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Reward expectation and spatial attention both exert powerful control over behaviour and modulate neural activity. The experiments in this thesis aimed to chart the dynamics of reward expectation effects across the time course of information processing and examine the relationship between reward and attention. Experiments 3.1 and 3.2 parametrically manipulated reward magnitude in the presence or absence of attention and demonstrated reward could influence reaction time (RT) under conditions of time pressure. Experiments 4.1 and 4.2 independently varied reward and spatial probabilities and illustrated independent and interactive effects of reward and attention at late stages of cognitive processing (the P300 potential), as well as modulation of detection sensitivity (d') by reward under conditions of uncertainty when reward was able to work through feature-based attention. The experiment of Chapter 5 cued reward and attention trial by trial and showed under these conditions, not only could reward influence late stages of information processing, but expectation of reward reduced peak latency of the visual N1 potential. Reward and attention also modulated motor preparation with both independent and interactive effects. The experiment of Chapter 6 examined the dynamics of reward association with task-relevant targets and irrelevant distracters during visual search and demonstrated that task-irrelevant but motivationally-salient distracter items could capture attentional resources away from the target, guided by endogenous reward association alone. The experiments of this thesis demonstrated the ability of reward expectation to modulate both behaviour and multiple stages of information processing, with effects predominantly independent from those of attention. Reward could influence processing from early visual analysis and target detection stages. Interaction between the two systems occurred at late processing stages, whereby reward and attentional information may have been integrated to provide a cohesive representation of the stimulus given the current environmental conditions.

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Despite the rising prevalence of mobile media in young children’s lives, little research exists that examines the effects of mobile media use on early childhood cognitive development. This study will explore how mobile media use, specifically iPad use, in early childhood affects development of visual spatial attention span. Researchers will recruit 160 participants, ages 3 to 6, and categorize them into three groups: TV viewers only, interactive iPad users, and passive iPad users. Children will complete a computer task to measure the length of their visual spatial attention span. Parents will report on the average daily amount of media use, their child’s top three most viewed or used programs and apps, and the pervasiveness of media use, as well as complete a demographics survey. Research assistants will rate the level of exogenous stimuli children are exposed to in their top three programs and apps. Researchers predict that iPad use will be associated with shorter visual spatial attention spans in comparison to TV viewing, due to longer amounts of use, higher levels of exogenous stimuli, and higher levels of pervasiveness. In addition, researchers hypothesize that interactive iPad use will correlate with the shortest visual spatial attention spans due to highest levels of exogenous stimuli and longest amounts of use. The results will help parents and educators to more effectively monitor young children’s mobile media usage.

Visual attention improves sensory processing, as well as perceptual readout and behavior. Over the last decades, many proposals have been put forth to explain how attention affects visual neural processing. These include the modulation of neural firing rates and synchrony, neural tuning properties, and rhythmic, subthreshold activity. Despite the wealth of knowledge provided by previous studies, the way attention shapes interactions between cortical layers within and between visual sensory areas is only just emerging. To investigate this, we studied neural signals from macaque V1 and V4 visual areas, while monkeys performed a covert, feature-based spatial attention task. The data were simultaneously recorded from laminar electrodes disposed normal to cortical surface in both areas (16 contacts, 150 μm inter-contact spacing). Stimuli presentation was based on the overlap of the receptive fields (RFs) of V1 and V4. Channel depths alignment was referenced to laminar layer IV, based on spatial current source density and temporal latency analyses. Our analyses mainly focused on the study of Local Field Potential (LFP) signals, for which we applied local (bipolar) re-referencing offline. We investigated the effects of attention on LFP spectral power and laminar interactions between LFP signals at different depths, both at the local level within V1 and V4, and at the inter-areal level across V1 and V4. Inspired by current progress from literature, we were interested in the characterization of frequency-specific laminar interactions, which we investigated both in terms of rhythmic synchronization by computing spectral coherence, and in terms of directed causal influence, by computing Granger causalities (GCs). The spectral power of LFPs in different frequency bands showed relatively small differences along cortical depths both in V1 and in V4. However, we found attentional effects on LFP spectral power consistent with previous literature. For V1 LFPs, attention to stimuli in RF location mainly resulted in a shift of the low-gamma (∼30-50 Hz) spectral power peak towards (∼3-4 Hz) higher frequencies and increases in power for frequency bands above low-gamma peak frequencies, as well as decreases in power below these frequencies. For V4 LFPs, attention towards stimuli in RF locations caused a decrease in power for frequencies < 20 Hz and a broad band increase for frequencies > 20 Hz. Attention affected spectral coherence within V1 and within V4 layers in similar way as the spectral power modulation described above. Spectral coherence between V1 and V4 channel pairs was increased by attention mainly in the beta band (∼ 15-30 Hz) and the low-gamma range (∼ 30-50 Hz). Attention affected GC interactions in a layer and frequency dependent manner in complex ways, not always compliant with predictions made by the canonical models of laminar feed-forward and feed-back interactions. Within V1, attention increased feed-forward efficacy across almost all low-frequency bands (∼ 2-50 Hz). Within V4, attention mostly increased GCs in the low and high gamma frequency in a 'downwards' direction within the column, i.e. from supragranular to granular and to infragranular layers. Increases were also evident in an ‘upwards’ direction from granular to supragranular layers. For inter-areal GCs, the dominant changes were an increase in the gamma frequency range from V1 granular and infragranular layers to V4 supragranular and granular layers, as well as an increase from V4 supragranular layers to all V1 layers.

Le phénomène de Clignement Attentionnel (Attentional Blink, AB), fait référence à une diminution transitoire du rapport exact d’une deuxième cible (C2) si celle-ci est présentée trop tôt après une première cible (C1) lors d’une présentation visuelle sérielle rapide (rapid serial visual presentation, RSVP), et ce, quand les deux cibles doivent être rapportées. Cette étude a examiné l’existence possible d’asymétries hémisphèriques dans le traitement attentionnel ainsi que l’éventualité que la présentation de cibles à deux hémisphères différents puisse diminuer le AB chez des participants neurologiquement sains et l’abolir dans le cas d’un patient callosotomisé. Pour ce faire, nous avons employé un paradigme modifié du AB dans lequel les cibles pouvaient apparaître dans n’importe quelle de quatre RSVP, une dans chaque quadrant du champ visuel, pour permettre des essais dans lesquels les deux cibles puissent être présentées au même hémisphère et d’autres où chaque cible était présentée à un hémisphère différent. Bien que nous n’ayons trouvé aucune diminution de l’effet AB lors de présentation inter-hémisphérique, dans les deux populations à l’étude, le taux de bonnes réponses globales à la deuxième cible était plus élevé quand les cibles étaient présentées à des hémisphères différents. Nous avons également trouvé un avantage de l’hémisphère gauche chez le patient callosotomisé. / The Attentional Blink (AB) refers to a transient impairment in the accurate report of a second target (T2) if it closely follows the presentation of a first target (T1) in a rapid serial visual presentation (RSVP), when both targets must be reported. This study investigated both the possibility of hemispheric asymmetries of attentional processes as well as the possibility that presenting targets to different hemispheres could diminish the AB in neurologically intact participants and abolish it in the case of a split-brain patient. To do so, a modified AB paradigm was used in which targets could appear in any of four simultaneous RSVP streams, one in each quadrant of the visual field, so as to have trials in which both targets were presented to the same hemispheres and trials in which targets were presented to different hemispheres. Although no evidence of a diminished AB was observed by presenting targets to separate hemispheres, in both neurologically intact individuals and the split-brain patient, overall accuracy was higher when targets were presented to separate hemispheres. A left hemisphere advantage was only observed in the split-brain patient.

Le déficit social, incluant la perturbation du traitement du regard et des émotions, est au cœur de l’autisme. Des études ont montré que les visages de peur provoquent une orientation rapide et involontaire de l’attention spatiale vers leur emplacement chez les individus à développement typique. De plus, ceux-ci détectent plus rapidement et plus efficacement les visages avec un regard direct (vs regard dévié). La présente étude vise à explorer l’effet de l’émotion de peur et de la direction du regard (direct vs dévié) sur l’attention spatiale chez les enfants autistes à l’aide d’une tâche d’attention spatiale implicite. Six enfants avec un trouble autistique (TA) ont participé à cette étude. Les participants doivent détecter l’apparition d’une cible à gauche ou à droite d’un écran. L’apparition de la cible est précédée d’une amorce (paire de visages peur/neutre avec regard direct/dévié). La cible peut être présentée soit dans le même champ visuel que l’amorce émotionnellement chargée (condition valide), soit dans le champ visuel opposé (condition invalide). Nos résultats montrent que les amorces avec un visage de peur (vs les amorces avec un visage neutre) provoquent un effet d’interférence au niveau comportemental et divergent l’attention de leur emplacement chez les enfants avec un TA. / Autism is characterized by a social deficit, including difficulties in using and responding to facial expressions and gaze. Previous studies showed that fearful faces elicit a rapid involuntary orienting of spatial attention towards their location in typically developing (TD) individuals. In addition, target faces with direct gaze are detected faster and more efficiently than those with averted gaze in TD individuals. The aim of the current study is to explore the effect of fear and gaze direction (direct vs averted) on spatial attention in children with autistic disorder (AD). Six children with AD performed a covert spatial orienting task. Each trial consisted of a pair of faces (fearful/neutral with direct/averted gaze) briefly presented followed by a target presented at the location of one of the faces. Participants had to judge the location of the target (right or left visual field). The target unpredictably appeared on the side of the emotional face (fear, direct) (valid condition) or on the opposite side (neutral, averted) (invalid condition). Our results show that fearful faces have an interferent effect on the performance of AD children and divert attention from their location.

A atenção visuoespacial pode ser considerada como a atividade neural que seleciona certas regiões do espaço em detrimento das demais. Existem dois tipos de orientação da atenção: atenção automática e atenção voluntária. Há evidências de que as áreas cerebrais associadas à estes dois tipos se sobrepõem, porém alguns autores observaram que há áreas distintas de ativação cerebral para atenção automática e voluntária. Estas diferenças resultaram em visões distintas a respeito de modelos cerebrais envolvendo a atenção visuoespacial. O objetivo de nosso trabalho foi identificar quais são as principais redes de ativação neuronal durante a mobilização da atenção automática e voluntária com Ressonância Magnética Funcional (RMf) relacionada à eventos, utilizando a tarefa de Posner modificada (1980). Participaram deste estudo vinte adultos jovens e saudáveis (17 mulheres). A tarefa foi programada no ambiente Eprime (Psylab, EUA) e os participantes treinaram antes de realizar o experimento de RMf. As condições foram pseudorandomizadas com otimização por algoritmos genéticos. Cada tentativa começava com um Ponto de Fixação na tela e dois anéis demarcados, um em cada lado. Após o aparecimento do Estímulo Precedente (E1), um Estímulo Alvo (E2) aparecia dentro de um dos anéis. Nestes experimentos foram consideradas as condições válida, neutra e inválida. Os dados foram adquiridos em 3 runs para cada Experimento. A aquisição das imagens foi realizada em um sistema de 3 tesla (Philips Achieva), acoplado à um sistema de detecção de movimentação ocular (eye tracker) compatível com ambiente de RM (Magconcept, USA). As imagens de RMf foram adquiridas com sequências BOLD, GRE-EPI com TR=2s, TE= 30s, voxels isotrópicos de 3mm. O tempo e a resposta ao estímulo foram registrados (Zurc&Zurc, São Paulo, Brasil). A análise das imagens de RMf foi realizada com o programa FSL 4.1 (Oxford University, Inglaterra) e incluiu a correção de movimento, filtro espacial, remoção de artefatos e transformação da imagem para o espaço comum. O mapas cerebrais representando o efeito de grupo (usando o modelo de regressão linear) foram produzidos com limiar de Z >2,3 e nível de significância de p<0,05 (corrigido para comparações múltiplas). O tempo de reação foi menor quando o E2 apareceu na condição válida em comparação com a condição inválida. Houve superposição dos mapas de ativação na condição de atenção automática e voluntária em extensa rede, envolvendo áreas: frontais (giros pré-centrais, frontais médios, frontais mediais e giro frontal inferior direito), parietais (bordas dos sulcos intraparietais, giros pós-centrais, angulares, supramarginais e pré-cuneo), temporais (giros temporais médios e no giro temporal superior esquerdo) e occipitais (giros fusiformes e no giro lingual direito. Observamos outras áreas: giros do cíngulo anteriores e posteriores, parahipocampais, ínsulas, colículos superiores e inferiores, e cerebelo). Concluímos que as redes frontoparietais foram detectadas tanto na mobilização da atenção visuoespacial automática quanto voluntária. No entanto, o giro frontal superior esteve presente apenas na mobilização da atenção voluntária. Estes resultados mostram que a distinção parece estar em áreas cerebrais envolvidas em subsistemas que incluem a orientação e reorientação da atenção automática e voluntária. / Visuospatial attention can be considered as the neural activity that selects certain regions of space at the expense of others. There are two types of orientation of attention: automatic attention and voluntary attention. There is evidence that the brain networks associated with these two types overlap, but some authors have observed that there are distinct areas of brain activation for automatic and voluntary attention. These differences resulted in different views about brains models involving visuospatial attention. The aim of our study was to identify brain networks associated with automatic and voluntary attention using Event-Related Functional Magnetic Resonance Imaging (fMRI) and a new modification of the Posner task (1980). The study included twenty young healthy adults (17 women and 3 men). The task was programmed in Eprime environment (Psylab, USA) and all participants trained before performing the experiment in the MRI machine. The conditions were pseudorandomized with the optimization method of genetic algorithms. Each trial began with a fixation point on the screen and two demarcated rings, one on each side. After the onset of the Prime Stimulus (S1), a Target Stimulus (S2) appeared inside one of the rings. In these experiments the valid, neutral and invalid conditions were considered. Data were acquired in three runs for each experiment. Image acquisition of this project was performed on a 3 Tesla system (Philips Achieva), coupled to an MR compatibel eye tracker system (Magconcept, USA). All fMRI images were acquired using BOLD sequences, GRE-EPI with TR= 2s, TE= 30s, with 3mm isotropic voxels. Response time and choice during fMRI experiment were recorded (Zurc&Zurc, Brazil). Image analysis of fMRI was performed using FSL 4.1 software package (Oxford University, England) including: motion correction, spatial filter, removal of artifacts and image transformation for the common space. Brain maps representing group effect (using the linear regression model) where threshold using a Z > 2.3 at cluster level and p < 0.05 (corrected for multiple comparisons). Reaction times were shorter when the S2 appeared in the valid condition compared with the invalid condition. Automatic and voluntary attention brain activation maps overlaped in frontal areas: precentral, middle frontal, medial frontal gyrus and right inferior frontal gyri; parietal areas: edges of intraparietal sulcus, postcentral, angular, supramarginal gyrus and pre-cuneus; temporal areas: middle temporal gyrus and left superior temporal gyrus; and occipital areas: fusiform gyrus and right lingual gyrus. Other areas was observed in anterior and posterior cingulate, parahippocampal gyrus, insulas, superior and inferior colliculus, and cerebellum. Superior frontal gyrus showed increased response in the voluntary attention when compared with automatic attention. We conclude that the frontoparietal networks were detected in both the mobilization of automatic and voluntary visuospatial attention. However the superior frontal gyrus showed response only in the voluntary attention. The distinction between these two subsystems involved in orientation and reorientation of automatic and voluntary attention.

Hemispatial neglect, is a major cause of post-stroke disability and poor functional recovery. Hence, identifying sensitive methods to assess and rehabilitate neglect is important. Chapters 3 and 4 focused on development of novel assessment techniques for representational neglect. The 'Shopping Mall' and 'Clock Cueing' tasks improved upon previous tests and were useful in identifying dissociations in representational neglect based on type of stimuli (topological, non-topological) and time of assessment (pre-stroke, post-stroke) in chronic stroke patients. Chapters 5 and 6 investigated the efficacy of offline inhibitory repetitive Transcranial Magnetic Stimulation (rTMS) in producing short (&LT;1 month) and long term (>6 months) changes in visual neglect behaviour. Overall, the findings from these chapters were limited due to lack of sufficient power. After controlling for the effect of baseline performance, the Intervention group's Activities of Daily Living scores significantly improved in the short-term post rTMS, as compared to the Control group. The fMRI task attempted to recruit attention-based top down modulation of sensory activity. It revealed relative hypoactivation of the right occipital lobe in the four left neglect patients tested, both pre and post rTMS, when compared to elderly controls. Chapter 7 explored cognitive predictors of spatial and object neglect in the sub-acute stage after controlling for demographic and stroke related factors, using multivariate blocked logistic regressions. Cognitive performance indicative of spatial attention and selective attention to local features predicted both spatial and object neglect. In addition, coding of spatial relations between features also predicted spatial neglect. Suggestions for combining neglect rehabilitation techniques to target these cognitive processes are discussed. Overall, this thesis provides novel methods to improve representational neglect assessment and highlights the importance of ancillary cognitive domains in contributing to both representational and visual neglect. The rTMS research provides study design-related insights to incorporate in future studies with larger patient samples.