A high pressure pool boiling experiment of pressurized R134a is designed and built, utilizing thermochromatic liquid crystal techniques. Liquid crystals thermo-chromatography uses encapsulated liquid crystals that are sensitive to temperature. When exposed to hot temperatures the crystal reflect a blue/violet color, and when exposed to cooler temperatures it reflects a red/orange color. The color value or hue is proportional to its temperature. Using this technique this experiment is capable of studying the physics and thermodynamics of refrigerants under nucleate pool boiling. The main objective of this experiment was the design of the experimental setup. Various designs were tested and validated, of which all incorporated a pressure resistant chamber constructed out of aluminum and glass viewing ports. Design parameters such as the heating element thickness were verified using a transient FEA thermal model. This model, which was developed in ANSYS, verified that this design would be able to capture the thermal response of the thermochromatic liquid crystals. This analysis concluded that a negligible error of 0.02°C is expected due to transient effects. Difficulties were encountered during early stages of development; most notable were imaging limitations such as low camera frame-rates and poor resolution. Since a TLC technique was used to measure the temperature of the boiling surface, a camera system fast enough to capture the thermal response was needed. At bubble frequencies of 30 nucleations per second, it was necessary for the camera to have much higher frame rates. Through the use of two synchronized cameras, the surface temperature, position, size and shape of the bubbles were recorded simultaneously. Two camera systems were designed and tested. The first system consisted of a high speed CMOS camera capable of capturing 1,000 frames per second, and an RBG CCD color camera capable of 30 Frames per second. However, this system was limited the slow frame rate and low resolution of the RBG camera. The second system used two high resolution and fast shutter speed cameras, which were able to capture fast bubble nucleations. This method required the assumption that under constant operating conditions, the path of one bubble was identical to the next. This method was tested utilizing the high speed camera, and was shown that there was less than a .04% deviation from the path any bubble to that of the next. Detailed analysis of nucleating surface temperatures using thermochromatic liquid crystal technique and temporal-temperature response under various heat flux and at 813.6kPa (118Psia) and 882.5kPa (128Psia) was performed. It is seen that temperature distribution is quite varied in each case. At high pressures the size of nucleation site decreases, giving rise to an increase in the surface temperature. Bubble growth is also analyzed through the use of high speed cameras and compared to temperature distributions. Simultaneous temperature and bubble size measurements provided a correlation between bubble growth and heat transfer. Boiling parameters such as bubble frequency, bubble size, and contact area are also analyzed. From the surface temperature plots, the local and average heat transfer coefficients were calculated as a function of time and bubble dynamics.

A nonlinear active vibration absorber to control the vibrations of plates is investigated. The absorber is based on the saturation phenomenon associated with dynamical systems with quadratic nonlinearities and a two-to-one internal resonance. The technique is implemented by coupling a second-order controller with the plate's response through a sensor and an actuator. Energy is exchanged between the primary structure and the controller and, near resonance, the plate's response saturates to a small value. Numerical as well as experimental results are presented for a cantilever rectangular plate. For numerical studies, finite-element methods as well as modal analysis are implemented. The commercially available software ABAQUS is used in the finite-element analysis together with a user-provided subroutine to model the controller. For the experimental studies, the plate is excited using a dynamic shaker. Strain gages are used as sensors, while piezoelectric ceramic patches are used as actuators. The control technique is implemented using a dSPACE digital signal processing board and a modeling software (SIMULINK). Both numerical and experimental results show that the control strategy is very efficient. A numerical study is conducted to optimize the location of the actuators on the structure to maximize its controllability. In this regard, the control gain is maximized for the PZT actuators. Furthermore, a more general method is introduced that is based on a global measure of controllability for linear systems. Finally, the control strategy is made adaptive by incorporating an efficient frequency-measurement technique. This is validated by successfully testing the control strategy for a non-conventional problem, where nonlinear effects hinder the application of the non-adaptive controller. / Ph. D.

We tackle the problem of suppressing high-amplitude vibrations of cantilever beams when subjected to either primary external or principal parametric resonances. Guided by results of previous investigations into the nonlinear dynamics of single- and multi-degree-of-freedom structures, we design mechatronic systems of sensors, actuators, and electronic devices and implement nonlinear active feedback control. In the case of external excitation, we devise two vibration absorbers based on either quadratic or cubic feedback. We conduct theoretical analyses and demonstrate that when a two-to-one (one-to-one) internal resonance condition is imposed between the plant and the quadratic (cubic) absorber, there exists a saturation phenomenon. When the plant is forced near its resonant frequency and the forcing amplitude exceeds a certain small threshold, the nonlinear coupling creates an energy-transfer mechanism that limits (saturates) the response of the plant. Our theoretical studies reveal that the cubic absorber creates regimes of high-amplitude quasiperiodic and chaotic responses, thereby limiting its utility. However, we show that superior results can be achieved when the natural frequency of the quadratic absorber is set equal to one-half the excitation frequency. Consequently, we apply the quadratic technique through a variety of linear and nonlinear actuators, sensors, and electronic devices. We design and build second-order analog circuits that emulate the quadratic absorber. Using a DC motor, piezoelectric ceramics, and Terfenol-D struts as actuators and potentiometers, strain gages, and accelerometers as sensors, we demonstrate successful single- and multi-mode vibration control. In order to realize a more versatile implementation of the control strategy, we resort to a digital signal processing (DSP) board. We compose a code in C and design a digital absorber by developing algorithms that, in addition to replacing the analog circuit, automatically detect the amplitude and frequency of oscillation of the plant and fine-tune the absorber parameters. We take advantage of the digital realization, implement a linear absorber, and compare the performance of the quadratic absorber with that of its linear counterpart. In the case of parametric excitation, we investigate two techniques. First, we explore application of the quadratic absorber. We prove theoretically and demonstrate experimentally that this control scheme is not reliable. Then, we propose an alternate approach. We devise a control law based on cubic velocity feedback. We conduct theoretical and experimental investigations and show that the latter strategy leads to effective vibration suppression and bifurcation control. / Ph. D.

Magnetic Resonance Imaging (MRI) is a widely used, non-invasive imaging technique that provides a means to reveal structural and functional information of different body tissues in detail. Susceptibility Weighted Imaging (SWI) is a field in MRI that utilizes the information from the magnetic susceptibility property of different tissues using the gradient echo phase information. Although longer echo times (TEs) have been widely used in applications involving SWI, there are a few problems related with the long TE data, such as the strong blooming effect and phase aliasing even at macroscopic levels. In this thesis, the use of very short TEs is proposed to study susceptibility mapping. The short TEs can be used to study structures with susceptibilities an order of magnitude larger (such as air and bones in and around the brain sinuses, skull and teeth) than those within soft tissue. Using a new iterative susceptibility mapping technique that we recently developed, it becomes possible to map the geometry of such structures, which to date has proven difficult due to the lack of water content (for sinuses) or due to very short T2* (for bones). The method of phase replacement inside the sinuses proposed in this thesis provides more accurate phase information for the inversion than assuming zero or some arbitrary constant inside these structures. The first and second iterations were responsible for most of the changes in mapping out the susceptibility values. The mean susceptibility value in the sphenoid sinus is calculated as +9.3 ± 1.1ppm, close to the expected value of +9.4ppm for air. The reconstruction of the teeth in the in-vivo data provides a mean Δχ(teeth-tissue)=–3.3ppm, thanks to the preserved phase inside the jaw. The mean susceptibility inside a relatively homogeneous region of the skull bone was measured to be Δχ(bone-tissue)=–2.1ppm. Finally, these susceptibilities can be used to help remove the unwanted background fields prior to applying either SHARP or HPF. In addition, the effects of the background field gradient on flow compensation are studied. Due to the presence of these background gradients, an unwanted phase term is induced by the blood flow inside the vessels. Using a 3D numerical model and in vivo data, the background gradients were estimated to be as large as 1.5mT/m close to the air-tissue interfaces and 0.7mT/m inside the brain (leading to a potential signal loss of up to 15%). The quantitative susceptibility mapping (QSM) results were improved in the entire image after removing the confounding arterial phase thanks to the reduced ringing artifacts. Lastly, a novel approach to improve the susceptibility mapping results was introduced and utilized to monitor the changes in venous oxygen saturation levels as well as the changes in oxygen extraction fraction instigated by the vasodynamic agents, caffeine and acetazolamide. The internal streaking artifacts in the susceptibility maps were reduced by giving an initial susceptibility value uniformly to the structure-of-interest, based on the a priori information. For veins, the iterative results, when the initial value of 0.45 ppm was used, were the best in terms of the highest accuracy in the mean susceptibility value (0.453 ppm) and the lowest standard deviation (0.013 ppm). Using this technique, the venous oxygen saturation levels (inside the internal cerebral veins (ICVs)) for normal physiological conditions, post-caffeine and post-Diamox for the first volunteer were calculated as (mean ± standard deviation): Y_Normal = 69.1 ± 3.3 %, Y_Caffeine = 60.5 ± 2.8 % and Y_Diamox = 79.1 ± 4.0%. For the caffeine challenge, the percentage change in oxygen extraction fraction (OEF) for pre and post caffeine results was calculated as +27.0 ± 3.8%; and for the Diamox challenge, the percentage change in OEF was calculated as −32.6 ± 2.1 % for the ICVs. These vascular effects of Diamox and caffeine were large enough to be easily measured with susceptibility mapping and can serve as a sensitive biomarker for measuring reductions in cerebro-vascular reserve through abnormal vascular response, an increase in oxygen consumption during reperfusion hyperoxia or locally varying oxygen saturation levels in regions surrounding damaged tissue. In conclusion, our new approach to QSM offers a means to monitor venous oxygen saturation reasonably accurately and may provide a new means to study neurovascular diseases where there are changes in perfusion that affect the oxygen extraction fraction. / Thesis / Doctor of Philosophy (PhD) / Magnetic Resonance Imaging (MRI) is a widely used, non-invasive imaging technique that provides a means to reveal structural and functional information of different body tissues in detail. Susceptibility Weighted Imaging (SWI) is a field in MRI that utilizes the information from the magnetic susceptibility property of different tissues using the gradient echo phase information. Firstly, we demonstrate that using our phase replacement technique, it becomes possible to map the geometry of structures with almost no MR signal, which to date has proven difficult due to the lack of water content (for sinuses) or due to very short T2* (for bones). Secondly, the effects of the background field gradient on flow compensation were studied. Due to the presence of these background gradients, an unwanted phase term is induced by the blood flow inside the vessels. And, lastly, we present our new approach utilizing SWI data, offering a means to monitor venous oxygen saturation reasonably accurately and, potentially, a new means to study neurovascular diseases where there are changes in perfusion that affect the oxygen extraction fraction.

Finding if color has an effect on depth perception in virtual reality (VR) is important, as it could be important for e.g. surgeons to perceive the depth correctly if they were to be trained in VR environments as a preparation for surgeries on real patients. If color has an effect on perceived depth in VR then producers of these simulations have to take their color choices into account when creating simulations. Previous research has shown that luminosity and hue can have effects on depth perception. It is also perceived that depth underestimation is prevalent in VR. Discerning if either the color of the focal object or the background is affecting the depth perception is important. Therefore finding what effect different color attributes of a focal object and background has on the depth perception in a VR environment is important. This experimental study examined this through a case study performed in a VR environment built in Unity. The tests were set up to emulate the piercing of a catheter into a plane, where the user pressed a button the moment the plane was pierced. To test different colors of the focal object, in this case a plane, the background was assigned neutral colors (white or black) and while testing the background the plane had a neutral color (white). Results from the study show that colors have a small effect, namely up to 13.2 mm error (for the yellow hue with high luminosity and high saturation), on users’ depth perception in VR. No single attribute was better than another but on the object, blue hue gave the largest error while red hue gave the smallest error. For the background, there was more variation on the data but green and blue hue gave the smallest errors and red and yellow the largest. In sum, color has differing effects on depth perception in VR depending on if the color is applied to a background or an object. Red color gave the most accurate depth perception when applied to the object. For color applied to the background, green hue with high luminosity and blue hue with low luminosity resulted in the most accurate depth perception. / Att ta reda på om färg har en påverkan på djupseende i virtuell verklighet (VR) är viktigt, eftersom det skulle vara viktigt för t.ex. kirurger att uppfatta djupet korrekt om de skulle bli tränade i VR miljöer som en förberedelse inför operationer på riktiga patienter. Om färg har en effekt på upplevd djup i VR, då måste tillverkarna av dessa simulationer ha deras färgval i åtanke när de skapar simulatorerna. Tidigare forskning har visat att ljusintensitet och kulörton kan ha en effekt på djupseende. Det har också upptäckts att djupunderskattning är allmänt förekommande i VR. Att urskilja om antingen färgen på fokusobjektet eller på bakgrunden påverkar djupseendet är viktigt. Således att hitta vilken effekt olika färg attribut av ett fokusobjekt och bakgrund har på djupseendet i en VR miljö. Studien undersökte detta genom en fallstudie i en VR miljö byggd i Unity. Testen var uppbyggda för att efterlikna en kateter som genomtränger ett plan där användaren trycker på en knapp då den trängde igenom planet. För att testa olika färger på fokusobjektet, i detta fall ett plan, blev bakgrunden tilldelad neutrala färger (vit och svart) och när bakgrunden testades var planet tilldelad en neutral färg (vit). Resultaten från studien visar att färg har en liten effekt, upp till 13.2 mm i fel (för den gula kulörtonen med hög ljusintensitet och hög mättnad), på djupseende i VR. Inget enskilt attribut var bättre än ett annat, men på objektet gav blå kulörton det största felet medan röd kulörton gav det minsta felet. För bakgrunden var det mer variation på data men grön och blå kulörton gav de minsta felen och röd och gul gav de största felen. Färgen har olika påverkan på djupseende i VR beroende på om färgen är applicerad på en bakgrund eller ett objekt. Röd färg gav det mest korrekta djupseendet när den var applicerad på objektet. För färg applicerad på bakgrund, resulterade grön kulörton med hög ljusintensitet och blå kulörton med låg ljusintensitet i det mest korrekta djupseendet.

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京都大学 / 新制・課程博士 / 博士(農学) / 甲第23617号 / 農博第2480号 / 新制||農||1088(附属図書館) / 学位論文||R4||N5365(農学部図書室) / 京都大学大学院農学研究科森林科学専攻 / (主査)教授 德地 直子, 教授 北島 薫, 教授 舘野 隆之輔 / 学位規則第4条第1項該当 / Doctor of Agricultural Science / Kyoto University / DGAM

<p>Quantitatively measuring oxygen saturation is important to characterize the physiological or pathological state of tissue function. In this thesis, we demonstrate the possibility of using susceptibility mapping to noninvasively estimate the venous blood oxygen saturation level. Accurate susceptibility quantification is the key to oxygen saturation quantification. Two approaches are presented in this thesis to generate accurate and artifact free susceptibility maps (SM): a regularized inverse filter and a k-space iterative method. Using the regularized inverse filter, with sufficient resolution, major veins in the brain can be visualized. We found that different sized vessels show a different level of contrast depending on their partial volume effects; larger vessels show a bias toward a reduced susceptibility approaching 90% of the expected value. Also, streaking artifacts associated with high susceptibility structures such as veins are obvious in the reconstructed SM. To further improve susceptibility quantification and reduce the streaking artifacts in the SMs, we proposed a threshold-based k-space iterative approach that used geometric information from the SM itself as a constraint to overcome the ill-posed nature of the inverse filter. Both simulations and in vivo results show that most streaking artifacts inside the SM were suppressed by the iterative approach. In simulated data, the bias toward lower mean susceptibility values inside vessels has been shown to decrease from around 10% to 2% when choosing an appropriate threshold value for the proposed iterative method, which brings us one step closer to a practical means to map out oxygen saturation in the brain.</p> / Doctor of Philosophy (PhD)