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431	Blocking the MyD88-Dependent Pathway Protects the Myocardium From Ischemia/Reperfusion Injury in Rat Hearts Hua, Fang, Ha, Tuanzhu, Ma, Jing, Gao, Xiang, Kelley, Jim, Williams, David L., Browder, I. William, Kao, Race L., Li, Chuanfu 16 December 2005 (has links) We examined whether blocking the MyD88 mediated pathway could protect myocardium from ischemia/reperfusion (I/R) injury by transfecting Ad5-dnMyD88 into the myocardium of rats (n = 8) 3 days before the hearts were subjected to ischemia (45 min) and reperfusion (4 h). Ad5-GFP served as control (n = 8). One group of rats was (n = 8) subjected to I/R without transfection. Transfection of Ad5-dnMyD88 significantly reduced infarct size by 53.6% compared with the I/R group (15.1 ± 3.02 vs 32.5 ± 2.59) while transfection of Ad5-GFP did not affect I/R induced myocardial injury (35.4 ± 2.59 vs 32.5 ± 2.59). Transfection of Ad5-dnMyD88 significantly inhibited I/R-enhanced NFκB activity by 50% and increased the levels of phospho-Akt by 35.6% and BCL-2 by 81%, respectively. Cardiac myocyte apoptosis after I/R was significantly reduced by 59% in the Ad5-dnMyD88 group. The results demonstrate that both inhibition of the NFκB activation pathway and activation of the Akt signaling pathway may be responsible for the protective effect of transfection of dominant negative MyD88. dominant negative MyD88 myocardial ischemia/reperfusion nuclear factor kappaB signaling pathway toll-like receptors Surgery
432	The Endocannabinoid System and Heart Disease: The Role of Cannabinoid Receptor Type 2 Fulmer, Makenzie L., Thewke, Douglas P. 01 January 2018 (has links) Decades of research has provided evidence for the role of the endocannabinoid system in human health and disease. This versatile system, consisting of two receptors (CB1 and CB2), their endogenous ligands (endocannabinoids), and metabolic enzymes has been implicated in a wide variety of disease states, ranging from neurological disorders to cancer. CB2 has gained much interest for its beneficial immunomodulatory role that can be obtained without eliciting psychotropic effects through CB1. Recent studies have shed light on a protective role of CB2 in cardiovascular disease, an ailment which currently takes more lives each year in Western countries than any other disease or injury. By use of CB2 knockout mice and CB2-selective ligands, knowledge of how CB2 signaling affects atherosclerosis and ischemia has been acquired, providing a major stepping stone between basic science and translational clinical research. Here, we summarize the current understanding of the endocannabinoid system in human pathologies and provide a review of the results from preclinical studies examining its function in cardiovascular disease, with a particular emphasis on possible CB2-targeted therapeutic interventions to alleviate atherosclerosis. 2-AG AEA atherosclerosis cannabinoids CB1 CB2 ischemia/reperfusion. Biomedical Sciences
433	Graft Reconditioning With Nitric Oxide Gas in Rat Liver Transplantation From Cardiac Death Donors. / ラット心停止ドナー肝移植に対する一酸化窒素を用いた臓器保存法の検討 Kageyama, Shoichi 25 November 2014 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第18645号 / 医博第3944号 / 新制\|\|医\|\|1006(附属図書館) / 31559 / 京都大学大学院医学研究科医学専攻 / (主査)教授伊達洋至, 教授羽賀博典, 教授千葉勉 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM Liver transplantation Cardiac death donor Organ preservation Ischemia-reperfusion injury Warm ischemia 490
434	Impact of the cardiac arrest mode on cardiac death donor lungs / 心停止条件の違いによる心停止ドナー肺への影響 Yamada, Tetsu 23 July 2015 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第19226号 / 医博第4025号 / 新制\|\|医\|\|1011(附属図書館) / 32225 / 京都大学大学院医学研究科医学専攻 / (主査)教授福田和彦, 教授木村剛, 教授三嶋理晃 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM Lung transplantation Donation after cardiac death Donor Ischemia-reperfusion injury 490
435	β2-Adrenoreceptor Agonist Inhalation During Ex Vivo Lung Perfusion Attenuates Lung Injury / 体外肺潅流中のβ2受容体アゴニスト吸入は肺障害を緩和する Kondo, Takeshi 23 March 2016 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第19556号 / 医博第4063号 / 新制\|\|医\|\|1012(附属図書館) / 32592 / 京都大学大学院医学研究科医学専攻 / (主査)教授小池薫, 教授福田和彦, 教授三嶋理晃 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM lung transplantation ischemia reperfusion injury ex vivo lung perfusion donation after cardiac death 490
436	Reconditioning Lungs Donated After Cardiac Death Using Short-Term Hypothermic Machine Perfusion / 短時間低温肺潅流保存による心停止ドナー肺の修復 Nakajima, Daisuke 25 July 2016 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第19923号 / 医博第4143号 / 新制\|\|医\|\|1017(附属図書館) / 33009 / 京都大学大学院医学研究科医学専攻 / (主査)教授木村剛, 教授福田和彦, 教授羽賀博典 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM Hypothermic machine perfusion DCD Ischemia-reperfusion injury Lung transplantation ROS 490
437	Protective effect of pre-recovery surfactant inhalation on lungs donated after cardiac death in a canine lung transplantation model / イヌ心停止ドナー肺移植モデルにおいて摘出前サーファクタント吸入は保護効果を持つ Ohsumi, Akihiro 23 January 2017 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20081号 / 医博第4174号 / 新制\|\|医\|\|1018(附属図書館) / 33197 / 京都大学大学院医学研究科医学専攻 / (主査)教授湊谷謙司, 教授福田和彦, 教授浅野雅秀 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM ischemia-reperfusion injury cardiac death transplantation surfactant inhalation warm ischemia 490
438	Oral administration of polyamines ameliorates liver ischemia-reperfusion injury and promotes liver regeneration in rats. / ポリアミンの経口投与は、ラットの肝虚血再灌流障害を軽減し、肝再生を促進させる Okumura, Shinya 23 March 2017 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20219号 / 医博第4178号 / 新制\|\|医\|\|1019(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授小西靖彦, 教授小池薫, 教授坂井義治 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM polyamine Oral administration ischemia-reperfusion injury liver regeneration liver transplantation 490
439	The Protective Function of Galectin-9 in Liver Ischemia and Reperfusion Injury in Mice / マウス肝虚血再灌流障害におけるガレクチン-9の保護効果 Hirao, Hirofumi 23 March 2017 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20251号 / 医博第4210号 / 新制\|\|医\|\|1020(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授妹尾浩, 教授湊谷謙司, 教授江藤浩之 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM galectin-9 ischemia reperfusion injury liver T-cell immunoglobulin and mucin domain 3 490
440	Thrombomodulin Attenuates Inflammatory Damage Due to Liver Ischemia and Reperfusion Injury in Mice in Toll-Like Receptor 4-Dependent Manner / マウス肝虚血再灌流障害におけるトロンボモデュリンのToll-Like Receptor 4依存性の抗炎症効果の解明 Kadono, Kentaro 23 March 2017 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20267号 / 医博第4226号 / 新制\|\|医\|\|1021(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授妹尾浩, 教授坂井義治, 教授竹内理 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DGAM liver ischemia and reperfusion injury thrombomodulin toll-Like Receptor 4 HMGB-1 490

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