddel terapie of algemene, nie-pasient verwante navrae. Daar is aangetoon dat oproepe ten opsigte van akute vergiftigings by volwassenes meer algemeen was as by kinders (61% en 39% respektiewelik). By kinders was die meeste vergiftigings per ongeluk (97%), terwyl by volwassenes die meeste doelbewus (55%) was. By kinders was 44% van die vroulike geslag teenoor 52% by volwassenes. By kinders was nie-geneesmiddel gifstowwe by 56% van akute vergiftigings betrokke en geneesmiddels by 44%. By volwassenes was dit 60% en 40%, respektiewelik. ‘n Verqelvkinq ten opsigte van Hospitaal toelatinqs en Verqifsentrum konsultasies: Om ‘n geldige vergelyking tussen Hospitaal toelatings en Vergifinligtingsentrum konsultasies te maak is gevalle van akute vergiftigings afkomstig uit dieselfde geografiese gebied.vergelyk. Toelatings tot Tygerberg Hospitaal 834 (90%) en 592 (25%) oproepe wat deur die Tygerbergse Vergifsentrum ontvang is, kom uit dieselfde opvangsgebied, naamlik die Tygerbergse substruktuur. Verskeie verskille tussen die twee instansies ten opsigte van die tipe vergiftigings is aangetoon. Volwassenes 688 (83%) en 145 (17%) kinders is met ‘n diagnose van akute vergiftiging by Tygerberg Hospitaal toegelaat in teenstelling met die Inligtingsentrum konsultasies waar 322 (54%) volwassenes en 270 (46%) kinders by betrokke was. By volwassenes was 99% van die toelatings die gevolg van doelbewuste vergiftiging (paraselfmoord), terwyl dit 59% van die Inligtingsentrum se navrae was. Drie en negentig persent van die volwassenes was in die Hospital toegelaat met geneesmiddel oordosering. Heelwat minder geneesmiddel oordosering (48%) was deur die Inligtingsentrum hanteer. Parasetamol en ander analgetika, trisikliese antidepressante, anti-epilepsie middels, alkohol en teofillien oordoserings by volwassenes was beduidend hoer by Hospitaal toelatings as by Vergifsentrum konsultasies. Akute vergiftiging deur paraffien en verwante vlugtige substanse by kinders was beduidend hoer by Hospitaal toelatings as wat gevind is by Inligtingsentrum navrae. Navrae ten opsigte van pestisied vergiftiging, gebruik van dwelmmiddels en blootstelling aan biologiese toksiene was beduidend hoer as by Hospitaal toelatings. Hierdie duidelike kontrasterende data dui daarop dat die tipe navrae wat deur die Tygerberg Vergifinligtingsentrum hanteer word nie noodwendig ‘n weerspieeling van die ware insidensie van akute vergiftiging in die gemeenskap is nie. Daar is 2 hoofredes hiervoor. 1. Onderrapportering by die Inligtingsentrum. Gesondheidverskaffers (dokters, verpleegsters, aptekers ens.) is vertroud met die behandeling van sekere algemene vergiftigings soos byvoorbeeld parasetamol oordosering en paraffien inname. Hulle ag dit derhalwe onnodig om die Sentrum hieroor te konsulteer. Dit lei dus tot onderrapportering. 2. Oorrapportering by die Inligtingsentrum. Die Tygerbergse Vergifinligtingsentrum is bekend vir sy vakkundigheid ten opsigte van blootstelling aan biologiese toksiene (spinnekopbyte, slangbyte, skerpioensteke, plante-en sampioen vergiftigings, ens). Dit is om hierdie rede dat vergiftigings deur biologiese agense, geraporteer aan die Sentrum, ‘n hoer syfer verteenwoordig as wat die werklike insidensie ten opsigte van die vergiftigings is. Hierdie studie toon dat vergifinligtingsentrum data nie noodwendig ‘n indikator van die ware insidensie van akute vergiftigings in die gemeenskap is nie. Dit is dus belangrik dat hospitaaltoelatingsdata asook data van primere gesondheidsklinieke ingesluit word om sodoende ‘n beter beeld te verkry van die ware insidensie van akute vergiftigings. ‘n Opmerklike bevinding tydens die studie was die hoe insidensie van doelbewuste geneesmiddel oordosering by volwasse vroue, met veral parasetamol as die middel van keuse. Programme wat fokus op die voorkoming van akute vergiftigings in volwassenes het dringende aandag nodig.

Orientador: Herling Gregorio Aguilar Alonzo / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-26T19:40:04Z (GMT). No. of bitstreams: 1 Costa_AlinedeOliveira_M.pdf: 9346622 bytes, checksum: e631fbbeb424ab7ad87d0fa2cdb55851 (MD5) Previous issue date: 2015 / Resumo: A ocorrência de exposições e intoxicações como um problema de saúde pública tem sido amplamente relatada na literatura. Embora o atendimento ao intoxicado possa ser realizado em âmbito hospitalar ou ambulatorial, são os Centros de Informação e Assistência Toxicológica (CIATs) que fornecem as informações especializadas para este atendimento. Na cidade de Campinas, o Centro de Controle de Intoxicações (CCI) é referência nos atendimentos das exposições tóxicas provenientes da região. O presente trabalho teve por objetivo descrever os casos de exposições e intoxicações atendidas pelo CCI de Campinas, no período de janeiro de 1998 a dezembro de 2011. Para tal, foram analisadas variáveis relacionadas ao atendimento, ao paciente, à exposição, ao agente tóxico e à evolução do caso. Os dados utilizados foram obtidos no banco de dados do CCI-Campinas, no qual está contido o registro dos atendimentos realizados no período estudado e analisados através do software Epi InfoTM CDC/WHO versão 7.1.3.10. O trabalho foi aprovado pelo Comitê de Ética em Pesquisa sob parecer nº 515.290/2013. Nos 14 anos estudados foram atendidos 51.665 casos, destes 27,9% foram classificados como exposições e 72,1% como intoxicações. Foi observado que 51,2% dos pacientes eram do sexo masculino e 48,3% do sexo feminino. A faixa etária predominante foi a de 1 a 4 anos com 28,6% dos casos, seguida pela faixa etária de 20 a 24 anos, com 9,4%. A circunstância prevalente foi a acidental, com 60,2% dos registros, seguida pela tentativa de suicídio, com 24,8%. Entre os principais grupos de agentes tóxicos, 32,5% eram medicamentos, 21% animais peçonhentos, 16,5% produtos químicos de uso domiciliar e 9,4% agrotóxicos. Como desfecho, 77,9% dos casos apresentaram a cura como evolução e, 0,6% evoluíram para óbito. A caracterização do perfil dos atendimentos realizados pelo CCI-Campinas, permitiu o conhecimento de suas especificidades e relevância para a saúde pública na região / Abstract: The occurrence of exposures and poisoning as a public health problem has been widely reported in the literature. Although the treatments to poisoned people can be performed in hospitals or outpatient basis, the Poison Control Centers are the service that provides specialized information for treatments. In the city of Campinas, the Poison Control Center is responsible for the treatment for toxic exposure from the region. This present study aims to describe the cases of toxic exposures treated by the Poison Control Centers of Campinas (CCI-Campinas), from january 1998 to december 2011. For this, variables were analyzed regarding treatment, patient, exposure, the toxic agent and evolution of the case. The data used were obtained from the database of the Poison Control Centers of Campinas, which contains the record of treatments made during the study period and analyzed using software Epi InfoTM CDC/WHO version 7.1.3.10. The work was approved by the Research Ethics Committee under report number 515.290/2013. In the 14 years studied 51.665 cases were treated, 27.9% of these were classified as exposures and 72.1% as poisoning. It was observed that 51.2% of patients were male and 48.3% female. The predominant age group was 1-4 years old, with 28.6% of cases, followed by the age group 20-24 years old, 9.4%. The prevalent condition was the accidental one, with 60.2% of the records, followed by attempted suicide, with 24.8%. Among the major groups of toxic agents, 32.5% were medications, 21% were poisonous animals, 16.5% were chemical products for domestic use and 9.4% were pesticides. As an outcome, 77.9% of cases evolved to healing, and 0.6% of cases died. The characterization of the profile of care provided by the CCI-Campinas allowed the knowledge of theis specific features and relevance to public health in the region / Mestrado / Epidemiologia / Mestra em Saúde Coletiva

Foodborne illnesses continue to have a negative impact on the nation's health, accounting annually for an estimated 76 million illnesses, 325,000 hospitalizations, and 5,000 deaths in the United States. Syndromic surveillance systems that analyze pre-diagnostic data, such as pharmaceutical sales data are being used to monitor diarrheal disease. The purpose of this study is to evaluate the usefulness of a poison control center (PCC) data collection and triage system for early detection of increases in foodborne illnesses.Data on calls to the Arizona Poison and Drug Information Center (APDIC) reporting suspected foodborne illnesses, and Pima County Health Department (PCHD) enteric illness reports were obtained for July 1, 2002 - June 30, 2007. Prediction algorithms were constructed using the first two and a half years, and validated in the remaining two and a half years. Multiple outcomes were assessed using unadjusted and adjusted raw counts, five and seven day moving averages, and exponentially weighted moving averages. Sensitivity analyses were conducted to evaluate model performance. Increases in PCHD laboratory reports of enteric illnesses were used as a proxy measure for foodborne disease outbreaks.Over the five year study period there were 1,094 APDIC calls reporting suspected foodborne illnesses, and 2,433 PCHD enteric illness cases. Seventy-five percent of cases were reported to PCHD within 23 days of symptom onset. In contrast, 62% of callers contacted APDIC within 24 hours of symptom onset. Forty percent of PCHD cases were missing symptom onset dates, which necessitated constructing and validating predictive algorithms using only those PCHD cases with known symptom onset dates.None of the prediction models performed at sensitivity levels considered acceptable by public health department standards. However, it is possible that a temporal relationship actually exists, but data quality (lack of outbreak dates, and missing symptom onset dates) may have prevented its detection. The study suggests that current surveillance by PCCs is insufficient as a univariate model for syndromic surveillance of diarrheal illness because of low caller volume reporting suspected foodborne illnesses; this can be improved. Methods were discussed to utilize PCCs for active surveillance of foodborne illnesses that are of public health significance.

Thèse (M.Ps.) -- Université du Québec à Chicoutimi, programme en extension de l'Université du Québec à Trois-Rivières, 2005. / La p. de t. porte en outre : Mémoire présenté à l'Université du Québec à Chicoutimi comme exigence partielle de la maîtrise en psychologie offerte l'Université du Québec à Chicoutimi en vertu d'un protocole d'entente avec l'Université du Québec à Trois-Rivières. Comprend des réf. bibliogr. : f. [115]-123. Document électronique également accessible en format PDF.

Made available in DSpace on 2015-07-22T20:50:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-27 / Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM) / Introdução: Centros de Informações Toxicológicas (CIT) prestam papel essencial na assistência de pacientes intoxicados, sem contar com financiamento seguro de suas atividades. Objetivo: verificar a diferença no tempo de internação dos pacientes intoxicados que receberam atenção remota de um CIT em comparação aos que não receberam. Métodos: foi organizada uma coorte retrospectiva incluindo todos pacientes intoxicados hospitalizados em um pronto-socorro de Manaus de 2005 a 2007, dos quais os pacientes selecionados (com agente tóxico conhecido, tempo de exposição inferior a 12 horas e sem comorbidades graves) tiveram a gravidade avaliada por dois revisores independentes e divergências resolvidas por outro revisor. A concordância foi calculada através do índice Kappa. Resultados: Foram incluídos 198 pacientes; aqueles com auxílio remoto do CIT ficaram em média 3,43 dias (- 6,10 a -0,77 IC 95%) a menos internados quando comparados a nenhum auxílio do CIT. Noventa pacientes tiveram gravidade avaliada; não houve diferença estatística na gravidade entre os pacientes com ou sem assistência do CIT (p > 0,5). A concordância entre os revisores foi significativa. Conclusão: Pacientes com assistência remota do CIT tiveram tempo de internação inferior a pacientes sem este auxílio. A análise de gravidade mostrou-se factível de ser incorporada à prática dos CIT brasileiros. / Introduction: Poison Control Centers (PCC) play an essential role in caring for poisoned patients, albeit without secure funding for their activities. Objective: to investigate differences in length of hospital stay among poisoned patients, between those who received remote assistance from a PCC and those who did not. Methods: a retrospective cohort including all poisoned patients hospitalized at an emergency service in Manaus between 2005 and 2007 was set up. Patients presenting a known toxic agent, with less than 12 hours elapsed since exposure and without severe comorbidities, were selected. Their severity of poisoning was evaluated by two independent reviewers and divergence was solved by another reviewer. Agreement was obtained by Kappa index. Results: 198 patients were included. Those who received remote assistance from a PCC stayed in hospital on average for 3.43 days less than those without PCC assistance (95% CI: -6.10 to -0.77). Severity was assessed in the cases of 90 patients: there was no statistical difference in severity between the patient groups (p > 0.5). Agreement between reviewers was substantial. Conclusion: Patients with PCC aid had a lower length of stay then patients without this aid. Severity assessment is likely to be incorporated into Brazilian PCC routine. / TEDE / BV UNIFESP: Teses e dissertações

Orientador: Maria da Graça Garcia Andrade / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-11T12:06:38Z (GMT). No. of bitstreams: 1 Gandolfi_Eliane_D.pdf: 2106286 bytes, checksum: 8033c283ed5232f22b2d680fe338d89d (MD5) Previous issue date: 2007 / Resumo: O estudo objetivou conhecer a toxicovigilância no Brasil, com ênfase no estado de São Paulo, e propor diretrizes e modelo para o SUS. Foi utilizado banco organizado com esta finalidade a partir dos eventos toxicológicos registrados pelos CEATOX no Estado de São Paulo. Realizou-se dois estudos epidemiológicos descritivos de série de casos: um para o período de 1991 a 2000, no qual observou-se a distribuição em relação às características gerais dos eventos, dos pacientes, dos agentes tóxicos e das circunstâncias em que ocorreram, e outro em 1998, no qual observou-se a distribuição dos eventos toxicológicos relacionados a medicamentos. Encontrou-se no primeiro 128.769 eventos toxicológicos em humanos, originados em sua maioria de ligações telefônicas (68,65%), de serviços de saúde hospitalares (51%); 60,8% dos atendimentos presenciais, foram oriundos de enfermarias e, 33,3%, de UTI. Predominaram as exposições agudas (84,5%), por via oral (68%), oriundas de área urbana (87,8%). O principal local de exposição foi a residência (74%). Predominou para o sexo masculino (52%), com maior concentração até os 10 anos (43%), sobretudo aos 2 e 3 anos de idade. Os agentes tóxicos predominantes foram os: medicamentos (38,6%), agrotóxicos (17,9%) e produtos de uso domiciliar (15,4%). As principais circunstâncias: acidentais (47,0%), tentativas de suicídio (19,8%) e ocupacionais (11,7%). Os medicamentos ocuparam o 1º lugar entre todos os tipos de agentes tóxicos registrados, e foram predominantemente registrados por telefone (78,5%), a partir de hospitais (86,6%); originados em exposições agudas, por via oral (90,2%), em residências (85,7%) de área urbana (95%). Predominou para o sexo feminino (59%) e nos primeiros 10 anos de vida (49,4%), sobretudo aos 2 e 3 anos. Preponderaram os grupos terapêuticos: psiquiatria, analgesia/anestesia e respiratório. Preponderaram os princípios ativos: fenobarbital, diazepam, haloperidol, carbamazepina e bromazepam, e as circunstâncias: acidentais (38,8%) e tentativas de suicídio (36,5%). Foram analisados documentos marcos da política internacional, nacional, e estadual e os aspectos operacionais da toxicovigilância no SUS relacionados à: informação, assistência, vigilância à saúde, constituição de equipes e integração de áreas. Diagnosticaram-se os principais sistemas de informação que registram agravos com o objetivo de verificar o estado da arte em relação às necessidades da toxicovigilância, para o qual estabeleceram-se critérios. Considerou-se estratégica a construção de sistema específico, propôs-se instrumentos e aspectos operacionais. Propôs-se o modelo no marco da vigilância da saúde, a inclusão da exposição e do evento toxicológico como objeto do registro de informações para a toxicovigilância e que as análises e ações consideram causa e contexto, atuando de modo integrado, articulado, programático, com parcerias intersetoriais, promovendo ações preventivas, de promoção da saúde e de precaução / Abstract: The study to make known the toxicological surveillance in the Brazil, with accentuation in the State of São Paulo, as well as toxicological surveillance according to the National Health System guidelines and suggest and model. To assess the epidemiological characteristics of related toxic events in the Toxicology Centers in the State of São Paulo, Brazil, in period 1991 and 2000. A descriptive epidemiological case series study was conducted, using the category related toxic event, and registered cases were analyzed. The variables studied comprised the characteristics of the events and the affected patients, toxic agents and the circumstances involved. In the study 97% (128.769) the related toxic event concerning to human cases, related toxic events were mostly reported by phone (68.65%) and hospitals (51%); they were originated from acute exposure (84,5%), oral (68%) at home (74%) and place to work (13%) in the urban area (87.8%). Most people affected were males (59%) in their first decade of life (43%), mainly between two and three years of age. Drugs ranked first among all toxic agents registered in the Centers (38.6%) and pesticides (17.9%) and the products to use in home (15.4%). The main circumstances were accidental ingestion (47%) and suicidal attempts (19.8%) and the occupactional (11.7%). Another descriptive epidemiological case series study was conducted. Using the category "drug-related toxic event", 6,673 registered cases were analyzed in the Toxicology Centers in the State of São Paulo throughout 1998. The variables studied comprised the characteristics of the events and the affected patients, toxic agents and the circumstances involved. The analysis of toxic agents took into consideration three levels of disaggregation: therapeutical groups, active ingredients and commercial brand names. Drugs ranked first among all toxic agents registered in the Centers. Drug-related toxic events were mostly reported by phone (78.5%) and hospitals (86.6%); they were originated from acute oral exposure (90.2%) at home (85.7%) in the urban area (95%). Most people affected were females (59%) in their first decade of life (49.4%), mainly between two and three years of age. The most common active ingredients found were: phenobarbital, diazepam, haloperidol, carbamazepine and bromazepam. The main circumstances were accidental ingestion (38.8%) and suicidal attempts (36.5%) and among the related active ingredients, the most prevailing therapeutical group were psychiatric, analgesic/anesthetic and respiratory. Law-abiding practices regarding prescription drugs are needed, as well as toxicological surveillance according to the National Health System guidelines. Are needed as well as toxicological surveillance according to the National Health System guidelines. The instruments principal strategy the following the toxic events and the articulate to epidemiological surveillance and sanitary surveillance the occurrence to approach integral and sectors association actions / Doutorado / Saude Coletiva / Doutor em Saude Coletiva