Thesis (Ph. D.)--Ohio State University, 2005. / Title from first page of PDF file. Document formatted into pages; contains xxiii, 454 p.; also includes graphics (some col.). Includes bibliographical references (p. 246-259). Available online via OhioLINK's ETD Center

Submitted by Rangel Sousa Jamile Kelly (jamile.kelly@ufba.br) on 2012-07-14T13:22:35Z No. of bitstreams: 1 dissertação ana regina.pdf: 633697 bytes, checksum: fc9e3e94ba75eae3d0d190d15384ceb1 (MD5) / Made available in DSpace on 2012-07-14T13:22:35Z (GMT). No. of bitstreams: 1 dissertação ana regina.pdf: 633697 bytes, checksum: fc9e3e94ba75eae3d0d190d15384ceb1 (MD5) Previous issue date: 2008-03-30 / Esta dissertação discute a diversidade dos discursos feministas sobre a maternidade, tomando como objetos as obras: de Simone de Beauvoir, O Segundo sexo ([1949] 1980), de Shulamith Firestone, A Dialética do Sexo: Um Estudo da Revolução Feminista ([1970] 1976) e de Nancy Chodorow, Psicanálise da Maternidade: Uma Crítica a Freud a Partir Da Mulher ([1978] 2002) sendo, estas duas últimas, representativas do movimento feminista radical dos anos 1960 e 1970. Entendendo a maternidade como um fenômeno plasmado nas relações sociais e partindo do pressuposto de que os papéis sociais de mulheres e homens são construídos, discursivamente, em situações de poder desigual, destaca a importância histórica dos discursos médico e religioso na fusão da identidade da mulher com a função materna, configurada na formação da família burguesa ocidental e seus desdobramentos atuais. As leituras realizadas pelas referidas autoras desse desenvolvimento histórico e as críticas às análises que dele fizeram a teoria marxista e a psicanálise contribuíram para a formação dos conceitos de gênero, trazendo aportes para as discussões que desnaturalizaram as categorias sexo, feminilidade, e sexualidade. A contextualização do pensamento feminista da Segunda Onda mostrou suas articulações com os movimentos sociais seus contemporâneos, notadamente, o movimento negro pelos direitos civis. / Salvador

High-resolution techniques to characterize the three-dimensional structure of nucleic acids are critical for understanding the mechanisms of action of biologically important RNA and DNA molecules. Methods based on chemical probing have been particularly useful in gaining insight into the structures of nucleic acids in solution. The hydroxyl radical has been widely adopted as a chemical probe for DNA and RNA structure since its first application to protein-DNA footprinting. This dissertation describes efforts to improve upon the current model of how the hydroxyl radical cleaves the RNA backbone, through the use of specifically deuterated ribonucleoside triphosphates (NTPs). The synthesis and purification of deuterated NTPs are described in detail, as well as their application to the study of two RNAs: the sarcin-ricin loop (SRL) RNA - a biologically active region of ribosomal RNA - and a short RNA designed to lack secondary structure. Measurement of deuterium kinetic isotope effects (KIEs) on the cleavage of these RNAs suggests that it is possible to use this experiment to identify the GUA base triple structural motif that is commonly found in RNA. Abstraction of a 5' ribose hydrogen atom in RNA yields a fragment containing a 5'-aldehyde terminus with the sugar and base intact. Comparison of primer extension products of cleaved SRL RNA with or without deuterium substituted at the C5' ribose position of uracil residues demonstrated that the 5' aldehyde-terminated fragment can serve as a template for reverse transcription. Implications of the presence of a 5'-aldehyde terminus on hydroxyl radical cleavage analysis are discussed in the context of reverse transcriptase-mediated primer extension, a commonly used method. Structural features of naked DNA molecules with known protein binding sequences were explored using hydroxyl radical cleavage analyzed by capillary gel electrophoresis. An application was written in MATLAB to deconvolute and integrate cleavage intensities of hundreds of peaks in an electropherogram. In many cases, comparison of the cleavage profile to the minor groove width found in an X-ray co-crystal structure of the DNA-protein complex revealed a high degree of correlation.

AGUIAR, Paulo Henrique Walter de. Linfonodo sentinela em câncer de mama localmente avançado pós-quimioterapia neoadjuvante. 2007. 94 f. Dissertação (Mestrado em Tocoginecologia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2007. / Submitted by denise santos (denise.santos@ufc.br) on 2013-12-24T13:18:20Z No. of bitstreams: 1 2007_dis_phwaguiar.pdf: 1203678 bytes, checksum: e08063e171cba74fc88a14fe65ea2e73 (MD5) / Approved for entry into archive by denise santos(denise.santos@ufc.br) on 2013-12-24T13:18:52Z (GMT) No. of bitstreams: 1 2007_dis_phwaguiar.pdf: 1203678 bytes, checksum: e08063e171cba74fc88a14fe65ea2e73 (MD5) / Made available in DSpace on 2013-12-24T13:18:52Z (GMT). No. of bitstreams: 1 2007_dis_phwaguiar.pdf: 1203678 bytes, checksum: e08063e171cba74fc88a14fe65ea2e73 (MD5) Previous issue date: 2007 / Aims: investigating sentinel lymph node in patients with locally advanced breast cancer whom were administered neoadjuvant chemotherapy, by contrast to non-sentinel axillary lymph nodes. Verifying the identification of sentinel lymph node rate in these patients, as well as estimating method’s sensibility, specificity, false-negative and accuracy. Methodology: transversal study for validation of a diagnostic test, with 34 patients from Maternidade-Escola Assis Chateaubriand’s ambulatory. The locally advanced breast cancer patients were treated with neoadjuvant chemotherapy, and the ones with cancer metastasis clinically negative axilla were submitted to sentinel lymph node biopsy and axillary lymphadenectomy, using subareolar patent blue, and, after its identification, it was studied with contact cytology and paraffin and it was compared with non-sentinel axillary lymph content. The descriptive analysis of tests used Student’s t-test, and tests proportions were considered significantly different when their similarity possibility was less or equal to 0.05. Results: When intraoperatory contact cytology study, paraffin sentinel lymph node and gold standar, sentinel and non-sentinel lymph nodes, the sentinel lymph node identification rate was 85.3%. Sensibility was 84.62%, and specificity was 100%. The predictive negative value was 87.99%, and the false-negative rate was 12.01%. Accuracy rate was 92.77%. The study points the significant difference of total lymph nodes mean number observed among the group with optimal time of surgical intervention p=0.037. When only the intraoperatory contact cytology of sentinel lymph node and gold pattern, the paraffin of sentinel and non-sentinel lymph nodes, sensibility was 62.50%, specificity 100%, predictive negative value 75.04%, false-negative 24.96%, and accuracy 82.38%. Conclusion: intraoperatory contact cytology of sentinel lymph node to locally advanced breast cancer patients with clinically negative axilla after neoadjuvant chemotherapy presents low sensibility and high false-negative rates. / estudar o linfonodo sentinela em pacientes portadoras de câncer na mama localmente avançado e que foram submetidos a quimioterapia neoadjuvante, compararando-o com os linfonodos axilares não-sentinelas. Verificar a taxa de identificação do linfonodo sentinela nestas pacientes, assim como estimar a sensibilidade, especificidade, falso-negativo, valor preditivo negativo e acurácia do método. Metodologia: estudo transversal de validação de teste diagnóstico, envolvendo 34 pacientes oriundas do Ambulatório da Maternidade-Escola Assis Chateaubriand. As pacientes portadoras de câncer na mama localmente avançado foram submetidas a quimioterapia neoadjuvante e aquelas que apresentaram axila clinicamente negativa para metástase de câncer de mama foram submetidas a biopsia do linfonodo sentinela e linfadenectomia axilar, utilizando administração subareolar de azul patente, e este, após sua identificação, foi estudado mediante o exame de citologia de contato e parafina e comparado com conteúdo linfático axilar não-sentinela. Realizada análise descritiva e análise dos testes utilizando teste t de Student, as proporções dos testes foram consideradas significativamente diferentes quando a probabilidade de estas serem semelhantes foi menor ou igual a 0,05. Resultados: Quando foi testada a citologia de contato intra-operatório e parafina linfonodo sentinela e padrão-ouro os linfonodos sentinelas e não-sentinelas, a taxa de identificação do linfonodo sentinela foi de 85,3%. A sensibilidade foi de 84,62% e a especificidade de 100%. O valor preditivo negativo de 87,99% e taxa de falso-negativo de 12,01%. A acurácia foi de 92,77%. Dado observado na amostra foi a diferença significativa do número médio do total de linfonodos observados entre o grupo de pacientes com tempo de intervenção cirúrgica ótimo p=0,037. Quando foi testada apenas a citologia de contato intraoperatória do linfonodo sentinela e padrão-ouro, a parafina dos linfonodos sentinelas e não-sentinelas a sensibilidade foi de 62,50%, a especificidade de 100%, valor preditivo negativo de 75,04%, falso-negativo de 24,96% e acurácia de 82,38%. Conclusão: a citologia de contato intraoperatório do linfonodo sentinela para pacientes com câncer de mama localmente avançados com axila clinicamente negativa após quimoterapia neoadjuvante apresenta baixa sensibilidade e taxa de falso-negativo elevada.

Made available in DSpace on 2014-06-11T19:23:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-03-04Bitstream added on 2014-06-13T20:10:27Z : No. of bitstreams: 1 ribeiro_ghfp_me_botfm.pdf: 202757 bytes, checksum: a228e2c941a14ad9806caa5f27608410 (MD5) / Empresa Privada / Fundação Pio Xii - Barretos / A mastectomia radical modificada ainda se constitui em um dos principais procedimentos cirúrgicos em mastologia. A principal complicação relacionada a cirurgia constitui o seroma axilar. O bisturi Harmônico, apesar de pouco difundido, foi descrito como um mecanismo para diminuir a formação do seroma axilar, associado a diminuição do tempo de utilização do dreno. Estudo prospectivo randomizado utilizando-se o bisturi harmônico ou o elétrico de pacientes submetidas a mastectomia radical no Hospital de Câncer de Barretos, no ano de 2008, sendo que a randomização ocorreu em função do índice de massa corpórea. As variáveis relacionadas às pacientes, às cirurgias e suas principais complicações pós operatórias (seroma, necrose de retalhos, hematomas e infecção) foram tabuladas e submetidas a análise estatística. Das 95 pacientes submetidas a mastectomia, em 49 foi utilizado o bisturi harmônico. A comparação entre os bisturis na realização da mastectomia radical mostrou diferença estatística na ocorrência da necrose de retalhos das cirurgias. Outras complicações (seroma, hematoma e infecção) não tiveram significância estatística. A utilização do bisturi harmônico em mastectomias radicais proporciona menor risco de necrose de retalhos. O tipo do bisturi utilizado não influencia na formação de seroma. O índice de massa corpórea, volume de drenagem ao sétimo dia pós-operatório e redução percentual da drenagem do 2° ao 7° dia pós-operatório são fatores independentes na formação de seroma. A utilização do bisturi harmônico proporciona diminuição significativa da necrose de retalho em relação ao bisturi elétrico. / This randomized prospective study has the purpose of comparing the post-operative complication rates on the electric scalpel and the harmonic scalpel. The study was accomplished in the Hospital de Câncer de Barretos from January to November, 2008. The breast cancer patients with radical mastectomy proposal were randomized into two groups according to their body mass index (bmi): electric scalpel (46) and harmonic scalpel (49). The variables related to the patients, to the surgeries and its their post-operative main complications (seroma, flap necrosis, haematomas and infections), were tabulated and submitted to statistical analysis. The comparison between the scalpels on the radical mastectomy has show statistic difference on the occurrence of the flap necrosis on the surgeries. Other complications (seroma, haematoma and infection) have not had statistic significance). The usage of the harmonic scalpel in radical mastectomies provides smaller risk of flap necrosis in comparison with the electric scalpel.

In the calendar year since the election of President Donald J. Trump, there has been a marked intensification of activist demonstrations that have permeated mainstream American culture. Roughly one century after its inception, a group of powerful, semi-underground activists and organizers have resurrected a radical social movement called the Antifa network. Antifa, which is short for anti-fascist, originated in early 20th century Germany, Italy and Spain. The group has now been reborn in response to what Antifa members have identified as a strong and dangerous wave of fascist mentality in American politics. They will not rest until they have succeeded in suppressing and defeating every inkling of fascist sentiment from the American political landscape, regardless of what they must do to accomplish that goal. This thesis examines the intentions, motivations and actions of Antifa by dissecting what they are, who they are, and how they work. I will provide a brief history of the movement in its various recorded forms—both in the United States and Europe. In addition to examining the stated goals and behaviors of the movement, I will assess and evaluate Antifa’s ideology by analyzing several key pieces of writing from their resource archives. Primarily, my goal is to determine the ideological legitimacy of Antifa’s efforts against those they have deemed fascist, and the legitimacy of the claims that it is members of Antifa who are the real perpetrators of fascist action in the United States.

Orientador : Francisco B. T. Pessine / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica / Made available in DSpace on 2018-08-03T18:13:18Z (GMT). No. of bitstreams: 1 Pereira_RobsonValentim_M.pdf: 3604170 bytes, checksum: c68fc73bb8db7965ef1628f301334132 (MD5) Previous issue date: 2002 / Mestrado

M.Ed. (Subject Didactics) / Please refer to full text to view abstract

This thesis is aimed at generalizing notions of rings to modules. In par-ticular, notions of completely prime ideals, s-prime ideals, 2-primal rings and nilpotency of elements of rings are respectively generalized to completely prime submodules and classical completely prime submodules, s-prime submodules, 2-primal modules and nilpotency of elements of modules. Properties and rad-icals that arise from each of these notions are studied.

Photoallergic compounds cause an allergy when applied to the skin and the skin is then exposed to light. Photoallergy is connected with the ability of the allergen to bind to the skin. This thesis describes much basic photochemistry of several photoallergens and has explained any differences in that photochemistry when on surfaces and in the presence of H.S.A.