Multidimensional analysis, trends analysis, summaries and drill-downs as data warehousing methods of choice provided rich, valuable and detailed perspective of cancer threats in terms of virtually any dimension covered by data. These allowed to model the risk of cancer including age, race, sex and survival chances among others, to spot most dangerous and incident cancers, revealed how little survival chances and treatment efficiency increased over last 30 years and how little early diagnosis was improved, presented trends and changes in them and changes in cancer risk related to place of residence and emphasized the importance of risk mitigation by screening and healthy lifestyle. These methods also turned out to be easy, requiring less computer science related knowledge as one could expect. With little support from IT staff, oncology domain professionals can easily benefit from vast data sets and analytical power applied to it. Data mining algorithms evaluated over melanoma of the skin data managed to extract what's already known in the domain. Therefore, when used by oncology professionals over less generic data one can expect data mining to have the potential of extending experts' knowledge. Neural networks, decision trees and clusters showed higher prediction accuracy than Naive Bayes classifiers and association rules but it is advised to merge results from many algorithms. Findings by particular algorithms are often disjoint and when combined, allow to reveal more despite varying predictive performance. Analysis of caCORE system and systemic integration experiment proved that building a large-scale oncological data system integrating distributed data is extremely complex. Integrating with it requires a lot of effort to understand its structures, prepare data mappings and implement integration procedures. Strict cooperation of IT and oncology professionals is mandatory. Suggestions were made to simplify the generic caCORE data model (ontology) or split it into smaller parts and expose as much integration functionality as web interfaces or encapsulated classes to decrease the complexity of the process. Tweaked like that, caCORE would be fully feasible and could be considered as the future of application of data warehousing and data mining techniques in oncology, providing distributed and common-model compliant dataset and leveraging the power of research community. / The thesis evaluates: application of data warehousing and mining analysis to SEERStat surveillance and epidemiology oncological database and aspects of future development of integrated and extensible data systems for oncology domain basing on integration experiment with caCORE project. In the thesis following is presented: results of the analysis of cancer diseases data with conclusions and advice, potential of this specific analytical application and conclusions as well as guidelines about how future, more powerful oncological analytical systems could be built. / dominiksm@o2.pl

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Submitted by FABIANA DA SILVA FRANÇA (fabiana21franca@gmail.com) on 2017-11-23T18:06:14Z No. of bitstreams: 1 ArquivoTotal.pdf: 2427997 bytes, checksum: 6a9dabc2a7dd80db6ff32d2454cafab2 (MD5) / Made available in DSpace on 2017-11-23T18:06:14Z (GMT). No. of bitstreams: 1 ArquivoTotal.pdf: 2427997 bytes, checksum: 6a9dabc2a7dd80db6ff32d2454cafab2 (MD5) Previous issue date: 2017-03-31 / To analyze the results of the implementation of the Electronic Journaling System (SEER), the Open Journal System customization by the Brazilian Institute of Science and Technology Information (IBICT), as part of a policy of free access to scientific information in Brazil between 2003 (Year of its creation) and 2016. It is proposed to create a context based on the concept of "open access", combining the conceptual threads of "scientific communication", intertwined with "scientific publishing", which in turn is interwoven with " Dissemination of scientific and technological information ", for a qualification of an access policy through the adoption of collaborative and free technology. The study allowed to raise important characteristics of Brazilian scientific journals. Today there are no major challenges in the Open Access Movement: a convergence of interests and needs of the editors of the SEER / OJS journals by cooperation networks; An enlargement without sharing and systematizing the successful experiences of journals with high impact indexes, perhaps the biggest challenge today is the integration of data from electronic journals with institutional repositories. Brazil along with the Cariniana preservation network has made significant progress in this integration. / Analisa os resultados da implementação do Sistema Eletrônico de Editoração de Revistas (SEER), customização do Open Journal System pelo Instituto Brasileiro de Informação em Ciência e Tecnologia (IBICT), enquanto dispositivo de uma política de acesso livre à informação científica, no Brasil entre 2003 (ano de sua criação) e 2016. Propõe-se tecer um contexto a partir do conceito de “acesso aberto”, reunindo os fios conceituais da "comunicação científica", entrelaçado ao da "editoração científica", que por sua vez está entremeado à "disseminação da informação científica e tecnológica", para a qual se propõe uma política de acesso mediante adoção de tecnologia colaborativa e livre. O estudo permitiu levantar características importantes dos periódicos científicos brasileiros. Hoje no Brasil existem grandes desafios no Movimento de Acesso Aberto: a convergência de interesses e necessidades dos editores dos periódicos do SEER/OJS por redes de cooperação; a ampliação no compartilhamento e sistematização das experiências de sucesso de periódicos com altos índices de impacto e, talvez o mais importante desafio atual é a integração dos portais de periódicos eletrônicos com os repositórios institucionais. O Brasil junto a rede de preservação Cariniana tem tido significativos avanços nessa integração.

Introductory: If the relations existing between the Native chiefs and the Colony which Sir George Grey found on his arrival are to be fully understood, a brief consideration of Cathcart’s policy and Frontier settlement is necessary. When Cathcart came out as Governor in 1852, he found the rebel chief Sandile, with associate chieftans’ and large bands of followers, still occupying their locations in the Amatola ranges. From this haunt no force had as yet been able to drive them. During the series of skirmishes known as the Eighth Kaffir War, their first crop of Indian corn was destroyed so early in the season as to allow of a second crop springing up. This unusual phenomenon inspired prophet Umlangeni to claim that he had worked a miracle. Fortunately later reverses and the expulsion of Sanailli from his mountain fastness discredited this thoughtful opportunist. Sandilli, as paramount chief of the Gaikas, might have held and influential position in the councils of the Kaffrarian chiefs, that he did not hold such a position, was due, in Charles Brownlee’s opinion, to his timid and suspicious nature and to the fact that his mental capacity was ‘hardly above mediocrity’. He was unable to fight owing to lameness, and he lacked ‘sufficient’ resciution and strength of mind to resist the evil influence of the bad advisers, nevertheless he could be obstinate and he never, to the end of his life, gave up on the idea of getting back to this old locations in the Amatolas. Macomo with some three thousand followers had likewise evaded all attempts to turn him out of this haunts in the mountain range. He, together with his associate the Tambookie chief Quesha, and diverse rebel Hotttentots, indulged in the frequent marauding forays into the surrounding country. Macomo was the eldest of Gaika’s sons and was “allowed by all to be the greatest politician and best warrior in Kaffraria’. During the minority of Sandilli Macomo had acted as his regent and had attained great influence over the tribe; this he afterwards lost for he moved to the neighbourhood of Fort Beaufort, where in a state of intoxication most of this time was passed. He had in Brownlee’s opinion, done more mischief in the war than any other chief. Great jealously was felt between Macomo and Sandilli, especially on the part of the former; this was shown through the cattle killing period in his efforts to involve Sandilli, while attempting to keep on the right side of the Government himself. Further south, indeed within the Colony itself, such petty chiefs as Seyolo and Botman, lurking in the Fish River bush, and the Keiskamma kloofs, rendered the main road dangerous, and even succeeded, for a time, in completely cutting the ling of communication between Kingwilliamstown and Grahamstown.

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