Le travail de recherche de cette thèse traite de la problématique de transfert de connaissances lors du processus de transition d’un projet informatique externalisé dans un EPST. En particulier, Comment transférer les connaissances, constituées des expériences-succès ou échecs passés, routines, assimilées et cumulées pendant la durée d’un projet externalisé par les membres d’une équipe sortante vers une nouvelle équipe entrante d’une manière efficiente ? Nous nous focalisons sur ce processus de transition en raison de son importance pour le succès de l’externalisation informatique, de sa complexité, de sa richesse théorique et le manque d’études dans ce domaine. Nous avons choisi d’approcher cette problématique par le biais de la gestion des connaissances. Dans un premier volet de cette thèse, nous nous sommes appuyées sur le paradigme Goal-Question-Metric proposant une démarche de définition de la qualité pour progresser de notre besoin opérationnel jusqu’à la définition des métriques d’évaluation de la robustesse utilisant des informations issues de l’analyse de réseaux informels sous-jacents aux activités effectuées dans le processus métier. Ces métriques permettent d’évaluer une partie de la qualité d’un processus métier en tenant compte de la connaissance tacite des acteurs du processus de transition. Dans un second volet de cette recherche, nous avons développés une méthode, en nous appuyant sur l’approche de capitalisation sur les connaissances et des mécanismes théoriques de transfert de connaissances, et un outil informatique pour mettre en œuvre ce processus de transfert de connaissances / The research of this thesis deals with the issue of knowledge transfer during the transition process of an IT project outsourced in EPST. In particular, How to transfer knowledge, experience and routines related to outsourced activities from outgoing team to a new incoming team? We focus on the transition due to its significance for outsourcing success, its complexity and theoretical richness, and its limited current understanding. We chose to approach this problem through knowledge management. In the first part of this thesis, based on the Goal-Question-Metric paradigm, we propose an approach for the definition of quality metrics covering the given operational requirements. The metrics we define take tacit knowledge into account, using information from the structural analysis of an informal network. In a second phase of this research, we developed a method, relying on capitalization on knowledge and theoretical mechanisms of knowledge transfer, and a tool to implement this process of knowledge transfer

京都大学 / 0048 / 新制・課程博士 / 博士(工学) / 甲第22417号 / 工博第4678号 / 新制||工||1730(附属図書館) / 京都大学大学院工学研究科社会基盤工学専攻 / (主査)教授 高橋 良和, 教授 清野 純史, 教授 八木 知己 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DFAM

No description available.

Intensity modulated proton therapy (IMPT) in head and neck squamous cell carcinoma (HNSCC) offers superior advantages over conventional photon therapy, by generating high conformal doses to the target volume and improved sparing of the organ at risks (OARs). Besides, robust treatment planning approaches, which account for uncertainties directly into the plan optimization process, are able to generate high quality plans robust against uncertainties compared to a PTV margin expansion approach. During radiation treatment, patients are prone to present anatomical variations during the treatment course, which can be random deviations in patient positioning, as well as treatment-induced tumor shrinkage and patient weight variations. For IMPT plans using a PTV margin expansion, these anatomical variations might disturb the calculated nominal plan, with a decrease to the dose delivered to the target volume and/or increased dose to the OARs above its tolerance, and a plan adaptation might be needed. However, the influence of these anatomical variations in robustly optimized plans for HNSCC entities has not been determined. The first part of this thesis compared two proton therapy methods, single-field optimization (SFO) and multi-field optimization (MFO), applied to the treatment of unilateral HNSCC target volumes, consisting of a cohort of 8 patients. For each method, a PTV-based and a robustly optimized plan were generated, resulting in four plans per patient. The four plans showed adequate target coverage on the nominal plan, with larger doses to the ipsilateral parotid gland for both SFO approaches. No plan showed a clear advantage when variations in the anatomy during the treatment course were considered, and the same was observe considering additional setup and range uncertainties. Hence, no plan showed a decisive superiority regarding plan robustness and potential need of replanning. In the second part of this thesis, an anatomical robustly optimized plan approach was proposed (aRO), which considers additional CT datasets in the plan optimization, representing random non-rigid patient positioning variations. The aRO approach was compared to a classical robustly optimized plan (cRO) and a PTV-based approach for a cohort of 20 bilateral HNSCC patients. PTV-based and cRO approaches were not sufficient to account for weekly anatomical variations, showing a degradation in the target coverage in 10 and 5 of 20 cases, respectively. Conversely, the proposed aRO approach was able to preserve the target coverage in 19 of 20 cases, with only one patient requiring plan adaptation. An extended robustness analysis conducted on both cRO and aRO plan approaches considering weekly anatomical variations, setup and range errors, showed that the variations in anatomy were the most critical variable for loss in target coverage, while setup and range uncertainties played a minor role. The price of the increased plan robustness for the aRO approach was a significant larger integral dose to the healthy tissue, compared to the cRO plan. However, the increase in integral dose was not reflected on the planned dose to the OARs, which were comparable between both plans. Therefore, the price for a superior plan robustness can be considered as low. In the current clinical practice, the implementation of the aRO approach would be able to reduce the need of plan adaptation. For its application, the acquisition of additional planning CT datasets, considering a complete patient repositioning between scans is required, in order to simulate random non-rigid position variations as simulated in this study by the use of the first two weekly cCTs in the plan optimization. Further studies using multiple planning CT acquisition, including strategies to reduce the patient CT dose such as dual-energy CT and iterative reconstruction algorithms, are needed to confirm the presented findings. Additionally, the aRO approach applied to other body sites and entities might also be investigated. In near future, further in-room imaging methods such as cone-beam CT and magnetic resonance imaging, optimized for proton therapy, might be used to acquire additional datasets. Moreover, alternative approaches capable of modeling variations in patient positioning as biomechanical models and deep learning methods might be able to generate in silico additional image datasets for use in proton treatment planning. In summary, this thesis proposes an additional contribution for robust treatment planning in IMPT, with the generation of treatment plans robust against anatomy variations, together with setup and range uncertainties, which can benefit the clinical workflow by reducing the need of plan adaptation.:Contents List of Figures List of Tables List of Abbreviations 1 Introduction 2 Proton Therapy 2.1 Rationale for Proton Therapy 2.2 Beam Delivery Techniques 2.2.1 Passive Scattering 2.2.2 Pencil Beam Scanning 2.3 Uncertainties in Proton Therapy 2.3.1 Target Volume Definition 2.3.2 Range Uncertainty 2.3.3 Setup Uncertainty 2.3.4 Biological Uncertainty 2.3.5 Anatomical Variations 3 Robust Treatment Planning and Robustness Evaluation 3.1 Robust Treatment Planning 3.1.1 Including Uncertainties in the Optimization 3.1.2 Differences Between Approaches 3.2 Robustness Evaluation 3.2.1 Error Scenarios 3.2.2 Visual Evaluation of Plan Robustness 3.2.3 Summary 4 Illustration of Robust Treatment Planning in a Simple Geometry 4.1 Plan Design 4.2 Plan Results 4.2.1 Doses on Nominal Plan 4.2.2 Influence of Uncertainties in Plan Robustness 4.3 Discussion and Conclusion 5 Evaluation of Robust Treatment Plans in Unilateral Head and Neck Squamous Cell Carcinoma 5.1 Study Design 5.1.1 Calculation Parameters 5.1.2 Plan Robustness Evaluation 5.2 Results 5.2.1 Evaluation of Nominal Plan Doses 5.2.2 Evaluation of Plan Robustness Against Uncertainties 5.3 Discussion 5.4 Conclusions 6 Assessment of Anatomical Robustly Optimized Plans in Bilateral Head and Neck Squamous Cell Carcinoma 6.1 Anatomical Robust Optimization 6.2 Study Design 6.2.1 Calculation Parameters 6.2.2 Assessment of Plan Robustness 6.3 Results 6.3.1 Evaluation of Nominal Plan Doses 6.3.2 Evaluation of Plan Robustness Against Uncertainties 6.4 Discussion 6.4.1 Robustness Against Anatomical Variations 6.4.2 Robustness Against Additional Setup and Range Uncertainties 6.4.3 Study Limitations 6.5 Conclusions 7 Summary 8 Zusammenfassung Bibliography Appendix

Dans le cadre de l'acquisition de l'information de profondeur de scènes texturées, un processus d'estimation de la profondeur basé sur la méthode de reconstruction 3D « Shape from Focus » est présenté dans ce manuscrit. Les deux étapes fondamentales de cette approche sont l'acquisition de la séquence d'images de la scène par sectionnement optique et l'évaluation de la netteté locale pour chaque pixel des images acquises. Deux systèmes d'acquisition de cette séquence d'images sont présentés ainsi que les traitements permettant d'exploiter celle-ci pour la suite du processus d'estimation de la profondeur. L'étape d'évaluation de la netteté des pixels passe par la comparaison des différents opérateurs de mesure de netteté. En plus des opérateurs usuels, deux nouveaux opérateurs basés sur les descripteurs généralisés de Fourier sont proposés. Une méthode nouvelle et originale de comparaison est développée et permet une analyse approfondie de la robustesse à différents paramètres des divers opérateurs. Afin de proposer une automatisation du processus de reconstruction, deux méthodes d'évaluation automatique de la netteté sont détaillées. Finalement, le processus complet de reconstruction est appliqué à des scènes agronomiques, mais également à une problématique du domaine de l'analyse de défaillances de circuits intégrés afin d'élargir les domaines d'utilisation / In the context of the acquisition of depth information for textured scenes, a depth estimation process based on a 3D reconstruction method called "shape from focus" is proposed in this thesis. The two crucial steps of this approach are the image sequence acquisition of the scene by optical sectioning and the local sharpness evaluation for each pixel of the acquired images. Two acquisition systems have been developed and are presented as well as different image processing techniques that enable the image exploitation for the depth estimation process. The pixel sharpness evaluation requires comparison of different focus measure operators in order to determine the most appropriate ones. In addition to the usual focus measure operators, two news operators based on generalized Fourier descriptors are presented. A new and original comparison method is developped and provides a further analysis of the robustness to various parameters of the focus measure operators. In order to provide an automatic version of the reconstruction process, two automatic sharpness evaluation methods are detailed. Finally, the whole reconstruction process is applied to agronomic scenes, but also to a problematic in failure analysis domain aiming to expand to other applications

Les circuits intégrés ne sont pas à l'abri d'interférences naturelles ou malveillantes qui peuvent provoquer des fautes transitoires conduisant à des erreurs (Soft errors) et potentiellement à un comportement erroné. Ceci doit être maîtrisé surtout dans le cas des systèmes critiques qui imposent des contraintes de sûreté et/ou de sécurité. Pour optimiser les stratégies de protection de tels systèmes, il est fondamental d'identifier les éléments les plus critiques. L'évaluation de la criticité de chaque bloc permet de limiter les protections aux blocs les plus sensibles. Cette thèse a pour objectif de proposer des approches permettant d'analyser, tôt dans le flot de conception, la robustesse d'un système numérique. Le critère clé utilisé est la durée de vie des données stockées dans les registres, pour une application donnée. Dans le cas des systèmes à base de microprocesseur, une approche analytique a été développée et validée autour d'un microprocesseur SparcV8 (LEON3). Celle-ci repose sur une nouvelle méthodologie permettant de raffiner les évaluations de criticité des registres. Ensuite, une approche complémentaire et plus générique a été mise en place pour calculer la criticité des différents points mémoires à partir d'une description synthétisable. L'outil mettant en œuvre cette approche a été éprouvé sur des systèmes significatifs tels que des accélérateurs matériels de chiffrement et un système matériel/logiciel basé sur le processeur LEON3. Des campagnes d'injection de fautes ont permis de valider les deux approches proposées dans cette thèse. En outre, ces approches se caractérisent par leur généralité, leur efficacité en termes de précision et de rapidité, ainsi que leur faible coût de mise en œuvre et leur capacité à ré-exploiter les environnements de validation fonctionnelle. / Integrated circuits are not immune to natural or malicious interferences that may cause transient faults which lead to errors (soft errors) and potentially to wrong behavior. This must be mastered particularly in the case of critical systems which impose safety and/or security constraints. To optimize protection strategies of such systems, it is essential to identify the most critical elements. The assessment of the criticality of each block allows limiting the protection to the most sensitive blocks. This thesis aims at proposing approaches in order to analyze, early in the design flow, the robustness of a digital system. The key criterion used is the lifetime of data stored in the registers for a given application. In the case of microprocessor-based systems, an analytical approach has been developed and validated on a SparcV8 microprocessor (LEON3). This approach is based on a new methodology to refine assessments of registers criticality. Then a more generic and complementary approach was implemented to compute the criticality of all flip-flops from a synthesizable description. The tool implementing this approach was tested on significant systems such as hardware crypto accelerators and a hardware/software system based on the LEON3 processor. Fault injection campaigns have validated the two approaches proposed in this thesis. In addition, these approaches are characterized by their generality, their efficiency in terms of accuracy and speed and a low-cost implementation. Another benefit is also their ability to re-use the functional verification environments.