by Poon Lai-king, Yip Wai-man Christina. / Thesis (M.B.A.)--Chinese University of Hong Kong, 1994. / Includes bibliographical references (leaves 78-79). / PREFACE AND ACKNOWLEDGMENTS --- p.iii / ABSTRACT --- p.v / TABLE OF CONTENTS --- p.vi / Chapter / Chapter I. --- INTRODUCTION AND METHODOLOGY --- p.1 / Introduction --- p.1 / Organization of the Paper --- p.2 / The Approach --- p.3 / Chapter II. --- COMPANY PROFILE --- p.5 / Introduction --- p.5 / History --- p.5 / Operating and Financial Results --- p.6 / Organization and Management --- p.7 / Motorola Asia Pacific Semiconductor Group --- p.8 / Motorola Semiconductors Hong Kong Limited --- p.9 / Chapter III. --- EVOLUTION OF QUALITY MANAGEMENT IN MOTOROLA --- p.11 / Introduction --- p.11 / Motorola's Quality Improvement Stages --- p.11 / Motorola-HK --- p.17 / Chapter IV. --- QUALITY GOAL - THE SIX SIGMA --- p.20 / The Six Sigma Concept --- p.21 / Six Steps to Six Sigma --- p.22 / Six Sigma and Beyond --- p.23 / Chapter V. --- QUALITY CULTURE --- p.24 / The Notion of Quality Culture --- p.24 / Shared Values and Assumptions --- p.25 / Top Management's Commitment --- p.28 / Organization --- p.29 / Communication --- p.30 / Teamwork --- p.33 / Training and Education --- p.35 / Motivation --- p.37 / Chapter VI. --- IMPLEMENTATION OF THE QUALITY MANAGEMENT --- p.41 / "Quality, Speed and Teamwork Program" --- p.41 / Implementation through Various Programs --- p.46 / VII. SUCCESS STORIES SHARED --- p.52 / Manufacturing Examples --- p.5 3 / Non-manufacturing Examples --- p.61 / Chapter VIII --- . MOTOROLA CORPORATE QUALITY SYSTEM REVIEW --- p.65 / Introduction --- p.65 / The Quality System Review (QSR) --- p.67 / Some Thoughts on the QSR --- p.70 / Chapter IX. --- CONCLUSION --- p.76 / BIBLIOGRAPHY --- p.78 / APPENDICES

by Lam Ka-chi, Ricky and Wong Suet-yee, Sheri. / Thesis (M.B.A.)--Chinese University of Hong Kong, 1994. / Includes bibliographical references (leaves 138-140). / ABSTRACT --- p.iii / TABLE OF CONTENTS --- p.iv / LIST OF FIGURES --- p.vii / LIST OF TABLES --- p.x / PREFACE --- p.xi / ACKNOWLEDGMENTS --- p.xii / Chapter / Chapter I. --- INTRODUCTION --- p.1 / Global Trend Towards Quality Improvement --- p.2 / Quality Improvement in Hong Kong --- p.5 / Chapter II. --- OBJECTIVES OF THE RESEARCH --- p.11 / General Objective --- p.11 / Ultimate Objective --- p.11 / Minor Objectives --- p.11 / Chapter III. --- METHODOLOGY --- p.13 / Primary Research - Questionnaire --- p.13 / Design of the Questionnaire --- p.13 / Content of the Questionnaire --- p.15 / Respondents of the Questionnaire --- p.16 / Primary Research - Interview --- p.18 / Secondary Research - Library Research --- p.19 / Chapter IV. --- LITERATURE REVIEW --- p.20 / Quality --- p.20 / Quality Productivity --- p.22 / Quality and Cost --- p.22 / Productivity and Cost --- p.24 / "Quality, Productivity and Cost" --- p.25 / Customers Satisfaction --- p.25 / Profitability --- p.25 / Quality: A Long-term Strategic Planning --- p.28 / Summing Up --- p.30 / Chapter V. --- DEFINITION --- p.33 / Some Operational Terms --- p.33 / Quality --- p.33 / Productivity --- p.33 / Company Performance --- p.34 / Quality Performance --- p.35 / Financial Performance --- p.35 / Gurus in Quality Management --- p.35 / Edward Deming --- p.35 / Joseph Juran --- p.39 / Philip Crosby --- p.42 / Armand V. Feigenbaum --- p.46 / Kaoru Ishikawa --- p.47 / Genichi Taguchi --- p.48 / Quality Improvement Techniques --- p.49 / Zero Defects --- p.49 / Quality Control Circle --- p.49 / Statistical Process Control (SPC) --- p.49 / Quality Control 7 Tools --- p.51 / Taguchi Method --- p.51 / Fool-proof (Poke Yoke) --- p.53 / Quality Function Deployment --- p.54 / International Standard Organization --- p.54 / Productivity Improvement Techniques --- p.56 / Work measurement --- p.56 / Layouts --- p.56 / Computer-integrated Manufacturing (CIM) --- p.56 / Material Requirements Planning (MRP) --- p.57 / Manufacturing Resources Planning (MRPII) --- p.57 / Just in Time (JIT) --- p.57 / Competitive Benchmarking --- p.58 / Self-directed Work Teams --- p.58 / Theory of Constraints --- p.58 / Chapter VI. --- HIGHLIGHT OF FINDINGS --- p.60 / Company Demographics --- p.60 / Company Size --- p.60 / Employees Turnover Rate --- p.60 / Company Sales Last Year --- p.61 / Number of Years Established --- p.61 / Overseas Branch or Subsidiary --- p.63 / Other Company Information --- p.65 / Company Performance --- p.69 / Customers Perception:Company Performance --- p.69 / Quality Performance --- p.73 / Financial Performance --- p.75 / Quality Improvement Techniques --- p.76 / Formal Approach to Quality Improvement --- p.76 / Separate Quality Department --- p.76 / Application of Quality Improvement Techniques --- p.81 / Quality Improvement -ISO 9000 --- p.92 / Quality Improvement - Understand & Specify Customer Requirements --- p.99 / Productivity Improvement Techniques --- p.105 / Formal Approach to Productivity Improvement --- p.105 / Productivity Improvement Techniques --- p.105 / Chapter VII. --- ANALYSIS AND DISCUSSION --- p.117 / Factor Analysis --- p.117 / Kaiser-Meyer-olkin Measure --- p.117 / Steps of Factor Analysis --- p.118 / VARIMAX Rotation --- p.118 / Interpretation of Factors --- p.118 / Factor 1 --- p.118 / Factor 2 --- p.121 / Factor 3 --- p.121 / Factor 4 --- p.122 / Factor 5 --- p.122 / Factor 6 --- p.123 / Regression --- p.123 / Total Quality Cost --- p.123 / Items Defective and Rework Cost --- p.126 / Returns and Warranty Cost --- p.126 / Internal Waste and Training Costs --- p.126 / Quality Performance --- p.127 / Financial Performance --- p.127 / Employee Turnover Rate --- p.127 / Employees' Satisfaction --- p.128 / Chapter VIII. --- CONCLUSION --- p.129 / APPENDIX --- p.131 / BIBLIOGRAPHY --- p.138

by Ho Shui Leung, Paul, Lau Kun Che, Choi Yin Chau. / Thesis (M.B.A.)--Chinese University of Hong Kong, 1995. / Includes bibliographical references (leaves 127-128). / ABSTRACT --- p.iii / TABLE OF CONTENTS --- p.iv / LIST OF FIGURES --- p.vii / PREFACE --- p.xii / ACKNOWLEDGMENTS --- p.xiv / CHAPTER / Chapter I. --- HONG KONG'S CLOTHING INDUSTRY --- p.1 / Historical development --- p.1 / Global Position --- p.2 / Domestic Position --- p.3 / Structure --- p.7 / Factory Classification --- p.10 / Number and Size of Establishment . --- p.10 / Labour --- p.12 / Market --- p.14 / Current Constraints --- p.16 / Increasing Costs --- p.16 / Labour Shortage --- p.16 / Increase Competition From Other Low-cost Countries --- p.17 / Pressure From Buyers --- p.18 / Chapter II. --- QUALITY IMPROVEMENT AS A STRATEGY TO KEEP COMPETITIVENESS --- p.20 / Total. Quality Management --- p.20 / Customer Focus --- p.21 / Identifying Your External Customer --- p.21 / Identifying Your Internal Customer --- p.23 / Listening To The Voice Of Customers --- p.24 / Achieve Zero Customer Defections . --- p.25 / Continuous Process Improvement --- p.25 / Improving Existing Production Process --- p.25 / Performance Measurement --- p.27 / Total Commitment --- p.27 / Leadership And Empowerment --- p.28 / Training And Education --- p.29 / Chapter III . --- PERFORMANCE & QUALITY ACHIEVEMENT --- p.30 / Postal Survey --- p.30 / Objective --- p.30 / Methodology --- p.31 / Company Demographics --- p.33 / Company Size --- p.34 / Turnover Rate --- p.34 / Company Sales --- p.34 / Year in Business --- p.34 / Employee Involved in Quality Improvement Activities --- p.35 / Overseas Establishmen --- p.35 / Company Information --- p.37 / Company Performance --- p.40 / Quality Performance --- p.44 / Financial Performance --- p.47 / Quality Improvement Techniques --- p.50 / Productivity Improvement Techniques --- p.73 / Further Analysis and Discussion --- p.85 / Factor Analysis --- p.85 / Kaiser-Meyer- Olkin Measure --- p.89 / Results of Factor Analysis --- p.94 / Chapter IV. --- COMPARISON WITH HONG KONG'S MANUFACTURING INDUSTRY --- p.96 / Quality Performance --- p.97 / Financial Performance --- p.99 / Other Quality And Financial Achievement . --- p.101 / Factor 1 --- p.102 / Factor 2 --- p.102 / Factor 3 --- p.103 / Factor 4 --- p.103 / Factor 5 --- p.104 / Factor 6 --- p.104 / Chapter V. --- FINDINGS IN FACTORY INTERVIEWS --- p.106 / Background of the Factory --- p.107 / Glorious Sun Group --- p.107 / Hinbase Limited --- p.108 / Quality Achievement --- p.108 / Informal Approach --- p.109 / Formal Approach --- p.111 / Quality Certification --- p.112 / Productivity Improvement --- p.114 / Traditional Cost Reduction --- p.114 / Industrial Engineering and Process Analysis --- p.116 / Market Pressure --- p.117 / Management Commitment --- p.118 / Chapter VI. --- CONCLUSION --- p.119 / APPENDIX --- p.120 / BIBLIOGRAPHY --- p.127

by Wong Kwai Lin Christine. / Thesis (M.B.A.)--Chinese University of Hong Kong, 1996. / Includes bibliographical references (leaves 47-48). / ABSTRACT / TABLE OF CONTENTS / LIST OF FIGURES / LIST OF TABLES / ACKNOWLEDGMENT / Chapter / Chapter I. --- Introduction --- p.1 / Chapter II. --- Research --- p.3 / Exploratory Research --- p.3 / Literature Search --- p.4 / Quality Concepts --- p.4 / W. Edward Deming --- p.5 / Joseph Juran --- p.8 / Philip Crosby --- p.10 / Quality --- p.11 / ISO 9000 Series --- p.12 / The Malcolm Baldrige National Quality Award --- p.13 / Status of Promotion of Quality Management --- p.13 / Specific Research --- p.14 / Theoretical Basis --- p.15 / Descriptive Research --- p.17 / Data Collection Method --- p.18 / Method of Administration --- p.19 / Sample Design --- p.21 / Target Population --- p.21 / Sampling Frame --- p.21 / Sampling Procedure --- p.22 / Questionnaire Design --- p.22 / Part I - Company Demographics --- p.20 / Part II - Company Performance --- p.23 / Part III - Quality Improvement Techniques --- p.23 / Data Analysis --- p.24 / Response --- p.24 / Managerial Knowledge --- p.29 / Quality Performance --- p.30 / Financial Performance --- p.30 / Past Quality Performance --- p.30 / Market Place Environment --- p.31 / Corporate Support for Quality --- p.31 / Role of Management Leadership and Quality --- p.32 / Quality Data and Reporting --- p.33 / Strategic Quality Planning --- p.33 / Employees' involvement and Participation --- p.34 / Employees' Training --- p.34 / Feedback and Recognition of Employees' Performance --- p.35 / Employees' Relations --- p.36 / Product Service Design --- p.36 / Process Management --- p.36 / Supplier Quality Management --- p.37 / Role of Quality Department --- p.38 / Customer Feedback --- p.39 / Chapter III. --- SUMMARY OF FINDINGS --- p.40 / Difference between Manufacturing and Service Companies --- p.41 / Difference between Companies with without Separate Quality Department --- p.41 / Difference between Companies with or without Certification --- p.42 / Chapter IV. --- CONCLUSIONS --- p.44 / Chapter V. --- RECOMMENDATIONS --- p.46 / BIBLIOGRAPHY / Chapter APPENDIX 1 --- Sample Questionnaire / Chapter 2 --- Figures 2 to 18

Lin Min Ying. / Summary in Chinese. / Thesis (M.B.A.)--Chinese University of Hong Kong. / Bibliography: l. 80-81.

Ng, Wai Hung Thomas. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2002. / Includes bibliographical references (leaves 103-112). / Abstracts in English and Chinese ; questionnaires in Chinese. / ABSTRACT (ENGLISH) --- p.i / ABSTRACT (CHINESE) --- p.iv / ACKNOWLEDGEMENT --- p.vi / TABLE OF CONTENTS --- p.vii / LIST OF TABLES --- p.ix / LIST OF FIGURES --- p.x / Chapter CHAPTER I --- INTRODUCTION --- p.1 / Chapter CHAPTER II --- LITERATURE REVIEW --- p.6 / Service Quality (SQ) --- p.6 / Conceptualizing SQ --- p.9 / SQ Perception Discrepancy between Employees and Customers --- p.14 / SQ Conceptualization Discrepancy / Discrepancy in Psychometric Properties of SQ scale / SQ Evaluation Discrepancy / Measurement Equivalence/Invariance(ME/I) --- p.19 / Testing Configural Invariance / Testing Factorial Invariance / Testing Unique Variance Equivalence / Testing Factor Variance Equivalence / Testing Intercept/Scalar Invariance / Testing Factor Correlations Equivalence / Testing Latent Means Equivalence / Chapter CHAPTER III --- OBJECTIVE --- p.25 / Chapter CHAPTER IV --- CONCEPTUALIZATION --- p.27 / SQ Conceptualization --- p.27 / Difference in Conceptual Model / Difference in Manifestation of Constructs (Dimensions) / Psychometric Properties of the Scale --- p.31 / Difference in Magnitude of Random Error / Difference in Perception Dispersion / Difference in Baseline Perception / SQ Evaluation --- p.35 / Difference in Interrelationships among Dimensions / Difference in Perceived SQ level / Summary --- p.39 / Chapter CHAPTER V --- METHODOLOGY --- p.41 / Data Collection --- p.41 / Survey Instrument / Interview / Method of Analysis --- p.42 / Testing Difference in Conceptual Model / Testing Difference in Manifestation of Constructs / Testing Difference in Magnitude of Random Error / Testing Difference in Perception Dispersion / Testing Difference in Baseline Perception / Testing Difference in Interrelationships among Dimensions / Testing Difference in Perceived SQ level / Other Methodologies in Examining ME/I --- p.51 / Chapter CHAPTER VI --- RESULTS --- p.56 / SQ Conceptualization --- p.59 / Difference in Conceptual Model / Difference in Manifestation of Constructs / Psychometric Properties of the Scale --- p.68 / Difference in Magnitude of Random Error / Difference in Perception Dispersion / Difference in Baseline Perception / SQ Evaluation --- p.75 / Difference in Interrelationships among Dimensions / Difference in Perceived SQ level / Summary of Results --- p.77 / SQ Conceptualization / Psychometric Properties / SQ Evaluation / Chapter CHAPTER VII --- DISCUSSION AND CONCLUSION --- p.85 / Managerial Implications --- p.85 / Using Employees Information / Training / Methodological Merits --- p.90 / Measurement Non-invariance as a Source of Information --- p.92 / Future Direction: / Application of the Multiple Forms of Discrepancy --- p.94 / Conclusion --- p.95 / APPENDIX --- p.96 / Chapter 1A. --- Employees Survey Questionnaire --- p.96 / Chapter 1B. --- Customers Survey Questionnaire --- p.99 / Chapter 2. --- Item Patterns of Three Testing Models --- p.102 / REFERENCES --- p.103

Le complexe de liaison de la coiffe des ARN (CBC) joue un rôle essentiel dans leur maturation et déclenche une variété de réactions biochimiques, via son interaction avec différents partenaires. Deux complexes, CBC-ARS2-PHAX (CBCAP), et CBC-ARS2-ZC3H18-NEXT (CBCN), ont récemment été montré comme important pour cibler les ARN vers l'export (CBCAP) ou la dégradation (CBCN). Cependant, les mécanismes par lesquels la sélection se fait pour l'une voie ou l'autre reste mystérieuse. Ainsi, une question majeure qui reste à résoudre est de savoir quand et comment ces complexes sont recrutés sur les ARN. Dans ce travail, j'ai utilisé la procédure du iCLIP (Cross-Linking and Immuno-Precipitation), afin d'identifier les cibles de ces complexes sur l'ensemble du transcriptome humain. J'ai réalisé un iCLIP sur cinq composants de CBCAP et CBCN, et j'ai comparé les résultats à ceux obtenus avec RBM7, un composant de NEXT précédemment étudié par iCLIP. Mes résultats indiquent que: (i) CBP20, ARS2, PHAX et ZC3H18 se lient près de la coiffe des ARN, tandis que RBM7 et MTR4 se lient partout; (ii) CBP20, ARS2, PHAX et ZC3H18 s'associent à un large ensemble d'ARN transcrits par l'ARN polymérase II et montrent une faible sélectivité; (iii) la liaison de ces protéines varie avec l'état de maturation des ARN, avec le CBC enrichi sur les ARN matures, tout comme ARS2/PHAX/ZC3H18 et MTR4 (bien que dans une moindre mesure), tandis que RBM7 est préférentiellement lié sur les pre-mRNAs non épissés; (iv) une liaison différentielle de RBM7 et MTR4 sur les ARN, avec RBM7 enrichi sur les introns et les PROMPTs, et MTR4 plus présent sur les ARN mature. Bien que des expériences additionnelles soient requises, nous proposons que le CBCAP et le CBCN se lient à un même ensemble d'ARN, ce qui indique à la fois une compétition entre ZC3H18 et PHAX pour la liaison à ces ARN, et l'absence de voies de routage bien déterminées qui ciblerait les ARN vers l'une ou l'autre de ces protéines. Le devenir des ARN pourrait ainsi être déterminé par d'autres caractéristiques des ARN, ou encore par des protéines additionnelles. Ces facteurs pourraient s'allier aux protéines liées à la coiffe afin de favoriser la formation du CBCAP ou du CBCN. Dans le but d’identifier des facteurs additionnels, j'ai réalisé un screen d'interaction par spectrométrie de masse après purification de ARS2 ou CBP80. Ceci a été fait dans des conditions natives ou après un cross-link des complexes à la formaldéhyde, afin de stabiliser les interactions transitoires. Ceci a permis d'identifier de nouveaux partenaires de ARS2 et de CBP80, dont la majorité sont impliqués dans l'épissage des ARN. Des expériences additionnelles seront nécessaires pour valider ces interactions. / The cap-binding complex (CBC) plays a pivotal role in post-transcriptional processing events and orchestrates a variety of metabolic pathways, through association with different interaction partners. Two CBC sub-complexes, the CBC-ARS2-PHAX (CBCAP) and the CBC-nuclear exosome targeting (NEXT) complex (CBCN), were recently shown to target capped RNA either toward export or degradation, but the mechanisms by which they can discriminate between different RNA families and route them toward different metabolic pathways still remain unclear. A major question to be answered is how and when the different CBC subcomplexes are recruited to the RNP. Here, we used an individual nucleotide-resolution UV cross-linking and immunoprecipitation (iCLIP) approach to identify the transcriptome-wide targets for 5 different components of the CBCAP and CBCN complexes, and compared results to the previously analysed NEXT-component RBM7. We report that: (i) CBP20, ARS2, PHAX and ZC3H18 bind close to the cap, while RBM7 and MTR4 bind throughout the mRNA body; (ii) CBP20, ARS2, PHAX and ZC3H18 associate with a broad set of RNA polymerase II (PolII)-derived RNAs and have only mild species preferences; (iii) binding varies with the RNA maturation stage, with the CBC being highly enriched on mature mRNA, ARS2/PHAX/ZC3H18/MTR4 less so, and RMB7 preferentially bound to pre-mRNAs; (iv) MTR4 and RBM7 show different specificities, with RBM7 being highly enriched on introns and promoter upstream transcripts (PROMPTs), while MTR4 is additionally present on mature RNAs. Although more experimental work is needed to fully support our model, we propose that CBCAP and CBCN bind overlapping sets of RNAs, indicating a competition between the proteins ZC3H18 and PHAX, and the lack of a strict RNA sorting mechanism. RNA fate may therefore be determined by additional RNA features and/or by other RNA-binding proteins, which may synergize with the cap and drive the formation of one specific CBC subcomplex instead of another. In an attempt to identify yet unknown factors that may interact with cap-bound CBCAP and CBCN, we performed a protein interaction screen leveraging affinity capture-mass spectrometry (ACMS), using ARS2 and CBP80 as bait proteins. As a complementary approach, we also employed a formaldehyde-based chemical cross-linking strategy, aimed at stabilizing weak/transient interactions. Although we failed to detect any transient interactions involving the CBC, we identified several potential CBC80 and ARS2 interactors, the majority of which are involved in pre-mRNA splicing. Additional quantitative experiments are required to validate our ACMS results and confirm the existence of such protein interactions in vivo.

published_or_final_version / Medical Sciences / Master / Master of Medical Sciences

M. Tech. Food Technology. / Aims to develop a standardised procedure for the production of soymilk that could be used to evaluate the food technological potential of the 30 different locally grown soybean cultivars. Such a procedure should have standardised soaking and cooking times and temperatures that could ensure the inactivation of lipoxygenase enzymes and other anti-nutritional factors that negatively affect the flavour or nutritional quality of the soymilk. A filtration technique would be needed to quantitatively and reproducibly separate the soymilk and okara fractions. The soymilk produced should have sensory properties that conform to the requirements of a soymilk that is acceptable to the consumer.

M. Tech. Industrial Engineering / The Reconfigurable Vibrating Screen is a newly designed beneficiation machine to be used for mineral particle separation in mines and quarries with adjustable screen capacity and structure in order to respond to changes in production and quantity demand required by the customers. In order to increase the durability, availability, reliability and maintainability of a reconfigurable vibrating screen, an effective method is required to functionally appraise and improve its working condition. The aim of this study is to develop a tool for functionally assessing reconfigurable vibrating screens and existing vibrating screens.