Under senare år har klimatförändringar blivit alltmer märkbara i och med ökade förekomster av naturolyckor. Bland annat har skogsbränder, översvämningar och torka ökat i frekvens och kommer att öka ännu mer i framtiden, vilket kommer att ha konsekvenser för samhället. Även i Sverige har effekterna av klimatförändringar märkts av, till exempel genom att omfattande skyfall har drabbat områden såsom Gävleborg, Hammarö och Hagfors. Skyfallen har lett till omfattande översvämningar och skador som har inneburit stora kostnader för samhället. Som en del av arbetet med att hantera effekterna av ett förändrat klimat jobbar kommuner och länsstyrelser med klimatanpassning, vilket bland annat innefattar att ha beredskap vid händelse av naturkatastrofer. Detta innefattar exempelvis att kartlägga effekter av skyfall genom att göra skyfallskarteringar. I Håbo kommun har man inkluderat klimatanpassning i flera av sina policys och har sedan en tid tillbaka arbetat med att utreda effekterna av skyfall i kommunen. Sedan 2023 finns en skyfallskartering över hela Uppsala län, som även inkluderar Håbo kommun. För att kunna planera förebyggande åtgärder vill nu kommunen kartlägga konsekvenserna av 100- och 500-årsregn för ett antal samhällsviktiga verksamheter inom centrala Bålsta samt utreda vilka kostnader kommunen kan ställas inför.  I studien undersöktes byggnader och transportleder som ansågs prioriterade av Håbo kommun. Dessa byggnader och transportleder benämns som av kommunen prioriterade verksamheter (KPV). Med hjälp av den skyfallskartering som tidigare gjorts identifierades de KPV som kan komma att drabbas vid ett 100- och 500-årsregn. Dessa utvärderades sedan genom en sårbarhetsanalys och en ekonomisk analys. Sårbarhetsanalysen syftade till att identifiera de byggnader som kan komma att drabbas värst samt en ekonomisk analys som beräknade de direkta kostnader som kan uppkomma vid ett extremt skyfall. Resultatet visar att det är två skolor i Bålsta, Fridegården och Potentiaskolan, som kan komma att bli de mest drabbade byggnaderna och att Centrumleden kan komma att bli opasserbar för räddningstjänsten vid ett 500-årsregn. Resultaten visar att de direkta kostnaderna för de KPV-klassade byggnaderna vid ett extremt skyfall kan uppgå till 2-4 miljoner kronor.

The demand for workers with college level training in computer related skills is growing rapidly. Although the number of computer science jobs is growing, the percentage of these jobs currently held by women is lower than in 1983 (Commission on Professionals in Science and Technology, 2004). The underrepresentation of women and minorities in postsecondary computing education has become a major national concern (Cohoon & Aspray, 2006). Despite a growing literature on women in STEM fields, there is a lack of theoretical development about women's participation and attrition in computer related majors. The findings are often inconsistent and there are few discipline-specific guidelines for policy. An important next step is to examine these insights with confirmatory quantitative methods. Larsen and Stubbs (2005) argue that efforts to increase diversity in computer fields should be broad-based and move beyond gender. Factors that are successful in attracting and retaining a diverse population of undergraduates in computer related majors will also benefit women and minorities. The purpose of this quantitative study was to develop and test a model of factors influencing the satisfaction and persistence of undergraduates in computer related majors at two universities in Virginia. There were three major independent constructs: academic, social, and institutional factors. Dependent constructs were persistence and satisfaction. The sample was a convenience sample of classes at differing academic levels. A total of 388 students in computer-related majors were surveyed during regularly scheduled class sessions. Data analysis was conducted using structural equation modeling (SEM) techniques. The goal of SEM is to determine the extent to which a theoretical model is supported by data. Both measurement and structural models were tested. Results indicate that these factors have significant and substantive effects on satisfaction and persistence. They highlight the importance of faculty, peers, and family support for student satisfaction and retention, and the need to examine instruction and content in computer related majors. The findings suggest the need for further work in the measurement of the constructs, and for further refinement of the final model. In addition, comparison of individual item means suggest that models may vary significantly among majors and between white and minority students. Future research should continue to test and refine the model for the influence of academic, social, and institutional factors on student satisfaction and persistence in computer related majors so that educators and policy makers can enhance the academic and social support structures for students in these majors. / Ph. D.

The purpose of the present study was to attempt to reconcile the seemingly overwhelming body of empirical evidence arguing for the preeminence of general cognitive ability in relation to specific abilities with the general resistance of the majority of Industrial-Organizational psychologists to such a position. The contention of the present study was that the primary evidence used to support the view that specific abilities are of little importance relative to general cognitive ability did not faithfully represent the classic selection model and was based on tenuous assumptions about the operationalizations of general and specific cognitive abilities. By virtue of being defined in un-interpretable terms with respect to content or function, prior operationalizations of specific abilities did not lend themselves to logical and theoretical relationships with job specific job performance. The general thesis of the present study was that if a "construct oriented approach" that is largely based on this classic selection model were implemented, a composite of psychologically interpretable job related specific abilities would prove equivalent or even superior to general cognitive ability in the prediction of job performance. Results suggest implementation of the construct oriented approach demonstrates potential for the value of this approach with respect to balancing criterion related validity and social equity. / Ph. D.

More than half of the world's population works full time and spends about one-third of their weekdays at workplaces (International Labor Organization, 2022). Mental disorders are one of the health problems that have emerged among working populations (World Health Organization, 2022). Previous empirical research and theories demonstrated that nature exposure positively impacts human health and wellbeing (Kaplan and Kaplan 1989). Green roofs can be one of the most easily accessible nature places for office workers in city centers. This study examines the relationship between green roofs and work-related distress, mental fatigue, and restoration. An online survey of 179 employees was used to evaluate the relationship between exposure to six different green roofs and employee work-related distress, mental fatigue, and mental restoration. The results show that the average time spent on green roofs and the frequency of visits have statistically significant relationships with the mental restoration. / Doctor of Philosophy / More than half of the world's population works full time and spends about one-third of their weekdays at workplaces (International Labor Organization, 2022). Mental health issues are one of the health problems that have emerged among employees (World Health Organization, 2022). Previous research and theories demonstrated that nature contributes to human health and wellbeing in a very positive way (Kaplan and Kaplan 1989). This study investigates the relationship between green roofs and work-related stress and mental fatigue. This study evaluates employees' perceived stress and mental fatigue at work, their perception of onsite green roofs, and the restorative capacity of workplace green roofs using a 32-item online survey. 179 employees from four companies with at least one onsite green roof each answered the survey. The results showed that the average time spent on green roofs per visit, the frequency of visits, employees' attitudes and perceptions towards workplace green roofs, the organization's relevance with nature, the presence of diverse species on the green roof, and employees' knowledge about green roofs are related to the perceived restoration capacity of the green roof. The study contributes to understanding the relationship between the restorative capacity of green roofs and work-related psychosocial outcomes, employees' green roof use patterns, preferences, and green roof design attributes. Green roof designers, the green roof industry, and business owners can benefit from the study findings and implications to create more restorative green roofs, as well as happier and healthier workplaces.

Age-related macular degeneration (AMD) is one of the leading causes of blindness in adults over the age of 60. Currently, at least 11 million patients in the United States have some form of macular degeneration and this number is projected to grow as the population ages. The more severe form of the disease – neovascular (wet) AMD, is characterized by intraocular neovascularization, inflammation, and retinal damage; however, the disease progression can be deterred through intraocular injections of anti-angiogenic agents. The complications and burden that arise from repetitive injections as well as the difficulty posed by targeting the posterior segment of the eye make this an interesting territory for the development of novel drug delivery systems. New methods for drug delivery are being investigated exploring the use of nanoparticles and other polymeric materials. The goal of this project is to study the potential use of poly(lactide-co-glycolic acid)-polyethylene glycol (PLGA-PEG) nanoparticles in thermoreversible gels as localized sustained intraocular drug delivery. We prepared stable and reproducible corticosteroid-encapsulated nanoparticles in thermoreversible gels to inhibit vascular endothelial growth factor (VEGF) overexpression characteristic of neovascular AMD. We characterized the drug delivery system by obtaining size, shape, and drug encapsulation data. We also demonstrated that the polymer could be injected into the vitreous as a solution and transition to a gel phase based on the temperature difference between regular indoor environment and the vitreous body. The drug delivery system was tested on human retinal pigment epithelial cells (ARPE-19), for cytotoxicity, uptake and VEGF expression. We also examined the drug delivery system's ability to mitigate the disease progression in a mouse model of choroidal neovascularization (CNV). The effect on blood vessel area was shown and the changes in the mRNA expression of angiogenesis mediators were analyzed by real-time reverse transcription polymerase chain reaction (RT-PCR). These results indicate that the proposed drug delivery systems has the promise to be developed for retinal diseases, involving CNV, including neovascular AMD. Further studies are warranted in developing this promising intraocular drug delivery system for wet AMD and similar ophthalmic diseases. / Ph. D.

Yes / Knowledge of the underlying mechanisms of effortful listening could help to reduce cases of social withdrawal and mitigate fatigue, especially in older adults. However, the relationship between transient effort and longer-term fatigue is likely to be more complex than originally thought. Here, we manipulated the presence/absence of monetary reward to examine the role of motivation and mood state in governing changes in perceived effort and fatigue from listening. In an online study, 185 participants were randomly assigned to either a ‘reward’ (n = 91) or ‘no-reward’ (n = 94) group and completed a dichotic listening task along with a series of questionnaires assessing changes over time in perceived effort, mood, and fatigue. Effort ratings were higher overall in the reward group, yet fatigue ratings in that group showed a shallower linear increase over time. Mediation analysis revealed an indirect effect of reward on fatigue ratings via perceived mood state; reward induced a more positive mood state which was associated with reduced fatigue. These results suggest that: (a) listening conditions rated as more ‘effortful’ may be less fatiguing if the effort is deemed worthwhile, and (b) alterations to one’s mood state represents a potential mechanism by which fatigue may be elicited during unrewarding listening situations.

The research presented herein is a combination of work done in two distinct subcategories of sport related head injury research. The body of work is aimed at increasing the understanding of head impact biomechanics across a broad spectrum of impact scenarios as well as the ability of helmets to affect head impact biomechanics over time. The first study utilizes in situ testing of controlled impacts of an instrumented head form to more fully characterize head accelerations resulting from impacts to the ice, board, and glass surfaces present in an ice hockey rink. The full characterization of head impacts across a spectrum of loading conditions and impact surfaces gives researchers insight into head impact tolerance and head protection capabilities and limitations in ice hockey. The second study details the development of a method to impact helmet pads for repeated loading studies based on published head impact exposure data. The third study uses this newly developed methodology to test the effects of a season of impacts on the energy absorbing properties of three different helmet padding technologies. The body of work is aimed at increasing understanding of head impact and concussion and the ability of existing helmet technologies to prevent these injuries with a goal of reducing the occurrence of injury. / Master of Science

Sexual victimization is a significant problem on college and university campuses, and it is important to evaluate risk factors for sexual victimization in order to attempt to reduce women's risk of victimization. This study investigated social interaction anxiety as a risk factor for sexual victimization. It was hypothesized that social interaction anxiety may increase risk of sexual victimization by decreasing sexual assertiveness and increasing alcohol-related problems. College women (n = 690) completed an online survey that assessed social interaction anxiety, sexual assertiveness, alcohol-related problems, and a variety of types of sexual victimization, in addition to other measures. When total effects were examined, social interaction anxiety only significantly predicted victimization by coercion. However, when indirect effects of sexual assertiveness were examined, social interaction anxiety had a significant effect on all types of sexual victimization (i.e., unwanted sexual contact, attempted coercion, coercion, attempted rape, and rape). Alcohol-related problems did not significantly account for the relationship between social interaction anxiety and sexual victimization. It is recommended that interventions designed to reduce women's risk of victimization include interventions designed to address both social interaction anxiety and sexual refusal assertiveness. / Master of Science

Yes / Objectives: Listening-related fatigue can be a significant problem for adults who struggle to hear and understand, particularly adults with hearing loss. However, valid, sensitive, and clinically useful measures for listening-related fatigue do not currently exist. The purpose of this study was to develop and validate a brief clinical tool for measuring listening-related fatigue in adults. Design: The clinical scale was derived from the 40-item version of the Vanderbilt Fatigue Scale for Adults (VFS-A-40), an existing, reliable, and valid research tool for measuring listening9 related fatigue. The study consisted of two phases. Phase 1 (N = 580) and Phase 2 (N = 607) participants consisted of convenience samples of adults recruited via online advertisements, clinical records review, and a pool of prior research participants. In Phase 1, results from item response theory (IRT) analyses of VFS-A-40 items were used to identify high quality items for the brief (10-item) clinical scale: the VFS-A-10. In Phase 2, the characteristics and quality of the VFS-A-10 were evaluated in a separate sample of respondents. Dimensionality was evaluated using exploratory factor analyses (EFA) and item quality and characteristics were evaluated using IRT. VFS-A-10 reliability and validity were assessed multiple ways. IRT reliability analysis was used to examine VFS-A-10 measurement fidelity. In addition, test-retest reliability was assessed in a subset of Phase 2 participants (n = 145) who completed the VFS-A-10 a second time approximately one month after their initial measure (range 5-90 days). IRT differential item functioning (DIF) was used to assess item bias across different age, gender, and hearing loss subgroups. Convergent construct validity was evaluated by comparing VFS-A-10 responses to two other generic fatigue scales and a measure of hearing disability. Known-groups validity was assessed by comparing VFS-A-10 scores between adults with and without self reported hearing loss Results: EFA suggested a unidimensional structure for the VFS-A-10. IRT analyses confirmed all test items were high quality. IRT reliability analysis revealed good measurement fidelity over a wide range of fatigue severities. Test-retest reliability was excellent (rs = .88, collapsed across participants). IRT DIF analyses confirmed the VFS-A-10 provided a valid measure of listening29 related fatigue regardless of respondent age, gender, or hearing status. An examination of associations between VFS-A-10 scores and generic fatigue/vigor measures revealed only weak31 to-moderate correlations (Spearman’s correlation coefficient rs = -.36 to .57). Stronger associations were seen between VFS-A-10 scores and a measure of perceived hearing difficulties (rs = .79 to .81) providing evidence of convergent construct validity. In addition, the VFS-A-10 was more sensitive to fatigue associated with self-reported hearing difficulties than generic measures. It was also more sensitive than generic measures to variations in fatigue as a function of degree of hearing impairment. Conclusions: These findings suggest that the VFS-A-10 is a reliable, valid, and sensitive tool for measuring listening-related fatigue in adults. Its brevity, high sensitivity, and good reliability make it appropriate for clinical use. The scale will be useful for identifying those most affected by listening-related fatigue and for assessing benefits of interventions designed to reduce its negative effects. / Starkey Inc, NIH National Institute on Deafness and Other Communication Disorders (NIDCD) Grant #R21DC012865, NICHD Grant P30HD15052 to the Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt Institute for Clinical and Translational Research grant (UL1 TR000445 from NCATS/NIH)

No / Runt-related (RUNX) transcription factors are evolutionarily conserved either in vertebrate or invertebrate. Lozenge (Lz), a members of RUNX family as well as homologue of AML-1, functions as an important transcription factor regulating the hemocytes differentiation. In this paper, we identified and characterized RUNX family especially Lz in silkworm, which is a lepidopteran model insect. The gene expression analysis illustrated that BmLz was highly expressed in hemocytes throughout the whole development period, and reached a peak in glutonous stage. Over-expression of BmLz in silkworm accelerated the melanization process of hemolymph, and led to instantaneously up-regulation of prophenoloxidases (PPOs), which were key enzymes in the melanization process. Further down-regulation of BmLz expression by RNA interference resulted in the significant delay of melanization reaction of hemolymph. These findings suggested that BmLz regulated the melanization process of hemolymph by inducing PPOs expression, and played a critical role in innate immunity defense in silkworm.