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Point process modeling and estimation: advances in the analysis of dynamic neural spiking dataDeng, Xinyi 12 August 2016 (has links)
A common interest of scientists in many fields is to understand the relationship between the dynamics of a physical system and the occurrences of discrete events within such physical system. Seismologists study the connection between mechanical vibrations of the Earth and the occurrences of earthquakes so that future earthquakes can be better predicted. Astrophysicists study the association between the oscillating energy of celestial regions and the emission of photons to learn the Universe's various objects and their interactions. Neuroscientists study the link between behavior and the millisecond-timescale spike patterns of neurons to understand higher brain functions.
Such relationships can often be formulated within the framework of state-space models with point process observations. The basic idea is that the dynamics of the physical systems are driven by the dynamics of some stochastic state variables and the discrete events we observe in an interval are noisy observations with distributions determined by the state variables. This thesis proposes several new methodological developments that advance the framework of state-space models with point process observations at the intersection of statistics and neuroscience. In particular, we develop new methods 1) to characterize the rhythmic spiking activity using history-dependent structure, 2) to model population spike activity using marked point process models, 3) to allow for real-time decision making, and 4) to take into account the need for dimensionality reduction for high-dimensional state and observation processes.
We applied these methods to a novel problem of tracking rhythmic dynamics in the spiking of neurons in the subthalamic nucleus of Parkinson's patients with the goal of optimizing placement of deep brain stimulation electrodes. We developed a decoding algorithm that can make decision in real-time (for example, to stimulate the neurons or not) based on various sources of information present in population spiking data. Lastly, we proposed a general three-step paradigm that allows us to relate behavioral outcomes of various tasks to simultaneously recorded neural activity across multiple brain areas, which is a step towards closed-loop therapies for psychological diseases using real-time neural stimulation. These methods are suitable for real-time implementation for content-based feedback experiments.
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State space time series clustering using discrepancies based on the Kullback-Leibler information and the Mahalanobis distanceFoster, Eric D. 01 December 2012 (has links)
In this thesis, we consider the clustering of time series data; specifically, time series that can be modeled in the state space framework. Of primary focus is the pairwise discrepancy between two state space time series. The state space model can be formulated in terms of two equations: the state equation, based on a latent process, and the observation equation. Because the unobserved state process is often of interest, we develop discrepancy measures based on the estimated version of the state process. We compare these measures to discrepancies based on the observed data. In all, seven novel discrepancies are formulated.
First, discrepancies derived from Kullback-Leibler (KL) information and Mahalanobis distance (MD) measures are proposed based on the observed data. Next, KL information and MD discrepancies are formulated based on the composite marginal contributions of the smoothed estimates of the unobserved state process. Furthermore, an MD is created based on the joint contributions of the collection of smoothed estimates of the unobserved state process. The cross trajectory distance, a discrepancy heavily influenced by both observed and smoothed data, is proposed as well as a Euclidean distance based on the smoothed state estimates. The performance of these seven novel discrepancies is compared to the often used Euclidean distance based on the observed data, as well as a KL information discrepancy based on the joint contributions of the collection of smoothed state estimates (Bengtsson and Cavanaugh, 2008).
We find that those discrepancy measures based on the smoothed estimates of the unobserved state process outperform those discrepancy measures based on the observed data. The best performance was achieved by the discrepancies founded upon the joint contributions of the collection of unobserved states, followed by the discrepancies derived from the marginal contributions.
We observed a non-trivial degradation in clustering performance when estimating the parameters of the state space model. To improve estimation, we propose an iterative estimation and clustering routine based on the notion of finding a series' most similar counterparts, pooling them, and estimating a new set of parameters. Under ideal circumstances, we show that the iterative estimation and clustering algorithm can potentially achieve results that approach those obtained in settings where parameters are known. In practice, the algorithm often improves the performance of the model-based clustering measures.
We apply our methods to two examples. The first application pertains to the clustering of time course genetic data. We use data from Cho et al. (1998) where a time course experiment of yeast gene expression was performed in order to study the yeast mitotic cell cycle. We attempt to discover the phase to which 219 genes belong.
The second application seeks to answer whether or not influenza and pneumonia mortality can be explained geographically. Data from a collection of cities across the U.S. are acquired from the Morbidity and Mortality Weekly Report (MMWR). We cluster the MMWR data without geographic constraints, and compare the results to clusters defined by MMWR geographic regions. We find that influenza and pneumonia mortality cannot be explained by geography.
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Time-domain Simulation of Multibody Floating Systems based on State-space Modeling TechnologyYu, Xiaochuan 2011 August 1900 (has links)
A numerical scheme to simulate time-domain motion responses of multibody floating systems has been successfully proposed. This scheme is integrated into a time-domain simulation tool, with fully coupled hydrodynamic coefficients obtained from the hydrodynamic software - WAMIT which solves the Boundary Value Problem (BVP). The equations of motion are transformed into standard state-space format, using the constant coefficient approximation and the impulse response function method. Thus the Ordinary Differential Equation (ODE) solvers in MATLAB can be directly employed. The time-domain responses of a single spar at sea are initially obtained. The optimal Linear Quadratic Regulator (LQR) controller is further applied to this single spar, by assuming that the Dynamic Positioning (DP) system can provide the optimized thruster forces. Various factors that affect the controlling efficiency, e.g., the time steps ∆τ and ∆t, the weighting factors(Q,R), are further investigated in detail. Next, a two-body floating system is studied. The response amplitude operators (RAOs) of each body are calculated and compared with the single body case. Then the effects of the body-to-body interaction coefficients on the time-domain responses are further investigated. Moreover, the mean drift force is incorporated in the DP system to further mitigate the motion responses of each body. Finally, this tool is extended to a three-body floating system, with the relative motions between them derived.
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An Integrative Approach to Reliability Analysis of an IEC 61850 Digital SubstationZhang, Yan 1988- 14 March 2013 (has links)
In recent years, reliability evaluation of substation automation systems has received a significant attention from the research community. With the advent of the concept of smart grid, there is a growing trend to integrate more computation and communication technology into power systems.
This thesis focuses on the reliability evaluation of modern substation automation systems. Such systems include both physical devices (current carrying) such as lines, circuit breakers, and transformers, as well as cyber devices (Ethernet switches, intelligent electronic devices, and cables) and belong to a broader class of cyber-physical systems. We assume that the substation utilizes IEC 61850 standard, which is a dominant standard for substation automation.
Focusing on IEC 61850 standard, we discuss the failure modes and analyze their effects on the system. We utilize reliability block diagrams for analyzing the reliability of substation components (bay units) and then use the state space approach to study the effects at the substation level. Case study is based on an actual IEC 61850 substation automation system, with different network topologies consideration concluded.
Our analysis provides a starting point for evaluating the reliability of the substation and the effects of substation failures to the rest of the power system. By using the state space methods, the steady state probability of each failure effects were calculated in different bay units. These probabilities can be further used in the modeling of the composite power system to analyze the loss of load probabilities.
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Dynamically Predicting Corridor Travel Time Under Incident Conditions Using a Neural Network ApproachZeng, Xiaosi 2009 December 1900 (has links)
The artificial neural network (ANN) approach has been recognized as a capable
technique to model the highly complex and nonlinear problem of travel time prediction.
In addition to the nonlinearity, a traffic system is also temporally and spatially dynamic.
Addressing the temporal-spatial relationships of a traffic system in the context of neural
networks, however, has not received much attention. Furthermore, many of the past
studies have not fully explored the inclusion of incident information into the ANN model
development, despite that incident might be a major source of prediction degradations.
Additionally, directly deriving corridor travel times in a one-step manner raises some
intractable problems, such as pairing input-target data, which have not yet been
adequately discussed.
In this study, the corridor travel time prediction problem has been divided into
two stages with the first stage on prediction of the segment travel time and the second
stage on corridor travel time aggregation methodologies of the predicted segmental
results. To address the dynamic nature of traffic system that are often under the influence
of incidents, time delay neural network (TDNN), state-space neural network (SSNN), and an extended state-space neural network (ExtSSNN) that incorporates incident inputs
are evaluated for travel time prediction along with a traditional back propagation neural
network (BP) and compared with baseline methods based on historical data. In the first
stage, the empirical results show that the SSNN and ExtSSNN, which are both trained
with Bayesian regulated Levenberg Marquardt algorithm, outperform other models. It is
also concluded that the incident information is redundant to the travel time prediction
problem with speed and volume data as inputs. In the second stage, the evaluations on
the applications of the SSNN model to predict snapshot travel times and experienced
travel times are made. The outcomes of these evaluations are satisfactory and the method
is found to be practically significant in that it (1) explicitly reconstructs the temporalspatial
traffic dynamics in the model, (2) is extendable to arbitrary O-D pairs without
complete retraining of the model, and (3) can be used to predict both traveler
experiences and system overall conditions.
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Adequacy Assessment in Power Systems Using Genetic Algorithm and Dynamic ProgrammingZhao, Dongbo 2010 December 1900 (has links)
In power system reliability analysis, state space pruning has been investigated to improve the efficiency of the conventional Monte Carlo Simulation (MCS). New algorithms have been proposed to prune the state space so as to make the Monte Carlo Simulation sample a residual state space with a higher density of failure states.
This thesis presents a modified Genetic Algorithm (GA) as the state space pruning tool, with higher efficiency and a controllable stopping criterion as well as better parameter selection. This method is tested using the IEEE Reliability Test System (RTS 79 and MRTS), and is compared with the original GA-MCS method. The modified GA shows better efficiency than the previous methods, and it is easier to have its parameters selected.
This thesis also presents a Dynamic Programming (DP) algorithm as an alternative state space pruning tool. This method is also tested with the IEEE Reliability Test System and it shows much better efficiency than using Monte Carlo Simulation alone.
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Distributed generation of state space for timed Petri nets /Rada, Irina, January 2000 (has links)
Thesis (M.Sc.)--Memorial University of Newfoundland, 2000. / Bibliography: p. 79-84.
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Decision diagram algorithms for logic and timed verificationWan, Min. January 2008 (has links)
Thesis (Ph. D.)--University of California, Riverside, 2008. / Includes abstract. Title from first page of PDF file (viewed March 10, 2010). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 166-170). Also issued in print.
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Applications of lattice theory to model checkingKashyap, Sujatha 27 April 2015 (has links)
Society is increasingly dependent on the correct operation of concurrent and distributed software systems. Examples of such systems include computer networks, operating systems, telephone switches and flight control systems. Model checking is a useful tool for ensuring the correctness of such systems, because it is a fully automatic technique whose use does not require expert knowledge. Additionally, model checking allows for the production of error trails when a violation of a desired property is detected. Error trails are an invaluable debugging aid, because they provide the programmer with the sequence of events that lead to an error. Model checking typically operates by performing an exhaustive exploration of the state space of the program. Exhaustive state space exploration is not practical for industrial use in the verification of concurrent systems because of the well-known phenomenon of state space explosion caused by the exploration of all possible interleavings of concurrent events. However, the exploration of all possible interleavings is not always necessary for verification. In this dissertation, we show that results from lattice theory can be applied to ameliorate state space explosion due to concurrency, and to produce short error trails when an error is detected. We show that many CTL formulae exhibit lattice-theoretic structure that can be exploited to avoid exploring multiple interleavings of a set of concurrent events. We use this structural information to develop efficient model checking techniques for both implicit (partial order) and explicit (interleaving) models of the state space. For formulae that do not exhibit the required structure, we present a technique called predicate filtering, which uses a weaker property with the desired structural characteristics to obtain a reduced state space which can then be exhaustively explored. We also show that lattice theory can be used to obtain a path of shortest length to an error state, thereby producing short error trails that greatly ease the task of debugging. We provide experimental results from a wide range of examples, showing the effectiveness of our techniques at improving the efficiency of verifying and debugging concurrent and distributed systems. Our implementation is based on the popular model checker SPIN, and we compare our performance against the state-of-the-art state space reduction strategies implemented in SPIN. / text
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Efficient and effective symbolic model checkingIyer, Subramanian Krishnan 28 August 2008 (has links)
Not available / text
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