Solar flare is a process which releases magnetic energy stored in the solar corona due to the effect of magnetic reconnection. Similar activity has been observed on other stellar types, namely type K and M stars, which usually have vast and strong magnetic field. Often during flares on M stars we observe asymmetry of profiles of some spectral lines with enhanced red wing. The cause of these asymmetries is not well understood. The aim of this thesis is to analyse spectra of AD Leo, which is frequently flaring dMe star, and to model radiation of the Hα line coming from flare loops analogically to flare loops on the Sun. The light curves of selected spectral lines rise sharply during initial phases of flares and gradually fall back to preflare state. The light curves of continua surrounding these selected spectral lines rise sharply in the blue part of the spectrum during flares. The continua in the red part exhibit only small rise. Simulations of Hα radiation coming from flare loops yield asymmetric profiles with highly enhanced red wings. 1

Detta examensarbete går ut på att överföra en metod- från ett Antaris NIR-instrument på AstraZeneca Macclesfield till ett Bomem 3600 NIR-instrument på AstraZeneca Gärtuna. Metoden används för att säkerställa att biprodukten form L ligger under specificerat gränsvärde för produkten. Kvantitativa NIR metoder är inte absoluta. De är prediktiva metoder som bygger på att man tar upp spektra för ett antal prover som man även analyserar med en referensmetod. Sedan använder man ett multivariat dataprogram som relaterar varje spektra till dess värde med referensmetoden med linjär regression. För att överföra en metod mellan två olika NIR-instrument behöver man matematiskt föra över de spektra som den multivariata modellen bygger på så att de matematiskt sett är analyserade på det instrumentet som man för över metoden till. De rådata som används till att bygga modellen är data från NIR instrumentet i Macclesfield och NIR-instrumentet i Gärtuna. Transformering av data utförs i Matlab med lokal centrering. De data som transformerats används sedan till att bygga modellen i SIMCA 14 som är en mjukvara för hantering av multivariata datamodeller. När modellens korrekthet kontrollerats skapas en metod i SenISS som använder sig av den nybyggda modellen för att prediktera Form L i produkten. Modellen är en PLS-modell med 2 komponenter som har de spektrala filtren SNV och andraderivatan. Dessa filter bidrar till signalkorrigering och minskar de individuella skillnaderna i spektrum. För att kontrollera modellens korrekthet har flera parametrar undersökts, dessa parametrar är: Linjäritet, riktighet, repeterbarhet och selektivitet. Linjäriteten kontrolleras med hjälp av ett valideringsset där modellen får prediktera halten Form L som sedan jämförs med det form L värdet som bestämts med referensmetoden. Regressions statistik beräknas för att undersöka att lutningen inkluderar värdet 1 och att interceptet inkluderar värdet 0 i ett 95%-igt konfidensintervall. Riktigheten kontrolleras genom att undersöka hur mycket prediktionerna avviker från referensmetoden värde. Den accepterade skillnaden är 20% RSD. Modellen har ett max RSD värde på 11,7%. Repeterbarheten kontrolleras genom att analysera 2 kapslar från 2 olika batcher 10 gånger var. Därefter beräknas den poolade standardavvikelsen och ett 95%-igt konfidensintervall. Den poolade standardavvikelsen är 0,55. Selektiviteten för modellen kontrolleras genom att analysera kapslar med annat innehåll, 5 kapslar med olika innehåll analyserades. Modellen ger höga värden på DModX (avståndet för varje observation till modellen) och/eller Hotelling’s T2 (avståndet från observationen till centrum av modellen) vilket innebär att de 5 analyserade kapslarna med annat innehåll avviker från modellen. / This diploma work treats the transferring of a method from an Antaris NIR-instrument at AstraZeneca Macclesfield to a Bomem 3600 NIR-instrument at AstraZeneca Gärtuna. The method is used to ensure that by-product form L is below the specified limit value for the product. Quantitative NIR methods are not absolute. They are predictive methods that are based on the inclusion of spectra for several samples that are also analyzed with a reference method. Then, a multivariate computer program is used that relates each spectra to its value with linear regression. To transfer a method between two different NIR-instruments, you need to mathematically transfer the spectra on which the multivariate model is based on, so that they are mathematically analyzed on the instrument that the method is transferred to. The raw data used to build the model is data from the NIR-instrument in Macclesfield and the NIR instrumentin Gärtuna. The transformation of data is performed in Matlab with local centering. The transformed data is then used to build the model in SIMCA 14 which is a software for managing multivariate data models. When the model's correctness is verified, a method is created in SenISS that uses the newly built model to predict Form L in the product. The model is a 2-component PLS model that has the SNV and second derivative spectral filters. These filters contribute to signal correction and reduce the individual differences in spectrum. To verify the correctness of the model, several parameters have been examined, these parameters are: linearity, accuracy, repeatability and selectivity. The linearity is verified by means of a validation set where the model can predict the content of Form L which is then compared with the Form L value determined with reference method. Regression statistics are calculated to verify that the slope includes the value 1 and that the intercept includes the value 0 in a 95% confidence interval. The accuracy is verified by examining how much the predictions deviates from the reference method. The accepted value is 20% RSD. The model has a maximum RSD value of 11.7%. The repeatability is verified by analyzing 2 capsules from 2 different batches 10 times each. Then the pooled standard deviation and a 95% confidence interval is calculated. The selectivity of the model is verified by analyzing capsules with other contents, 5 capsules with different contents is analyzed. The model gives high values of DModX (the distance for each observation to the model) and/or Hotelling's T2 (the distance from the observation to the center of the model) which means that the analyzed capsules with different content deviate from the model.

Title: Specifics of motor development in children with autism spectrum disorder Objectives: The aim of this thesis is to summarize the accessible literary sources about possibilities of early diagnostic of autism spectrum disorders, characteristic features of motor development and presence of movement and other abnormalities during early development in children who were later diagnosed with some disorder of autism spectrum. Methods: The study is divided into two main parts. In the first part, general information about autism spectrum disorders is presented. The ethiopatogenesis, characteristic features and different types of autism spectrum disorders are described. The second, descriptively analitical part, contains a brief description and resume of many studies, which deal with early identification of autism spectrum disorder, with examination of features of autism spectrum disorder in early development and motor abnormalities in individuals with autism spectrum disorder or high risk infants. Results: The results of this study indicate, that there are differences in social behaviour, motor development and specific autistic features already in the early development of children later diagnosed with autism spectrum disorder. Among motor abnormalities in early development in this children there are...

This Master's thesis deals with proposal of Flexible Spectrum Usage (FSU) algorithm based on policy agreed among operators. The introduction presents basic information about properties of next generation mobile communication ITM-Advanced system. After the introductory part the attention is given to the items efficient for FSU implementation as well as parameters used for evaluation of FSU algorithm efficiency. Several variants policy based FSU algorithm utilize value of Signal to Interference plus Noise Ratio (SINR) is designed. The SINR information is used to combat with mutual interference which is caused by coexistence of several operators in the same geographical area sharing over the same spectrum pool. Individual needed as traffic and quality of service requirements of each operator is taken into consideration as well. The main aim is to maximize cell troughput as well as data- rates for each user of HBS. For simulation of proposal algorithm is considered deployment of four Currently Home Base Stations (HBS) in indoor loacal area scenerio with random number of users in given range. Each operator makes independent dicision without signalling exchange among other. The only considered information that HBS can use is gotten by scenning its environment. This problem soliving is considered to use Cognitive Radio (CR)

This Master's thesis deals with proposal of Flexible Spectrum Usage (FSU) algorithm based on policy agreed among operators. The introduction presents basic information about properties of next generation mobile communication ITM-Advanced system. After the introductory part the attention is given to the items efficient for FSU implementation as well as parameters used for evaluation of FSU algorithm efficiency. Several variants policy based FSU algorithm utilize value of Signal to Interference plus Noise Ratio (SINR) is designed. The SINR information is used to combat with mutual interference which is caused by coexistence of several operators in the same geographical area sharing over the same spectrum pool. Individual needed as traffic and quality of service requirements of each operator is taken into consideration as well. The main aim is to maximize cell troughput as well as data- rates for each user of HBS. For simulation of proposal algorithm is considered deployment of four Currently Home Base Stations (HBS) in indoor loacal area scenerio with random number of users in given range. Each operator makes independent dicision without signalling exchange among other. The only considered information that HBS can use is gotten by scenning its environment. This problem soliving is considered to use Cognitive Radio (CR)

The thesis concerns the topic of parental care for children with autism spectrum disorder. In the theoretical part there are described the main areas in which the autistic spectrum disorders manifest and the description of particular disorders. Next chapter describes this issue from point of view of parental care, it describes the difficulty of the situation, the impact on the lives of parents and whole families, factors affecting the adaptation to the situation and its overall management. The qualitative study was chosen for the research. The sample is composed of 11 mothers of children with autism spectrum disorder. Data for study was collected by half-structured interviews and supplemented by Logo-test. The results of study describe the impact of care for a child with autism spectrum disorder to the lives of parents, emotions in different situations, stressing and supporting aspects of the situation, scarce factors and external factors which the most affect the situation of parents. It seems that the situation causes numerous of changes in the lives of parents and affects their values and attitude to life. Difficulty of the situation is perceived in the area of time managment, psychological, physical and financial area. In the same time there are strong supporting factors, mainly family and...

in English: This diploma thesis is focused on parents coping with the burden of having children with autism spectrum disorder. It's goal is to analyze parent's strategy to cope with such burden in relation to taking care of a child with autistic spectrum disorder. Thesis is constructed as an emprical qualitativeresearch which also involves quantitative data. Data were acquired via half - structured interviews with parents of children with autism spectrum disorder.Furthermore, a questionnaire SVF 78 "Strategy of stress management" was used and filled out by the parents. The data were subsequently qualitatively analyzed and interpreted using content analysis. Finally, a comparison to specialized literature was performed. The text of the thesis itself is composed of three parts. First part includes theoretical solutions that are based on both Czech and foreign literature concerned with autism theory and coping with stress of parents bringing up an autistic child. Second part is focusing on the methodology and data analysis procedure. The final third part is dedicated to the interpretation of interviews and discussion results, combined with results of available literature research. The benefit of this diploma thesis is discovery of what helps to parents of autistic children to cope with the stress...

Charles University of Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medicinal Sciences Student: Bc. Veronika Hončová Supervisor: Doc. MUDr. Josef Herink, DrSc. Consultant: MUDr. Jela Hrnčiarová Title: Signs of the temporolimbic dysfunction in gamblers Background: The aim of this thesis was to determine whether pathological gamblers exhibit symptoms related to epileptic spectrum disorder. Methods: To investigate, symptoms of the temporolimbic dysfunction were examined by means of the structured questionnaires CPSI (Complex Partial Symptoms Inventory) and LSCL-33 (Limbic System Checklist-33). Mann-Whitney U test and Spearman's correlation coefficient were used for statistical evaluation. Results: The mean score in the questionnaire CPSI of gamblers was 38,9 points, which is an abnormal score. With the questionnaire LSCL-33, the mean score of 21,5 points, corresponds to suspected findings. From the mean results it can be concluded that pathological gamblers may have a higher incidence of the symptoms of the temporolimbic dysfunction. When comparing the groups of gamblers with smokers, it was evaluated that in the questionnaire CPSI was a statistically significant difference between the appearances of symptoms of epileptic spectrum disorder, while it was not in the...

An analysis of the state interventions into a broadcasting market will be the aim of this thesis. A state is in the most of countries represented by a special broadcasting market commission. In my thesis I will focus on the commission's behaviour. In the first part of my thesis I would like to consider a theoretical background, history and actual legislation of the electromagnetic spectrum regulation, particularly the legislation of both types of regulation -- structural and content regulation. Conclusions reached will be applied to the situation in the Czech Republic. The thesis should answer questions as whether the members of the commissions are objective, independent in their decision-making and behave within the defined legal frame. Acting of the Czech commission will be analyzed on the example of "Radio Wave affair". This radio station was taken from analog broadcast after the pressure from the Council of the Czech Radio.

This diploma thesis is focused on Snoezelen as special educational support for children with autistic spectrum disorder. Snoezelen can be understood as a way of relaxation, spending free time, pedagogical action or comprehensive therapy. It can be practiced in different facilities and it brings profit to general public with different impairment. Autistic spectrum disorder is one of diagnoses in which therapists decide to use the effect of Snoezelen. There are some researches focusing on quantitative detection of the circumstances associated with Snoezelen. This is why this thesis is dedicated to a qualitative study of the use of Snoezelen in a special pedagogical institution. This Thesis aims to analyse literary sources to comprehensively characterize problems of autistic spectrum disorders and to outline the principles, benefits and requirements of Snoezelen. Subsequently, using a qualitative survey, describe coherently the way in which Snoezelen is practiced to children with autistic spectrum in a particular special pedagogical institution, evaluate this way and recommend possible improvements. KEYWORDS Autistic spectrum disorder, autism, Snoezelen, sensory stimulation, multisensory room