We present surgical clipping of a giant middle cerebral artery aneurysm. The patient is a 64-year-old woman who suffered subarachnoid hemorrhage in 2005. She was treated with coiling of the aneurysm at an outside institution. She presented to our clinic with headaches and was found on angiography to have giant recurrence of the aneurysm. To allow adequate exposure for clipping, we performed the surgery through a cranio-orbito-zygomatic (COZ) skull base approach, which is demonstrated. The surgery was performed in an operating room/angiography hybrid suite allowing for high quality intraoperative angiography. The technique and room flow are also demonstrated.

No description available.

A brain tumor is detected and classified by biopsy that is conducted after the brain surgery. Advancement in technology and machine learning techniques could help radiologists in the diagnosis of tumors without any invasive measures. We utilized a deep learning-based approach to detect and classify the tumor into Meningioma, Glioma, Pituitary tumors. We used registration and segmentation-based skull stripping mechanism to remove the skull from the MRI images and the grab cut method to verify whether the skull stripped MRI masks retained the features of the tumor for accurate classification. In this research, we proposed a transfer learning based approach in conjunction with discriminative learning rates to perform the classification of brain tumors. The data set used is a 3064 T MRI images dataset that contains T1 flair MRI images. We achieved a classification accuracy of 98.83%, 96.26%, and 95.18% for training, validation, and test sets and an F1 score of 0.96 on the T1 Flair MRI dataset.

During the course of time, artificial selection has given rise to a great diversity among today's dogs. Humans and dogs have evolved side by side and dogs have come to understand human body language relatively well. This study investigates whether selection pressure and domestication could reveal differences in dogs’ skill to interpret human directional cues, such as distal pointing. In this study, 46 pet dogs were tested from 27 breeds and 6 crossbreeds for performance in the two-way object choice task. Breeds that are selected to work with eye contact of humans were compared with breeds that are selected to work more independently. Dogs of different skull shape were also compared, as well as age, sex and previous training on similar tasks. No significant differences in performance were found between dogs of various age, sex or skull shape. There was a tendency for significant difference in performance if the dog had been previously trained on similar tasks. When dogs that made 100% one-sided choices were excluded, a tendency appeared for there to be a difference between the cooperative worker breeds compared to the other breeds for the time it took for dogs to make a choice. There is a correlation between the number of correct choices made and the latency for the dogs from being release to making a choice (choice latency). All groups of dogs, regardless of my categorization, performed above chance level, showing that dogs have a general ability to follow, and understand, human distal pointing.

京都大学 / 新制・課程博士 / 博士(理学) / 甲第24181号 / 理博第4872号 / 新制||理||1697(附属図書館) / 京都大学大学院理学研究科生物科学専攻 / (主査)教授 中務 真人, 教授 森 哲, 准教授 森本 直記 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

No description available.

No description available.

Connective tissue growth factor (CTGF/CCN2) is axiomatically necessary for proper skeletal development and function. We need not look further than the studies that have been done to date utilizing mice genetically engineered to lack CTGF production. These CTGF null or knockout (KO) mice fail to form a normal murine skeleton and instead yield one littered with bony dysmorphisms, including incompetent craniofacial development, kinked limb bones, and misshapen ribs that are not conducive to proper respiratory function. As a result, the global lack of CTGF is incompatible with postnatal life. A closer look at several sites demonstrated defects in physiologic processes necessary for bone formation - angiogenesis, chondrogenesis, and osteogenesis. Therefore, the dogma in the CCN protein field to date has been that systemic ablation of CTGF production in vivo results in global defects in bone development. We believe this dogma is an oversimplification of the role of CTGF on skeletal development. Our initial impetus leading us to this belief was the gross identification of the specific skeletal sites malformed in CTGF KO mice, in particular the bones of the limbs. While in the lower limb of CTGF KO mice the tibiae and fibulae are misshapen, the adjacent femora and digits are phenotypically normal. The same is true for the upper limb, in which the radii and ulnae are phenotypically abnormal while the humeri and digits are normal. Therefore, we believe that the role of CTGF in skeletogenesis is site-specific such that its loss affects local skeletal patterning and/or mechanobiological cues resulting in the unique phenotype seen in CTGF KO mice. The research of this dissertation constitutes a comprehensive skeletal analysis of CTGF KO mice and in so doing we determined the extent and location of skeletal abnormalities. We found skeletal site-specific changes in growth plate organization, bone microarchitecture and shape and gene expression levels in CTGF KO compared to wild-type (WT) mice. Growth plate malformations included reduced proliferation zone and increased hypertrophic zone lengths. Appendicular skeletal sites demonstrated decreased metaphyseal trabecular bone, while having increased mid-diaphyseal bone and osteogenic expression markers. Axial skeletal analysis showed decreased bone in caudal vertebral bodies, mandibles, and parietal bones in CTGF KO mice, with decreased expression of osteogenic markers. Analysis of skull phenotypes demonstrated global and regional differences in CTGF KO skull shape resulting from allometric (size-based) and non-allometric shape changes. Localized differences in skull morphology included increased skull width and decreased skull length. We further continued the skeletal characterization of CTGF KO bones with an analysis of bone cell ultrastructure and matrix composition. These studies demonstrated that, while CTGF is not necessary for complete morphologic maturation of bone cells, global ablation results in ultrastructural features not commonly seen in WT bones. Our findings include drastically dilated rough endoplasmic reticulum (RER) in osteoblasts of the tibial diaphyseal region, comprising the phenotypic kink in CTGF KO mice and ultrastructural dysmorphologies of CTGF KO osteoclasts including multi-layered, membranous inclusions, decreased vacuolization and ruffled border extents, and disproportionately large clear zones. Lastly, FT-IR analysis demonstrated heterogeneity in CTGF KO bone composition. The results of this dissertation have revealed a more complex role for CTGF in osteogenesis and have identified potential mechanisms and future research directions to fully understand this intricate story. / Cell Biology

This study's primary ambition is to present an overview of the key texts from a genre of Tibetan craniological manuals (Tib. thod brtags) as well as some of their translations, thus illustrating the diversity of this tradition. Based on the reviewed material, a comparison with secondary literature will be made and a few re-evaluations of known facts suggested. Because the only available comprehensive translation of any craniological text was published in 1888 (!) and all the subsequent works have relied on it without necessary critical approach, I decided to translate that original text once again and reveal any possible misinterpretations. As a result, I hope this thesis will contribute to the already present academic (mainly ethnographical oriented) discussion about the use of skulls in Tibet, as its philological support, hence filling up this blank methodological spot. Keywords Tibetan studies, Tibetology, Philology, Tibet, Buddhism, vajrayāna, tantra, ritual object, ritual vessel, human skull, calvaria, cranium, skull cup, craniology, manual, Kapālika gal gnad ming tshig bod, chos, bon, kapāla, ka li, thod pa, thod phor, thod bum, thod zhal, thod rus, bha+ndha, bhandha, ban+dha, bhan ja, dung chen, thod brtag, thod brtags, thod rabs, thod bshad, thod pa'i mtshan, snod, sgrub rdzas, thod sgrub,...

Cette étude porte sur le «Skull Building» de Çayönü (Sud-Est anatolien, Néolithiqueprécéramique), qui est l’un des plus anciens bâtiments à usage funéraire au Proche-Orient. Les restes humains provenant des différents dépôts osseux (110.460fragments) du «Skull Building» ont été étudiés au travers d’une approche archéoantropologiqueet taphonomique qui n’avait encore jamais été appliquée à un sitepréhistorique anatolien. Nous avons mis au point un logiciel de dénombrement,estimé le nombre minimum d’individus inhumés lors de chacune des deux phasesd’utilisation (NMI = 97 pour le bâtiment ovalaire, NMI = 231 pour le bâtimentrectangulaire) et mis en évidence un changement des pratiques entre le bâtimentovalaire (le plus ancien) et le bâtiment rectangulaire (le plus récent). Les résultatsobtenus permettent de proposer une nouvelle interprétation du fonctionnement de cebâtiment, dans la mesure où les analyses ont montré que les différents dépôts de laseconde phase d’utilisation (bâtiment rectangulaire) étaient liés entre eux. / This study focuses on the "Skull Building" of Çayönü (Southeast Anatolian PrepotteryNeolithic), which is one of the oldest buildings for burial use in the MiddleEast. Human remains from different bone deposits (110,460 fragments) of the "SkullBuilding" have been studied through an archaeo-anthropological and taphonomicapproach which had never been applied to a prehistoric site in Anatolia. We havedeveloped a software for counting, estimated the minimum number of individualsburied in each of the two phases of use (NMI = 97 for the Oval Building, NMI = 231for the Rectangular Building) and highlighted a change in practices between the ovalbuilding (the oldest) and the rectangular building (most recent). The results obtainedallow proposing a new interpretation for the functions of this building, insofar as theanalysis showed that different deposits of the second phase of use (RectangularBuilding) were interrelated.