<p>Efforts to create a reliable, long–term implantable glucose sensor have been stymied by the effects of the foreign body response and wound healing that introduce delayed response times as well as unpredictable sensor performance. Loss of vascularization from fibrotic encapsulation around implanted sensors is purported as a key contributor to sensor failure, as glucose and oxygen transport to the sensor becomes impeded. Improving sensor performance by increasing angiogenesis and/or reducing capsule thickness using tissue-modifying textured coatings is attractive because texturing is not dependent upon a depletable drug reservoir. A significant range of materials and pore sizes are capable of promoting angiogenesis and reducing capsule thickness, provided pores have open-architecture with dimensions sufficiently large enough to allow inflammatory cell infiltration. </p><p><br></p><p>Poly–L–lactic acid was gas foamed/salt leached with ammonium bicarbonate to produce porous coatings for Medtronic MiniMed SOF–sensor glucose sensors. Coating properties included 30μm pore diameters, 90% porosity, and 50μm wall thickness. Cytotoxicity, degradation, and sensor response time studies were performed to ensure the porous coatings were non–toxic and negligibly retarded glucose diffusion prior to <italic>in vivo</italic> testing. Histology was used to evaluate angiogenesis and collagen deposition adjacent to porous coated and bare (i.e. smooth, uncoated) non–functional sensor strips after three weeks in the rat dorsal subcutis. Functional Medtronic glucose sensors, with and without porous coatings, were percutaneously implanted in the rat dorsum to assess if the angiogenic–inducing properties observed around the non–functional porous coated sensor strips translated into stable, non–attenuated sensor signals over two and three weeks. MiniLink<super>TM </super>transmitters were attached to the rats, permitting continuous glucose monitoring. Vessel counts and collagen deposition adjacent to sensors were determined from histological analysis. A one–sided dorsal window model was developed to further evaluate the interplay between vascularization and sensor performance Sensors were inserted beneath the windows, allowing visualization of microvascular changes adjacent to sensor surfaces, with simultaneous evaluation of how vascular changes impacted interstitial glucose monitoring. </p><p><br></p><p>Porous coating did have angiogenic–inducing effects on the surrounding tissue. When fully implanted in the rat dorsum, sensor strips with porous coatings induced three–fold more vessels within 100μm<super>2</super> of the sensor strip surface after three weeks and two-fold more cumulative vessel lengths within 1mm<super>2</super> after two weeks, compared to bare surfaces. In contrast, when percutaneously implanted in the rat dorsum, porous coated and bare sensors were equally highly vascularized, with two–fold more vessels than fully implanted bare sensors. </p><p><br></p><p>Despite increased angiogenesis adjacent to percutaneous sensors, sensor signal attenuation occurred over 14 days, suggesting that angiogenesis plays a secondary role in maintaining sensor function. Percutaneously implanted porous coated sensors had greater reductions in baseline current (20 to 50+%) over two weeks than bare sensors (10 to 30%). Mechanical stresses imposed by percutaneous tethering may override the beneficial effects of porous coatings. Furthermore, integration of the porous coating with the surrounding tissue may have increased tissue tearing at the porous coating–tissue, increasing inflammation and collagen deposition resulting in greater signal attenuation compared with bare sensors. Future investigations of the role mechanical irritation has on wound healing around percutaneous glucose sensors are warranted.</p> / Dissertation

The transmission of electric power over long distances has historically posed challenges. However, the advent of high-voltage engineering has not only addressed distance barriers and power losses in electricity transmission and distribution, but it has also significantly improved the efficiency and transmission capacity of power grids. However, the use of high-voltage techniques has presented new challenges in identifying suitable insulator materials capable of withstanding high electrical stresses associated with elevated voltages. A significant issue arising from these extreme electrical stresses is the occurrence of partial discharges (PDs). Those are electrical sparks or pulses in the magnitude order of pico- or nano-coulombs (pC or nC) emitted from high voltage conductors due to the presence of impurities, contaminants or defects in their insulation system. PDs pose a serious threat to the insulation material due to their aggressive nature in breaking down weak points or links inside the insulation system leading to short-circuit and system failure. Means of offline or conventional testing of power assets against partial discharges has proven to be extremely precise but it is often an unavailable option since it requires a total power shutdown. In this paper, the performance of existing online PD detection techniques is tested and evaluated in terms of performance against conventional PD monitoring methods. Five non-intrusive detectors including an infrared camera (IR-camera), an ultrasonic sensor , a temperature and relative humidity sensor (TRH-sensor), high-frequency current transformer (HFCT sensor) and transient earth voltage antenna (TEV-antenna) were tested in a laboratory experiment for detection of PDs emitted by artificially-created defects inside a medium-voltage cable termination. The results showed varying sensitivity levels among the sensors, with the HFCT sensor demonstrating the highest sensitivity to all types and magnitudes of PDs. The IR-camera and ultrasonic sensor also showed potential, while the TRH-sensor exhibited poor sensitivity. The TEV-antenna had limited reliability. The findings of this study are that the HFCT system proved to be highly reliable for online PD monitoring, followed by the IR-camera and ultrasonic sensor, while the TEV-antenna and TRH-sensor showed lower reliability. In future work, further research on testing the HFCT system on-site can be conducted along with performing longer thermographic detection tests using the IR-camera to further investigate their potential in online PD detection. / Överföring av elektrisk kraft över långa avstånd har historiskt sett varit utmanande. Införandet av högspänningsteknik har inte bara övervunnit avståndsbarriärer och effektförluster vid överföring och distribution av elkraft, utan det har också avsevärt förbättrat kraftnätens effektivitet och överföringskapacitet. Användningen av högspänningsteknik har dock också inneburit nya utmaningar såsom utveckling av lämpliga isoleringsmaterial som tål höga elektriska påfrestningar vid höga spänningar. Ett betydande problem som härrör från dessa extrema elektriska spänningar är förekomsten av partiella urladdningar. Dessa urladdningar identifieras vara elektriska gnistor eller pulser i storleksordningen pico- eller nanocoulombs (pC eller nC) som emitteras från högspänningsledare på grund av närvaron av föroreningar eller defekter i närliggande isoleringssystem. PD:er utgör ett allvarligt hot mot isoleringsmaterialet på grund av deras aggressiva natur för att bryta ner svaga punkter eller länkar i isoleringssystemet, vilket kan leda till kortslutningar och systemfel. Konventionella metoder för att testa nätkomponenter mot partiella urladdningar har visat sig vara extremt noggranna, men detta är ofta inte ett tillgängligt alternativ eftersom det kräver ett totalt strömavbrott för att utföras. I denna studie testades och utvärderades prestandan hos befintliga metoder för online-detektering av partiell urladdning i förhållande till konventionella övervakningsmetoder. Fem icke-invasiva detektorer, inklusive en infraröd kamera, en ultraljudssensor, en temperatur- och relativ fuktighetssensor, en högfrekvent strömtransformator och en transient jordspänningsantenn, testades i ett laboratorieexperiment för att upptäcka partiella urladdningar orsakade av artificiellt skapade defekter i en mellanspänningskabelavslutning. Resultaten visade varierande känslighetsnivåer bland sensorerna, där högfrekventa strömtransformatorn visade den högsta känsligheten för alla typer och storlekar av partiella urladdningar. Den infraröda kameran och ultraljudssensorn visade också potential, medan temperatur- och relativ fuktighetssensorn visade låg känslighet. Den transienta jordspänningsantennen hade begränsad tillförlitlighet. Slutsatsen av denna studie är att den högfrekventa strömtransformatorn visade sig vara mycket tillförlitlig för online-övervakning av partiella urladdningar, följt av den infraröda kameran och ultraljudssensorn, medan den transienta jordspänningsantennen, temperatur- och fuktighetssensorn visade lägre tillförlitlighet. I framtida forskning kan ytterligare undersökningar av det högfrekventa strömtransformatorsystemet utföras på plats, tillsammans med längre termografiska detekteringstester med hjälp av den infraröda kameran för att ytterligare undersöka deras potential för onlinedetektering av partiella urladdningar.

<p>There are no commercially available wearable shoe in-sole sensors that are capable of measuring and distinguishing between shear and compression forces. Companies have already developed shoe sensors that simply measure pressure and make general inferences on the collected data with elaborate software [2, 3, 4, 5]. Researchers have also attempted making sensors that are capable of measuring shear forces, but they are not well suited for biomedical applications [61, 62, 63, 64]. This work focuses on the development of a novel wearable sensor system that is capable of identifying and measuring shear and compression forces through the use of capacitive sensing. Custom hardware and software tools such as materials test systems and capacitive measurement systems were developed during this work. Numerous sensor prototypes were developed, characterized, and optimized during the scope of this project. Upon analysis of the data, the best capacitive measurement system developed in this work utilized the CAV444 IC chip, whereas the use of the Arduino-derived measurement system required data filtering using median and Butterworth zero phase low pass filters. The highest dielectric constant reported from optimization experiments yielded 9.7034 (+/- 0.0801 STD) through the use of 60.2% by weight calcium copper titanate and ReoFlex-60 silicone. The experiments suggest certain sensors developed in this work feasibly measure and distinguish between shear and compressional forces. Applications for such technology focus on improving quality of life in areas such as managing diabetic ulcer formation, preventing injuries, optimizing performance for athletes and military personnel, and augmenting the scope of motion capture in biomechanical studies.</p>