Thesis (M.S.)--University of Michigan, 1986.

Thesis (M.S.)--University of Michigan, 1986.

Este estudo buscou verificar a ocorrência de casos de cisto radicular em incisivos superiores decíduos traumatizados e descrever suas características relacionadas à criança, ao dente, ao trauma e ao cisto. Para tanto, realizou-se um levantamento das informações clínicas e radiográficas, de 2498 prontuários de pacientes atendidos na Clínica do Centro de Pesquisa e Atendimento de Traumatismo de Dentes Decíduos da Disciplina de Odontopediatria da FOUSP, no período de 1998 a setembro de 2013. Foi utilizado o método exploratório descritivo de uma série de casos. Foram avaliados 30 prontuários com casos de cistos, totalizando 32 incisivos superiores decíduos traumatizados com cisto. A ocorrência de cisto em pacientes com incisivos superiores decíduos traumatizados foi de 1,2%. Os resultados mostraram que a maioria dos cistos acometeram o gênero feminino (59,4%), os incisivos centrais superiores decíduos (93,8%), em crianças maiores de 5 anos (81,2%), mas que sofreram traumatismos com menos de 4 anos de idade (81,2%). A maioria dos casos não apresentou alteração clínica que levasse a suspeita de lesão cística, pois não foi encontrado em 90,7% retração gengival, 65,6% alteração de cor da mucosa vestibular, 65,6% fistula, 75% abscesso, 56,2% abaulamento gengival, 78,1% depressão da mucosa vestibular e 56,3% flutuação cistíca. A alteração clínica mais frequente foi a alteração de cor da coroa (56,3%). A média da idade do paciente no momento do trauma foi de 2,7 anos e do diagnóstico do cisto de 5,9 anos, sendo que a média de tempo do trauma até o diagnóstico do cisto foi de 2,8 anos. Em 46,9% dos dentes ocorreu trauma dental. A maioria dos traumas foram de baixa severidade (59,3%). Em 46,8% dos casos, o dente decíduo envolvido na lesão apresentava maior formação radicular que seu homólogo e em 62,5% o germe sucessor do dente decíduo com a lesão cística encontrava-se em estágio de Nolla anterior que o homólogo. A maioria das lesões císticas (81,2%) não envolveu dentes adjacentes, mas promoveram deslocamento de germes em 56,2%. Na dentição permanente foram encontrados repercussões em 31,3,% dos casos e retenção prolongada do permanente em 15,6%. Diante dos achados deste estudo observou-se que o cisto radicular em incisivos decíduos traumatizados é raro, assume um perfil menos agressivo, de crescimento controlado e necessitando de um tempo longo para se desenvolver. Além do mais, parece causar sequelas menos danosas às dentições, influenciar no processo de rizólise e rizogênese e estar relacionado a traumas de baixa severidade. O diagnóstico deve ser realizado pelos achados radiográficos, sendo que a reabsorção radicular externa sem formação óssea, assimetria no tamanho do folículo do germe dentário sucessor ao dente envolvido com a lesão cística e o folículo homólogo, bem como a diferença de altura e/ou posição entre os germes dentários homólogos deveriam ser considerados como sinais radiográficos no diagnóstico de cistos radiculares. / The present study aimed to verify the occurrence of radicular cyst in traumatized primary upper incisors and describe their characteristics in relation to the children, teeth, trauma and cysts. The survey of 2, 498 patients that presented and were treated at the Research and Clinical Center of Dental Trauma in Primary Teeth of the School of Dentistry of the University of Sao Paulo from 1998 to September 2013 was carried out, in order to collect clinical and radiographic information. A descriptive and exploratory approach was taken in the study. A total of thirty clinical records involving radicular cysts included thirty two traumatized primary upper incisors were studied in detail. The overall occurrence of cysts in patients with traumatized primary incisors was 1.2% with females affected more (59.4%) often than males 93.8% involved the upper central incisors. 81.2% of the children were older than 5 year of age but suffered traumatic injuries before 4 years old. In most cases, gingival recession (90.7%); color change of the vestibular mucosa (65.6%); fistula (65.6%); abscess (75%); gingival bulging (56.2%); depression of the vestibular mucosa (78.1%) and cystic fluctuation (56.3%) were not present showing no clinical alterations that might suggest cystic lesion. The most frequent clinical alteration was the color change of the crown (56.3%). The mean patient age at the time of traumatic injury was 2.7 years and the diagnosis of cyst at 5.9 years, and the mean time from trauma to diagnosis of cysts was 2.8 years. The hard tissue trauma occurred in 46.9% of teeth. Most injuries (59.3%) were of low severity. The radicular formation in the primary tooth involved in the lesion in 46.8% of cases was larger than its homologous and 62.5 % of cases the successor tooth germ of primary tooth with the cystic lesion was at a Nolla stage earlier than the homologous. The majority (81.2%) of cystic lesions did not involve adjacent teeth but promoted displacement of tooth germs in 56.2%. Repercussions in the permanent dentition were found in 31.3% of cases and prolonged retention of permanent in 15.6%. Given the findings, this study observed that the radicular cyst in traumatized primary incisors is rare. It assumes a less aggressive profile, controlled growth and requiring a long time to develop. Moreover, it seems to cause less harmful sequelae in dentitions, influence the process of root resorption and root formation and is associated with low severity trauma. The diagnosis must be made by radiographic findings. An external root resorption without bone formation, asymmetry in size between dental follicle (dental follicle of successor germ to the primary tooth involved with the cystic lesion and th homologous tooth follicle) and the difference in height and/or position between homologous teeth germs should also be considered amongst the radiographic signs in the diagnosis of radicular cysts.

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / Os cistos dos ossos maxilares sÃo classificados como odontogÃnicos e nÃo odontogÃnicos. Dentre os odontogÃnicos inflamatÃrios, destaca-se o cisto radicular, e entre os de desenvolvimento, o dentÃgero. Estes cistos e suas variantes apresentam etiopatogÃnese e comportamento biolÃgico diferentes, mas sÃo igualmente lÃticos. A atividade proliferativa do epitÃlio de revestimento, dos componentes da membrana basal e da matriz extracelular, possivelmente, interferem nos mecanismos de crescimento, constituindo alvos de pesquisas. Este trabalho teve por objetivo avaliar a relaÃÃo do infiltrado inflamatÃrio mononuclear com a expressÃo de marcadores de proliferaÃÃo (Ki 67) e das proteÃnas da membrana basal e matriz extracelular nos cistos radiculares. Trata-se de um estudo retrospectivo e observacional tendo sido realizado um levantamento dos casos catalogados no ServiÃo de Biopsia do Departamento de Patologia e Medicina Legal (FAMED) e no LaboratÃrio de Patologia Bucal (FFOE) (UFC). ApÃs a revisÃo histolÃgica, os grupos foram divididos em cisto radicular intensamente inflamado (CRII) (n=17), cisto radicular levemente inflamado(CRLI)(n=.9) e cisto dentÃgero (CD) (n= 9). A presenÃa e intensidade do infiltrado inflamatÃrio histiolinfoplasmocitÃrio e preservaÃÃo do epitÃlio de revestimento foram os parÃmetros utilizados para seleÃÃo dos casos. Os espÃcimes foram submetidos à reaÃÃo de imuno-histoquÃmica por estreptoavidina biotina, utilizando-se os anticorpos Ki 67 (DakoÂ, 1:50), anti-colÃgeno IV (DBSÂ, 1:40) e anti-laminina (DBSÂ, 1:20). A expressÃo de Ki 67 foi mais intensa no grupo CRLI, quando comparada ao grupo CRII e CD. A expressÃo de colÃgeno tipo IV na membrana basal foi significante no grupo CRLI, quando comparada com o grupo CRII e CD. Jà a imunomarcaÃÃo de matriz extracelular variou de ausente a fraca nos grupos CRII e CRLI, enquanto no CD se exibiu de forma fraca a moderada, sendo esta diferenÃa significativa. A expressÃo de laminina em membrana basal nos grupos CRII e CD foi negativa e no grupo dos CRLI foi fraca e pontual. Concluiu-se que a presenÃa e a intensidade do conteÃdo inflamatÃrio na parede dos cistos radiculares parecem modificar a expressÃo dos fatores de proliferaÃÃo no epitÃlio de revestimento, e colÃgeno tipo IV e laminina na membrana basal, mas nÃo interferem no comportamento do colÃgeno IV da matriz extracelular nos cistos radiculares. A expressÃo de componentes da membrana basal (laminina e colÃgeno tipo IV) à maior nos cistos radiculares com leve infiltrado inflamatÃrio. / Jawbone cysts are classified as odontogenic and non-odontogenic cysts. The radicular cyst is the most common odontogenic cyst of inflammatory origin, whereas the detigerous cyst is the most common type of developmental odontogenic cyst. These cysts and their variations have different etiopathogenesis and biological behavior, but are equally lytic. The proliferation activity of the epithelial lining and the components of the basement membrane and extracellular matrix constitute targets of research. The aim of this study was to evaluate the relation between mononuclear inflammatory infiltrate and the expression of proliferative immunomarkers (Ki 67), and proteins of basement membrane and extracellular matrix in radicular cysts. In this retrospective observational study, all cases of jawbone cysts that had been recorded in the files of the Department of Pathology and Legal Medicine (FAMED), and of the Laboratory of Oral Pathology (FFOE) of the Federal University of Cearà (UFC) and reviewed. After histological revision, the groups were divided into heavily inflamed radicular cysts (HIRC) (n=17), slightly inflamed radicular cysts (SIRC) (n=9) and dentigerous cysts (DC) (n=9). The presence and intensity of the lymphoplasmacytic inflammatory infiltrate and the preservation of the epithelial lining were the parameters used to select the cases. Immunohistochemical analyses were performed using the standard streptavidin-biotin-peroxidase method. The primary antibodies used in this study included Ki 67 (DakoÂ, 1:50), Anti-Collagen Type IV (DBSÂ, 1:40) and Anti- Laminin (DBSÂ, 1:20).The immunoexpression of Ki-67 was more intense in the SIRC group compared to the HIRC group and DC. Likewise, the immunoexpression of Anti-Collagem Type IV in the basement membrane of the SIRC group presented a statistically significant difference compared to the HIRC group and DC . The expression of laminin in the basement membrane and in group HIRC and DC was negative and the group of SIRC was weak and punctual. It was concluded that presence and severity of inflammatory content wall of radicular cysts appear to modify the expression of proliferation factors in the coating epithelium and collagen type IV and laminin in the basement membrane but not modific with the behavior of extracellular matrix in radicular cyst. The expression of basement membrane components (laminin and collage type IV) is higher in radicular cyst with mild inflammatory infiltrade.

Este estudo buscou verificar a ocorrência de casos de cisto radicular em incisivos superiores decíduos traumatizados e descrever suas características relacionadas à criança, ao dente, ao trauma e ao cisto. Para tanto, realizou-se um levantamento das informações clínicas e radiográficas, de 2498 prontuários de pacientes atendidos na Clínica do Centro de Pesquisa e Atendimento de Traumatismo de Dentes Decíduos da Disciplina de Odontopediatria da FOUSP, no período de 1998 a setembro de 2013. Foi utilizado o método exploratório descritivo de uma série de casos. Foram avaliados 30 prontuários com casos de cistos, totalizando 32 incisivos superiores decíduos traumatizados com cisto. A ocorrência de cisto em pacientes com incisivos superiores decíduos traumatizados foi de 1,2%. Os resultados mostraram que a maioria dos cistos acometeram o gênero feminino (59,4%), os incisivos centrais superiores decíduos (93,8%), em crianças maiores de 5 anos (81,2%), mas que sofreram traumatismos com menos de 4 anos de idade (81,2%). A maioria dos casos não apresentou alteração clínica que levasse a suspeita de lesão cística, pois não foi encontrado em 90,7% retração gengival, 65,6% alteração de cor da mucosa vestibular, 65,6% fistula, 75% abscesso, 56,2% abaulamento gengival, 78,1% depressão da mucosa vestibular e 56,3% flutuação cistíca. A alteração clínica mais frequente foi a alteração de cor da coroa (56,3%). A média da idade do paciente no momento do trauma foi de 2,7 anos e do diagnóstico do cisto de 5,9 anos, sendo que a média de tempo do trauma até o diagnóstico do cisto foi de 2,8 anos. Em 46,9% dos dentes ocorreu trauma dental. A maioria dos traumas foram de baixa severidade (59,3%). Em 46,8% dos casos, o dente decíduo envolvido na lesão apresentava maior formação radicular que seu homólogo e em 62,5% o germe sucessor do dente decíduo com a lesão cística encontrava-se em estágio de Nolla anterior que o homólogo. A maioria das lesões císticas (81,2%) não envolveu dentes adjacentes, mas promoveram deslocamento de germes em 56,2%. Na dentição permanente foram encontrados repercussões em 31,3,% dos casos e retenção prolongada do permanente em 15,6%. Diante dos achados deste estudo observou-se que o cisto radicular em incisivos decíduos traumatizados é raro, assume um perfil menos agressivo, de crescimento controlado e necessitando de um tempo longo para se desenvolver. Além do mais, parece causar sequelas menos danosas às dentições, influenciar no processo de rizólise e rizogênese e estar relacionado a traumas de baixa severidade. O diagnóstico deve ser realizado pelos achados radiográficos, sendo que a reabsorção radicular externa sem formação óssea, assimetria no tamanho do folículo do germe dentário sucessor ao dente envolvido com a lesão cística e o folículo homólogo, bem como a diferença de altura e/ou posição entre os germes dentários homólogos deveriam ser considerados como sinais radiográficos no diagnóstico de cistos radiculares. / The present study aimed to verify the occurrence of radicular cyst in traumatized primary upper incisors and describe their characteristics in relation to the children, teeth, trauma and cysts. The survey of 2, 498 patients that presented and were treated at the Research and Clinical Center of Dental Trauma in Primary Teeth of the School of Dentistry of the University of Sao Paulo from 1998 to September 2013 was carried out, in order to collect clinical and radiographic information. A descriptive and exploratory approach was taken in the study. A total of thirty clinical records involving radicular cysts included thirty two traumatized primary upper incisors were studied in detail. The overall occurrence of cysts in patients with traumatized primary incisors was 1.2% with females affected more (59.4%) often than males 93.8% involved the upper central incisors. 81.2% of the children were older than 5 year of age but suffered traumatic injuries before 4 years old. In most cases, gingival recession (90.7%); color change of the vestibular mucosa (65.6%); fistula (65.6%); abscess (75%); gingival bulging (56.2%); depression of the vestibular mucosa (78.1%) and cystic fluctuation (56.3%) were not present showing no clinical alterations that might suggest cystic lesion. The most frequent clinical alteration was the color change of the crown (56.3%). The mean patient age at the time of traumatic injury was 2.7 years and the diagnosis of cyst at 5.9 years, and the mean time from trauma to diagnosis of cysts was 2.8 years. The hard tissue trauma occurred in 46.9% of teeth. Most injuries (59.3%) were of low severity. The radicular formation in the primary tooth involved in the lesion in 46.8% of cases was larger than its homologous and 62.5 % of cases the successor tooth germ of primary tooth with the cystic lesion was at a Nolla stage earlier than the homologous. The majority (81.2%) of cystic lesions did not involve adjacent teeth but promoted displacement of tooth germs in 56.2%. Repercussions in the permanent dentition were found in 31.3% of cases and prolonged retention of permanent in 15.6%. Given the findings, this study observed that the radicular cyst in traumatized primary incisors is rare. It assumes a less aggressive profile, controlled growth and requiring a long time to develop. Moreover, it seems to cause less harmful sequelae in dentitions, influence the process of root resorption and root formation and is associated with low severity trauma. The diagnosis must be made by radiographic findings. An external root resorption without bone formation, asymmetry in size between dental follicle (dental follicle of successor germ to the primary tooth involved with the cystic lesion and th homologous tooth follicle) and the difference in height and/or position between homologous teeth germs should also be considered amongst the radiographic signs in the diagnosis of radicular cysts.

INTRODUCTION: The diagnosis and treatment of endodontic infections is a multi-step fact gathering process, with the gold standard of periapical lesion diagnosis being histological biopsy. With common diagnoses, such as periapical granulomas and radicular cysts, representing the bulk of biopsies, the possibility of a less invasive method of lesion identification ought to be examined. In recent years Cone Beam Computed Tomography (CBCT) imaging has been proposed as a potential diagnostic tool for periapical diagnosis, but this theory requires further testing and data in order to verify its appropriateness. OBJECTIVE: The aim of this study was to evaluate six criteria used for assessing periapical lesions of teeth seen on CBCT scan from the textbook Oral Radiology White and Pharoah. MATERIAL AND METHODS: Three blinded endodontists observed radiographic features of oral periapical lesions of teeth previously diagnosed as either radicular cysts or periapical granulomas via histological biopsy. All lesions had previously been scanned via CBCT, and endodontic apical surgery was performed allowing for a pathology sample of the lesion. The observers viewed 40 CBCT and 40 corresponding periapical (PA) radiographic images, all randomized, and reported which of the six criteria (Location- apex of tooth, periphery- corticated border, shape- curved or circular, internal structure- radiolucent, effects on surrounding structures- displace or resorb roots, corticated plate perforation- present) were present in the scans. Data was analyzed using a Logistical Regression Fleiss Kappa statistic with a 95% confidence level. RESULTS: CBCT cyst showed no agreement between examiners criteria selected to statistical significance. The most selected criteria by all examiners were shape and internal structure. PA radiographic Cyst showed moderate agreement for ‘Location’ and ‘Periphery’ and substantial agreement on ‘none’ criteria. The most selected criteria by all examiners were internal structure and location. CBCT Granuloma showed moderate agreement for ‘location’ and perfect agreement for ‘none’. The most selected criteria by all examiners were shape, location, and internal structure. PA radiographic Granuloma showed substantial agreement for ‘periphery’ and moderate agreement for internal structure (radiolucency). The most selected criteria by all examiners were location, and occasionally shape and internal structure. Logistic regression of selected criteria shows with each additional criteria present on each lesion the chance of the lesion being a granuloma decreases 24.9% on PA radiographs and 33.9% on CBCT images. CONCLUSION: The current study shows an inter-examiner agreement of moderate to perfect kappa statistic does not align with the most commonly selected criteria among examiners, showing poor examiner agreement among lesions. / 2024-06-21T00:00:00Z

Los avances tecnológicos para mejorar la calidad del tratamiento endodóntico en todos los aspectos son insuficientes si no se complementa con un adecuado tratamiento protésico. La filtración bacteriana causada por tratamientos protésicos desadaptados puede promover la migración bacteriana hacia el canal radicular y el material de obturación, en caso presente un tratamiento endodóntico. Si esta situación no es controlada, la infección podría continuar hacia los tejidos periapicales, causando un quiste periapical. Para tratar el quiste periapical será necesario identificar el diente donde se originó la infección, retratar los canales radiculares y realizar el retiro quirúrgico del quiste. Sin embargo, es posible realizar un abordaje no quirúrgico con resultados favorables. / Technological advances to improve the quality of endodontic treatment in all aspects are insufficient if they are not complemented by adequate prosthetic treatment. The bacterial cause caused by the maladaptive prosthetic treatments can promote bacterial migration towards the root canal and the filling material, in case of endodontic treatment. If this situation is not controlled, the infection could continue into the periapical tissues, causing a periapical cyst. To treat the periapical cyst, identify with the tooth where the infection originated, portray the root canals and perform the surgical removal of the cyst. However, it is possible to perform a non-surgical approach with favorable results. / Trabajo académico

Made available in DSpace on 2014-12-17T15:32:21Z (GMT). No. of bitstreams: 1 PedroCRN_DISSERT.pdf: 3117630 bytes, checksum: 2544a3022fe67731388c2238d7dc5289 (MD5) Previous issue date: 2012-02-29 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / Odontogenic cysts are pathologic cavities covered by odontogenic epithelium and filled by liquid, desquamated cells or other materials. The intraosseous lesions, such as radicular cyst and dentigerous cyst, present a potential of expansion capable of promoting the destruction of the surrounding osseous tissue. The mechanisms related to this process of expansion are the proliferation of cystic epithelium, the increase of the osmolarity of the cystic fluid and the synthesis of reabsorption factors such as IFN-? and TGF-?1. The aim of this study was to evaluate and compare the immunohistochemical expression of IFN-? and TGF-?1 between radicular cysts and dentigerous cysts in order to understand the role and behavior of these proteins in the expansion of these cysts. We selected 20 cases of radicular cyst and 20 cases of dentigerous cyst chosen from the files of UFRN s Laboratory of Oral Pathology. After analyzing the clinical data, the cases underwent the routine staining technique (HE) and immunohistochemistry for the appearance of IFN-? and TGF-?1 in the epithelium and capsule of these cysts. The statistical analysis using the Mann-Whitney test revealed no statistically significant difference in immunoexpression of IFN-? between the epithelium (p = 0.565) and capsules (p = 0.414) of radicular cysts and dentigerous cysts. Moreover, there was no statistically significant difference of immunoexpression of TGF-?1 between the epithelium (p = 0.620) and capsules (p = 0.056) of radicular cysts and dentigerous cysts. The Wilcoxon test revealed no statistically significant difference between IFN-? and TGF-?1 imunoexpressions in the epithelium (p = 0.225) and capsules (p = 0.370) of radicular cysts. There was no statistically significant difference between IFN-? and TGF-?1 imunoexpressions in the epithelium (p = 0.361) of dentigerous cysts. However, there was a statistically significant difference between IFN-? and TGF-?1 immunoexpressions in the capsule (p = 0.001) of dentigerous cysts, being TGF-?1 the factor which presented the most significant immunoexpression. Given these results, we conclude that there was no difference in immunohistochemical expression of IFN-? and TGF-?1 between radicular and dentigerous cysts and that TGF-?1 was more significant than the IFN-? in the capsule of dentigerous cysts / Os cistos odontog?nicos s?o cavidades patol?gicas revestidas por epit?lio odontog?nico e preenchidas por l?quido, c?lulas descamadas, ou outros materiais. As les?es intra-?sseas, como o cisto radicular e o cisto dent?gero, apresentam um potencial de expans?o capaz de promover a destrui??o do tecido ?sseo circunjacente. Os mecanismos relacionados a esse processo de expans?o s?o a prolifera??o do epit?lio c?stico, o aumento da osmolaridade do fluido c?stico e a s?ntese de fatores de reabsor??o ?ssea como IFN-? e TGF-?1. O objetivo deste estudo foi avaliar e comparar a express?o imuno-histoqu?mica do IFN-? e do TGF-?1 entre cistos radiculares e cistos dent?geros com a finalidade de compreender o papel e o comportamento dessas prote?nas no processo de expans?o destes cistos. Selecionamos 20 casos de cisto radicular e 20 casos de cisto dent?gero retirados dos arquivos do Laborat?rio de Patologia Oral da UFRN. Ap?s an?lise dos dados cl?nicos, os casos foram submetidos a t?cnica de colora??o de rotina (HE) e ao m?todo imuno-histoqu?mico para evidencia??o da express?o do IFN-? e do TGF-?1 no epit?lio e na c?psula dos referidos cistos. A an?lise estat?stica dos dados utilizando o teste de Mann-Whitney revelou que n?o houve diferen?a estatisticamente significativa da imunoexpress?o do IFN- entre os epit?lios (p=0,565) e c?psulas (p=0,414) dos cistos radiculares e cistos dent?geros. Al?m disso, n?o houve diferen?a estatisticamente significativa da imunoexpress?o do TGF-?1 entre os epit?lios (p=0,620) e c?psulas (p=0,056) dos cistos radiculares e cistos dent?geros. O teste de Wilcoxon revelou que n?o houve diferen?a estatisticamente significativa entre as imunoexpress?es do IFN- e do TGF-?1 no epit?lio (p=0,225) e na c?psula (p=0,370) dos cistos radiculares. N?o houve diferen?a estatisticamente significativa entre as imunoexpress?es do IFN- e do TGF-?1 no epit?lio (p=0,361) dos cistos dent?geros. No entanto, houve diferen?a estatisticamente significativa entre as imunoexpress?es do IFN- e do TGF-?1 na c?psula (p=0,001) dos cistos dent?geros, sendo o TGF-?1 o que apresentou a imunoexpress?o mais significativa. Diante destes resultados, conclu?mos que n?o houve diferen?a de express?o imuno-histoqu?mica do IFN-? e do TGF-?1 entre os cistos radiculares e dent?geros e que o TGF-?1 foi mais expressivo do que o IFN-? na c?psula dos cistos dent?geros

Made available in DSpace on 2014-12-17T15:32:23Z (GMT). No. of bitstreams: 1 VivianeAOM_DISSERT.pdf: 3188421 bytes, checksum: 338aa2ec46045198a33e6eea1db0d483 (MD5) Previous issue date: 2014-02-13 / The radicular cysts (RCs) and dentigerous (DCs), despite having different etiologies, form a pathological cavity lined by epithelium, which grows due to the buildup of fluid inside, as the surrounding bone is reabsorbed and the epithelium will being induced to proliferate. The epithelial proliferation, which has been identified as one of the key processes in the growth of odontogenic cystic lesions, is influenced by growth factors such as EGFR (epidermal growth receptor factor) and podoplanin (PDPN), many of which may have its production stimulated mainly during inflammatory processes. The objective of this research was to evaluate and compare the immunohistochemical expression of EGFR and PDPN in 30 cases of RCs and 30 cases of DCs, semiquantitatively, in light microscopy, associating it with the degree of inflammation, cellular localization of immunostaining and with the immunostained epithelial layers. Data were statistically analyzed by Chi-square test and Fisher exact test, considering a significance level of 5 %. The results showed high immunoreactivity of both proteins in the lesions studied, only statistically significant difference was observed in immunostaining of PDPN (p=0.033), which proved higher in RCs. The other analyzed parameters showed no relevant significant differences. We conclude that, as EGFR and PDPN showed high immunoreactivity in cystic lesions analyzed, these proteins participate the pathogenesis of these lesions through the epithelial stimulation process, despite having different etiologies. Furthermore, it can infer that the higher immunostaining of PDNP in RCs that DCs showed no distinction indicator between the two lesions, regarding their etiologies, once this protein also showed a considerable expression in DCs, independent of the intensity of the inflammatory infiltrate / Os cistos radiculares (CRs) e dent?geros (CDs), apesar de possu?rem etiologias diferentes, formam uma cavidade patol?gica revestida por epit?lio, a qual cresce em fun??o do ac?mulo de l?quido em seu interior, ? medida que o osso ao redor ? reabsorvido e o epit?lio vai sendo induzido a proliferar. A prolifera??o epitelial, que tem sido apontada como um dos processos determinantes no crescimento das les?es c?sticas odontog?nicas, ? influenciada por fatores de crescimento como o EGFR (receptor do fator de crescimento epid?rmico) e a podoplanina (PDPN), muitos dos quais podem ter sua produ??o estimulada principalmente durante processos inflamat?rios. O objetivo desta pesquisa foi avaliar e comparar a express?o imunoistoqu?mica do EGFR e da PDPN em 30 casos de CRs e 30 casos de CDs, de forma semiquantitativa, em microscopia de luz, associando-a com o grau de inflama??o, localiza??o celular da imunocolora??o e com as camadas epiteliais imunomarcadas. Os dados foram avaliados estatisticamente por meio de testes do Qui-quadrado e Exato de Fisher, considerando-se um n?vel de signific?ncia de 5%. Os resultados mostraram que houve elevada imunorreatividade das duas prote?nas nas les?es estudadas, sendo observada apenas diferen?a estat?stica significativa na imunoexpress?o da PDPN (p=0,033), que se mostrou mais elevada nos CRs. Os demais par?metros analisados n?o demonstraram diferen?as significativas relevantes. Conclui-se que, como o EGFR e a PDPN apresentaram elevada imunoexpress?o nas les?es c?sticas analisadas, essas prote?nas participam da patog?nese dessas les?es atrav?s da estimula??o epitelial, apesar de apresentarem etiologias diferentes. Al?m disso, pode-se inferir que a maior imunomarca??o da PDPN em CRs do que em CDs n?o se mostrou indicador de distin??o entre as duas les?es, com rela??o ?s suas etiologias, uma vez que nestes ?ltimos essa prote?na tamb?m apresentou express?o consider?vel, independente da intensidade do infiltrado inflamat?rio