Made available in DSpace on 2017-06-01T18:20:47Z (GMT). No. of bitstreams: 1 cristina_maria_alves_morais_albuquerque.pdf: 1521157 bytes, checksum: d960407ed7e9ea44fa869c3b4d283641 (MD5) Previous issue date: 2016-12-06 / The plaster projection was developed as a cast material over, to be incorporated into construction systems used in construction.Your application must include interior of the houses and buildings, both commercial and residential, shops, malls,hospitals,etc.These grounds requires is a perfect technique for use in order to have quality and performance to ensure the standards required by the current market, mainly to reduce the consumption of natural resources, ensuring the least possible amount of waste produced during and after the application process. The literature has given very little.scientific information on the production of this type of plaster, due to the essentially commercial nature of this area.In practice it is known that in Plaster Pole of Araripe-Pernambuco, this type of plaster has been made improperly, with inadequate dehydration of the mineral gypsum ore (on conversionreaction), being completed with the incorporation of additives - limited substances, such as the glue plaster; that the high cost adds value.This work, therefore, the objective is to show how the development of a basic projection process of gypsum production, with the aid of totally dehydrated gypsum (anhydrite II). Consisted of hemihydrates and anhydrite II in suitable percentage for fixing setting time required for a better workability.of the mass. This type of plaster has advantages in relation to those produced by current procedures practiced in the Plasterer Polo Araripe, associated with a significant reduction of waste - basic concern that one should have in relation to the duration of deposits. / O gesso de projeção foi desenvolvido como um material a mais, para ser incorporado aos sistemas construtivos. Sua aplicação deve abranger o interior das casas e edifícios, tanto comerciais como residenciais, lojas, shopping centers, hospitais, etc. Nesses recintos exige-se uma técnica perfeita para a sua utilização, de forma a se ter qualidade e desempenho que garantam os padrões exigidos pelo mercado atual, principalmente a redução do consumo das reservas naturais , garantindo a menor quantidade possível de resíduos produzidos durante e após o processo de aplicação. A literatura tem dado pouquíssimas informações científicas sobre a produção desse tipo de gesso, em virtude do caráter essencialmente comercial dessa área. Na prática sabe-se que no Polo Gesseiro do Araripe-Pernambuco, esse tipo de gesso tem sido produzido de forma imprópria, com a desidratação inadequada do minério de gipsita (sobre conversão da reação), complementando-se com a incorporação de aditivos - substâncias limitadas, a exemplo do gesso cola; que pelo alto custo agrega valor. Este trabalho, portanto, objetiva mostrar como ocorre o desenvolvimento de um processo básico de produção de gesso de projeção, com o auxílio de gipsita totalmente desidratada (anidrita II). Constituído de semi-hidrato e anidrita II, em percentuais adequados para a fixação de tempos de pega necessários para uma melhor trabalhabilidade da massa.Esse tipo de gesso apresenta vantagens em relação àqueles produzidos por procedimentos atuais praticados no Polo Gesseiro do Araripe, associado a uma significativa redução de rejeitos - preocupação básica que se deve ter em relação à duração das jazidas.

Orientador: Roger Darros Barbosa / Resumo: O beiju, produto de cultura indígena milenar, é obtido a partir do aquecimento da fécula de mandioca salgada e hidratada, com cerca de 40 a 45% de umidade, para a formação de um gel rígido e opaco, com baixa umidade (máx. 10%). As características de textura crocante, de cor branca e opaca e de sabor neutro levemente salgado, posicionam o beiju como concorrente de biscoitos crocantes. A pesquisa sobre hábitos de consumo mostrou preferência de compra associada aos atributos sensoriais de sabor, cor e crocância. O produto ofertado ao mercado do Nordeste é de baixa qualidade devido ao processo artesanal e instabilidade da textura. Esta pesquisa investigou os parâmetros do processo que influenciam na qualidade do beiju, entre os quais a razão fécula/água na hidratação, temperatura e tempo de exposição ao calor no processo térmico, para o qual foi desenvolvido um equipamento de bancada específico. A caracterização dos beijus comerciais em termos dos atributos sensoriais e de análises instrumentais de textura e cor, juntamente com informações de produtores artesanais de beiju, auxiliaram na determinação das condições para o processamento do beiju em laboratório. Adicionalmente, foram realizados estudos de estabilidade do beiju durante a estocagem com base nas características de textura e equilíbrio higroscópico. O beiju obtido em todas as condições investigadas apresentou parâmetros de textura instrumental com valores que permitem caracterizá-lo como um produto crocante e moderado g... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Beiju, a product of ancient indigenous culture, is obtained by heating the salted and hydrated cassava starch, with 40 to 45% moisture, to form a rigid and opaque gel, with low moisture (maximum 10 %). The characteristics of crispy texture, white and opaque and with a slightly salty neutral flavor, make beiju as a competitor for crispy crackers or snacks. A survey on consumption habits showed the purchase preference associated with the sensory attributes of flavor, color and crispness. The product offered to the market is of low quality due to the artisanal process and texture instability. This research investigated the process parameters that may influence the quality of beiju, among which the starch/water ratio in hydration, temperature and time of exposure to heat in the thermal process, for which a specific bench equipment was developed. The characterization of commercial beijus in terms of sensory attributes and instrumental analyzes of texture and color, along with artisanal producers processing information, helped in determining process variables range for laboratory processing. Additionally, beiju stability studies were carried out during storage based on texture and hygroscopic equilibrium characteristics. The beiju obtained in all investigated conditions presented instrumental texture parameters with values that allow to characterize it as a crispy product and a moderate degree of hardness. The main responses for the characterization of the crispness were attributed... (Complete abstract click electronic access below) / Mestre

<p>Developments in the technology are followed by the methods and frameworks in industry to intensify the production of information, tools, goods, and services. This trend has been followed by the pharmaceutical industry which is highly regulated by administrations to meet the quality requirements of the drugs and produce more for cheaper in a shorter time. As the knowledge and understanding of crystallization systems have been increasing with the development of process analytical technology (PAT) tools, it is inevitable to use the experience and data coming with it to develop data-driven, better processes. In the light of these developments, Industry 4.0 has started becoming the new paradigm in pharmaceutical industry pushing the data-driven design of pharmaceutical processes. This thesis demonstrates the development and usage of a framework for data-driven, model-based design of pharmaceutical processes that fall in line with this latest paradigm shift. The proposed framework can be summarized in four levels showing the benefits of the collected data and model development. These levels are data collection from specially designed experiments, model writing, using the data collected from the first step to train the model, validation of the model to call it ‘Digital Twin’ of the process, using the digital twin for process design via in-silico design of experiments (DoE) or process optimization. The chapters in this thesis are different case studies that follow these steps for model-based process design. The systems studied are batch cooling crystallization with temperature cycling to produce a drug compound, batch cooling crystallization with integrated milling and temperature cycling for the shape optimization of the same drug compound from previous step, and hot melt extrusion for amorphization of another drug compound. In addition to demonstrating the development of the whole framework and its possible benefits in each chapter, Chapter 4 is the solely experimental proof of concept of a previous, more general model-based design of a mill integrated crystallization work.</p>

Master thesis focuses on payment process automatization of selected company XY, which will eliminate repetitive manual work and routine and will lead to shortening of the whole process. To reach this solution RPA – Robotic Process Automation was used. RPA was designed based on data analysis, which showed areas of process best suited for automatization. Part of the thesis is also evaluation of impacts of implemented RPA solution.

The thesis is focused on the identification of service and administrative processes and sub processes inside the chosen company and proposal of their possible separation and outsourcing using the Business Process Management methods. Potential changes should be aimed to release capacity of the monitored team of the company and optimize their processes and related capacity during busy season and also from the long term perspective. The company set the conditions for potential changes by keeping current standards about quality of products and services and keeping current rules for client communication. Additionally company expects decreasing of personal costs related to inquired services.

The disposal of large amounts of waste still containing energetic value is a central challenge in the waste management of the Brazilian sugarcane industry. As a sustainable solution, the biogas process appears to be a suitable technology for treating sugarcane waste products and for providing valuable commodities such as energy-rich biogas and digestate with fertilizer properties. Additionally, the proper treatment of the four major waste types (straw, bagasse, filter cake and vinasse) would avoid greenhouse gas emissions, air pollution and environmental contamination of soil and water. In order to investigate the feasibility and reliability of biogas production from sugarcane wastes, the microbial community dynamics of laboratory-scale reactors were assessed under different start-up strategies. Despite the promising results of the methane potential for all the waste products, chemical and physical pre-treatments were applied successfully to increase the methane yield of straw, bagasse and filter cake. The microbial community dynamics observed during co-digestion of filter cake and bagasse showed, together with the process parameters, that cattle manure can be effectively used as an inoculum for the start-up of a biogas process in the remote-located sugarcane industry. Monitoring methanogenic community dynamics at high organic loading rate of filter cake and bagasse demonstrated that the genera Methanosarcina and Methanobacterium are the major methanogens that produce biogas, even under process imbalances. Moreover, the results obtained from the process parameters and methanogenic community analyses revealed that the stable isotope fingerprinting technique may be a potential monitoring tool for quickly identifying changes in the methanogenic pathway, which indicates process disturbances. In conclusion, these studies established techniques for the efficient substrate processing and start-up procedure of a biogas process designed for the anaerobic digestion of sugarcane wastes, and by these means provided a highly detailed profile of the microbial community in relation to process parameters.

Supply chain visibility has become a crucial factor for companies in times of globalization and customer satisfaction. Track-and-trace technologies are important tools in order to enhance supply chain visibility. This thesis was written in cooperation with a Swedish retailer and evaluates potential track-and-trace technologies in order to develop a solution to close their current track-and-trace gap in their outbound logistics. Currently the handover point between the retailer and the postal service provider is not clearly defined, so that shipments get lost during the transition. Therefore, a literature review about currently used track-and-trace technologies was carried out. Several technologies with a wide price and applicability range are currently used and have been analysed regarding their strength and weaknesses. A qualitative study in form of interviews was conducted within the Swedish market about how this gap could possibly be closed. Empirical findings show that the existing track-and-trace technologies do not provide a best practice solution. Especially in the field of outbound logistics, several factors and the individual process requirements of a company have to be considered in order to develop an efficient solution, so that the existing track-and-trace gap can be closed. Each company has its unique set of challenges, which have to be solved in order to successfully implement a long- lasting tracking solution. A high dependence from the postal service provider is additionally given since all process steps need to be aligned to guarantee reliability of the data afterwards. In the case of the Swedish retailer, an automatized scanning bow with a separated area for outbound parcels is expected to improve transparency of the handover and lower the total amount of lost shipments. The breakeven point would be reached within the next years, so that operational saving could soon be achieved. Due to the global outbreak of COVID-19, as well as significant problems of the retailer, the practical application could not be tested. It should therefore be part of further academic studies.

<p>A significant number of resources are allocated to maintaining the resiliency of pharmaceutical supply chain as failure to do so thoroughly can result in drug shortages of essential medicines. Recently, the effects of COVID-19 exacerbated flaws in the current system causing the pharmaceutical industry and government organizations and to reassess relief strategies that could also strengthen the supply chain. Flow chemistry has become an attractive and prominent platform enabling continuous manufacturing (CM) technologies to synthesize active pharmaceutical ingredients (API) quickly according to demand. Compared to traditional batch chemistry, flow chemistry has demonstrated to be more robust in terms of throughput, scalability, and hazard reduction while maintaining a high degree of control and product quality. This work demonstrates these capabilities in reaction optimization and discovery with the overarching goal of domesticating CM to make essential medicines more affordable. A two-step process for the synthesis in diazepam was developed using a Chemtrix Labtrix S1 and Start microfluidic systems where purities as high as 98% were achieved. The system was successfully scaled up to a larger system that was able to produce 96% pure diazepam at a 91% yield. </p>

The main purpose of this thesis work was to halve the cycle time of a grinding process of the groove of carbonitrided ball bearings rings. The study was conducted as a Six Sigma project at SKF in Bari, Italy. Reaching the goal was important for the company as it meant avoiding the purchase of another grinding machine. The groove grinding process on carbonitrided rings features double the cycle time than the same process on through hardened rings and halving it was required to fulfill the volumes demanded. The Six Sigma methodology was applied through the implementation of DMAIC. The analysis of the problems and identification of areas for improvement were carried out deploying different tools such as an Ishikawa diagram, Hypothesis Testing and Statistical Process Control. The outcome of this was the need to optimize the carbonitriding process minimizing the depth of the layer without enlarged carbides in order to render the design of the part easier to machine and subsequently find the process parameters for the groove grinding yielding a cycle time of six seconds. Many trials were conducted with the supplier of carbonitriding, until the carbon and ammonia potentials were set at levels resulting in a depth of the layer allowing the change of the design. An optimizing DOE was instead performed for the grinding process which highlighted the parameters settings yielding the target cycle time. Finally actions and controls to perform in order to maintain the gains were defined.

No description available.