The aim of this project is two-fold: 1) to investigate developmental differences in intelligibility gains from visual cues in speech perception-in-noise, and 2) to examine how different types of maskers modulate visual enhancement across age groups. A secondary aim of this project is to investigate whether or not bilingualism differentially modulates audiovisual integration during speech in noise tasks. To that end, both child and adult, monolingual and bilingual participants completed speech perception in noise tasks through three within-subject variables: (1) masker type: pink noise or two-talker babble, (2) modality: audio-only (AO) and audiovisual (AV), and (3) Signal-to-noise ratio (SNR): 0 dB, -4 dB, -8 dB, -12 dB, and -16 dB. The findings revealed that, although both children and adults benefited from visual cues in speech-in-noise tasks, adults showed greater benefit at lower SNRs. Moreover, although child monolingual and bilingual participants performed comparably across all conditions, monolingual adults outperformed simultaneous bilingual adult participants. These results may indicate that the divergent use of visual cues in speech perception between bilingual and monolingual speakers occurs later in development. / text

京都大学 / 新制・論文博士 / 博士(医学) / 乙第13632号 / 論医博第2323号 / 新制||医||1074(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 辻川 明孝, 教授 滝田 順子, 教授 森田 智視 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

Research on clear speech has shown that the type of clear speech produced can vary depending on the speaker, the listener and the medium. Although prior research has suggested that clear speech is more intelligible than conversational speech for normal-hearing listeners in noisy environments, it is not known which acoustic features of clear speech are the most responsible for enhanced intelligibility and comprehension. This thesis focused on investigating the acoustic characteristics that are produced in clear speech to foreigners and infants. Its aim was to assess the utility of these features in enhancing speech intelligibility and comprehension. The results of Experiment 1 showed that native speakers produced exaggerated vowel space in natural interactions with foreign-accented listeners compared to native-accented listeners. Results of Experiment 2 indicated that native speakers exaggerated vowel space and pitch to infants compared to clear read speech. Experiments 3 and 4 focused on speech perception and used transcription and clarity rating tasks. Experiment 3 contained speech directed at foreigners and showed that speech to foreign-accented speakers was rated clearer than speech to native-accented speakers. Experiment 4 contained speech directed at infants and showed that native speakers rated infant-directed speech as clearer than clear read speech. In the fifth and final experiment, naturally elicited clear speech towards foreign-accented interlocutors was used in speech comprehension tasks for native and non-native listeners with varying proficiency of English. It was revealed that speech with expanded vowel space improved listeners’ comprehension of speech in quiet and noise conditions. Results are discussed in terms of the Lindblom’s (1990) theory of Hyper and Hypoarticulation, an influential framework of speech production and perception.

Speech often occurs in challenging listening environments, such as masking noise. Visual cues have been found to enhance speech intelligibility in noise. Although the facilitatory role of audiovisual integration for perception of speech has been established in native speech, it is relatively unclear whether it also holds true for speech produced by nonnative speakers. Native listeners were presented with English sentences produced by native English and native Korean speakers. The sentences were in either audio-only or audiovisual conditions. Korean speakers were rated as more accented in audiovisual than in the audio-only condition. Visual cues enhanced speech intelligibility in noise for native English speech but less so for nonnative speech. Reduced intelligibility of audiovisual nonnative speech was associated with implicit Asian-Foreign association, suggesting that listener-related factors partially influence the efficiency of audiovisual integration for perception of speech produced by nonnative speakers. / text

The aim of this study is to investigate whether blind individuals display cognitive advantages over sighted individuals with regard to second language acquisition. Previous studies from neuropsychology have indicated that this is the case. It has been found that blind L1 speakers can compensate for loss of vision by developing better perceptual and cognitive skills compared to sighted individuals, skills that are highly relevant to language acquisition. These studies do not, however, investigate blind L2 speakers, for whom it is not clear whether these advantages are also found.  In all, 80 adults participated in the study: 40 L2 speakers of Swedish (11 early blind, 9 late blind, 20 sighted, AO<18) and a matching group and subgroups of L1 speakers. These speakers underwent tests on speech perception in noise, accentedness in an L2 and memory functions. The results revealed that L2 speakers are at a great disadvantage perceiving speech in noise compared to L1 speakers, and that there was no advantage associated with blindness. In the L1 speakers group, however, the results revealed that the early blind had advantages compared to the late blind and sighted in white noise, but that both blind groups were more negatively affected by babble noise than the sighted. The results in relation to accentedness in an L2 revealed that there were no advantages associated with blindness. The results further revealed there were no advantages associated with blindness on the episodic memory test. The results did, however, reveal that the early blind performed significantly better than the late blind and sighted on all phonological short-term memory tests and that both the early and late blind were significantly better than the sighted on recognition memory for new words, irrespective of language background. The conclusion is that blindness is associated with advantages in, for example, ability to learn new words and syntax, acquisition rate, ultimate L2 attainment, and language aptitude.

<p dir="ltr">Individuals with typical audiometric sensitivity exhibit varying speech perception abilities in noisy environments, which may decline with age. Temporal processing plays a pivotal role in speech perception, especially in challenging listening conditions. Auditory decline due to aging involves both peripheral pathology and central auditory system changes, impacting temporal processing. To delineate the contributions of these changes, measurements of within- and across-channel temporal processing were conducted in a wide age range of normal-hearing individuals. Robust perception of within-channel temporal cues requires precise coding at both peripheral and central auditory pathway levels, while cross-channel processing relies on central mechanisms. Comprehensive data collection involved behavioral and electrophysiological measures, revealing age-related increases in behavioral thresholds, less robust cortical responses to gaps and temporal-coherence changes, and declining SPIN performance. Cross-channel measures proved to be more predictive of speech perception outcomes, emphasizing the significance of central auditory changes in age-related perceptual deficits.</p><p dir="ltr">A mini-EEG cap to record cortical EEG auditory responses to gaps in chinchillas using a new sedation protocol was validated. This advancement enhances translational potential and paves the way for exploring cortical auditory processing using complex stimuli in animal models. By facilitating simultaneous exploration of both subcortical and cortical consequences of auditory system pathologies, this development contributes to a more comprehensive understanding of auditory processes across species.</p>

Un biais fonctionnel entre les oreilles droites et gauches a été largement documenté, avec un avantage de l'oreille droite (AOD) dans les tâches perceptives, en particulier celles utilisant le traitement verbal. Les sons complexes tels que la parole sont perçus plus facilement dans l'oreille droite (OD) que dans l'oreille gauche (OG) pour les tâches d’écoute dichotique (ED) ainsi que pour les tâches de perception de la parole dans le bruit (PDB). Des études sur les tâches d’ED ont démontré que le vieillissement est associé à une réduction globale des performances des deux oreilles, avec un déficit de performance plus important pour les stimuli présentés à l'OG par rapport à ceux présentés à l'OD entraînant une augmentation de l’AOD. Ce déficit à l'OG pourrait être le résultat d'une baisse de l'efficacité du transfert inter hémisphérique d'informations auditives via le corps calleux due au vieillissement ou de changements liés au vieillissement dans les fonctions cognitives. Cependant, des preuves chez les jeunes adultes ayant une audition normale suggèrent que les différences interaurales (DI) dans le traitement sensoriel au niveau des parties inférieures du système auditif pourraient également expliquer l'ampleur de l’AOD pour les tâches d’ED. L'objectif principal de cette thèse est d'étudier si les DI dans le traitement sensoriel aux niveaux inférieurs du système auditif sont associés à l'ampleur de l’AOD chez les personnes âgées. De plus, ce projet vise également à déterminer si les DI dans le traitement sensoriel au niveau des parties inférieures du système auditif sont associées aux processus de perception de la PDB chez les personnes âgées. Pour ce faire, 70 personnes âgées ont participé à cette étude. Tous les participants ont été évalué avec une batterie complète de tests auditifs examinant les seuils de sons purs, les émissions otoacoustiques évoquées transitoires avec et sans stimulation acoustique controlatérale, la réponse auditive du tronc cérébral et la performance sur les tâches d'ED et de perception de la PDB. Afin de contrôler la fonction cognitive, les habiletés cognitives telles que la vitesse de traitement, la flexibilité cognitive et la mémoire de travail ont également été évaluées. Les DI dans le traitement sensoriel aux niveaux inférieurs du système auditif ont été dérivées en calculant la différence entre l’OD et l’OG pour chacune des mesures auditives. Des modèles de régression bivariées et multivariées ont été réalisés en intégrant les variables d’habiletés cognitives dans les modèles de régression. Les résultats ont révélé que la DI pour les seuils de sons purs et la DI pour les émissions otoacoustiques évoquées transitoires avec suppression étaient associés significativement à l'ampleur de l’AOD chez les personnes âgées. De même, la DI pour les émissions otoacoustiques évoquées transitoires et la DI pour la réponse auditive du tronc cérébral expliquent la performance de la perception de la PDB chez les personnes âgées. De plus, les résultats ont révélé que les habiletés cognitives contribuent de manière significative à l'ampleur de l’AOD ainsi que pour la performance de la perception de la PDB chez les personnes âgées. Dans l'ensemble, la présente thèse fournit des données qui suggèrent que les DI dans le traitement sensoriel au niveau des parties inférieures du système auditif explique en partie l'ampleur de l’AOD pour les tâches d’ED ainsi que les problèmes de perception de la PDB chez les personnes âgées. / A functional bias between the right and left ears has been widely documented, with a right-ear advantage (REA) in perceptual tasks, particularly those employing verbal processing. Complex sounds such as speech are more accurately perceived in the right ear (RE) compared to the left ear (LE) for dichotic listening (DL) and speech perception in noise (SIN) tasks. Although previous studies have shown that aging is associated with an overall decline in DL performance in both ears among older adults, the left ear (LE) performance often decreases more dramatically relative to the right ear (RE) performance, causing an increased REA for speech stimuli. This greater LE deficit may be the result of age-related changes in (A) cognitive functions; (B) functions of the right hemisphere (RH); and /or (C) the efficiency of interhemispheric transfer of auditory information via the corpus callosum. However, evidence in normal hearing young adults suggest that interaural difference (ID) in sensory processing at lower portions of the auditory system might also explain the magnitude of the REA for DL. The main aim of this thesis is to investigate whether ID in sensory processing at lower levels of the auditory system are associated with the magnitude of the REA for DL among older adults. In addition, this project aimed to investigate whether ID in sensory processing at lower levels of the auditory system is associated with SIN performance in older adults. A total of 70 older adults participated in this study. To assess sensory processing at lower levels of the auditory system, hearing thresholds, transient evoked otoacoustic emission (TEOAE), contralateral suppression of TEOAE, a proxy measure of medial olivocochlear (MOC) activation and click-and-speech auditory brainstem response to speech stimuli were measured in both ears separately. The ID in sensory processing was derived by calculating the difference between the right and left ears for each auditory measure. The mobile device app version for iPhone of the Bergen Dichotic Listening test, the iDichotic, was used to evaluate DL. In addition, SIN performance was evaluated with the hearing-in-noise test (HINT). With the aim to control for cognitive function, cognitive abilities such as speed of processing, cognitive flexibility and working memory were also evaluated. Bivariate and multivariate regression models were performed, and cognitive measures were accounted for in the regression models. Results revealed that ID in pure-tone thresholds and ID in MOC-induced TEOAE suppression were significantly associated with the magnitude of the REA for DL among older adults. Similarly, ID in TEOAE and ID in speech-ABR measures explained SIN performance in older adults. In addition, results revealed that cognitive measures significantly contributed to the magnitude of the REA for DL and SIN performance in older adults. The present thesis provides evidence indicating that ID in sensory processing at lower levels of the auditory system partially explain the magnitude of the REA for DL as well as SIN performance among older adults.

Bilateral cochlear implantation is accepted medical practice since 2008 in clinically suitable adults and children to enhance bilateral processing benefits. Bilateral implantation may lead to the restoration of some bilateral hearing advantages, such as improved speech recognition in noise, localisation, head shadow effect, summation, and squelch. The majority of the advantages stated in literature, though, are characteristic of the simultaneously implanted cochlear implant population. Simultaneous implantation is not yet a reality in South Africa due to funding constraints, therefore determining the bilateral processing abilities in sequentially implanted adults is essential. Determining bilateral processing benefits achievable with sequential implantation could result in evidence-based recommendations in terms of candidacy considerations, surgery protocols, motivations for medical aid funding for simultaneous cochlear implantation, and relevant measures to determine the bilateral processing benefit attainable. Furthermore, it might enhance audiologists‟ insight regarding post-implantation performance of sequentially implanted patients and enable them to counsel prospective candidates realistically. The aaim of this study was to determine the bilateral benefit attained by sequentially implanted adults. A quantitative, cross-sectional research approach was followed in a one group post-test-only exploratory research design. A purposive convenient sampling method with specified selection criteria was used to select 11 adult clients of an established cochlear implant programme in Pretoria. Tests of sound localisation in the horizontal plane and speech perception in noise were performed. During the test of sound localisation, performance with only the first or only the second implant was found to be very similar. For the majority of participants the second cochlear implant (CI 2) was the superior performing implant during xviii speech perception in noise testing, in spatially separated speech and noise conditions where noise was directed to the first implant, as well as in spatially coincident speech and noise. A statistical significant bilateral benefit (p < 0.05) was attained by sequentially implanted adults for sound localisation. A bilateral benefit for speech perception in noise was observed when noise was directed to the first implant and in the diotic listening condition with average benefits of 1.69 dB and 0.78 dB, respectively. It was not statistically significant (p > 0.05), however, and was smaller than bilateral benefit values achieved by simultaneously implanted adults in previous studies. The head shadow effect at 180° was found to be the strongest and most robust bilateral spatial benefit. Squelch and summation benefit values ranged from negative values to 2 dB and 6 dB, respectively. This corresponded with values found in previous studies. The improvement in speech perception in spatially distinct speech and noise from adding the ear with a better SNR (signal to noise ratio) indicated that the contribution of CI 2 seems to be greater than that of CI 1 for bilateral spatial benefit. It can be concluded that adults with sequential implants may achieve some extent of bilateral benefit even with many years of unilateral implant use, when speech processors differ, when the second implant is done ≥ 10 years after the first implant, and in cases of prelingual deafness. A key benefit of sequential implantation appears to be related to the advantage of having hearing on both sides so that the ear with the more favourable environmental signalto-noise ratio is always available. AFRIKAANS : Bilaterale kogleêre inplanting is sedert 2008 aanvaarde mediese praktyk vir klinies geskikte volwassenes en kinders, ten einde bilaterale prosesseringsvoordeel te verhoog. Bilaterale inplanting kan lei tot die herstel van sommige van die voordele van bilaterale gehoor, soos verbeterde spraakherkenning in lawaai, klanklokalisering, die kopskadueffek, sommering en selektiewe onderdrukking (“squelch”). Die meeste van die voordele wat in die literatuur bespreek word, is egter kenmerkend van dié persone by wie twee kogleêre inplantings gelyktydig gedoen is. Gelyktydige inplanting is as gevolg van beperkte befondsing nog nie in Suid-Afrika 'n werklikheid nie, daarom is dit noodsaaklik om te bepaal watter bilaterale prosesseringsvoordele by opeenvolgend-geïnplanteerde volwassenes voorkom. Die bepaling van watter bilaterale prosesseringsvoordele met opeenvolgende inplanting bereik kan word, sou kon lei tot getuienis-gebaseerde aanbevelings met betrekking tot besluite oor die geskiktheid van kandidate, protokol vir sjirurgie, motiverings vir die befondsing van gelyktydige kogleêre inplantings deur mediese voorsorgfondse, en toepaslike maatstawwe om te bepaal watter mate van bilaterale prosesseringsvoordeel haalbaar sou wees. Dit sou verder oudioloë se insig kon verbreed met betrekking tot die na-operatiewe prestasie van opeenvolgend-geïnplanteerde persone en hulle sodoende in staat stel om voornemende kandidate van realistiese raad te bedien. Die doel van hierdie studie was om te bepaal wat die bilaterale prosesseringsvoordele is wat deur opeenvolgend-geïnplanteerde volwassenes verkry kan word. 'n Kwantitatiewe navorsingsbenadering met 'n dwarsprofiel van „n enkelgroep is gevolg, met 'n post-toets verkennende navorsingsontwerp. 'n Doelgerigte gerieflikheidssteekproef met 'n gespesifiseerde seleksiekriteria is gebruik om 11 volwasse kliënte van 'n gevestigde kogleêre inplantprogram in Pretoria te selekteer. Klanklokalisering in die horisontale vlak en die waarneming van spraak in lawaai is getoets. Tydens die toets vir klanklokalisering is gevind dat prestasie met slegs die eerste of slegs die tweede inplanting soortgelyk was. Vir die meeste deelnemers aan die studie het die tweede kogleêre inplanting (KI 2) die beste prestasie gelewer tydens spraakwaarneming in lawaai, in omstandighede waar spraak en lawaai ruimtelik geskei is en die lawaai op die eerste inplanting gerig is, asook in omstandighede waar spraak en lawaai ruimtelik saamvoorkomend aangebied is. 'n Statisties beduidende bilaterale voordeel (p < 0.05) is deur opeenvolgend-geïnplanteerde volwassenes vir klanklokalisering behaal. 'n Bilaterale voordeel vir spraakwaarneming in lawaai is waargeneem waar lawaai op die eerste inplanting gerig is en ook in diotiese luistertoestande, met 'n gemiddelde voordeel van 1.69 dB en 0.78 dB, onderskeidelik. Dit was egter nie statisties beduidend nie en was ook kleiner as die bilaterale voordeelwaardes wat in vorige studies deur gelyktydig-geïnplanteerde volwassenes behaal is. Die kopskadu-effek by 180° was die sterkste en mees robuuste bilaterale ruimtelike voordeel. Voordeelwaardes vir selektiewe onderdrukking en sommering het gewissel van negatiewe waardes tot 2 dB en 6 dB onderskeidelik. Dit stem ooreen met waardes wat in vorige studies gevind is. Die verbetering in spraakwaarneming in ruimtelik geskeide spraak en lawaai wat verkry is deur die oor met 'n beter STR (sein-tot-ruis ratio) by te voeg, het daarop gedui dat die bydrae van KI 2 tot bilaterale ruimtelike voordeel waarskynlik groter as die bydrae van KI 1 is. Die gevolgtrekking kan gemaak word dat volwassenes met opeenvolgende inplantings 'n mate van bilaterale voordeel verkry selfs na vele jare van unilaterale inplantingsgebruik, wanneer die spraakprosesseerders in die twee inplantings van mekaar verskil, wanneer die tweede inplanting ≥ 10 jaar na die eerste plaasvind, en in gevalle van prelinguale doofheid. 'n Sleutelvoordeel van opeenvolgende inplanting hou klaarblyklik verband met die voordeel van gehoor aan albei kante te hê sodat die oor met die gunstigste sein-tot-lawaai ratio altyd beskikbaar is. / Dissertation (MCommunication Pathology)--University of Pretoria, 2011. / Speech-Language Pathology and Audiology / Unrestricted

La surdité professionnelle constitue un problème de santé publique important, avec une prévalence estimée de 10 à 16%. Les études animales ont mis en évidence une perte des synapses entre les cellules ciliées internes et le nerf auditif et des fibres auditives présentant une activité spontanée faible. Cette synaptopathie cochléaire se manifesterait avant la dégradation des seuils auditifs et la perte des cellules ciliées externes, étant ainsi un précurseur à la surdité professionnelle. L’audiogramme utilisé en milieu clinique ne permet pas de mesurer la synaptopathie cochléaire, se contentant seulement de quantifier la perte d’audibilité causée par l’exposition au bruit. Des études post-mortem humaines ont permis d’identifier une synaptopathie cochléaire, similaire à celle observée dans le modèle animal. Étant donné que la quantification des synapses chez l'humain vivant n'est pas possible, les chercheurs se sont concentrés sur le développement d’outils pouvant servir de marqueur indirect de la synaptopathie cochléaire. À cet égard, les résultats sont divergents d’une étude à l’autre. Il est possible que ces outils ne soient pas sensibles ou que l’exposition au bruit investiguée dans la littérature ne soit pas suffisante pour entraîner une synaptopathie cochléaire chez l’humain. L’objectif de cette thèse est donc d’évaluer les effets d’une exposition au bruit industriel continu et au bruit impulsionnel, qui pourraient s’avérer plus nocives et entraîner un processus précoce de synaptopathie cochléaire. Des individus présentant des seuils auditifs et des émissions otoacoustiques dans la normale ont été investigués à l’aide de mesures électrophysiologiques et psychoacoustiques. Dans la première étude, 40 participants exposés au bruit industriel continu et 40 participants sans exposition au bruit industriel continu ont été recrutés et évalués à l’aide d’un test de perception de la parole dans le bruit (SPiN) et de différentes composantes du potentiels évoqués auditifs du tronc cérébral (PEATC). L’exposition au bruit des participants a été mesurée par dosimétrie. Les résultats ne montrent pas d’association entre l’exposition au bruit et les variables du PEATC et du SPiN. Dans la deuxième étude, 27 participants militaires exposés au bruit impulsionnel et 13 participants sans exposition au bruit impulsionnel ont été recrutés. Les PEATC, l’électrocochléographie, le SPiN et la largeur des filtres auditifs rectangulaires équivalents (ERB) ont été mesurés. L’exposition au bruit des participants a été quantifiée à l’aide du Noise Exposure Structured Interview. Les résultats montrent une réduction de l’amplitude de l’onde I, un allongement de la latence de l’onde V, des performances réduites de SPiN et un ERB plus large à 4 kHz chez les militaires exposés au bruit impulsionnel, en comparaison aux participants sans exposition au bruit impulsionnel. Cette thèse est importante d’un point de vue de santé publique puisqu’elle suggère que certains outils cliniques simples, comme la mesure des filtres auditifs, pourraient permettre de détecter les premiers signes d’un dommage auditif avant l’apparition d’une surdité professionnelle mesurée par l’audiogramme. Les résultats renforcent l’importance de la sensibilisation aux risques induits par l’exposition au bruit afin de prévenir l’apparition des troubles de communication et des situations de handicap découlant de la présence d’une surdité professionnelle. / Occupational hearing loss constitutes an important public health problem, with an estimated prevalence of 10 to 16%. Animal studies have shown a phenomenon of synapses dysfunction between the inner hair cells and the auditory nerve and a preferential loss of low spontaneous rate auditory fibers. This cochlear synaptopathy manifests itself before the degradation of hearing thresholds and the loss of outer hair cells, thus being a precursor damage to occupational hearing loss. The audiogram used in a clinical setting does not measure cochlear synaptopathy, only quantifying the loss of audibility caused by noise exposure. In humans, post-mortem studies have identified a process of cochlear synaptopathy, similar to that observed in the animal model. Since quantification of synapses in living humans is not possible, researchers focused on developing a noninvasive measurement that could serve as an indirect marker for cochlear synaptopathy. Several tools have been proposed, but the results vary from one study to another. It is possible that these tools are not sensitive or that noise exposures investigated in the literature is not sufficient to cause cochlear synaptopathy in humans. The objective of this thesis is therefore to evaluate the effects of exposure to continuous industrial noise and impulse noise, which could prove to be more harmful and lead to an accelerated process of cochlear synaptopathy. To this end, individuals with normal hearing thresholds and otoacoustic emissions were investigated using electrophysiological and psychoacoustical measurements. In the first study, 40 participants with occupational noise exposure and 40 participants without occupational noise exposure were recruited and evaluated using a speech perception in noise (SPiN) test and different components of the auditory brainstem response (ABR). Participants’ noise exposure was measured by dosimetry. The results do not show an association between noise exposure and the ABR and SPiN variables. In the second study, 27 military participants exposed to impulse noise and 13 participants without exposure to impulse noise were recruited. ABR, electrocochleography, SPiN and the equivalent rectangular bandwidth (ERB) of auditory filters were measured. Participants' noise exposure was quantified using the Noise Exposure Structured Interview. Results show a reduced wave I amplitude, a lengthened wave V latency, a reduced SPiN performance, and a broader ERB at 4 kHz in military recruits exposed to impulse noise, compared to participants without exposure to impulse noise. This thesis is important from a public health point of view since it suggests that certain simple clinical tools, such as the measurement of auditory filters, might make it possible to detect the first signs of auditory damage before the onset of hearing loss measured by the audiogram. Results reinforce the importance of raising awareness to the risks induced by noise exposure in order to prevent the appearance of communication disorders and handicaps resulting from the presence of occupational hearing loss.