Cross-cultural exchange between individuals, both through face-to-face encounter and, more recently, electronic media, has been widely promoted as a means of educating against prejudice. Through the integration of structured field study, practical experience, educational and social theory, and contemporary philosophy, this thesis challenges the very foundations upon which such initiatives are built, and develops an alternative basis from which to approach cross-cultural exchange. An exploration of social categorisation posits the foundations of prejudice in essentialist conceptualisations, whether under the umbrella of universalism or relativism. The historical propensity for antiracist and multicultural education to reify group difference and reinforce such essentialist conceptualisations of identity thus presents an interesting conundrum. The fact that similar tendencies are noted in contemporary practice, educational resources, and official guidance, gives this more than an academic interest. Despite the apparent advantages of abandoning essentialist categorisations, studies of communication and identity formation reveal contradictory evidence - the need to locate others socially and to predict their behaviour accordingly, both in face-to-face and electronic communication. Thus, the challenge for educators is to develop innovative pedagogical approaches that translate contemporary, non-essentialist, understandings of group categorisation into workable practices to overcome inequality. While, within such a programme, cross-cultural exchange might be seen to have a valuable role to play alongside structural reform, it is clear that alone it cannot provide a panacea for prejudice. In the light of the above, the thesis addresses guidance for good practice in crosscultural exchange, and the related complexity of programme evaluation, alongside the training of future facilitators of such projects. A particular emphasis is placed upon the use of participatory arts and the unique tools this medium can bring to inclusive, cross-cultural collaboration. The thesis demonstrates, that cross-cultural exchange has the potential to provide valuable and significant learning experiences, some of which have previously been given little recognition.

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Typescript. / Thesis (Ph. D.)--University of Hawaii, 1966. / Bibliography: leaves 71-74. / ix, 74 l illus., tables

Typescript. / Thesis (Ph. D.)--University of Hawaii, 1966. / Bibliography: leaves 69-74. / iv, 74 l illus., tables

Floods are considered to be among of the deadliest, costliest and most common natural disasters. Rapid onset, catastrophic floods inundate the shore quickly and manifest as deep water with high velocities. The deep water and high velocities caused by these floods inflict great pressures and forces on the built and natural environments and pose a threat to human safety. Recent disasters such as Hurricane Katrina in the Southern United States and the Sumatra tsunami in the Indian Ocean have revealed that communities at risk require improved preparations for these types of dangerous events. Current building codes, design practices and disaster planning methods account for potential earthquake and wind loads on simple wood frame buildings typical of North American residential construction, however, flood impacts have not been considered in the same level of depth. The objectives of this research are to develop a theoretical model that describes flood impacts on wood frame residential buildings and relates building response to physical flood properties such as depth and velocity. This thesis provides a brief synopsis of previous approaches used to describe building response to flooding. An overview of the major loads caused by rapid onset flooding, along with a description of the structural system utilized in wood design to resist these forces is provided. The failure mechanisms considered and the model logic are described and applied to assess the response of a typical Canadian wood frame home to flood conditions that might be experienced in a rapid onset flood event like a tsunami. Building response results are discussed along with recommendations for future analysis and applications.

In this thesis, I explore the implications of integral theory for sustainable development and climate change response. Integral theory seeks to integrate objective and subjective perspectives using a developmental orientation. It addresses issues of subjectivity that have received inadequate attention in mainstream approaches to sustainable development, while also providing theoretical grounding for the developmental aspect of sustainable development. According to integral theory, there are four main epistemological approaches to any problem: behavioural, systemic, psychological and cultural. The first is objective and individual, the second objective and collective, the third subjective and individual and the fourth subjective and collective. Development occurs within each of these realms. To test the value and implications of integral theory for sustainable development, I adopt a case study on climate change response in Australia. I begin the case study by using the four perspectives of integral theory to guide a review of the energy and climate change literature. I follow the literature review with a critical review of Australian energy and greenhouse policy, providing the starting point for development of an integral climate change response. While there is attention to subjectivity in the literature, it is not reflected in Australian policy practices. An objective perspective and an instrumental form of rationality dominate policy. In the literature review, I identify two gaps in the literature that deserve attention. The first is the role of public subsidies in creating the observed cost differential between renewable energy sources and fossil fuel energy. I examine the relative magnitude of subsidies to fossil fuels and renewable energy in the Australian energy and transport sectors and conclude that the distribution of these subsidies distorts the market in favour of fossil fuels, particularly in the transport sector. The second is the application of a developmental perspective to cultural theories of climate policy discourse. I introduce a method called meta-discourse analysis to identify consistencies and relationships across discourse descriptions by different authors and demonstrate that aspects of each discourse can be related developmentally. Drawing on the literature review, policy review and other work, I propose an integral policy response to climate change that could be applied in Australia. The policy response combines participatory integrated assessment, normative futures work, a modified version of the cooperative discourse model for public participation, an evolutionary policy orientation and several methods to promote subjective development. The proposed policy approach should be equally applicable to other sustainable development issues.

Research Doctorate - Doctor of Philosophy (PhD) / Asthma involves chronic inflammation of the airways that is heterogeneous in nature. Eosinophilic airway responses are well described in asthma, however non-eosinophilic subtypes of asthma have been recently reported, and can involve the influx of neutrophils into the airways (neutrophilic asthma). Neutrophils are important effector cells of the innate immune system. These cells are the first to migrate to inflammatory sites, where they contain and eliminate pathogenic microorganisms. Neutrophils also release cytokines and chemokines that initiate and amplify inflammatory responses. The mechanisms of neutrophilic asthma remain largely unknown; however activation of the innate immune response is implicated, particularly increased levels of proinflammatory cytokines Interleukin (IL)-8 and IL-1beta and gene expression of Toll Like Receptor (TLR)-4 and TLR2 have been demonstrated in induced sputum samples. This thesis examines innate immune responses of airway and circulating neutrophils, with a focus on neutrophilic asthma. Innate immune neutrophil activation occurs in response to exposure to Lipopolysaccharide (LPS), which activates TLR4. The activation response consists of the release of preformed granule associated mediators such as Matrix Metalloproteinase (MMP)-9 and Oncostatin M (OSM), new gene transcription and release of inflammatory cytokines such as IL-8, IL-1beta and Tumor Necrosis Factor (TNF)-alpha, and new gene transcription of TLR2 & TLR4 which serve to amplify neutrophil responses. In addition, this thesis examines whole genome gene expression profiles of circulating neutrophils in neutrophilic and eosinophilic asthma. The aims of this thesis are based on the hypothesis that dysregulation of innate immune neutrophil responses occurs with ageing and airway disease, particularly neutrophilic asthma and chronic obstructive pulmonary disease (COPD). With advancing age, there were alterations in the innate immune responses of neutrophils, which were characterised by enhanced spontaneous activation of both airway and circulating neutrophils, and a decreased response of circulating neutrophils to LPS. There was a decreased activation of airway neutrophils in airway disease that was most pronounced in neutrophilic asthma and COPD, with decreased production and release of proinflammatory cytokines most likely due to a downregulation of TLR4. TLR2 was downregulated in resting and LPS stimulated circulating neutrophils in asthma, particularly neutrophilic asthma. Circulating neutrophils had a decreased spontaneous release of total MMP-9, and downregulation of OSM, TLR2 and TLR4 at rest in COPD. However when stimulated with LPS, subjects with COPD had an enhanced proinflammatory cytokine release, with increases in IL-8 and TNF-alpha compared to subjects with asthma or healthy controls. Analysis of whole genome gene expression of circulating neutrophils in asthma revealed distinct gene profiles relating to asthma subtype. There was upregulation of genes relating to cell motility, inhibition of apoptosis and the NF-kB in neutrophilic asthma, which would contribute to their accumulation in the airways. The innate immune response is critical in controlling infections by bacteria and viruses. The reduced innate immune response of airway neutrophils in airway disease could contribute to impaired local defense, which may lead to an increased susceptibility to infection by invading pathogens. Systemically, the molecular mechanisms of neutrophilic asthma are distinct from eosinophilic asthma and may involve the enhancement of neutrophil chemotaxis and survival, contributing to their accumulation in the airways.

Aims of the research:To characterise the tissue histology and tissue distribution patterns of C. albicans during systemic murine candidiasis.To develop a reliable, reproducible and sensitive SQ-RT-PCR for the quantitation of in vivo cytokine gene transcription.To use this technique to determine the in vivo pattern of tissue specific cytokine gene expression during systemic candidiasis.To determine if cytokine gene expression patterns vary between resistant BALB/c and sensitive CBA/CaH mice during primary systemic candidiasis.To determine if differences in tissue distribution of C. albicans in infected mice is matched by differences in tissue responses to infection.To determine if cytokine mRNA expression patterns during secondary systemic candidiasis, are different to those during primary systemic candidiasis.To determine if cytokine gene expression patterns vary between resistant BALB/c and sensitive CBA/CaH mice during secondary systemic candidiasis.