Spelling suggestions: "subject:"adiation effects"" "subject:"aadiation effects""
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Radiation-controlled gene expression : a novel approach to oxygenation-dependent radiotherapyWorthington, Jenny January 2000 (has links)
No description available.
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Localization of targets for regulation of gene expression after ionising radiationAl-Assar, Osama January 1999 (has links)
No description available.
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Development of a focused X-ray source as a microprobe of cellular radiation responseSchettino, Giuseppe January 2000 (has links)
No description available.
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Structure and function relationships in the colon : the role of the pericryptal sheathThiagarajah, Jay Ram January 2001 (has links)
No description available.
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Semiconductor detectors for the inner tracker of the ATLAS experiment at CERNMorgan, Debbie January 1998 (has links)
No description available.
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Investigation of stillbirth risk among the offspring of male radiation workers at the Sellafield nuclear installation, west CumbriaPearce, Mark Stephen January 2000 (has links)
No description available.
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Radiation effects on biochemical systemsSeddon, Gavin M. January 2000 (has links)
No description available.
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New methods to overcome radioresistanceShort, Susan Christine January 2000 (has links)
No description available.
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Channelling investigation of the behaviour of urania under low-energy ion irradiation / Étude par canalisation du comportement du dioxyde d’uranium irradié avec des ions de basse énergieNguyen, Tien Hien 05 December 2013 (has links)
Cette thèse est consacrée à l'étude de la déstabilisation structurale du dioxyded' uranium monocristallin. L'irradiation avec des ions Xe de 470 keV, Ce de 500 keV et La de 500 keV (correspondant à un parcours projeté Rp 85 nm et à l'écart type delta Rp 40 nm selon le code de calcul SRIM) ont été réalisées pour étudier la déstabilisation du monocristal induit, d'une part, par la création de défauts dû au processus de ralentissement nucléaire des fragments de fission à la fin de leur parcours (contribution balistique),et, d'autre part, par l'incorporation de produits de fission à forte concentration (contribution chimique). L'énergie cinétique des éléments incorporés a été choisie de sorte que leurs parcours dans le solide soient identiques afin de comparer directement les effets induits par des espèces solubles (La et Ce) et insolubles (Xe) dans le dioxyde d'uranium.La Spectrométrie de Rétrodiffusion Rutherford en canalisation (RBS/C) a été appliquée pour caractériser et quantifier les défauts générés par l'irradiation. Les données ont été analysées par simulation Monte-Carlo en considérant un modèle original comportant de deux-type de défauts (i) des atomes aléatoirement déplacés dans le cristal (RDA) et (ii) des distorsions des ranges atomiques (BC). L'accumulation de la fraction d'atomes déplacés RDA avec l'augmentation de la fluence conduit à une forte augmentation du nombre dedéfauts observé entre 4 et 7 dpa, indépendamment de la nature des ions. Une seconde augmentation spectaculaire est observée à partir de 300 dpa (correspondant à une concentration excédant 5 % atomique d'ions implantes) pour le cas spécifique des cristaux irradiés avec des ions Xe. Un comportement différentié est clairement observé pour les espèces solubles par rapport à leurs homologues insolubles. Cette différence se traduit d'une part par l'augmentation spectaculaire de RDA lorsque le cristal est implanté à très haute concentration dans le cas d'espèce insolubles, et, d'autre part, par un endommagement plus prononcé entre 7 et 300 dpa. Ce phénomène est notamment la conséquence des différences de taille entre les rayons atomiques de La et de Ce, très inférieure à celles du Xe. A contrario, l'accumulation de défauts de type distorsion des rangées atomiques BC avec l'augmentation de la fluence conduit à une évolution très similaire quelle que soit la nature de l'élément incorpore. Cette augmentation se produit principalement entre 10 et 100 dpa - correspondant à un plateau pour l'évolution des défauts de type RDA – et traduit une importante évolution structurale du dioxyde d'uranium irradie, explorée pour la première fois dans ce travail de thèse. / This thesis is dedicated to the investigation of the structural destabilisation of UO2 single crystal. Irradiations with 470-keV Xe, 500-keV Ce and 500-keV La ions (with corresponding ion range of Rp 85 nm and range straggling of Delta Rp _ 40 nm according to SRIM calculation) have been performed to investigate the destabilisation of UO2 single crystals induce by (i) the radiation damage effects due to the nuclear stopping process of a fission fragment at the end of their trajectories (ballistic contribution) and by (ii) the incorporation of a fission product at high concentration (chemical contribution). The energies and masses of bombarding ions were deliberately chosen so that they would have very similar projected range in UO2 in order to compare the effects induced by solubles (La and Ce) versus non soluble Xe species in UO2. Rutherford Backscattering Spectrometry in channelling geometry (RBS/C) was applied to study the defects induced. Channelling data were analysed afterwards by Monte-Carlo simulation with McChasy code assuming a two-class model of defects comprising (i) the randomly displaced atoms (RDA) and the bent channels (BC) defects. The accumulation of RDA with increasing ion fluence leads to a steep increase (build-up of defects) observed from 4 to 7 dpa regardless of nature of ions and a dramatic increase observed from 300 dpa (corresponding to _ 5 at. % of implanted ions) only for Xe irradiated crystal. The difference due to the soluble versus insoluble species was clearly observed. Such a difference was observed via the dramatic increase of RDA when the crystal is implanted at very high concentration only for crystal implanted with insoluble species. Moreover, the difference is also observed via the higher fraction of RDA created in the crystal irradiated with insoluble element. This phenomenon is mostly due to the size of implanted species in the matrix. Insoluble Xe atoms have the atomic radius which is larger than twice the atomic radius of U sub-lattice while soluble La and Ce atoms have the atomic radii of similar size as compared to U atom. Xe creates a much stronger stress field in UO2 crystal in comparison to La or Ce; a higher fraction of RDA is thus created. Conversely, the accumulation of BC with increasing ion fluence leads to very similar evolution versus ion fluence in all crystals implanted with the three elements .
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Body weight alterations in patients with nasopharyngeal cancer: a model of nutritional alterations due to radiation therapy.January 2003 (has links)
Ng Kenway. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2003. / Includes bibliographical references (leaves 169-189). / Abstracts in English and Chinese ; questionnaire also in Chinese. / ABSTRACT --- p.I / 摘要 --- p.IV / ACKNOWLEDGEMENT --- p.V / TABLE OF CONTENTS --- p.VII / ABBREVIATION --- p.XI / LIST OF TABLES --- p.XIII / LIST OF FIGURES --- p.XIV / Chapter CHAPTER 1 --- INTRODUCTION --- p.1 / Chapter CHAPTER 2 --- LITERATURE REVIEW --- p.4 / Chapter 2.1 --- SIDE EFFECTS OF RADIATION THERAPY IN HEAD & NECK CACNER PATIENTS --- p.6 / Chapter 2.2 --- NUTRITIONAL ALTERATIONS IN CANCER PATIENTS --- p.9 / Chapter 2.3 --- FACTORS INFLUENCING ALTERATION IN CALORIE INTAKE IN CANCER PATIENTS --- p.12 / Chapter 2.3.1 --- Evidence for impaired calorie intake in cancer patients --- p.12 / Chapter 2.3.2 --- Anorexia --- p.13 / Chapter 2.3.2.1 --- Mucositis of upper food passage --- p.13 / Chapter 2.3.2.2 --- "Change in saliva and taste, food aversions" --- p.14 / Chapter 2.3.2.3 --- Psychological and emotional factors --- p.14 / Chapter 2.3.2.4 --- Cytokines --- p.15 / Chapter 2.4 --- FACTORS INFLUENCING ENERGY EXPENDITURE IN CANCER PATIETNS --- p.17 / Chapter 2.4.1 --- Introduction --- p.17 / Chapter 2.4.2 --- Components of total energy expenditure --- p.22 / Chapter 2.4.2.1 --- Measurement of Basal metabolic rate --- p.22 / Chapter 2.4.2.2 --- Energy cost of physical activity --- p.25 / Chapter 2.4.2.3 --- Thermic effect of food (TEF) --- p.26 / Chapter 2.5 --- METHODS FOR NUTRITIONAL ASSESSMENT --- p.27 / Chapter 2.5.1 --- Body weight and body composition --- p.27 / Chapter 2.5.2 --- Dietary intake --- p.30 / Chapter 2.6 --- METHODS FOR ENERGY EXPENDITURE MEASUREMENT --- p.35 / Chapter 2.7 --- CYTOKINES AND LEPTIN CHANGES IN CANCER PATIENTS --- p.40 / Chapter 2.7.1 --- Cytokines --- p.40 / Chapter 2.7.1.1 --- Tumor necrosis factor --- p.40 / Chapter 2.7.1.2 --- Interleukin 1 and interleukin 6 --- p.44 / Chapter 2.7.2 --- Leptin --- p.45 / Chapter 2.8 --- THE IMPACT OF MALNUTRITION ON CANCER SURVIVAL --- p.49 / Chapter CHAPTER 3 --- OBJECTIVES OF STUDY --- p.53 / Chapter CHAPTER 4 --- METHODS --- p.55 / Chapter 4.1 --- RETROSPECTIVE STUDY --- p.56 / Chapter 4.1.1 --- Patients --- p.56 / Chapter 4.1.2 --- Cancer staging --- p.56 / Chapter 4.1.3 --- Cancer treatment --- p.57 / Chapter 4.1.4 --- Outcome endpoints --- p.57 / Chapter 4.1.5 --- Determinants --- p.58 / Chapter 4.1.6 --- Statistical analysis --- p.58 / Chapter 4.2 --- PROSPECTIVE STUDY --- p.59 / Chapter 4.2.1 --- "Patients, oncological treatment, and assessment time points" --- p.59 / Chapter 4.2.2 --- Assessment of nutritional intake by food record --- p.60 / Chapter 4.2.3 --- Assessment of radiotherapy-induced symptoms --- p.61 / Chapter 4.2.4 --- Assessment of Basal metabolic rate --- p.62 / Chapter 4.2.5 --- Assessment of total energy expenditure and energy balance --- p.63 / Chapter 4.2.6 --- Assessment of body composition --- p.65 / Chapter 4.2.7 --- Measurement of cytokines --- p.68 / Chapter 4.2.7.1 --- Serum TNF-α --- p.69 / Chapter 4.2.7.2 --- Serum Human Leptin --- p.72 / Chapter CHAPTER 5 --- RESULTS --- p.80 / Chapter 5.1 --- RETROSPECTIVE STUDY --- p.81 / Chapter 5.1.1 --- The 5-year profile of bodyweight change during and after the end of radiotherapy --- p.81 / Chapter 5.1.2 --- Analysis on relation between weight loss and survival --- p.82 / Chapter 5.1.2.1 --- Patient and cancer stage --- p.82 / Chapter 5.1.2.2 --- Percentage of patients with weight loss at end of radiotherapy --- p.82 / Chapter 5.1.2.3 --- Cancer treatment outcome --- p.82 / Chapter 5.1.2.4 --- Univariate analysis --- p.82 / Chapter 5.1.2.5 --- Multivariate analysis --- p.83 / Chapter 5.2 --- PROSPECTIVE STUDY --- p.84 / Chapter 5.2.1 --- The profile of nutritional measurements during radiotherapy --- p.84 / Chapter 5.2.1.1 --- Bodyweight and body composition before and during RT --- p.84 / Chapter 5.2.1.2 --- Calorie intake before and during RT --- p.85 / Chapter 5.2.1.3 --- Energy expenditure before and during RT --- p.86 / Chapter 5.2.1.4 --- Energy balance before and during RT --- p.88 / Chapter 5.2.2 --- The profile of nutritional measurements during the 6-month period after radiotherapy --- p.88 / Chapter 5.2.2.1 --- Body weight and body composition during the 6 months after radiotherpay --- p.88 / Chapter 5.2.2.2 --- Calorie intake during the 6 months after radiotherapy --- p.90 / Chapter 5.2.2.3 --- Energy expenditure during the 6 months after radiotherapy --- p.91 / Chapter 5.2.2.4 --- Energy balance during the 6 months after radiotherapy --- p.92 / Chapter 5.2.3 --- Radiotherapy-induced Symptoms --- p.92 / Chapter 5.2.3.1 --- Profile of symptoms after RT --- p.92 / Chapter 5.2.3.2 --- Detailed profile of symptoms during RT --- p.95 / Chapter 5.2.4 --- The profile of cytokines during and after completion of RT --- p.95 / Chapter 5.2.4.1 --- SerumTNF-α --- p.96 / Chapter 5.2.5.2 --- Serum leptin --- p.96 / Chapter CHAPTER 6 --- DISCUSSION --- p.144 / Chapter 6.1 --- RETROSPECTIVE STUDY --- p.145 / Chapter 6.2 --- PROSPECTIVE STUDY --- p.147 / Chapter 6.2.1 --- The magnitude of the problem --- p.147 / Chapter 6.2.2 --- The potential determinants of weight loss --- p.147 / Chapter 6.2 3 --- Is weight loss due to the cancer or due to its treatment? --- p.148 / Chapter 6.2.4 --- "Is the weight loss influenced by pre-treatment factors, i. e. anthropometrical data?" --- p.148 / Chapter 6.2.5 --- "Is the pattern weight loss compatible with the model of calorie-protein malnutrition, similar to a starvation state?" --- p.149 / Chapter 6.2.6 --- Is the weight loss due to increased energy expenditure? --- p.150 / Chapter 6.2.7 --- Is the weight loss due to reduced calorie intake? --- p.151 / Chapter 6.2.8 --- Is weight loss during radiotherapy due to negative energy balance? --- p.151 / Chapter 6.2.9 --- What causes reduced calorie intake: Are radiotherapy-induced symptoms contributive? --- p.152 / Chapter 6.2.10 --- What are the observations on and implications of cytokine changes? --- p.155 / Chapter 6.2.11 --- What determines the recovery of body weight during 6 months after end of radiotherapy? --- p.158 / Chapter 6.2.12 --- Is the weight loss in the post RT recovery period due to negative energy balance? --- p.159 / Chapter 6.2.13 --- What are the implications on nutritional intervention? --- p.159 / Chapter 6.2.14 --- Limitations and future studies --- p.164 / Chapter CHAPTER 7 --- CONCLUSIONS --- p.166 / REFERENCES --- p.169 / APPENDIX 1 CONSENT FORM I (IN ENGLISH) --- p.190 / APPENDIX 2 CONSENT FORM I (IN CHINESE) --- p.193 / APPENDIX 3 CONSENT FORM II (IN ENGLISH) --- p.196 / APPENDIX 4 CONSENT FORM II (IN CHINESE) --- p.199 / APPENDIX 5 3-DAY DIET RECORD --- p.202 / APPENDIX 6 24-HOUR DIETARY RECALL --- p.206 / APPENDIX 7 SUBJECTIVE NUTRITIONAL ASSESSMENT --- p.208 / APPENDIX 8 PHYSICAL ACTIVITY QUESTIONNAIRE --- p.210 / APPENDIX 9 BONE SCAN REPORT --- p.215
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