<p>The modern world is facing a revolutionary development in the clinical medicine and biomedical sciences. Due to the different life supporting systems, it is easily possible to keep patients with severe diseases alive. With organ transplantation a lot of people, who would otherwise die can live long and happy lives. In vitro fertilization allows a woman to bear the child that is not genetically related to her. Due to the possibility of contraception, safe abortions and prenatal diagnosis, women and couples can make preferable choices concerning their future child. Such medical developments and improvements have a great impact on our life, and provoke a lot of ethical questions and moral dilemmas.</p><p>The aim of this thesis is to answer the question whether prenatal diagnosis can be justified as it mainly leads to the selective abortion, whether and when the fetus counts as a person and whether the prospective parents can perform selective abortion on the basis of fetal disability; and to discuss ethical problems that are experienced by the doctor, who brings the news into the family and what is his/her role in the decision-making process.</p>

<p>Many security services today only provides one security configuration at run-time, and cannot then utilize the trade-off between performance and security. In order to make use of this trade-off, tunable security services providing several security configurations that can be selected at run-time are needed. To be able to make intelligent choices on which security configuration to use for different situations we need to know how good they are, i.e., we need to order the different security configurations with respect to each security attribute using measures for both security and performance.</p><p>However, a key issue with computer security is that it is due to its complex nature hard to measure.</p><p>As the title of this thesis indicates, it discusses both security measures and tunable security services. Thus, it can be seen to consist of two parts. In the first part, discussing security measures for tunable security services, an investigation on the security implications of selective encryption by using guesswork as a security measure is made. Built on this an investigation of the relationship between guesswork and entropy. The result shows that guesswork,</p><p>after a minor redefinition, is equal to the sum of the entropy and the relative entropy.</p><p>The second part contributes to the area of tunable security services, e.g., services that provides several security configurations at run-time. In particular, we present the mobile Crowds (mCrowds) system,</p><p>an anonymity technology for the mobile Internet developed at Karlstad University, and a tunable encryption service, that is based on a selective encryption paradigm and designed as a middleware. Finally, an investigation of the tunable features provided by Mix-Nets and Crowds are done, using a conceptual model for tunable security services.</p>

<p>Spectrally selective solar absorber using composite Ni-NiO as coating materials was studied. Samples were prepared by dc magnetron sputtering unit named <i>Rulle</i>, which is a miniature copy of an industrial roll-coater unit. Using asymmetric location of the oxygen nozzele, it is possible to form the desired metallic concentration distribution along the sputtering zone under optimized conditions. This distribution can be transferred into a graded film profile by moving the substrate, obtaining good spectral selectivity. For specified mechanical settings (such as locations of gas sprays, target and pump positions etc.), the ratio of used oxygen flow to the corresponding critical oxygen flow, <b>RO</b>, is a dimensionless parameter to control the zone specification. The optimal value is around 0.80 for the <i>Rulle</i>. Optimized zone shows properties with two main parts: the metallic composite part of varied nickel volume fraction and the dielectric part. Two parts of the sputtering zone can form a graded absorbing layer with the right ratio of base and middle layer by the moving substrate technique. Distribution of normalized conductivity, <i>NC</i>, along the absorbing sputtering zone is a simple and good specification of zone property. Profile of graded film prepared by the moving substrate technique can be tailored according to <i>NC</i> distribution. XRD and XPS study confirms the <i>NC</i> results. Simulation reveals that absorption should mainly rely on the intrinsic, but less on the interference mechanism. Used metallic volume fraction of Ni-NiO is 0.3 for main absorbing layer. The front surface reflection loss due to high refractive index can be reduced by adding a layer with low refractive index on the top. Simulation shows that three-layer coatings are a good and simple coating structure. High solar absorptance of 0.97 has been achieved with low thermal emittance of 0.05 by theoretical simulation as well as experimentally prepared samples.</p>

An algorithm was developed to enable efficient segmentation of dimensionally-large objects into smaller components that can be fabricated within the given Rapid Prototyping (RP) machine workspace. The algorithm uses vertical and horizontal flat plane cuts, as well as feature-based volume decomposition. Due considerations were given to the optimisation of the surface accuracy, the build time, the strength and the number of segments generated by the segmentation process. A computer-aided design (CAD) application programme that interfaces with Unigraphics (UG) was also developed to allow import of objects in Standard Triangulated Language (STL) files into UG without loss of accuracy. In addition, the application software provides the functions that facilitate the implementation of the segmentation algorithm in UG. Two case studies were carried out using the algorithm in a Selective Laser Sintering (SLS) RP system. The resulting objects had properties that matched the research objectives with which the proposed algorithm was validated. / Singapore-MIT Alliance (SMA)

Genetic engineering is important to enhance crop characteristics and certain traits. Genetically engineered crop cultivation brings environmental and ecological concerns with the potential of unwanted transgene escape and introgression. Transgene escape has been considered as a major environmental and regulatory concern. This concern could be alleviated by appropriate biocontainment strategies. Therefore, it is important to develop efficient and reliable biocontainment strategies. Removing transgenes from pollen has been known to be the most environmentally friendly biocontainment strategy. A transgene excision vector containing a codon optimized serine resolvase CinH recombinase (CinH) and its recognition sites RS2 were constructed and transformed into tobacco (Nicotiana tabacum cv. Xanthi). In this system, the pollen-specific LAT52 promoter from tomato was employed to control the expression of CinH recombinase. Loss of expression of a green fluorescent protein (GFP) gene under the control of the LAT59 promoter from tomato was used as an indicator of transgene excision. Efficiency of transgene excision from pollen was determined by flow cytometry (FCM)-based pollen screening. While a transgenic event in the absence of CinH recombinase contained about 70% of GFP-synthesizing pollen, three single-copy transgene events contained less than 1% of GFP-synthesizing pollen based on 30,000 pollen grains analyzed per event. This suggests that CinH-RS2 recombination system could be effectively utilized for transgene biocontainment. A novel approach for selective male sterility in pollen was developed and evaluated as a biocontainment strategy. Overexpression of the EcoRI restriction endonuclease caused pollen ablation and/or infertility in tobacco, but exhibited normal phenotypes when compared to non-transgenic tobacco. Three EcoRI contained 0% GFP positive pollen, while GFP control plants contained 64% GFP positive pollen based on 9,000 pollen grains analyzed by flow cytometry-based transgenic pollen screening method. However, seven EcoRI events appeared to have 100% efficiency on selective male sterility based on the test-crosses. The results suggested that this selective male sterility could be used as a highly efficient and reliable biocontainment strategy for genetically engineered crop cultivation.

One major focus of anxiety research in recent years has been the identification of cognitive factors that promote increased vulnerability to anxiety. Cognitive formulations propose that anxiety is characterised by an increased tendency to attend to negatively valenced emotional information, and that this bias may play a causal role in the development and maintenance of clinical anxiety. Evidence suggests that this anxiety-linked processing bias occurs even in conditions in which the stimuli are masked in order to prevent awareness of the content (i.e., preattentive bias). The present thesis focused principally on the preferential processing of threat-related information that occurs outside awareness. Two different outcome measures were used to index preferential preattentive processing of threat-related information in non-clinical populations: The emotional Stroop task was used to index selective attention to masked presentation of threatening word stimuli, whereas skin conductance responses were used to index selective autonomic responses to masked presentation of threatening pictorial stimuli. The empirical studies in the present thesis showed that elevated levels of trait anxiety promote preferential preattentive processing of negatively valenced information, whereas elevated levels of social desirability (interpreted as defensiveness) generally prevent preferential preattentive processing of negatively valenced information, especially among those at higher levels of trait anxiety, irrespective of outcome measure used. Moreover, previous research has demonstrated that a person’s most common emotional reaction when encountering a stressful event is causally influenced by that person’s habitual tendency to selectively encode the most threatening aspects of all available information. Thus, preattentive bias (as measured with the emotional Stroop task) was used to predict the emotional responses (as seen on self-reported emotional distress and autonomic reactivity) following exposure to a laboratory stressor. This study showed that preattentive bias to negative information had significant effects on both self-reported and physiological measures in response to a laboratory stressor, but in diametrically opposite directions. Specifically, whereas preattentive bias was positively associated with self-reported negative emotional response, it was negatively associated with a physiological indicator of emotional response. The results were discussed in terms of an inability to automatically inhibit the processing of threatening cues, which seems to be a vulnerability marker for anxiety. Whether this bias is ultimately sufficient for the development of clinical anxiety remains to be examined in future research. Additionally, more information is needed before it can be established that the emotional Stroop task can be viewed as a reliable diagnostic tool for determining an individual’s anxiety status.

Spectrally selective solar absorber using composite Ni-NiO as coating materials was studied. Samples were prepared by dc magnetron sputtering unit named Rulle, which is a miniature copy of an industrial roll-coater unit. Using asymmetric location of the oxygen nozzele, it is possible to form the desired metallic concentration distribution along the sputtering zone under optimized conditions. This distribution can be transferred into a graded film profile by moving the substrate, obtaining good spectral selectivity. For specified mechanical settings (such as locations of gas sprays, target and pump positions etc.), the ratio of used oxygen flow to the corresponding critical oxygen flow, <b>RO</b>, is a dimensionless parameter to control the zone specification. The optimal value is around 0.80 for the Rulle. Optimized zone shows properties with two main parts: the metallic composite part of varied nickel volume fraction and the dielectric part. Two parts of the sputtering zone can form a graded absorbing layer with the right ratio of base and middle layer by the moving substrate technique. Distribution of normalized conductivity, NC, along the absorbing sputtering zone is a simple and good specification of zone property. Profile of graded film prepared by the moving substrate technique can be tailored according to NC distribution. XRD and XPS study confirms the NC results. Simulation reveals that absorption should mainly rely on the intrinsic, but less on the interference mechanism. Used metallic volume fraction of Ni-NiO is 0.3 for main absorbing layer. The front surface reflection loss due to high refractive index can be reduced by adding a layer with low refractive index on the top. Simulation shows that three-layer coatings are a good and simple coating structure. High solar absorptance of 0.97 has been achieved with low thermal emittance of 0.05 by theoretical simulation as well as experimentally prepared samples.

This research and development work deals with the design methodology for Cascaded Multilevel Converter (CMC) based Transmission STATCOM (TSTATCOM) and development of a &plusmn / 12MVAR, 12kV line-to-line wye-connected, 11-level CMC. This CMC module constitutes the basic building block of TSTATCOM systems. Sizing of the CMC module, number of H-Bridges in each phase of the CMC, AC voltage rating of the CMC, the number of paralleled CMC modules in the T-STATCOM system, optimum value of series filter reactors and determination of busbar in the power grid to which the T-STATCOM system is going to be connected are also discussed in the thesis in view of IEEE Std.519-1992, current status of HV IGBT technology and the required reactive power variation range for the T-STATCOM application. In the field prototype of the CMC module, the AC voltages are approximated to sinusoidal waves by Selective Harmonic Elimination Method (SHEM) and by the use of an optimized series input filter reactor. The use of n number of HBs in each phase provides us n number of freedom in the application of SHEM. One of them is allocated to the fundamental component while n-1 is for the elimination of low order harmonics. Since n is chosen to five in the prototype system, 5th, 7th,11th and 13th harmonic components are successfully eliminated in the AC voltage waveforms of the CMC module. The equalization of DC link capacitor voltages is achieved according to Modified Selective Swapping (MSS) algorithm. MSS is applied every 400&mu / s period if needed to obtain a perfect equalization of DC link capacitor voltages at the expense of higher switching frequency and hence switching losses. In this research work, an L-shaped laminated bus has been designed and the HV IGBT driver circuit has been modified for optimum switching performance of HV IGBT modules in each HB circuit. The performances of the HB circuit and the resulting 11-level CMC module have been obtained not only in the laboratory but also in the field. Design works for HB and the CMC are based on MATLAB and PSCAD simulations. The laboratory and field performance of the HB circuit and CMC module is found to be satisfactory and quite consistent with the theoretical results and design objectives. In addition to these, 154 kV, &plusmn / 50MVAr T-STATCOM prototype has been designed, implemented and installed at Sincan Transformer Substation-Ankara primarily for the purposes of reactive power compensation and terminal voltage regulation. The T-STATCOM prototype is composed of five parallel operated CMC modules developed within the scope of this PhD thesis research work. The T-STATCOM configuration permits the operation of any number of CMC modules in the range from one to five for experimental purposes. The performance of this T-STATCOM system is also presented in this PhD thesis as a sample application.

The diesel engine is growing in popularity due to its energy efficiency and solving the emissions issues associated with diesel engine exhaust would clear the way for further growth. The key pollutants are NOx, particulate matter and unburned hydrocarbons. Selective catalytic reduction (SCR) catalysis is likely the best choice for NOx control. In SCR, NH3 selectively reacts with NOx to form N2 – the selectivity refers to NH3 reacting with NOx instead of the abundant O2. Urea is used as the NH3 source, being injected into the exhaust as an aqueous solution where the urea decomposes and NH3 is generated. Spatial resolution characterization techniques have been gaining attention in the catalysis field because of the higher level of information provided. In this thesis, a new spatial resolution technique, called SpaciFTIR (spatially-resolved, capillary-inlet Fourier transform infra-red spectroscopy), was developed, which overcomes the interference of water in the detection of NH3 in an earlier developed technique, SpaciMS (spatially-resolved, capillary-inlet mass spectrometry). With the new test method, three SCR topics were addressed. First, the three key SCR reactions were spatially resolved. These are the standard SCR reaction (2NO + 2NH3 + 1/2O2 = 2N2 + 3H2O), the fast SCR reaction (NO + NO2 + 2NH3 = 2N2 + 3H2O), and NO2-SCR, (6NO2 + 8NH3 = 7N2 + 12H2O). Results show that in the presence of NO2, but at a NO2/NOx ratio < 0.5, the fast SCR reaction proceeds followed by the standard SCR reaction, i.e. in series. If the NO2/NOx ratio exceeds 0.5, the NO2-SCR and fast SCR reactions occur in parallel. Compared to the standard integral test method, this spatial resolution technique clearly showed such trends. Secondly, the spatial resolution technique was used to characterize the effects of thermal aging on catalyst performance. It was found that for a highly aged catalyst, there was a radial activity profile due to an inhomogeneous temperature distribution in the process of aging. Aging effects on various key SCR reactions, i.e. NO oxidation, NH3 oxidation, and the reduction reactions, were studied. Last but not least, for the purpose of passive SCR system development, transient NH3 storage profiles along the monolith channel were measured with SpaciFTIR. Passive SCR is a system where the NH3 is generated on an upstream catalyst, such as a three-way catalyst or lean-NOx trap, instead of via urea injection. In such a system, NH3 is therefore not constantly being fed to the SCR catalyst, but “arrives” in pulses. Factors such temperature, NH3 concentration, pulsing time, flow rate and thermal aging were investigated. For the first time, NH3 migration was observed and its effect on SCR reactions along the length of catalyst was studied.

Catalytic ethylene oligomerization is a well understood industrially viable process. The large majority of scientific literature and patents concerning this process has been developed with the use of chromium catalysts. Commercial systems producing selective tri/tetramerization, non-selective oligomerization and polymerization are all based on this metal with the exception of a few systems based on other transition metals (Zr, Ti, Ni etc.). This versatility raises interesting questions about chromium’s unique behaviour. Essentially, selective or non-selective oligomerization and polymerization processes could be regarded as belonging to the same category of C-C bond forming reactions, though different mechanisms are involved. The first part of this thesis explores a variety of chromium complexes for ethylene oligomerization purposes. In order to gather further information about the unique behaviour of chromium, we have explored a variety of nitrogen and phosphorus containing ligands. We started with a simple bi-dentate anionic amidophosphine (NP) ligand and assessed the role of the ligand’s negative charge and number of donor atoms in determining the type of catalytic behaviour in relation to the metal oxidation state. This ligand proved capable of generating a series of chromium dimeric, tetrameric or polymeric and even heterobimetallic chromium-aluminate complexes in different valence states. This allowed us to isolate a “single component” self activating Cr(II) complex as well as a rare example of mixed valence Cr(I)/Cr(II) species. Additionally, each of these species acted as switchable catalyst depending on the type of co-catalyst