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1	IL-7 Responses In Th17 Cells Are Dysregulated During HIV Infection Stilla, Alana January 2016 (has links) In the gut-associated lymphoid tissues, Th17 cells mediate mucosal homeostasis and inflammation. During HIV infection, Th17 cells become depleted and functionally impaired, which is implicated in the pathogenesis of chronic inflammation in patients treated with highly active antiretroviral therapy. IL-7 is a cytokine that mediates homeostatic responses in T lymphocytes, such as proliferation and survival, which are dysregulated during HIV infection. Whether similar dysregulation occurs in Th17 cells has yet to be reported. IL-7 receptor α (CD127) expression and IL-7 responses were therefore measured in blood-derived Th17 cells from uninfected individuals and effectively treated, HIV-infected individuals by flow cytometry. Th17 cells from uninfected individuals expressed CD127 and, in response to IL-7, exhibited phosphorylation of STAT5, upregulation of Bcl-2, and proliferation. During HIV infection, expression of CD127 and pSTAT5 in Th17 cells was comparable to that observed in cells from uninfected individuals. Interestingly, expression of Bcl-2 was upregulated while proliferation was dramatically impaired. These findings may provide further insight into the mechanisms by which Th17 cells fail to become restored during HIV infection. Th17 cells IL-7 HIV infection HAART proliferation Bcl-2 pSTAT5 CD127 Alana Stilla Jonathan Angel
2	När Storkyrkan ställde om : En studie av Stilla veckan och påsken i Storkyrkan under pandemin 2020 / The readjustment of Storkyrkan : A study of Holy Week and Easter in the Cathedral of Stockholm during the 2020 pandemic Molander, Adelie January 2020 (has links) In times of social distancing and restrictions, ecclesiological challenges arise for the church as a room that under normal circumstances gather people for services. When the church cannot be used the way it is intended to, it raises questions about the functions of the room. The new corona virus pandemic is a crisis that challenges our perception of the church buildings’ functions and aspects. This thesis is a case study that took place in the Cathedral of Stockholm, also called Storkyrkan, during Holy week and Easter. The purpose of this thesis is to study what ecclesiological implications this new reality has on how co-workers and visitors make use of the room. Through observation of the room and interviews of visitors and co-workers I identify five aspects of Storkyrkan that characterize what functions a church building can have during a crisis. The study finds that through the circumstantial changes of the usage of the room, the materiality of it is amplified. It also shows that many types of people visit and use the room in various ways. They are all connected as a collective in a network through the words, artifacts, music, and practises that are a part of this space. Instead of closing due to the pandemic, Storkyrkan was an open room which generated possibilities for people to use it. In times of social distancing, when people are encouraged to stay away from each other, the church brought people together, though in a much smaller number. This happened both in the physical room and in the virtual room online. These are all sources of lived ecclesiology, which is understood through people’s lives and actions. Ecclesiology Church of Sweden Cathedral of Stockholm Covid-19 Corona virus Crisis Churches Holy week Easter Pandemic Lived Ecclesiology Readjustment Ecklesiologi Svenska kyrkan Storkyrkan Covid-19 Coronavirus Kris Kyrkorum Stilla veckan Påsk Pandemi Levd ecklesiologi Omställning Religious Studies Religionsvetenskap

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IL-7 Responses In Th17 Cells Are Dysregulated During HIV Infection

När Storkyrkan ställde om : En studie av Stilla veckan och påsken i Storkyrkan under pandemin 2020 / The readjustment of Storkyrkan : A study of Holy Week and Easter in the Cathedral of Stockholm during the 2020 pandemic