Interfacial mechanical properties of adhesive joints are very crucial in board applications, including composites, multilayer structures, and biomedical devices. Establishing traction-separation (T-S) relations for interfacial adhesion can evaluate mechanical and structural reliability, robustness, and failure criteria. Due to the short range of interfacial adhesion such as micro to nanoscale, accurate measurements of T-S relations remain challenging. The advent of machine learning (ML) became a promising tool to predict materials behaviors and establish data-driven mechanical models. In this study, we integrated a state-of-the-art ML method, finite element analysis (FEA), and standard experiments to develop data-driven models for characterizing the interfacial mechanical properties precisely. Macroscale force-displacement curves are derived from FEA with incorporation of double cantilever beam tests to generate the dataset for ML model. The eXtreme Gradient Boosting (XGBoost) multi-output regressions and classifier models are used to determine T-S relations with R2 score of 98.8% and locate imperfections at the interface with accuracy of around 80.8%. The outcome of the XGBoost models demonstrated accurate predictions and fast calculation speed, outperforming several other ML methods. Using 3D printed double cantilever beam specimens, the performance of the ML models is validated experimentally for different materials. Furthermore, a XGBoost model-based package is designed to obtain different adhesive materials T-S relations without creating a database or training a model.

Barn vars förälder är frihetsberövad är en dold grupp i samhället som inte uppmärksammas.Dessa barn går därför miste om den hjälp som de behöver för att vardagen ska underlättas.Syftet med denna studie är att få en bredare förståelse för hur ett barn påverkas av att ha enförälder som är frihetsberövad. Detta utifrån vilken påverkan separationen mellan barnet ochdess förälder har, utifrån ett emotionellt och beteendemässigt perspektiv men även utifrån hurvardagslivet i olika aspekter påverkas av att ha en frihetsberövad förälder. Studien är enkvalitativ studie där vår empirin till vår studie bygger på fyra semistrukturerade intervjuermed två intervjupersoner från Solrosen, en intervjuperson från Bufff samt en forskare inomområdet. Det är intervjupersonernas erfarenhet som studien grundar sig i. Vi har utgått fråntidigare forskning samt anknytningsteorin för att bearbeta och analysera resultaten. Det somframförs i resultat- och analysdelen är främst att alla barn påverkas på olika sätt och att detinte finns ett klart svar. Svaret på vårt syfte varierar och beror på relationen barnet har till denfrihetsberövade föräldern.

An investigation into whether Plato was committed to separate Forms in the Phaedo. Two accounts of separation are distinguished: Gail Fine's modal account where separation is a capacity to exist independendently from sensible particulars, and Daniel D. Devereux' non-modal account where separation is equivalent with non-immanence. I analyse multiple key passages of the Phaedo using these accounts of separation, to see whether any passage commits Plato to separation understood in either modal or non-modal terms. I argue and conclude that there is no evidence of Plato being committed to separation in the Phaedo, understanding separation in either modal or non-modal terms.

Due to the fact that approximately 50% of US first marriages ending in divorce, there is a growing need to identify and understand the causal mechanisms behind these separations and what effects this event has upon the family unit. This study employed secondary data analyses on the Fragile Families and Child Well-Being Study to identify the differences in the frequency of adverse health behaviors among fathers that are coupled with their partner and those who are divorced/separated. Trends of the fathers from the baseline survey to the five-year follow-up allowed us to observe the following: Differences in adverse health behaviors, self-reported mental health status, and the potential impact relationship dynamics have upon the family unit. A bio-behavioral marker was created to assist in identifying possible future effects of adverse health behaviors upon the family. Results show the non-married fathers participate in alcohol consumption, illegal substances, cigarette consumption and show more symptoms of depression at higher rates and more frequently than the married fathers. The non-married fathers put their children at the greatest risk of developing adverse health behaviors later in life.

Sepsis is a “life-threatening organ dysfunction caused by a dysregulated host response to infection” that has a widespread impact on human life around the world. It affects more than 1.5 million people, killing at least 250,000 each year in the US alone and affects 90,000 people annually, with estimated mortality rates of up to 30% in Canada. Our understanding of the different biochemical pathways that in the progression of sepsis has improved patient care for sepsis patients. One part of patient care is the use of biomarkers for patient prognosis that draws on the full range of relevant and available information to model the possible outcomes for an individual. Numerous biomarkers have been studied for patient prognosis that includes Procalcitonin (PCT), C-reactive protein (CRP), TNF-α, cfDNA, protein C and PAI 1. Using a panel of multiple biomarkers provided more accuracy in patient prognosis than using individual biomarkers and one such panel that was proposed used cfDNA, protein C, platelet count, creatinine, Glasgow Coma Scale [GCS] score, and lactate. Commercial, low cost POC techniques were available for the measurement of all biomarkers besides cfDNA and protein C. The objective of this doctoral thesis was chosen to develop low cost, microfluidic devices for the measurement of protein C and cfDNA using nonspecific fluorescence dyes that would enable the eventual integration of the systems and improve patient prognosis. The measurement of protein C in plasma required the separation of protein C from interfering proteins in plasma. This was done through the development of a two-stage separation process that included the development of tunable agarose isoelectric gates for separating proteins using their isoelectric point and the miniaturization of immobilized metal affinity chromatography and its extension to Barium for the selective binding of proteins using their chemical affinity. This was performed in a xurographically fabricated chip to reduce costs and enable the use of geometric focusing of the electric field to enable the operation of the device at a lower applied voltage. The challenges faced with cfDNA were different due to the different characteristics of the material and less interference from plasma. The requirement was to measure the total cfDNA content with minimal cost in comparison to currently available techniques. This was achieved through the development of thread microfluidic devices that showed the use of thread for automated aliquoting of samples by controlling length and twists of the thread. Preconcentration and use of external apparatus was avoided by showing that thread could be used to amplify fluorescence response to a range that was sufficient for the measurement of cfDNA in sepsis patients. A portable fluorescence imaging setup was developed for this purpose and was used in demonstration for the measurement of cfDNA in plasma with sufficient resolution. In conclusion, we developed technologies for rapid and low-cost measurement of protein C and cfDNA using xurographic and thread-based microfluidics that may serve as valuable in improving patient prognosis. / Thesis / Doctor of Philosophy (PhD) / Sepsis is a major reason for hospitalization and cause of death in hospitals worldwide. Its treatment is highly time sensitive with each hour of delay in diagnosis causing a significant increase in chances of death. Due to the wide range of symptoms that can be caused by sepsis, its diagnosis uses a scoring method that relies on the expertise of the onsite doctors and nurses increasing their workload. A more objective system for detection requires the measurement of the quantities of different biomarkers in blood. Biomarkers are proteins present in plasma that change in quantity due to the body’s reaction to sepsis. Several of these biomarkers have been identified and studied for their use in both diagnosing the presence of sepsis and in predicting the outcome with the current treatment plan. In this PhD study, we chose two of these biomarkers – circulating free DNA (cfDNA) and protein C and developed low-cost techniques for rapidly measuring their concentration in blood plasma. To do this, we made microfluidic devices with techniques that use low-cost materials such as plastic sheets and threads.The device for the measurement of protein C required separating it from many other proteins in plasma. We showed that a device fabricated from stacked plastic sheets and integrated with agarose gels could be used for the measurement of protein C in plasma with sufficient resolution to help with treating septic patients at a cost of less $5 per device. Similarly, we showed that a device that integrated threads with plastic sheets could be used for measuring the quantity of cfDNA in plasma in a portable format within 15 minutes. Overall, we developed tools for rapid measurement of two biomarkers of sepsis using low cost device that cost under $5 to run and could led to improving the quality of care for sepsis patients.

In an effort to understand the behavior of the laminar separation bubbles on NACA 0012 and Liebeck LA2573a airfoils at different Reynolds numbers and angles of attack, the boundary layers on the solid airfoils were investigated by measuring the mean and fluctuating components of the velocity profiles over the upper surfaces of the airfoils. Surface pressure measurements were carried out to complete the mapping of the laminar separation bubble and to calculate the lift generated by the airfoils. The experiments were carried out at Reynolds numbers of 150,000 and 250,000. The locations of separation, transition and reattachment were determined as functions of angle of attack and Reynolds number for the two airfoils. The drag was estimated from wake pressure measurements and was based on the momentum deficit generated by the airfoil. The size and location of the laminar separation bubble did not show significant changes with Reynolds number and angle of attack for values of the angle of attack between 0 and 6 d grees. The baseline results of the size and location of the laminar separation bubble on the LA2573a airfoil were used to design a suction distribution. This suction distribution was designed based on Thwaites’ criterion of separation. The effects of applying suction on the size and location of the laminar separation bubble were investigated. The results showed that the suction distribution designed in this work was effective in controlling the size of the laminar separation bubble, maintaining an un-separated laminar boundary layer to the transition point, and controlling the location of transition. The effects of different suction rates and distributions on the drag were investigated. Drag reductions of 14-24% were achieved. A figure of merit was defined as drag reductions divided by the equivalent suction drag to assess the worthiness of the utilizing suction on low Reynolds number flows. The values of the figure of merit were around 4.0 which proved that the penalty of using suction was significantly less than the gain obtained in reducing the drag.

京都大学 / 新制・課程博士 / 博士(医学) / 甲第24134号 / 医博第4874号 / 新制||医||1060(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 竹内 理, 教授 中川 一路, 教授 髙折 晃史 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

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