Indiana University-Purdue University Indianapolis (IUPUI) / Haemophilus ducreyi is the causative agent of the genital ulcer disease chancroid, which has been shown to facilitate the transmission of HIV. H. ducreyi is likely exposed to multiple sources of antimicrobial peptides in vivo. APs are small, cationic molecules with both bactericidal and immunomodulatory functions. Because H. ducreyi is able to establish and maintain an infection in an environment rich with antimicrobial peptides, we hypothesized that the bacterium was resistant to the bactericidal effects of these peptides. Using a 96-well AP bactericidal assay, we examined H. ducreyi susceptibility to eight human APs likely to be encountered at the site of infection, including the α-defensins human neutrophil peptide-1, human neutrophil peptide-2, human neutrophil peptide-3, and human defensin 5, the β-defensins human β defensin-2, human beta defensin-3, and human beta defensin-4, and the human cathelicidin, LL-37. H. ducreyi survival was compared to the survival of Escherichia coli ML35, a strain known to be susceptible to several antimicrobial peptides. H. ducreyi was significantly more resistant than E. coli ML35 to the bactericidal effects of all peptides tested. Furthermore, we found that representative class I and class II strains of H. ducreyi were each resistant to APs of each functional category, indicating that resistance to antimicrobial peptides could represent a conserved method of pathogenesis for H. ducreyi as a species. The H. ducreyi genome contains a homolog for the Sap influx transporter. To study the role of the H. ducreyi Sap transporter in AP resistance, we generated an isogenic sapA mutant and used the 96-well AP bactericidal assay to compare the AP susceptibility profiles of wild-type H. ducreyi, the sapA mutant and the sapA trans-complement to α-defensins, β-defensins, and LL-37. We observed a 25% decrease in the survival of the sapA mutant when it was exposed to LL-37. These findings suggest that the H. ducreyi Sap transporter plays a role in H. ducreyi resistance to LL-37, but it is likely that other AP resistance mechanisms co-exist within the bacterium.

During the Progressive Era in the United States, social hygiene reformers underwent a fundamental change in their stance toward women accused of prostitution or promiscuous behavior. Rather than viewing such women as unfortunate victims of circumstance who were worthy of compassion, many Progressives deemed them as predatory villains who instead deserved incarceration, forced rehabilitation, and non-consenting medical interference. Texas, due to the many military bases within its borders, became a key battleground in this moral crusade against women as the carriers and proliferators of VD. "Promiscuous" women were seen as not only dangerous to the soldiers but also as a threat to the nation's security, creating an environment that led Texas Progressives to suppress women's civil liberties in the name of protecting soldiers. The catalyst for this change in attitude was World War I. The Great War brought to the forefront an unpleasant reality facing a significant percentage of America's fighting men: venereal disease. While combating sexually transmitted diseases was a serious medical and manpower concern for the military in the era before penicillin, the sole focus on women as the carriers and proliferators of VD led to a nationwide campaign against the "social evil" that demonized women and led to the suspension of thousands of women's habeas corpus rights. This dissertation examines how the twin crusades of Progressivism and the War to End All Wars created conditions in Texas that for many women meant appalling repression rather than progress toward the enjoyment of greater equality.

This study attempts to understand prostitution from their definition of the situation. It differs in its method from other studies on prostitution in that the investigation was based on the prostitutes' own perspectives as interpreted by the researcher using the interpretative epistemological tradition. A comparative analysis of prostitution in two economically stable African Countries, namely Nigeria and Botswana was made. This study investigated society's perception of prostitutes and how it impacts upon their empowerment and emancipation as vulnerable members of the society and their participation in prevention and control of sexually transmitted infection including HIV/AIDS. Also the role of governments and individuals in creating and sustaining prostitution, an extensive insight to the modus operandi of prostitution and suggestions on how best to address prostitution in society, were discussed. A triangulated methodology of three hundred and twenty five sexworkers (325) that includes a quantitative study of two hundred and five sex workers complimented with a qualitative study of one hundred and twenty sex workers participating in focus group discussion and case studies informed the study. The findings of the research suggest that in the prostitutes' own definition of the situation; prostitutes contribute to the maintenance of societal equilibrium, the society creates and sustains prostitution. Economic need rather than lack of morals creates prostitutes and their situation of vulnerability as women is being reinforced by their status as prostitutes. Violence from partners that includes the police and the inability to reprimand their clients, are some hazards of prostitution and these result in their mobility and creates a challenge in adequately addressing the issue of prostitution in society, including their limited participation in the control of STDs. Respondents in Botswana had a very good knowledge of STI's /HIV/AIDS and had no difficulties in going to hospital in the event of any STD's as compared with Nigerian respondents. The Nigerian respondents' indulged in self-medication with antibiotics and traditional herbs mixed in local gin before and after a sexual act, rather than go to hospitals. The research findings should assist the government and international community's policies and programmes aimed at addressing prostitution and STDs/HIV/AIDS. / Sociology / D.Litt. et Phil.(Sociology)

The study sought to explore and describe the risk behaviour regarding HIV transmission among youth in Bulawayo, their knowledge of HIV transmission and the sources of information on HIV transmission accessible to them. A quantitative, descriptive exploratory design was used and 238 youth from three secondary schools in Bulawayo, the second largest city in Zimbabwe were the respondents. The Health Belief Model (HBM) was used to facilitate and acquire insight into the risk behaviour among the youth. The inferences drawn from the study were that youth have inadequate knowledge about HIV transmission and therefore do not fully understand their risk of infection. Youth also find shyness and fear of rejection serious barriers to communicating openly about sexuality, sexual and HIV/AIDS issues. The findings of the study have implications for programmes to limit HIV transmission among youth and should assist policymakers and educators in developing and implementing such programmes in order to improve the health of youth in Zimbabwe. / Health Studies / M.A. (Health Studies)

Background: Herpes Simplex Virus Type 2 (HSV 2) is one of the most common sexually transmitted infections (STIs) worldwide. HSV 2 infection is a risk factor for the acquisition and transmission of other STIs. Aim: The aim of this study is to determine prevalence and predictors of HSV 2 infection in Durban, South Africa by using available data that has not been previously analysed for the purpose of adding scientific evidence to the existing body of knowledge relating to HSV 2. Method: The study involves secondary analyses of data collected as a prospective study which enrolled women who participated in a clinical trial. A total of 3472 sexually active women were screened in the primary study from two clinics in Durban. All consenting participants were tested for HIV, HSV 2, Trichomonas vaginalis (TV), Neisseria gonorrhoea (NG) and Chlamydia trachomatis (CT) infection. Results: There were 2532 women who had HSV 2 giving a prevalence of 73%. Of these, 53% also tested positive for HIV infection. In univariate analysis, co-infection with HIV was strongly associated with HSV2 (Odds Ratio (OR): 7.4, 95% Confidence Interval (CI): 6.0, 9.1, p<0.001). There was also an association between other STIs, such as CT, NG and syphilis and HSV 2, although only NG was significantly associated with prevalent of HSV 2 (OR: 2.3, 95% CI: 1.3, 4.1, p=0.005). Women older than 25 years of age more likely to have HSV 2 (OR: 2.4, 95% CI: 2.0,2.8, p<0.001). A risk of being infected with HSV 2 increased with the number of reported lifetime sexual partners Those with two and three or more were 2,5 and 4.6 times more likely to have HSV2 respectively (OR: 2.5, 95% CI: 2.1,3.1, p<0.001 and OR: 4.6, 95% CI: 3.8, 5.6, p<0.001 respectively). Women who had less than high school education were also found to have higher risk for HSV 2. Conclusion: The secondary analysis showed a high prevalence of HSV 2 infection and a strong association of HSV 2 and HIV. A significant association of HSV 2 was noted in women having more than two sex partners and lower high school education. Therefore, it is recommended that screening for HSV 2 among high risk populations be incorporated into the STI screening and treatment packages. / Prevalence and risk factors associated with HSV 2 / Herpes Simplex Virus Type 2 / HSV 2 / Department of Health Studies / M. (Public health)

This study examines how African American gender scripts influence condom use for disease and pregnancy prevention. One-hundred African American California State University, San Bernardino (CSUSB) students were selected to participate in this study. Fifty African American males and fifty African American females were surveyed for this study to be representative of the African American community on campus.

Includes bibliographical references (leaves 280-305). Argues that despite the liberal use of social control theory in the literature on the social history of venereal diseases, rationale discourses do not necessarily lead to government intervention. Comparative analysis reveals that culturally similar locations can experience similar impulses and constraints to the development of social policy under differing constitutional arrangements.

Includes bibliographical references (leaves 280-305). / iii, 305 leaves ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Argues that despite the liberal use of social control theory in the literature on the social history of venereal diseases, rationale discourses do not necessarily lead to government intervention. Comparative analysis reveals that culturally similar locations can experience similar impulses and constraints to the development of social policy under differing constitutional arrangements. / Thesis (Ph.D.)--University of Adelaide, Dept. of History, 2001

The study sought to explore and describe the risk behaviour regarding HIV transmission among youth in Bulawayo, their knowledge of HIV transmission and the sources of information on HIV transmission accessible to them. A quantitative, descriptive exploratory design was used and 238 youth from three secondary schools in Bulawayo, the second largest city in Zimbabwe were the respondents. The Health Belief Model (HBM) was used to facilitate and acquire insight into the risk behaviour among the youth. The inferences drawn from the study were that youth have inadequate knowledge about HIV transmission and therefore do not fully understand their risk of infection. Youth also find shyness and fear of rejection serious barriers to communicating openly about sexuality, sexual and HIV/AIDS issues. The findings of the study have implications for programmes to limit HIV transmission among youth and should assist policymakers and educators in developing and implementing such programmes in order to improve the health of youth in Zimbabwe. / Health Studies / M.A. (Health Studies)

This study attempts to understand prostitution from their definition of the situation. It differs in its method from other studies on prostitution in that the investigation was based on the prostitutes' own perspectives as interpreted by the researcher using the interpretative epistemological tradition. A comparative analysis of prostitution in two economically stable African Countries, namely Nigeria and Botswana was made. This study investigated society's perception of prostitutes and how it impacts upon their empowerment and emancipation as vulnerable members of the society and their participation in prevention and control of sexually transmitted infection including HIV/AIDS. Also the role of governments and individuals in creating and sustaining prostitution, an extensive insight to the modus operandi of prostitution and suggestions on how best to address prostitution in society, were discussed. A triangulated methodology of three hundred and twenty five sexworkers (325) that includes a quantitative study of two hundred and five sex workers complimented with a qualitative study of one hundred and twenty sex workers participating in focus group discussion and case studies informed the study. The findings of the research suggest that in the prostitutes' own definition of the situation; prostitutes contribute to the maintenance of societal equilibrium, the society creates and sustains prostitution. Economic need rather than lack of morals creates prostitutes and their situation of vulnerability as women is being reinforced by their status as prostitutes. Violence from partners that includes the police and the inability to reprimand their clients, are some hazards of prostitution and these result in their mobility and creates a challenge in adequately addressing the issue of prostitution in society, including their limited participation in the control of STDs. Respondents in Botswana had a very good knowledge of STI's /HIV/AIDS and had no difficulties in going to hospital in the event of any STD's as compared with Nigerian respondents. The Nigerian respondents' indulged in self-medication with antibiotics and traditional herbs mixed in local gin before and after a sexual act, rather than go to hospitals. The research findings should assist the government and international community's policies and programmes aimed at addressing prostitution and STDs/HIV/AIDS. / Sociology / D.Litt. et Phil.(Sociology)