Externalizing disorders, as described by DSM-V (2013), are an empirically supported group of mental health conditions characterized by impulsiveness, antisocial behaviors, and disruptive conduct. These include Conduct Disorder (CD), Oppositional Defiant Disorder (ODD), Attention-Deficit/Hyperactivity Disorder (ADHD), and Impulse Control Disorders (ICDs). Symptoms often emerge during childhood or adolescence, when brain development is still ongoing. A prematurely-developed prefrontal cortex, paired with reward-seeking and emotional responses in youth, can contribute to impulsive behaviors and limited ability to predict the consequences of one’s actions (Casey, Jones, & Hare, 2008). Compared to females, males tend to be diagnosed with higher rates of externalizing disorders (Kerr, Reinke, & Eddy, 2013), which may place them at higher risk for engaging in risky and/or harmful behaviors. Research indicates that youth with externalizing disorders engage in a number of risky/harmful behaviors that could have negative consequences. A meta-analysis by Allely (2014) suggests that certain externalizing disorders, such as ADHD, may be a risk factor for self-harm behaviors in child, adolescent, and adult populations. Further, those with externalizing disorders in late childhood tend to have co-morbid depression and are more prone to suicidal ideation and suicide attempts during late adolescence and early adulthood (Kerr, Reinke, & Eddy, 2013). Others have also found a strong connection between externalizing disorders and suicidal behaviors among youth (Beautrais, 2000; Goldston et al., 1998; Hills, Cox, McWilliams, & Sareen, 2005; Verona & colleagues, 2000; 2001; 2004). Moreover, externalizing disorders, such as ADHD or CD, are correlated with sexual offending behaviors, which may be a result of sexual disinhibition (Kafka, 2012). While diverse, persons who have engaged in sexually abusive behavior often evidence antisocial behaviors and diagnoses of ADHD and CD (Prendergast, 2004; Shields, 1995). Grant et al. (2009) additionally indicated that the presence of trauma may also contribute to behavioral problems that resemble externalizing disorders. The current study aims to investigate male adolescents with and without externalizing disorders (i.e., ADHD, ODD, CD, and ICDs) by investigating a sample of youth in a residential treatment facility for sexually abusive behaviors (N = 295). Data related to adolescents’ self-harm behaviors, suicidal ideation and/or attempts, sexual offending behaviors, arrest histories, and diagnostic mental health histories were gathered from archival records. Within the sample, 234 participants were diagnosed with at least one externalizing disorder, including ADHD (n = 209), ODD (n = 91), CD (n = 102), and ICDs (n = 50). Chi-square analyses and one-way ANOVAs will be conducted to explore relationships among externalizing disorders, presence and frequency of self-harm behaviors and/or suicide attempts, frequency and types of sexual offenses committed, and frequency and types of arrest. Presence of PTSD diagnoses and Adverse Childhood Experiences (ACE) will also be taken into consideration, as previous literature suggests that early sexual, physical, and emotional trauma may also contribute to behavioral problems and sexual offending behaviors in adolescents (Grant et al., 2009). The goal of the current study is to fill gaps within the literature by identifying areas of concern among adolescents with externalizing disorders. The findings from the current study will be discussed in terms of clinical implications regarding risk reduction, prevention, and treatment.

The dynamics of pathogen and host relationships relative to disease transmission in wildlife populations are important ecological processes to understand, particularly since spatial dynamics of disease can be driven by movement, behavior, and dispersal of animals. Chronic Wasting Disease (CWD) is an example of this important interface, where little is known regarding origin of the disease or routes of transmission. Surveillance data for CWD in free-ranging mule deer indicates that breeding-age male deer have 2-4 times higher prevalence rates than females or younger age males. In an effort to understand differences that might increase risk for exposure to CWD infective agents, I used GPS data to examine breeding behavior and home range sizes of mule 11 deer. GPS radiocollars were placed on adult (> 2 ½ years) males, females, and young ( < 2 ½ years) males. Data collected during the breeding season was used to infer visitation rates of males to females. Cluster analysis was used to separate data into periods of movement (spatio-temporal clusters) and non-movement. Females formed more spatio-temporal clusters and movement paths than males. However, males spent more time moving, had more long-term periods of movement, moved an estimated 1 km/day more than females, and had more tortuous movement paths. Male home ranges for winter, summer, and breeding seasons were also larger than those of females. Overall, data indicates that males may have an increased risk of exposure to CWD relative to females, because of larger movements and greater space use. These male behavioral differences may result in increased encounter rates with CWD infectious material through greater exposure in the environment to sources such as carcasses from infected animals, their excreta, or contaminated soils. Furthermore, during the breeding season increased male sociality, as suggested by increased movement rates and movement path tortuousity, combined with larger space use may further enhance direct contact with infected individuals and increase exposure to excreta sources such as feces and alimentary secretions due to licking and tending behaviors.

Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2014-10-02T17:01:18Z No. of bitstreams: 1 DISS MP CLAUDIA RANGEL 2012.pdf: 2251277 bytes, checksum: ad4de14409973534f6f2eb1b758a0f95 (MD5) / Approved for entry into archive by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2014-10-02T17:38:38Z (GMT) No. of bitstreams: 1 DISS MP CLAUDIA RANGEL 2012.pdf: 2251277 bytes, checksum: ad4de14409973534f6f2eb1b758a0f95 (MD5) / Made available in DSpace on 2014-10-02T17:38:39Z (GMT). No. of bitstreams: 1 DISS MP CLAUDIA RANGEL 2012.pdf: 2251277 bytes, checksum: ad4de14409973534f6f2eb1b758a0f95 (MD5) / O presente trabalho tem como objetivo analisar a situação sanitária da rede de serviços hemoterápicos do Estado da Bahia, no período de 2010 a 2011, com o propósito de fornecer subsídios para as políticas públicas de sangue, bem como orientar as ações de vigilância sanitária no planejamento de suas atividades. Trata-se de um estudo descritivo que caracteriza e analisa a situação de risco dos serviços hemoterápicos, estimada pelo Método de Avaliação de Risco Potencial – MARP, desenvolvida pela Gerencia de Sangue e Componentes - GESAC/ANVISA, que se fundamenta no risco potencial dos pontos críticos de controle do ciclo do sangue Essa metodologia classifica os serviços em cinco categorias de risco: Baixo Risco, Médio Baixo Risco, Médio Risco, Médio Alto Risco e Alto Risco. Inicialmente, a hemorrede, composta por 84 unidades hemoterápicas, foi caracterizada por número e tipo serviço, natureza jurídica, produção hemoterápica e distribuição geográfica nas macro e microrregiões do Estado da Bahia. Em seguida, foi realizada a análise da situação de risco de 78,5% do universo, destes, 18% classificados em Médio Alto Risco e 50% em Alto Risco. As não conformidades mais frequentes encontradas, que contribuem para essa situação foram as relacionadas a recursos humanos, área física, equipamentos e garantia de qualidade que abrange registros, treinamento e procedimentos escritos. Na análise dos resultados da problemática investigada ressaltou-se a dimensão legal, cotejando-se a situação encontrada com os respectivos instrumentos normativos; a dimensão técnica, considerando-se os requisitos de qualidade do ciclo do sangue e a dimensão político-institucional, face à Política Estadual de Saúde.

This thesis is about hazardous of ETL processes in their data warehouse. In the first part of this thesis I have defined the ETL processes and the aim of this thesis. The second part is about theoretical solutions needed to create a data warehouse, the definition of ETL processes and discovering potential risks. The third part is about discovering potential risks of ETL processes using an analysis and risk assessment. This part also includes a control of the potential risks. The fourth part concentrates on modifying the ETL processes to prevent potential risks. An important part of this chapter is an emergency plan containing necessary processes which must be applied in case of a risk. The fifth part of this thesis is a summary of all knowledge found during the analysis and development.

abstract: This study explores the potential risks associated with the 65 U.S.-based commercial nuclear power plants (NPPs) and the distribution of those risks among the populations of both their respective host communities and of the communities located in outlying areas. First, I examine the relevant environmental justice issues. I start by examining the racial/ethnic composition of the host community populations, as well as the disparities in socio-economic status that exist, if any, between the host communities and communities located in outlying areas. Second, I estimate the statistical associations that exist, if any, between a population's distance from a NPP and several independent variables. I conduct multivariate ordinary least square (OLS) regression analyses and spatial autocorrelation regression (SAR) analyses at the national, regional and individual-NPP levels. Third, I construct a NPP potential risk index (NPP PRI) that defines four discrete risk categories--namely, very high risk, high risk, moderate risk, and low risk. The NPP PRI allows me then to estimate the demographic characteristics of the populations exposed to each so-defined level of risk. Fourth, using the Palo Verde NPP as the subject, I simulate a scenario in which a NPP experiences a core-damage accident. I use the RASCAL 4.3 software to simulate the path of dispersion of the resultant radioactive plume, and to investigate the statistical associations that exist, if any, between the dispersed radioactive plume and the demographic characteristics of the populations located within the plume's footprint. This study utilizes distributive justice theories to understand the distribution of the potential risks associated with NPPs, many of which are unpredictable, irreversible and inescapable. I employ an approach that takes into account multiple stakeholders in order to provide avenues for all parties to express concerns, and to ensure the relevance and actionability of any resulting policy recommendations. / Dissertation/Thesis / Ph.D. Environmental Social Science 2014

La détection et la caractérisation des nanoparticules manufacturées (NPM) est l’une des premières étapes pour contrôler et diminuer leurs risques potentiels sur la santé humaine et l’environnement. Différents systèmes d’échantillonnage dans l’air existent pour l’évaluation d’une exposition aux NPM. Cependant, ils ne mesurent pas le risque potentiel de cette exposition à la santé humaine ni les mécanismes cellulaires qui en seraient responsables. Nos objectifs de recherche sont 1) Évaluer les effets de différents types de nanoparticules sur des cellules pulmonaires humaines et 2) Identifier de nouveaux mécanismes intracellulaires activés lors de l’exposition à divers types de NPM. Méthodologie: La lignée de cellules A549 a été utilisée. Trois types de NPM ont été étudiés (différentes concentrations et temps d’exposition): les nanoparticules de dioxyde de titane de type anatase (TiO2), les nanotubes de carbone simple paroi (NTCSP) et les nanoparticules de noir de carbone (NC). La viabilité cellulaire a été mesurée par le test MTS, le test PrestoBlue et le test d’exclusion du bleu de Trypan (uniquement pour les NTCSP). La mesure du stress oxydatif a été déterminée par la mesure des dérivés réactifs de l’oxygène (ROS) en utilisant l’essai DCFH-DA. L’activation d’une réponse anti-oxydative a été déterminée par la mesure de la forme réduite (GSH) et oxydée (GSSG) du glutathion, ainsi que du ratio GSH/GSSG (seulement avec NTCSP et TiO2). Résultats: Les trois nanoparticules ne semblent pas être toxiques pour les cellules A549 car il y a une diminution significative mais minime de la viabilité cellulaire. Cependant, elles induisent une augmentation du contenu intracellulaire en ROS qui est à la fois dépendante du temps et de la concentration. Aucun changement dans les concentrations de GSH et GSSG n’a été observé. En conclusion, nos données indiquent que la mesure de la viabilité n’est pas un critère suffisant pour conclure à la toxicité des NPM. La production de ROS est un critère intéressant, cependant il faudra démontrer l’activation de systèmes anti-oxydatifs pour expliquer l’absence de mortalité cellulaire suite à l’exposition aux NPM. / Detection and characterization of manufactured nanoparticles (NPs) is one of the first steps to control and reduce potential risks to human health and the environment. Various sampling schemes in air exist for the evaluation of exposure to NPs. However, they do not measure the potential risk of this exposure to the human health and the cellular mechanisms that are responsible. Our research objectives are 1) To evaluate the effects of different types of nanoparticles on human lung cells and 2) Identify new intracellular mechanisms activated during exposure to various types of NPs. Methodology: The cell line A549 was used. Three types of NPs were studied (different concentrations and exposure time): titanium dioxide nanoparticles of anatase (TiO2), the simple wall carbon nanotubes (SWCN) and black carbon nanoparticles (BC). Cell viability was measured by the MTS assay, the PrestoBlue assay and the Trypan blue due exclusion test (only for the SWCN). To investigate whether the NPs stimulated ROS generation in A549 cels, the intracellular ROS level was measured using the DCFH-DA assay. The potential induction of oxidative stress responses in cells when exposed to TiO2 and SWCN was determined by the quantification of the extracellular levels of reduced (GSH) and oxidized glutathione (GSSG) forms. Results: The three nanoparticles do not appear to be toxic to A549 cells because there is a significant but small decrease in cell viability. However, they induce ROS production which is both time and concentration dependent. No change in the concentrations of GSH and GSSG were observed. In conclusion, our data indicate that measuring the cell viability is not a sufficient criterion for concluding if the NPs are toxic. ROS production is an interesting criterion, however, we have to demonstrate the activation of anti-oxidative systems to explain the absence of cell death following exposure to the NPs.

L’extensa implantació del control digital als entorns industrials, científics, comercials, professionals i domèstics ha revelat, d’ençà dues dècades, la gran sensibilitat d’aquests dispositius davant sobtats i breus descensos de tensió al subministrament elèctric de xarxa: aturades de plantes a processos productius, re – arrancades a processadors i sistemes de telecomunicació, etc.; i la causa sol esdevenir aparentment inexplicable pels usuaris. La normalització de les conseqüències, però, pot equivaler a un dia sencer de producció nul•la. L’ínfima correlació mostrada pels fenòmens esmentats amb anomalies al sistema elèctric proper (un client pot patir sèries conseqüències, per bé que el client veí només ha percebut una oscil•lació a l’enlluernat, i tots dos comparteixen la mateixa escomesa) sumada amb l’absència contrastada d’interrupció elèctrica suposà, al començament, un major grau d’incertesa, no només pels consumidors; també per a les empreses elèctriques. Fou necessari analitzar el problema en les seves vessants “microscòpica” i “macroscòpica” per a determinar la causa eficient: registrar la forma d’ona al punt de subministrament afectat i fer l’inventari de tots els incidents al Sistema Elèctric del mateix moment. La causa: els sots de tensió produïts per incidents elèctrics a xarxes remotes respecte el subministrament. Davallades sobtades (entre el 80 i el 10% del valor nominal) i ràpides (entre 10 ms i 1 s) al valor eficaç de la tensió subministrada, sense pas per “Zero”, produïdes, principalment, per curt - circuits perfectament detectats i eliminats a xarxes d’Alta Tensió (AT), molt allunyats de la conseqüència observada. A Catalunya, hom comptabilitzen afectacions davant curt - circuits a les interconnexions amb l’Aragó, Castelló i França. La present Tesi Doctoral estableix: • La metodologia per a modelar el Sistema Elèctric de Potència; • La sistematització del binomi causa (curt - circuit) – efecte (sot de tensió); • La personalització estadística de risc pel sot de tensió segons comarques; • Un sistema de protecció eficaç per a limitar la durada dels sots. La metodologia ha estat enfocada a la utilització sistemàtica, tal que per a cada curt - circuit esdevingut a la xarxa AT es pugui establir, en temps real, las capçaleres de subministrament afectades pel sot de tensió, així com la magnitud i la durada del mateix. L’entorn d’aplicació triat ha estat el Sistema Elèctric de Catalunya, per bé que la metodologia i sistemàtica són exportables, de forma natural, a qualsevol altre sistema elèctric trifàsic de corrent altern. / La implantación masiva del control digital en entornos industriales, científicos, comerciales, profesionales y domésticos ha puesto de manifiesto, durante los últimos veinte años, la gran sensibilidad de los mismos ante súbitos y breves descensos de tensión en la alimentación eléctrica procedente de la red: paradas de planta en procesos productivos, re – arranques en procesadores y sistemas de telecomunicación tienen lugar; y la causa de los mismos suele ser aparentemente inexplicable para los usuarios. La normalización de las consecuencias, en ocasiones, equivale a un día de producción nula. La escasa correlación mostrada por dichos fenómenos con anomalías en el sistema eléctrico cercano (un cliente padece consecuencias serias, mientras que el cliente vecino solamente ha percibido una oscilación en el alumbrado y ambos se alimentan del mismo tramo eléctrico) sumada con la ausencia contrastada de interrupción eléctrica supuso, en los inicios, un mayor grado de incertidumbre tanto para los consumidores como para las empresas eléctricas. Fue necesario analizar el problema a nivel “microscópico” y “macroscópico” para determinar la causa eficiente: registrar la forma de onda en el punto de suministro afectado y revisar todos los incidentes habidos en el Sistema Eléctrico en dicho instante. La causa: los huecos de tensión producidos por incidentes eléctricos en redes alejadas del suministro. Descensos súbitos (entre el 80 y el 10% del valor nominal) y rápidos (entre 10 ms y 1 s) en el valor eficaz de la tensión suministrada, sin paso por “cero” de la misma, producidos, principalmente, por cortocircuitos perfectamente detectados y eliminados en redes de Alta Tensión (AT), y situados muy lejos de la consecuencia observada. En el caso de Catalunya, se han contabilizado afectaciones ante cortocircuitos en interconexiones con Aragón, Castellón de la Plana y Francia. La presente Tesis Doctoral establece: • La metodología para modelar el Sistema Eléctrico de Potencia; • La sistematización para el binomio causa (cortocircuito) – efecto (hueco); • La personalización del riesgo estadístico de hueco vs. comarcas; • Un sistema protectivo eficaz para limitar duración de los huecos. Dicha metodología se ha orientado a la utilización sistemática, tal que para cada cortocircuito que tenga lugar en la red AT pueda establecerse, en tiempo real, las cabeceras de suministro afectadas por hueco de tensión, la magnitud y la duración del mismo. Como entorno de aplicación, se ha utilizado el Sistema Eléctrico de Catalunya, si bien la metodología y sistematización son exportables, de forma natural, a cualquier otro sistema eléctrico trifásico de corriente alterna. / The massive introduction of digital control in industrial, scientific, commercial, professional and domestic environments has revealed, over the last twenty years, the great sensitivity of them to sudden and short voltage dips in the electrical power grid: shutdowns of productive process plants, re - starts of processors and telecommunications systems take place, and the cause of them is often apparently inexplicable to the users. The normalization of the consequences sometimes is equivalent to a day without production. The weak correlation shown by these phenomena with anomalies in the nearby electrical system (i.e. in the same portion of a common distribution network, a customer may suffer serious consequences, while the adjacent customer has only percept a swing in the lighting) together with the absence of electrical power interruption represented, in the beginning, a great degree of uncertainty for both consumers and utilities. It was necessary to analyze the problem at the "microscopic" and "macroscopic" levels to determine the efficient cause: record the waveform at the affected plants and review all the disturbances occurred in the Power System at the same instant of time. The cause: voltage dips caused by electrical disturbances away from the supply. Sudden decreases (between 80 and 10% of the nominal value) and fast (between 10 ms and 1 s) in the supplied rms voltage, produced mainly by short-circuits perfectly detected and eliminated in High Voltage (HV) networks, and located far away from the observed consequence. In the case of Catalonia, affectations due to short-circuits in interconnects with Aragon, Castellón de la Plana and France have been recorded. This thesis provides: • A methodology useful to model the Power System; • A systematic analysis for cause – effect: from short – circuit to voltage dip; • A particularization voltage dip statistic risk for each county; • A reliable protective system to ensure time – limitation for voltage dips. The presented methodology is oriented to the systematic use, such that for every short - circuit that takes place in the HV network, the magnitude and duration of voltage dips that appear in the distribution can be established in real-time. As the application framework, the Catalan Power System is used, although the methodology and systematization are exportable, to any other alternating three-phase power system.