Experiências armazenadas acerca de regularidades passadas permitem a previsão do ambiente e, consequentemente, a possibilidade de ações antecipadas. Esta capacidade cognitiva é expressa em modelos de aprendizagem de sequências, que são capazes de acessar a previsibilidade das sequências de eventos e gerar descrições do desempenho em protocolos experimentais como a tarefa de tempo de reação serial. Nos experimentos 1, 2 e 3 deste trabalho, a abordagem informacional foi aplicada à descrição do desempenho na tarefa de tempo de reação serial. A relação entre medidas de entropia e desempenho na tarefa de tempo de reação serial envolvendo diferentes tipos de sequência foi investigada nos Experimentos 1a e 1b. As medidas de entropia foram feitas pelo processamento das frequências de eventos das sequências (i.e., pares, trios, quadras etc). Os resultados revelaram que a entropia informacional das sequências é um bom descritor do desempenho: (1) sequências de baixa entropia são realizadas mais rapidamente e são mais frequentemente reconhecidas ao final da sessão do que as de alta entropia; (2) uma curva sigmóide relaciona valores de entropia aos de tempo de reação: parâmetros \"min\" (tempo de reação com a previsão total), \"max\" (tempo de reação sem previsão) e \"x50\" (valor de entropia relacionada ao limiar de previsão); (3) o treinamento torna previsíveis sequências de alta entropia (o \"x50\" aumenta com o treinamento); e (4) com o treinamento, mais elementos prévios da sequência passam a ser utilizados para a previsão do próximo elemento. A relação entre desempenho e expectativas probabilísticas geradas durante o treinamento foi investigada no Experimento 2. Esse experimento envolveu múltiplas combinações de sequências de treino e teste, aplicadas a voluntários em sessões únicas. A diferença entre as previsibilidades das sequências de teste e treino foi quantificada pela distância de Kullback-Leibler: pequenas distâncias indicam que o treino proporciona boa previsão sobre o teste. Desconsiderando os efeitos de entropia (descrito no Experimento 1), a distância de Kullback-Leibler entre as sequências de teste e treino está relacionada ao desempenho: (1) distâncias pequenas levam à manutenção das expectativas (prévias) e tempos de reação curtos; (2) distâncias grandes levam à negligência das previsões e tempos de reação intermediários; e (3) distâncias intermediárias estão relacionadas a um conflito entre as estratégias de manutenção e negligência das expectativas, e geram tempos de reação elevados. Portanto, a flexibilidade das previsões ocorre em distâncias pequenas; uma estratégia alternativa, de negligência das previsões, é adotada em distâncias grandes. A estratégia desenvolvida nos Experimentos 1a e 1b foi útil para avaliar, no Experimento 3, a equivalência funcional entre treinamento imaginativo e real na aprendizagem de sequências. Este experimento envolveu voluntários testados na tarefa de tempo de reação serial ao longo de várias sessões de treinamento imaginativo e real. Os desempenhos durante o treinamento imaginativo e real foram descritos e comparados; o experimento mostrou também que a previsibilidade da sequência acessada por meio do treinamento imaginativo pode ser expressa posteriormente no desempenho real da tarefa. No entanto, o limite de previsibilidade das sequências acessado pelo treinamento imaginativo é inferior ao limite acessado por treinamento real, descrita pelo menor \"x50\" do (1) treinamento imaginativo em relação ao treinamento real e (2) desempenho real após o treinamento imaginativo em relação ao desempenho real após o treinamento real. Em conclusão, é possível afirmar que o modelo de entropia informacional é capaz de descrever a variabilidade do desempenho na tarefa de tempo de reação serial. Estes achados apóiam a existência de um princípio geral de acesso à previsibilidade para explicação da aprendizagem e memória. / Stored experiences of past regularities allow the prediction of the environment and, consequently, the possibility of anticipatory actions. This cognitive capacity is expressed in models of sequence learning, which are able to access the predictability of sequences of events and to generate descriptions of performance on experimental protocols as serial reaction time task. In Experiments 1, 2 and 3 of this work the informational framework was applied to the description of performance in serial reaction time task. The relationship between entropy measures and performance on serial reaction time task involving multiple sequence types was investigated on Experiments 1a and 1b. The entropy measures were done by processing the frequencies of events of the sequences (i.e. pairs, triads, quads etc). The results revealed that information entropy of the sequences is an impressively good descriptor of performance: (1) low entropy sequences were performed more rapidly and were more frequently recognized in the end of the session than the high entropy ones; (2) a sigmoid curve relates entropy to reaction time: parameters \"min\" (reaction time with total prediction), \"max\" (reaction time with no prediction) and \"x50\" (entropy value related to threshold of prediction); (3) training makes high entropy sequences predictable (the \"x50\" increases with training); and (4) with training, more previous elements of sequence are used for prediction of the next one. The relationship between performance and probabilistic expectancies generated during training was investigated on Experiment 2. This experiment involved multiple arrangements of training and testing sequences, applied to volunteers on single sessions. The difference between the predictabilities of testing and training sequences was quantified by the Kullback-Leibler divergence: small divergence indicates that training provides good prediction on testing. Disregarding the entropy effects (described on Experiment 1), Kullback-Leibler divergence between training and testing sequences is related to performance: (1) short divergences lead to (previous) predictions maintenance and low reaction times; (2) large divergences lead to predictions negligence and intermediate reaction times; and (3) intermediate divergences are related to conflict between the strategies of maintenance and negligence of predictions, and generate high reaction times. Therefore, the flexibility of predictions occurs on short divergences; an alternative strategy, of predictions negligence, is adopted on large divergences. The strategy developed on Experiments 1a and 1b was useful to evaluate, on Experiment 3, the functional equivalence between imagery and actual training on sequence learning. This experiment involved volunteers tested on serial reaction time task along multiple imagery and actual training sessions. Performances on both imagery and actual training were described and compared; the experiment also showed that the sequence predictability accessed on imagery training can be expressed on posterior actual performance. However, the limit of sequence predictability accessed by imagery training is lower than the limit accessed by actual training, described by the lower \"x50\" of (1) imagery training compared to actual training and (2) actual performance after imagery training compared to actual performance after actual training. In conclusion, it is possible to state that the entropy model is able to describe the variability of performance on serial reaction time task. These findings support the existence of a general principle of accessing the predictability to explain learning and memory.

Thesis (Ph. D.)--University of Oklahoma. / Includes bibliographical references (leaves 148-162).

This thesis consisted of experiments designed to explore the construct of attention and investigate the disruptive effects of psychotomimetics, with a specific focus on NMDA antagonists. Phencyclidine (PCP) was administered through a variety of treatment regimens in order to to determine the ability of inducing cognitive-specific disruptions in attentional functioning. The hypothesis that sub-chronic exposure to PCP would result in persistent attentional impairment was tested, using the 5-choice serial reaction time task (5-CSRTT). The 5-CSRTT assesses not only visuospatial attention, but also components of impulsivity, compulsivity, speed of processing and motivation. It was determined that an additional task-related intervention that increased the attentional load was required to elucidate attentional impairment following sub-chronic PCP treatment. The ability of rats to perform the modified version of the 5-CSRTT, known as the 5-choice continuous performance test (5C-CPT), was investigated. The 5C-CPT was implemented to provide a task that may have greater analogy to the human CPT, than the original 5-CSRTT. The consequence of dopaminergic D1 system activation was investigated. It was revealed that D1 partial agonism improved attentional performance in a baseline-dependent manner. Following successful acquisition of the task, it was shown that repeated PCP treatment induced cognitive disruption that was cognitive-specific, and not confounded by generalised response disruption. Furthermore, a partial attenuation of the PCP-induced performance disruption was achieved following administration of the D1 partial agonist, SKF 38393. Moreover, sub-chronic PCP treatment was shown to impair 5C-CPT performance in the drug-free state. However, an additional challenge that further increased the attentional load was needed to elucidate a performance deficit. This highlighted that sustained attention/vigilance is sensitive to persistent impairment following sub-chronic PCP administration in a manner consistent with deficits observed in schizophrenia patients. This prompted the investigation that tested the hypothesis that sub-chronic PCP treatment could induce enduring structural deficits in regions associated with attentional performance. Magnetic resonance imaging (MRI) was conducted, in conjunction with 5-CSRTT and pre-pulse inhibition (PPI). It was revealed that sub-chronic PCP treatment resulted in morphological brain abnormalities in brain regions associated with 5-CSRTT performance. This was coupled with deficits in sustained attentional performance following an increase in attentional load, yet PPI was unaffected. Taken together, these findings suggested sub-chronic PCP treatment impairs attentional functionality, an effect that dissociates between effortful and passive attentional processes.

Tyrimo objektas: kojų judesių reakcijos laiko bei judesių atlikimo greičio vertinimas. Tyrimo problema: daugumai žmonių po insulto stebimas kojų judesių valdymo sutrikimas. Sutrikęs kojų judesių valdymas padidina griuvimų riziką, sutrikdo eiseną, apsunkina kasdieninę veiklą, riboja fizinį aktyvumą. Žmogaus rankų bei kojų dinaminių parametrų analizatoriaus DPA-1 pagalba galima tirti psichomotorinę reakciją, judesių dinamines bei kinematines charakteristikas, o tai suteikia didesnes galimybes įvertinti insulto liekamųjų reiškinių poveikį kojų judesių valdymui. Tyrimo tikslas: nustatyti kojų judesių valdymo atsigavimą persirgus galvos smegenų insultu. Tyrimo metodai ir organizavimas: tyrimas buvo atliekamas Lietuvos kūno kultūros akademijoje (LKKA) Žmogaus motorikos laboratorijoje 2009 – 2010 metais. Tiriamųjų kontingentą sudarė dvi grupės: tiriamoji ir kontrolinė. Tiriamąją grupę sudarė 10 žmonių patyrusių galvos smegenų insultą, amžiaus vidurkis: 70,1 ± 1,3 metai. Kontrolinę grupę sudarė 10 vyresnio amžiaus, neurologinių sutrikimų neturinčių žmonių, amžiaus vidurkis: 66,6 ± 1,8 metai. Kojų dinaminių judesių tyrimui buvo naudojamas LKKA mokslininkų ir UAB „Katra“ specialistų sukurtas originalus prietaisas - žmogaus rankų ir kojų judesių dinaminių parametrų analizatorius DPA-1. Tyrimo metu buvo registruojamas dešinės ir kairės kojos judesių reakcijos laikas (RT) bei dešinės ir kairės kojos maksimalus judesių greitis (V ) atliekant reakcijos, greitumo ir tikslumo užduotis... [toliau žr. visą tekstą] / Problem of study: lots of people feel disorder of controlling legs dynamic movement after stroke. Disordered control of legs movement rise the risk of fallings, unbalances gait, prejudice casual activity, limits physical activity. With help of human hands and legs dynamic parameter analyzer (DPA-1) it is possible to feel psychomotorical reaction, movements dynamic and kinematic characteristics, and this gives better opportunities to value remanant stroke influence for control of legs dynamic movement. Object of study: evaluation of legs movement reaction time and speed of movement performance. Aim of study: to determine recovery of legs motor control after stroke. Methods and organization of sudy: this research was carried out in the Laboratory of Human motor control at the Lithuanian Academy of physical Education (LAPE) during 2009 - 2010. Investigative contingent included two groups: trial and control. In trial group there were included 10 people, who had a stroke of head brains. Average of age - 70±3 years. In control group there were included 10 older people without neurological disorder. Average of age - 60±3 years. For legs dynamic movement research was used new original gear made by LAPE scientists and company “Katra” – human hands and legs dynamic parameter analyser DPA-1. During research there was registering the reaction time (RT) of right and left leg and the maximal movement speed (V ) of right and left leg performing tasks of reaction, speed and accuracy. Goals... [to full text]

L’objectif de ce projet de recherche était de vérifier la présence de changements de sensibilité de la rétine et du système circadien suite à deux semaines d'exposition à un milieu faiblement ou fortement éclairé, dans des conditions contrôlées en laboratoire. De plus, comme un changement de sensibilité peut modifier l'ajustement du système circadien au cycle jour-nuit extérieur, nous voulions également vérifier si la phase circadienne serait modifiée par le traitement et si la vigilance et l’humeur seraient affectées. Dix sujets ont été exposés à de la lumière tamisée (70 lux [LT]) et 10 ont été exposés à de la lumière vive (3000 lux [LV]) pendant 12 jours consécutifs en laboratoire de 8h45 à 19h00 tous les jours. L’exposition à la lumière a été mesurée 5 jours avant l’entrée au laboratoire dans l’habitat naturel du sujet et pendant la période en laboratoire à l’aide de l’Actiwatch-L®. La sensibilité rétinienne a été mesurée avant et après le traitement lumineux, par un électrorétinogramme (ERG) et la sensibilité circadienne, par le test de suppression de mélatonine salivaire. Tout au long du protocole, la vigilance, la somnolence et l'humeur ont été évaluées à plusieurs moments de la journée à intervalles prédéterminés. Après 12 jours d’exposition en lumière contrôlée, l’amplitude de l’onde-a au Vmax à l’ERG photopique a diminué en LV alors qu’elle a augmenté en LT. À l’ERG scotopique, une différence de sensibilité rétinienne (log K) entre les groupes avant le traitement expérimental s’est amenuisée à la fin du traitement (p=.053). La suppression de mélatonine après 90 minutes d’exposition au test de suppression a diminué en LV alors qu’il n’y a pas eu de modification en LT, cependant cette interaction n’était pas significative (p=.16). La phase circadienne des sujets exposés à LV a été devancée de 58 minutes (p=.04) alors qu’elle a été retardée de 26 minutes en LT (p=.32). Les mesures de vigilance subjective (EVA) ont indiqué que les sujets LV se considéraient plus éveillés que les sujets LT après le traitement (p=.02). Par contre, aucune différence n’est apparue quant aux mesures de performance psychomotrice ni de l’humeur. L’histoire lumineuse n’a pas modifié la sensibilité rétinienne dans le sens prévu par les hypothèses alors qu’il y a eu une tendance vers une augmentation de la sensibilité circadienne en condition de lumière tamisée. L’amélioration de la vigilance subjective après l’exposition en LV n’a pas été soutenue par les résultats de la performance psychomotrice. L’histoire lumineuse n’a eu aucun effet sur l’humeur des sujets. Cette étude souligne l’importance d’utiliser des mesures permettant de départager les effets immédiats d’un traitement lumineux des effets à long terme autant sur le plan rétinien que circadien. Il reste également complexe d’étudier en laboratoire des changements adaptatifs qui se produisent dans le milieu naturel en raison du confinement et des modifications physiologiques et psychologiques pouvant y être associées. / The purpose of this study was to evaluate the impact of two weeks exposure in a dim or bright light environment on retinal and circadian sensitivity to light in a controlled laboratory setting. Given that a change in sensitivity to light could modify the circadian adjustment to the external light-dark cycle, it was expected that the circadian phase would be modified with the light treatment and have an effect on alertness and mood. Ten participants were exposed to a dim light (DL) environment (70 lux) and 10 participants to a bright light (BL) environment (3000 lux) 10 hours per day for 12 consecutive days. Light exposure was measured 5 days prior to the onset of the experiment in the subject’s natural environment and during the entire laboratory experiment with an Actiwatch-L®. Retinal function was assessed with the electroretinogram (ERG). Circadian light sensitivity was evaluated with a salivary melatonin suppression test. Retinal and circadian sensitivity measures were taken before and after the experimental condition. Alertness, sleepiness and mood were measured several times per day at fixed intervals. After 12 days of controlled light exposure, the amplitude of amax of the photopic ERG was decreased in BL whereas it was increased in DL. In scotopic ERG, there was a difference in the retinal sensitivity (log K) between the two groups before light treatment that disappeared at the end of light exposure (p=.053). The percentage of melatonin suppression after 90 minutes exposure to the melatonin suppression test was decreased in BL while it did not changed in DL condition. This interaction, however, did not reach significance (p=.16). We measured a 58 minutes phase advance in the BL condition (p=.04) and a 26 minutes phase delay in DL (p=.32). Measures of subjective vigilance (EVA) suggested that BL subjects were more alert after the light treatment than DL subject (p=.02). However, there was no difference in the psychomotor vigilance task or mood. Light history did not modify the retinal sensitivity as predicted by the hypotheses. However, there was a trend toward an increased circadian sensitivity in the dim light condition. The improvement of subjective vigilance in the BL condition was not supported by the results at the psychomotor vigilance task. Light history had no effect on the mood of the subjects. Long-term effects of a light treatment are difficult to isolate from shorter direct effects of light. Moreover, the study of adaptative environmental changes that spontaneously appeared in the field are possibly masked in a laboratory setting where confinement could induce physiological and psychological changes.

An important strand of research has investigated the question of how children acquire a morphological system using offline data from spontaneous or elicited child language. Most of these studies have found dissociations in how children apply regular and irregular inflection (Marcus et al. 1992, Weyerts & Clahsen 1994, Rothweiler & Clahsen 1993). These studies have considerably deepened our understanding of how linguistic knowledge is acquired and organised in the human mind. Their methodological procedures, however, do not involve measurements of how children process morphologically complex forms in real time. To date, little is known about how children process inflected word forms. The aim of this study is to investigate children’s processing of inflected words in a series of on-line reaction time experiments. We used a cross-modal priming experiment to test for decompositional effects on the central level. We used a speeded production task and a lexical decision task to test for frequency effects on access level in production and recognition. Children’s behaviour was compared to adults’ behaviour towards three participle types (-t participles, e.g. getanzt ‘danced’ vs. -n participles with stem change, e.g. gebrochen ‘broken’ vs.-n participles without stem change, e.g. geschlafen ‘slept’). For the central level, results indicate that -t participles but not -n participles have decomposed representations. For the access level, results indicate that -t participles are represented according to their morphemes and additionally as full forms, at least from the age of nine years onwards (Pinker 1999 and Clahsen et al. 2004). Further evidence suggested that -n participles are represented as full-form entries on access level and that -n participles without stem change may encode morphological structure (cf. Clahsen et al. 2003). Out data also suggests that processing strategies for -t participles are differently applied in recognition and production. These results provide evidence that children (within the age range tested) employ the same mechanisms for processing participles as adults. The child lexicon grows as children form additional full-form representations for -t participles on access level and elaborate their full-form lexical representations of -n participles on central level. These results are consistent with processing as explained in dual-system theories. / Ein wichtiger Forschungsbereich hat anhand von offline Daten erforscht wie Kinder das morphologische System erwerben. Die meisten dieser Studien haben berichtet, dass Kinder die regelmäßige und die unregelmäßige Flexion unterschiedlich anwenden (Marcus et al. 1992, Weyerts & Clahsen 1994, Rothweiler & Clahsen 1993). Diese Studien haben dazu beigetragen den Erwerb und Organisation von linguistischem Wissen besser zu verstehen. Die offline Methoden messen morphologische Verarbeitung allerdings nicht in Echtzeit. Bis heute ist wenig darüber bekannt wie Kinder flektierte Wortformen in Echtzeit verarbeiten. Die vorliegende Arbeit hat diese Frage in 6- bis 11jährigen monolingualen Kindern (in zwei Altersgruppen) und in einer Erwachsenen-Kontrollgruppe anhand von -t Partizipien (z.B. gemacht), -n Partizipien ohne Stammveränderung (z.B. geschlafen) und -n Partizipien mit Stammveränderung (z.B. gebrochen) untersucht. Dekomposition von Partizipien und deren ganzheitliche Speicherung in assoziativen Netzwerken wurden auf zwei Repräsentationsebenen (zentrale Ebene, Zugriffebene) und, auf der Zugriffsebene, in zwei Modalitäten (Produktion, Verstehen) experimentell getestet. Ein cross-modal priming experiment untersuchte die zentrale Repräsentation von Partizipien. Volle morphologische Primingeffekte sprechen für eine dekomponierte Repräsentation, partielle Primingeffekte für ganzheitliche aber verbundene Repräsentationen. In einem speeded production experiment wurde die auditive Zugriffsrepräsentation und in einem lexical decision experiment die visuelle Zugriffsrepräsentation von Partizipien untersucht. (Ganzwort-) Frequenzeffekte wurden als Beleg für Ganzwortrepräsentationen gewertet. Bezüglich der zentralen Ebene zeigen die Ergebnisse, dass -t Partizipien aber nicht -n Partizipien dekomponiert repräsentiert sind. Bezüglich der Zugriffsebene zeigen die Ergebnisse, dass -t Partizipien entsprechend ihrer Morpheme repräsentiert sind und zusätzlich Ganzwortrepräsentationen haben können, zumindest im Altersbereich von Neun- bis Elfjährigen (Pinker 1999 and Clahsen et al. 2004). Weitere Ergebnisse zeigten, dass -n Partizipien auf der Zugriffsebene Ganzwortrepräsentationen haben, und dass -n Partizipien ohne Stammveränderung die morphologische Struktur enkodieren können (cf. Clahsen et al. 2003). Die Daten weisen auch darauf hin, dass die Verarbeitungsstrategien für -t Partizipien, zumindest in Neun- bis Elfjährigen, unterschiedlich angewandt werden. Die Ergebnisse werden als Evidenz dafür interpretiert, dass Kinder (in dem getesteten Altersbereich) dieselben Verarbeitungsmechanismen für Partizipien nutzen wie Erwachsene. Das kindliche Lexikon wächst, wenn Kinder zusätzliche Ganzwortrepräsentationen für -t Partizipien auf der Zugriffsebene bilden und ihre Ganzwortrepräsentationen für -n Partizipien auf der zentralen Ebene ausdifferenzieren. Diese Ergebnisse sind konsistent mit den Annahmen dualer Verarbeitungstheorien.

Background: The proportion of older individuals in the driving population is predicted to increase in the next 50 years. This has important implications for driving safety as abilities which are important for safe driving, such as vision (which accounts for the majority of the sensory input required for driving), processing ability and cognition have been shown to decline with age. The current methods employed for screening older drivers upon re-licensure are also vision based. This study, which investigated social, behavioural and professional aspects involved with older drivers, aimed to determine: (i) if the current visual standards in place for testing upon re-licensure are effective in reducing the older driver fatality rate in Australia; (ii) if the recommended visual standards are actually implemented as part of the testing procedures by Australian optometrists; and (iii) if there are other non-standardised tests which may be better at predicting the on-road incident-risk (including near misses and minor incidents) in older drivers than those tests recommended in the standards. Methods: For the first phase of the study, state-based age- and gender-stratified numbers of older driver fatalities for 2000-2003 were obtained from the Australian Transportation Safety Bureau database. Poisson regression analyses of fatality rates were considered by renewal frequency and jurisdiction (as separate models), adjusting for possible confounding variables of age, gender and year. For the second phase, all practising optometrists in Australia were surveyed on the vision tests they conduct in consultations relating to driving and their knowledge of vision requirements for older drivers. Finally, for the third phase of the study to investigate determinants of on-road incident risk, a stratified random sample of 600 Brisbane residents aged 60 years and were selected and invited to participate using an introductory letter explaining the project requirements. In order to capture the number and type of road incidents which occurred for each participant over 12 months (including near misses and minor incidents), an important component of the prospective research study was the development and validation of a driving diary. The diary was a tool in which incidents that occurred could be logged at that time (or very close in time to which they occurred) and thus, in comparison with relying on participant memory over time, recall bias of incident occurrence was minimised. Association between all visual tests, cognition and scores obtained for non-standard functional tests with retrospective and prospective incident occurrence was investigated. Results: In the first phase,rivers aged 60-69 years had a 33% lower fatality risk (Rate Ratio [RR] = 0.75, 95% CI 0.32-1.77) in states with vision testing upon re-licensure compared with states with no vision testing upon re-licensure, however, because the CIs are wide, crossing 1.00, this result should be regarded with caution. However, overall fatality rates and fatality rates for those aged 70 years and older (RR=1.17, CI 0.64-2.13) did not differ between states with and without license renewal procedures, indicating no apparent benefit in vision testing legislation. For the second phase of the study, nearly all optometrists measured visual acuity (VA) as part of a vision assessment for re-licensing, however, 20% of optometrists did not perform any visual field (VF) testing and only 20% routinely performed automated VF on older drivers, despite the standards for licensing advocating automated VF as part of the vision standard. This demonstrates the need for more effective communication between the policy makers and those responsible for carrying out the standards. It may also indicate that the overall higher driver fatality rate in jurisdictions with vision testing requirements is resultant as the tests recommended by the standards are only partially being conducted by optometrists. Hence a standardised protocol for the screening of older drivers for re-licensure across the nation must be established. The opinions of Australian optometrists with regard to the responsibility of reporting older drivers who fail to meet the licensing standards highlighted the conflict between maintaining patient confidentiality or upholding public safety. Mandatory reporting requirements of those drivers who fail to reach the standards necessary for driving would minimise potential conflict between the patient and their practitioner, and help maintain patient trust and goodwill. The final phase of the PhD program investigated the efficacy of vision, functional and cognitive tests to discriminate between at-risk and safe older drivers. Nearly 80% of the participants experienced an incident of some form over the prospective 12 months, with the total incident rate being 4.65/10 000 km. Sixty-three percent reported having a near miss and 28% had a minor incident. The results from the prospective diary study indicate that the current vision screening tests (VA and VF) used for re-licensure do not accurately predict older drivers who are at increased odds of having an on-road incident. However, the variation in visual measurements of the cohort was narrow, also affecting the results seen with the visual functon questionnaires. Hence a larger cohort with greater variability should be considered for a future study. A slightly lower cognitive level (as measured with the Mini-Mental State Examination [MMSE]) did show an association with incident involvement as did slower reaction time (RT), however the Useful-Field-of-View (UFOV) provided the most compelling results of the study. Cut-off values of UFOV processing (>23.3ms), divided attention (>113ms), selective attention (>258ms) and overall score (moderate/ high/ very high risk) were effective in determining older drivers at increased odds of having any on-road incident and the occurrence of minor incidents. Discussion: The results have shown that for the 60-69 year age-group, there is a potential benefit in testing vision upon licence renewal. However, overall fatality rates and fatality rates for those aged 70 years and older indicated no benefit in vision testing legislation and suggests a need for inclusion of screening tests which better predict on-road incidents. Although VA is routinely performed by Australian optometrists on older drivers renewing their licence, VF is not. Therefore there is a need for a protocol to be developed and administered which would result in standardised methods conducted throughout the nation for the screening of older drivers upon re-licensure. Communication between the community, policy makers and those conducting the protocol should be maximised. By implementing a standardised screening protocol which incorporates a level of mandatory reporting by the practitioner, the ethical dilemma of breaching patient confidentiality would also be resolved. The tests which should be included in this screening protocol, however, cannot solely be ones which have been implemented in the past. In this investigation, RT, MMSE and UFOV were shown to be better determinants of on-road incidents in older drivers than VA and VF, however, as previously mentioned, there was a lack of variability in visual status within the cohort. Nevertheless, it is the recommendation from this investigation, that subject to appropriate sensitivity and specificity being demonstrated in the future using a cohort with wider variation in vision, functional performance and cognition, these tests of cognition and information processing should be added to the current protocol for the screening of older drivers which may be conducted at licensing centres across the nation.

Diss. Linköping : Univ., 2002.

The purpose of the present investigation was to examine whether across-trials inconsistency in reaction time (RT), in addition to level of cognitive performance, is predictive of older adults’ performance on a measure of everyday problem solving through a series of three investigations. A sample of community dwelling non-demented older adults, ranging in age from 62 to 92, completed the Everyday Problems Test (EPT), a measure of everyday problem solving that indexes instrumental activities of daily living (IADLs). Performance on the EPT varied according to age, cognitive status, and education, and was significantly predicted by measures of global cognitive status, cognitive decline, and various basic cognitive abilities (i.e., speed of processing, fluid abilities, episodic memory, crystallized abilities). Both inconsistency and mean latencies on measures of RT were found to be significantly associated with concurrent EPT performance, such that slower and more inconsistent RTs were associated with poorer everyday problem solving abilities. Finally, inconsistency in RT made a unique contribution in predicting performance on the EPT two years later, over and above age, education, and various basic cognitive abilities. Structural equation modeling analyses indicated that the relationship between inconsistency in RT and future EPT performance was mediated by fluid and crystallized abilities. Neither inconsistency nor cognitive functioning were significantly associated with changes in EPT performance across two years. Examination of the relationships between IADL functioning, as assessed through self- and informant-report, and inconsistency and basic cognitive abilities demonstrated that everyday problem solving and measures of IADLs tap into related but distinct constructs. The overall pattern of results obtained lends support to the idea that inconsistency in RT represents a behavioural marker of neurological dysfunction. In addition, the present investigation is the first to suggest a relationship between inconsistency in RT and real-world outcomes, such as everyday problem solving and IADL functioning.

Η επιρροή του παράγοντα χρονοαπόσταση σε ένα σύστημα ακολουθίας οχημάτων μπορεί να προσδιορίσει την επικινδυνότητα του πλήγματος που υφίσταται το σύστημα. Με βάση μια παρ’ολίγον οπισθο-μετωπική σύγκρουση σε αυτοκινητόδρομο 3 λωρίδων, εξετάζεται ο ρόλος της χρονοαπόστασης μεταξύ των οχημάτων σε συνδυασμό με τους χρόνους αντίδρασης των οδηγών στην αντίληψη του επικείμενου κινδύνου. Το μοντέλο ακολουθίας οχημάτων κατά Brill, που συσχετίζει την χρονοαπόσταση, τον χρόνο αντίδρασης του οδηγού και την επιβράδυνση με τη συχνότητα των ατυχημάτων, χρησιμοποιείται ως κύριο εργαλείο για την εκτίμηση της ευαισθησίας της πιθανότητας ενός ατυχήματος. Μέσω της μικροσκοπικής ανάλυσης του βίντεο καταγραφής του ατυχήματος και της επεξεργασίας των δεδομένων και με πηγή έμπνευσης τα προγενέστερα επίμαχα ερωτήματα που θέτει και απαντά ο G. Davis και οι συνεργάτες του, προκύπτουν οι απαραίτητες πληροφορίες για την αριθμητική περιγραφή του ατυχήματος. Με τη χρήση έπειτα του λογισμικού προγράμματος OpenBUGS, το οποίο βασίζεται στη μέθοδο Monte Carlo Markov Chain, γίνεται προσομοίωση του προτύπου ατυχήματος και υπολογίζονται οι τιμές των παραμέτρων που επηρεάζουν τη μορφή του πλήγματος. Από τα αποτελέσματα προκύπτει ο βαθμός που ο συνδυαστικός παράγοντας χρονοαπόσταση και χρόνος αντίδρασης επηρεάζει το πλήγμα και αξιολογείται. Τέλος, με συγκεκριμένες επεμβάσεις επιχειρείται η βελτίωση ολόκληρου του συστήματος ακολουθίας οχημάτων. / The influence of time headway on a car-following system can determine the severity of a shockwave. Based on a near-miss rear-end collision on a 3-lane highway, this study examines the importance of time headway in combination with the driver’s reaction time upon perception of the upcoming hazard. The car-following model developed by Ed. Brill, relating driver’s reaction time, temporal headway and deceleration response to accident frequency, is used as a main tool for assessing the sensitivity of collision probability. Through a microscopic analysis of the video record and data processing and inspired by earlier critical questions that G. Davis and his associates have posed and answered, all the necessary information for the arithmetical description of the accident is extracted. Using the OpenBUGS software, and based on the Monte Carlo Markov Chain method, simulation of the collision prototype is achieved along with the calculation of other main parameters that affect the shockwave form. Simulation results, revealing the influence that the combined factor headway-reaction time has on a shockwave are derived and evaluated. Through certain modifications, the improvement of the whole car-following system is attempted.