No description available.

Indiana University-Purdue University Indianapolis (IUPUI) / Introduction: Profound pulpal anesthesia is not always adequate in mandibular teeth after the administration of local anesthesia, especially in the presence of irreversible pulpitis. Failure to achieve anesthesia has been seen in 30–80% of patients in teeth with a diagnosis of irreversible pulpitis. Onpharma™ developed an FDA-approved device that uses sodium bicarbonate to buffer a standard local anesthetic (LA) solution so that its pH may become closer to its pKa. Claims have been made that buffering a local anesthetic increases the anesthetic’s effect. Previous studies on the anesthetic efficacy of Onpharma’s Onset buffering system were inconclusive and may be dependent on the techniques used. Objectives: The aim of this study is to determine whether a buffered local anesthetic can lead to more profound and faster pulpal anesthesia in mandibular molars diagnosed with symptomatic irreversible pulpitis as compared to a standard, unbuffered local anesthetic. Materials and Methods: 40 total subjects completed the study. Screened and eligible subjects with a mandibular molar diagnosed with symptomatic irreversible pulpitis were randomly allocated into 2 groups so 1 group received a total of 3 cartridges of a standard, unbuffered 2% lidocaine with 1:100,000 epinephrine via inferior alveolar nerve block (IANB) followed by supplemental buccal and lingual infiltrations, while the other received the equivalent yet buffered formulation. An electronic pulp tester (EPT) was used to objectively determine baseline pulpal status of the affected tooth, followed by 2-minute interval testing following the administration of all local anesthesia. The onset of pulpal anesthesia was defined by the first of 2 consecutive EPT=80 readings, and the endodontic treatment could begin. Profound pulpal anesthesia was ultimately determined if the patient reported a comfortable pulpotomy as reflected on the Wong-Baker FACES Visual Analog Scale. Null Hypothesis 1: Subjects possessing mandibular molars diagnosed with symptomatic irreversible pulpitis will not achieve pulpal anesthesia more profoundly using buffered 2% lidocaine w/ 1:100,000 epinephrine in comparison to the standard, unbuffered anesthetic formulation. Null hypothesis 2: Subjects possessing mandibular molars diagnosed with symptomatic irreversible pulpitis will not achieve pulpal anesthesia faster using buffered 2% lidocaine w/ 1:100,000 epinephrine in comparison to the standard, unbuffered anesthetic formulation. Results: We observed a local anesthetic success rate of 45% in the buffered group, 70% in the unbuffered group, and ultimately 57.5% between both groups. The findings further indicate that the VAS scores after pulpotomy is significantly different between the 2 groups (p=0.019), with the unbuffered group having a more profound mean VAS score of 1.2 (as opposed to a buffered mean of 3.1). Regarding the time of onset for pulpal anesthesia, there was no statistically significant difference noted between the buffered and unbuffered groups. Conclusion: Based on the findings of this study, the null hypothesis 1 cannot be rejected since unbuffered 2% lidocaine with 1:100,000 epinephrine had a statistically significant increase in profound pulpal anesthesia compared to the buffered equivalent. The null hypothesis 2 cannot be rejected since there was no evidence of a significant difference in the time to pulpal anesthesia between the buffered and unbuffered groups.

No description available.

Mature dendritic cells (DCs) in inflamed tissues may promote inflammation but the status of DCs in pulpitis is not known. We hypothesized that DC maturation would correlate with carious lesion depth and that CD4+ cells would be found in association with mature DCs. Pulps were collected from teeth exhibiting: (I) no caries (n=9), (II) shallow dentinal caries (n=5), and (III) deep caries (n=9). Pulpal tissues were cryo-sectioned and positive cells were examined with immunohistochemistry, Mature DCs (CD83+) were almost exclusively restricted to pulps from deep caries. Furthermore, CD209+ DCs in deep caries were elevated over other groups and CD209+ cells about doubled the CD83+ cells suggesting that immature DCs had accumulated and were available for terminal maturation. CD4+ cells were found associated with both mature DCs and macrophages in pulps from deep caries suggesting that T cells may be a source of pro-inflammatory cytokines at this inflamed site. This document was created in Microsoft Word 2000.

O termo odontalgia engloba várias doenças dentárias capazes de causar dor, entre elas a pulpite irreversível sintomática (PIS), caracterizada por um pico inflamatório que afeta irreversivelmente as células da polpa dental, gerando uma dor excruciante. Os medicamentos são capazes de gerar analgesia parcial, porém com uma parcela de efeitos colaterais e contraindicações. O tratamento definitivo é realizado preferencialmente através da pulpectomia ou na impossibilidade, através da exodontia. A acupuntura apresenta poucas contraindicações, baixo risco e efetividade analgésica comprovada em diversas condições álgicas. De acordo com os livros texto, vários pontos de acupuntura apresentam efetividade analgésica nas odontalgias, entre elas a PIS. Entretanto, não foram encontrados estudos que suportassem essas conclusões. Assim, o objetivo desse estudo é verificar a existência de tendência de analgesia da acupuntura através de dois pontos de fácil acesso e aplicação: estomago 6 (ST6) e estômago 7 (ST7), em indivíduos portadores exclusivamente de PIS, em apenas um dente. O estudo foi realizado no Serviço de Urgências Odontológicas da FOUSP, seguindo delineamento cross-over em sessão única, randomizado e duplo-cego. Observa-se que os pontos ST6 e ST7 apresentam tendência a reduzir a dor da PIS independentemente de serem utilizados antes ou depois de seu respectivo placebo. Desponta-se assim a necessidade de mais estudos que confirmem essa eficácia, de forma a possibilitar a indicação precisa e o alento para os portadores de uma das odontalgias mais intensas que se tem conhecimento. / The term odontalgia emcompasses several diseases capable to cause pain, including symptomatic irreversible pulpitis (SIP), characterized by an inflammatory peak which irreversibly affects the cells of the dental pulp, causing excruciating pain. The drugs are capable of generating partial analgesia, but with a quota of side effects and contraindications. The definitive treatment is preferably carried out by pulpectomy, or on the inability of it, through the exodonty. Acupuncture has few contraindications, low risk and proven analgesic efficacy in several algic conditions. According to the textbooks, many acupuncture points bring forward analgesic effectiveness in odontalgias, including the SIP. However, no studies that supported these conclusions were found. The aim of this study is to verify the existence of propensity of acupuncture analgesia through two points of easy access and application: stomach 6 (ST6) and stomach 7 (ST7), exclusively in individuals of SIP in just one tooth. The study was conducted in the Department of Emergency Dental FOUSP, following cross-over design in a single session, randomized, double-blind. It is observed that ST6 and ST7 points have a tendency to reduce the pain of SIP whether used before or after the respective placebo. Thus it suggests the need for further studies confirming its effectiveness, in order to enable the precise diagnostic and the breath for patients with one of the most intense odontalgias that are known.

Neste estudo, randomizado, duplo cego, avaliamos a eficácia anestésica em quarenta e dois pacientes, do Setor de Urgência da Faculdade de Odontologia da Universidade de São Paulo, com pulpite irreversível, que receberam mepivacaína 2% (n=21) ou lidocaína 2% (n=21) associadas à epinefrina 1:100.000 para bloqueio do nervo alveolar inferior (BNAI). O sinal subjetivo de anestesia do lábio e língua, a presença de anestesia pulpar e ausência de dor durante o procedimento de pulpectomia foram avaliados, respectivamente, por indagação ao paciente, pelo testador elétrico pulpar (TEP) e pela escala de dor verbal (VAS). Pela técnica pterigomandibular indireta das três posições, foi injetado primeiramente um tubete (1,8mL), e depois de 10 minutos, foi testada a anestesia pulpar (AP), pelo TEP, por duas leituras negativas ao estímulo máximo (80A) do aparelho. Quando não instalada a AP, um segundo tubete (mais 1,8mL) era reinjetado. Confirmada a anestesia pulpar, iniciava-se a pulpectomia. O sucesso do BNAI foi definido como a capacidade de acessar a câmara pulpar e a realização da pulpectomia sem relato de dor (VAS) pelo paciente (escore 0 ou 1), enquanto o insucesso foi caracterizado pelo incomodo/dor (escore 2 ou 3), que impedisse a continuação. Nesse caso, um terceiro e último tubete foi dado por técnicas complementares (intraligamentar ou intrapulpar) para finalizar o procedimento. Na análise estatística utilizou-se o teste Exato de Fisher e ANOVA com nível de significância fixado em 5%. Obtivemos que no grupo Mepivacaína com 1,8mL, a taxa de anestesia pulpar (AP) foi de 52% (11/21), e sucesso no BNAI de 55% (6/11); a injeção de mais 1,8mL (2º tubete) aumentou a AP para 86% (18/21) e o sucesso no BNAI para 55% (10*/18). No Grupo Lidocaína, com 1.8mL, a taxa da AP foi de 33% (7/21), o BNAI foi de 0%; com mais 1,8mL (2º tubete), a AP aumentou para 67% (14/21) e sucesso no BNAI para 14% (2*/14) (*com diferença estatística onde p0,05). A mepivacaína com volume menor proporcionou, clinicamente, maior índice de anestesia pulpar e sucesso do BNAI (pulpectomia total), e permitiu chegar mais próximo da polpa quando comparada a lidocaína. Concluímos que a mepivacaína obteve melhores resultados no sucesso do BNAI para a realização da pulpectomia em molares inferiores com pulpite irreversível. / The aim of this, double blind randomized study, was to evaluate the anesthetic efficacy of inferior alveolar nerve block (IANB) using 2% mepivacaine and 2% lidocaine both associated with adrenaline 1:100,000 in molars with irreversible pulpitis. The sample of these study consisted of forty-two healthy patients diagnosed with irreversible pulpitis actively experiencing pain. For blocking the IAN was established the following protocol: injection of one cartridge (1.8 mL) by the technique pterigomandibular of three indirect positions, expected 10 minutes and electric pulp test (EPT) Vitality Scanner®-SybronEndo, USA was accomplishment. If tooth sensitivity pain persisted another cartridge (plus 1.8 mL) was given by the same technique and the same methodology was performed. The pulpectomy was continued after the confirmation of pulpal anesthesia, which was established as the lack of response at maximum stimulation (80A) of EPT. In cases where the patient reported pain during pulpectomy even confirmed the blockage, a third cartridge was given by complementary techniques (intraligamentary or intrapulpal) to complete the endodontic procedure. The anesthetic efficacy in IANB was established when the pulpectomy was performed without report of pain and without complementation. For analysis and comparison of results we used the Fisher exact statistical test and ANOVA with significance level set at 5%. Regarding the effectiveness of the anesthetic with 1,8 mL mepivacaine, determined pulpar anesthesia (PA) was 52% (11/21), and success in IANB (pulpectomy) 55% (6/11), the most injection of 1,8 mL, increased 86% (18/21) for AP and success in IANB to 55% (10*/18). In the lidocaine group, with 1.8mL, AP rate was 33% (7/21), the IANB was 0%, with a further 1.8 mL (cartridge 2) the AP increased to 67% (14/21) and success was to IANB 14 % (2*/14), (*statistically difference p 0.05). Mepivacaine with smaller volume clinically provided a higher rate of pulpal anesthesia and most successful of IANB (pulpectomy total), allowing to reach nearest dental pulp than lidocaine. Concluded that mepivacaine performed better in success of IANB (pulpectomy) that lidocaine in molars with irreversible pulpitis

O termo odontalgia engloba várias doenças dentárias capazes de causar dor, entre elas a pulpite irreversível sintomática (PIS), caracterizada por um pico inflamatório que afeta irreversivelmente as células da polpa dental, gerando uma dor excruciante. Os medicamentos são capazes de gerar analgesia parcial, porém com uma parcela de efeitos colaterais e contraindicações. O tratamento definitivo é realizado preferencialmente através da pulpectomia ou na impossibilidade, através da exodontia. A acupuntura apresenta poucas contraindicações, baixo risco e efetividade analgésica comprovada em diversas condições álgicas. De acordo com os livros texto, vários pontos de acupuntura apresentam efetividade analgésica nas odontalgias, entre elas a PIS. Entretanto, não foram encontrados estudos que suportassem essas conclusões. Assim, o objetivo desse estudo é verificar a existência de tendência de analgesia da acupuntura através de dois pontos de fácil acesso e aplicação: estomago 6 (ST6) e estômago 7 (ST7), em indivíduos portadores exclusivamente de PIS, em apenas um dente. O estudo foi realizado no Serviço de Urgências Odontológicas da FOUSP, seguindo delineamento cross-over em sessão única, randomizado e duplo-cego. Observa-se que os pontos ST6 e ST7 apresentam tendência a reduzir a dor da PIS independentemente de serem utilizados antes ou depois de seu respectivo placebo. Desponta-se assim a necessidade de mais estudos que confirmem essa eficácia, de forma a possibilitar a indicação precisa e o alento para os portadores de uma das odontalgias mais intensas que se tem conhecimento. / The term odontalgia emcompasses several diseases capable to cause pain, including symptomatic irreversible pulpitis (SIP), characterized by an inflammatory peak which irreversibly affects the cells of the dental pulp, causing excruciating pain. The drugs are capable of generating partial analgesia, but with a quota of side effects and contraindications. The definitive treatment is preferably carried out by pulpectomy, or on the inability of it, through the exodonty. Acupuncture has few contraindications, low risk and proven analgesic efficacy in several algic conditions. According to the textbooks, many acupuncture points bring forward analgesic effectiveness in odontalgias, including the SIP. However, no studies that supported these conclusions were found. The aim of this study is to verify the existence of propensity of acupuncture analgesia through two points of easy access and application: stomach 6 (ST6) and stomach 7 (ST7), exclusively in individuals of SIP in just one tooth. The study was conducted in the Department of Emergency Dental FOUSP, following cross-over design in a single session, randomized, double-blind. It is observed that ST6 and ST7 points have a tendency to reduce the pain of SIP whether used before or after the respective placebo. Thus it suggests the need for further studies confirming its effectiveness, in order to enable the precise diagnostic and the breath for patients with one of the most intense odontalgias that are known.

Thesis (doctoral)--University of Turku, 1980. / Includes 6 separately published papers in support of the thesis. "Also published in Proceedings of the Finnish Dental Society, vol. 76, suppl. 1." Includes bibliographical references.

Thesis (doctoral)--University of Turku, 1980. / Includes 6 separately published papers in support of the thesis. "Also published in Proceedings of the Finnish Dental Society, vol. 76, suppl. 1." Includes bibliographies.

Neste estudo, randomizado, duplo cego, avaliamos a eficácia anestésica em quarenta e dois pacientes, do Setor de Urgência da Faculdade de Odontologia da Universidade de São Paulo, com pulpite irreversível, que receberam mepivacaína 2% (n=21) ou lidocaína 2% (n=21) associadas à epinefrina 1:100.000 para bloqueio do nervo alveolar inferior (BNAI). O sinal subjetivo de anestesia do lábio e língua, a presença de anestesia pulpar e ausência de dor durante o procedimento de pulpectomia foram avaliados, respectivamente, por indagação ao paciente, pelo testador elétrico pulpar (TEP) e pela escala de dor verbal (VAS). Pela técnica pterigomandibular indireta das três posições, foi injetado primeiramente um tubete (1,8mL), e depois de 10 minutos, foi testada a anestesia pulpar (AP), pelo TEP, por duas leituras negativas ao estímulo máximo (80A) do aparelho. Quando não instalada a AP, um segundo tubete (mais 1,8mL) era reinjetado. Confirmada a anestesia pulpar, iniciava-se a pulpectomia. O sucesso do BNAI foi definido como a capacidade de acessar a câmara pulpar e a realização da pulpectomia sem relato de dor (VAS) pelo paciente (escore 0 ou 1), enquanto o insucesso foi caracterizado pelo incomodo/dor (escore 2 ou 3), que impedisse a continuação. Nesse caso, um terceiro e último tubete foi dado por técnicas complementares (intraligamentar ou intrapulpar) para finalizar o procedimento. Na análise estatística utilizou-se o teste Exato de Fisher e ANOVA com nível de significância fixado em 5%. Obtivemos que no grupo Mepivacaína com 1,8mL, a taxa de anestesia pulpar (AP) foi de 52% (11/21), e sucesso no BNAI de 55% (6/11); a injeção de mais 1,8mL (2º tubete) aumentou a AP para 86% (18/21) e o sucesso no BNAI para 55% (10*/18). No Grupo Lidocaína, com 1.8mL, a taxa da AP foi de 33% (7/21), o BNAI foi de 0%; com mais 1,8mL (2º tubete), a AP aumentou para 67% (14/21) e sucesso no BNAI para 14% (2*/14) (*com diferença estatística onde p0,05). A mepivacaína com volume menor proporcionou, clinicamente, maior índice de anestesia pulpar e sucesso do BNAI (pulpectomia total), e permitiu chegar mais próximo da polpa quando comparada a lidocaína. Concluímos que a mepivacaína obteve melhores resultados no sucesso do BNAI para a realização da pulpectomia em molares inferiores com pulpite irreversível. / The aim of this, double blind randomized study, was to evaluate the anesthetic efficacy of inferior alveolar nerve block (IANB) using 2% mepivacaine and 2% lidocaine both associated with adrenaline 1:100,000 in molars with irreversible pulpitis. The sample of these study consisted of forty-two healthy patients diagnosed with irreversible pulpitis actively experiencing pain. For blocking the IAN was established the following protocol: injection of one cartridge (1.8 mL) by the technique pterigomandibular of three indirect positions, expected 10 minutes and electric pulp test (EPT) Vitality Scanner®-SybronEndo, USA was accomplishment. If tooth sensitivity pain persisted another cartridge (plus 1.8 mL) was given by the same technique and the same methodology was performed. The pulpectomy was continued after the confirmation of pulpal anesthesia, which was established as the lack of response at maximum stimulation (80A) of EPT. In cases where the patient reported pain during pulpectomy even confirmed the blockage, a third cartridge was given by complementary techniques (intraligamentary or intrapulpal) to complete the endodontic procedure. The anesthetic efficacy in IANB was established when the pulpectomy was performed without report of pain and without complementation. For analysis and comparison of results we used the Fisher exact statistical test and ANOVA with significance level set at 5%. Regarding the effectiveness of the anesthetic with 1,8 mL mepivacaine, determined pulpar anesthesia (PA) was 52% (11/21), and success in IANB (pulpectomy) 55% (6/11), the most injection of 1,8 mL, increased 86% (18/21) for AP and success in IANB to 55% (10*/18). In the lidocaine group, with 1.8mL, AP rate was 33% (7/21), the IANB was 0%, with a further 1.8 mL (cartridge 2) the AP increased to 67% (14/21) and success was to IANB 14 % (2*/14), (*statistically difference p 0.05). Mepivacaine with smaller volume clinically provided a higher rate of pulpal anesthesia and most successful of IANB (pulpectomy total), allowing to reach nearest dental pulp than lidocaine. Concluded that mepivacaine performed better in success of IANB (pulpectomy) that lidocaine in molars with irreversible pulpitis