O controle químico é uma das medidas mais empregadas no manejo de doenças de plantas, sendo imprescindível em inúmeros patossistemas agrícolas. Portanto, compreender a dinâmica das interações entre os produtos e a planta tem grande importância prática, pois poderá embasar ajustes nas estratégias de controle. O trabalho teve por objetivo estudar a tenacidade e a sistemicidade dos fungicidas epoxiconazol, piraclostrobina e fluxapiroxade em plantas de soja e videira. Para avaliar a tenacidade dos produtos foram simuladas chuvas de diferentes intensidades e intervalos após a aplicação. Procedeu-se a inoculação dos patógenos, Phakopsora pachyrhizi e Phakopsora euvitis, e avaliou-se a severidade e a área abaixo da curva de progresso das doenças. Para os estudos de absorção e translocação, utilizaram-se as moléculas radiomarcadas, 14C-epoxiconazol, 14C-piraclostrobina e 14C-fluxapiroxade, que foram diluídas com suas respectivas formulações comerciais. As variáveis foram avaliadas as 3, 9, 24, 48 e 72 horas após a aplicação (HAA). Especificamente para o fungicida fluxapiroxade foram avaliados os efeitos de sua associação ao adjuvante óleo mineral e ao fosfito de potássio em plantas de soja, e sua absorção e translocação em folhas novas e velhas de videira. Em geral, a eficiência dos fungicidas foi crescente com o aumento do intervalo entre a aplicação e a simulação da chuva. A adição do adjuvante aumentou a tenacidade do fluxapiroxade e o fosfito de potássio não teve o mesmo efeito. A sistemicidade na soja foi alta para o epoxiconazol, intermediária para o fluxapiroxade e baixa para a piraclostrobina. Na videira a piraclostrobina foi a mais absorvida, seguida pelo epoxiconazol e o fluxapiroxade. Os fungicidas epoxiconazol e fluxapiroxade translocaram-se predominantemente no sentido acropetal e a piraclostrobina não apresentou translocação a longas distâncias. A adição de adjuvante ao fluxapiroxade promoveu maior e mais rápida absorção e translocação nas plantas de soja, enquanto que, o fosfito de potássio teve efeito antagônico, que resultou em 53% de redução na absorção. Não houve diferença na absorção e translocação do fluxapiroxade em folhas velhas e novas de videira, porém a redistribuição foi maior nas folhas novas. O fluxapiroxade mostrou-se ser um fungicida com potencial protetor e curativo. Protetor, pois grande quantidade do produto (>65%) permanece na parte externa das folhas da soja e videira até as 72 HAA, e curativo pois mostrou uma absorção crescente com o tempo, o que significa que há uma liberação contínua do produto para o interior das folhas. Os folíolos de soja absorveram mais os três fungicidas do que as folhas de videira. A translocação à longa distância em ambas as culturas foi baixa (<1%) para todos os fungicidas avaliados. A translocação do epoxiconazol e fluxapiroxade aumenta com o decorrer das horas nas plantas de soja e não em mudas de videira e a piraclostrobina tem uma translocação limitada e constante em ambas as culturas. Quanto maior e mais rápida for a absorção dos fungicidas, menores serão as perdas decorrentes das intempéries, e por consequência maior será a eficácia dos produtos. / The chemical control is one of the measures most used in the management of plant diseases, being essential in many agricultural pathosystems. Therefore, understanding the dynamics of the interactions between products and plants has great practical importance in providing knowledge that can support better the control strategies. The work has aimed to study the rainfastness and systemicity of the fungicides epoxiconazole, pyraclostrobin and fluxapyroxad in soybean and vine plants. The rainfall was simulated in different intensities and intervals after application in order to assess the rainfastness of the products.The pathogens, Phakopsora pachyrhizi and Phakopsora euvitis were inoculated and the severity and the area under the disease progress curve were assessed. For the uptake and translocation studies, it was used the radiolabeled molecules, 14C-epoxiconazole, 14C-pyraclostrobin and 14C-fluxapyroxad, which were diluted with their respective commercial formulations. The parameters were assessed at 3, 9, 24, 48 and 72 hours after application (HAA). In particular for the fluxapyroxad were assessed the effects of its association with adjuvant and potassium phosphite on soybean plants, and their absorption and translocation in old and new vine leaves. Overall, the fungicides efficiency were boosted with the increasing interval between the application and the rainfall simulation. The addition of adjuvant improved the rainfastness of fluxapyroxad and the phosphite did not have the same effect.The systemicity on soybeans was high for the epoxiconazole, intermediate for fluxapyroxad and low for pyraclostrobin. In vine, pyraclostrobin was more absorbed, followed by epoxiconazole and fluxapyroxad. The fungicides epoxiconazole and fluxapyroxad translocated mainly acropetally and pyraclostrobin did not show translocation to long distances. The addition of adjuvant to fluxapyroxad has promoted greater and more rapid uptake and translocation on soybean plants, while potassium phosphite had antagonistic effect, which resulted in 53% reduction in uptake. There was no difference in the absorption and translocation of fluxapyroxad in old and new vine leaves. Nevertheless, the redistribution was higher in young leaves. The fluxapyroxad proved to be a fungicide with protective and curative potential. Protective because large amount of product (>65%) remains outside of the soy and vine leaves up to 72 HAA and curative because it showed an increased absorption over the time, which means that there is a continuous release of the product into the leaves. The soybean leaflets absorbed more the three fungicides than the vine leaves. The translocation to long distances in both crops were low (<1%) for all evaluated fungicides. The translocation of epoxiconazole and fluxapyroxad increases with the course of time on soybean plants and not in nursery trees of vine and the pyraclostrobin has limited and constant translocation in both crops. In nutshell, as bigger and faster the absorption of fungicides smaller are the losses resulting from the weather and most effective will be the products.

O controle químico é uma das medidas mais empregadas no manejo de doenças de plantas, sendo imprescindível em inúmeros patossistemas agrícolas. Portanto, compreender a dinâmica das interações entre os produtos e a planta tem grande importância prática, pois poderá embasar ajustes nas estratégias de controle. O trabalho teve por objetivo estudar a tenacidade e a sistemicidade dos fungicidas epoxiconazol, piraclostrobina e fluxapiroxade em plantas de soja e videira. Para avaliar a tenacidade dos produtos foram simuladas chuvas de diferentes intensidades e intervalos após a aplicação. Procedeu-se a inoculação dos patógenos, Phakopsora pachyrhizi e Phakopsora euvitis, e avaliou-se a severidade e a área abaixo da curva de progresso das doenças. Para os estudos de absorção e translocação, utilizaram-se as moléculas radiomarcadas, 14C-epoxiconazol, 14C-piraclostrobina e 14C-fluxapiroxade, que foram diluídas com suas respectivas formulações comerciais. As variáveis foram avaliadas as 3, 9, 24, 48 e 72 horas após a aplicação (HAA). Especificamente para o fungicida fluxapiroxade foram avaliados os efeitos de sua associação ao adjuvante óleo mineral e ao fosfito de potássio em plantas de soja, e sua absorção e translocação em folhas novas e velhas de videira. Em geral, a eficiência dos fungicidas foi crescente com o aumento do intervalo entre a aplicação e a simulação da chuva. A adição do adjuvante aumentou a tenacidade do fluxapiroxade e o fosfito de potássio não teve o mesmo efeito. A sistemicidade na soja foi alta para o epoxiconazol, intermediária para o fluxapiroxade e baixa para a piraclostrobina. Na videira a piraclostrobina foi a mais absorvida, seguida pelo epoxiconazol e o fluxapiroxade. Os fungicidas epoxiconazol e fluxapiroxade translocaram-se predominantemente no sentido acropetal e a piraclostrobina não apresentou translocação a longas distâncias. A adição de adjuvante ao fluxapiroxade promoveu maior e mais rápida absorção e translocação nas plantas de soja, enquanto que, o fosfito de potássio teve efeito antagônico, que resultou em 53% de redução na absorção. Não houve diferença na absorção e translocação do fluxapiroxade em folhas velhas e novas de videira, porém a redistribuição foi maior nas folhas novas. O fluxapiroxade mostrou-se ser um fungicida com potencial protetor e curativo. Protetor, pois grande quantidade do produto (>65%) permanece na parte externa das folhas da soja e videira até as 72 HAA, e curativo pois mostrou uma absorção crescente com o tempo, o que significa que há uma liberação contínua do produto para o interior das folhas. Os folíolos de soja absorveram mais os três fungicidas do que as folhas de videira. A translocação à longa distância em ambas as culturas foi baixa (<1%) para todos os fungicidas avaliados. A translocação do epoxiconazol e fluxapiroxade aumenta com o decorrer das horas nas plantas de soja e não em mudas de videira e a piraclostrobina tem uma translocação limitada e constante em ambas as culturas. Quanto maior e mais rápida for a absorção dos fungicidas, menores serão as perdas decorrentes das intempéries, e por consequência maior será a eficácia dos produtos. / The chemical control is one of the measures most used in the management of plant diseases, being essential in many agricultural pathosystems. Therefore, understanding the dynamics of the interactions between products and plants has great practical importance in providing knowledge that can support better the control strategies. The work has aimed to study the rainfastness and systemicity of the fungicides epoxiconazole, pyraclostrobin and fluxapyroxad in soybean and vine plants. The rainfall was simulated in different intensities and intervals after application in order to assess the rainfastness of the products.The pathogens, Phakopsora pachyrhizi and Phakopsora euvitis were inoculated and the severity and the area under the disease progress curve were assessed. For the uptake and translocation studies, it was used the radiolabeled molecules, 14C-epoxiconazole, 14C-pyraclostrobin and 14C-fluxapyroxad, which were diluted with their respective commercial formulations. The parameters were assessed at 3, 9, 24, 48 and 72 hours after application (HAA). In particular for the fluxapyroxad were assessed the effects of its association with adjuvant and potassium phosphite on soybean plants, and their absorption and translocation in old and new vine leaves. Overall, the fungicides efficiency were boosted with the increasing interval between the application and the rainfall simulation. The addition of adjuvant improved the rainfastness of fluxapyroxad and the phosphite did not have the same effect.The systemicity on soybeans was high for the epoxiconazole, intermediate for fluxapyroxad and low for pyraclostrobin. In vine, pyraclostrobin was more absorbed, followed by epoxiconazole and fluxapyroxad. The fungicides epoxiconazole and fluxapyroxad translocated mainly acropetally and pyraclostrobin did not show translocation to long distances. The addition of adjuvant to fluxapyroxad has promoted greater and more rapid uptake and translocation on soybean plants, while potassium phosphite had antagonistic effect, which resulted in 53% reduction in uptake. There was no difference in the absorption and translocation of fluxapyroxad in old and new vine leaves. Nevertheless, the redistribution was higher in young leaves. The fluxapyroxad proved to be a fungicide with protective and curative potential. Protective because large amount of product (>65%) remains outside of the soy and vine leaves up to 72 HAA and curative because it showed an increased absorption over the time, which means that there is a continuous release of the product into the leaves. The soybean leaflets absorbed more the three fungicides than the vine leaves. The translocation to long distances in both crops were low (<1%) for all evaluated fungicides. The translocation of epoxiconazole and fluxapyroxad increases with the course of time on soybean plants and not in nursery trees of vine and the pyraclostrobin has limited and constant translocation in both crops. In nutshell, as bigger and faster the absorption of fungicides smaller are the losses resulting from the weather and most effective will be the products.

The field of innovation management has gained extensive knowledge; however, there has been a tendency to study its various aspects in isolation rather than with a systems perspective, resulting in a potential oversight of interconnections between important aspects. While systems perspectives have been employed in organization and management research for over half a century, systems perspectives have more recently gained relevance in innovation management research. A sign of the growing relevance is the creation of an international guidance standard for innovation management systems, ISO 56002, published in 2019. Research indicates that implementing innovation management systems, with or without using a standard, has facilitated the transition from ad hoc practices to more integrated ones. Thus, it is interesting to investigate how systems approaches influence innovation capabilities. Furthermore, managing radical and incremental innovation may require different approaches, which presents challenges, particularly for large companies that prioritize projects typically involving incremental innovation. Consequently, studying how incremental and radical innovation are influenced when managing both types within the same system becomes relevant. In this study, the concept of systemicity was used to describe how systemic a system is through three system dimensions comprehensiveness, coherence and correspondence, which overlap with those commonly used in literature to describe and define a system. The purpose of the study was to gain a better understanding of innovation management from a systems perspective by investigating how different systemic dimensions influence and relate to innovation capabilities, analysing these capabilities from a systems perspective, exploring hindrances and opportunities with a systems approach, and investigating the relationship between these systemic dimensions and incremental and radical innovation capabilities respectively. The study was part of a research project with the overarching aim to investigate important future development trends and evaluate the innovation capabilities of the Swedish metallic materials industryto use as a basis to develop strategies for how the industry can support the transition towards sustainability. A multiple-case study of two companies within the metallic materials industry was conducted using an abductive approach, including a literature study, data collection, coding, and analysis. Semi-structured interviews were employed, where interview questions were based on the ISO 56002 standard and its seven system elements. The analysis involved within-case and cross-case analysis. The findings from the study imply that having capabilities related to all seven system elements seem to be important for an organization's overall innovation capability, highlighting the significance of comprehensiveness. The interconnections between elements highlight the significance of coherence, and establishing correspondence between capabilities and goals enhances innovation capability. While exhibiting comprehensiveness, coherence, and correspondence is beneficial, the suitable level of systemicity remains uncertain. Further research is needed to determine the balance between systemicity and flexibility for effective support of innovation capabilities. Furthermore, in relation to managing incremental and radical innovation together, the study indicates the importance of considering systemicity to identify opportunities and hindrances when managing both types in the same system. The analysis of comprehensiveness highlights the need for distinct management approaches and capabilities for each innovation type. The analysis of coherence emphasizes the importance of considering interdependencies between system elements to avoid obstacles resulting from interdependencies being overlooked. The analysis of correspondence suggests separate goal setting for incremental and radical innovation due to their distinct objectives and outcomes. Based on the method and findings, a tentative framework was developed for analysis and evaluation of innovation management systemicity. / Trots att det finns mycket kunskap om innovationsledning har det funnits en tendens att studera olika aspekter inom området separat snarare än med ett systemperspektiv, vilket har resulterat i att viktiga samband mellan olika aspekter potentiellt har förbisetts. Systemperspektiv har använts i över 50 år inom organisationsforskning men har på senare år fått ökad relevans inom forskningen om innovationsledning. Ett tecken på denna ökande relevans är skapandet av en internationell vägledande standard för innovationsledningssystem, ISO 56002, som publicerades 2019. Forskning har visat att implementering av innovationsledningssystem genom att använda en standard eller inte, har underlättat för organisationer att övergå från ad hoc till mer integrerade innovationsledningsmetoder. Därför är det intressant att studera hur innovationsförmåga påverkas av att ta en systemansats till innovationsledning. Vidare kan hantering av radikal och inkrementell innovation kräva olika tillvägagångssätt, vilket skapar utmaningar, särskilt för stora företag eftersom de prioriterar projekt som oftast inkluderar inkrementell innovation. Därför är det relevant att studera hur inkrementell respektive radikal innovation påverkas av att hanteras inom samma system. I denna studie används begreppet systemiskhet (eng: systemicity) för att beskriva hur systemiskt ett system är genom tre systemdimensioner: omfattning (eng: comprehensiveness), sammankoppling (eng: coherence) och överrensstämmelse (eng: correspondence), vilka överlappar med dimensioner som vanligtvis används i litteraturen för att beskriva och definiera ett system. Syftet med studien var att få en bättre förståelse för innovationsledning ur ett systemperspektiv genom att undersöka hur olika systemdimensioner påverkar och relaterar till innovationsförmåga, analysera dessa förmågor ur ett systemperspektiv, utforska hinder och möjligheter med en systemansats, samt undersöka förhållandet mellan dessa systemdimensioner och inkrementell respektive radikal innovationsförmåga. Studien ingick i ett forskningsprojekt med det övergripande syftet att undersöka viktiga framtida utvecklingstrender och utvärdera den svenska metallindustrins innovationsförmåga för att använda som grund för att ta fram strategier för hur industrin kan stödja omställningen mot hållbarhet. En flerfallsstudie av två företag inom metallindustrin genomfördes med en abduktiv metod, inklusive en litteraturstudie, datainsamling, kodning och analys. Semistrukturerade intervjuer användes, där intervjufrågorna baserades på ISO 56002 och dess sju systemelement. Analysen gjordes i två steg genom att först analysera varje företag för sig och sedan jämföra de två fallen med varandra. Resultaten visar på vikten av att ha förmågor relaterade till alla sju systemelementen för en organisations övergripande innovationsförmåga, vilket lyfter fram betydelsen av dimensionen omfattning. Sammankopplingarna mellan element framhäver betydelsen av systemdimensionen sammankoppling, och att etablera överensstämmelse mellan förmågor och mål förbättrar innovationsförmågan. Även om studien pekar på att det är fördelaktigt för en organisation att uppvisa omfattning, sammankoppling och överrensstämmelse i sitt arbete med innovationsledning, kan resultaten inte användas för att dra slutsatser om vilken nivå av systemiskhet som är lämplig. Därför behövs ytterligare forskning för att fastställa balansen mellan systemiskhet och flexibilitet för att effektivt stödja innovationsförmåga. I relation till att hantera inkrementell och radikal innovation tillsammans, visar studien på vikten av att ta systemiskhet i beaktning för att identifiera möjligheter och hinder vid hantering av båda typerna av innovation i samma system. Analysen av omfattning belyser behovet av olika hantering och olika innovationsförmågor i relation till varje innovationstyp. Analysen av sammankoppling betonar vikten av att studera beroenden mellan systemelement för att undvika att hinder som uppstår av kopplingarna blir förbisedda. Analysen av överrensstämmelse föreslår separata målsättningar för inkrementell och radikal innovation på grund av deras distinkta mål och resultat. Baserat på metoden och resultaten har ett tentativt ramverk tagits fram i syfte att användas för analys och utvärdering av systemiskhet i innovationsledning.

Le but de notre travail est de développer une stratégie de vectorisation pour conférer la mobilité phloémienne aux produits agrochimiques en appliquant le concept de prodrogue dans l'élaboration de composés phytopharmaceutiques. Le fenpiclonil, fongicide non systémique de la famille des phénylpyrroles, a été choisi comme composé parent modèle et modifié en l'associant à un acide alpha-aminé ou à un monosaccharide.La mobilité phloémienne des conjugués entre le fenpiclonil et les acides L ou D-glutamique ou le D-glucose (D-GFC) a été évaluée chez des plantules de ricin. Le test de systémie a montré que le L-aminoacide était nettement plus favorable à la mobilité phloémienne que l'acide D-aminé ou le D-glucose. Les résultats suggèrent que le conjugué fenpiclonil/L-aminoacide est reconnu et manipulé par un système de transport d'acide aminé stéréospécifique énergisé par la force proton-motrice. Des expériences complémentaires ont montré que le D-GFC était un inhibiteur puissant et sélectif de l'absorption du saccharose par les tissus foliaires et du chargement phloémien du saccharose. En raison de l'inhibition spécifique des transporteurs de saccharose (par exemple AtSUC2), le D-GFC peut être envisagé comme un nouvel outil en phloémologie.Enfin, nous avons exploré l'impact de la modification de structure de l'espaceur afin d'optimiser la stratégie de prodrogue. Après avoir introduit différentes structures d'espaceur entre le fenpiclonil et la fonction acide aminé, le conjugué qui contient un cycle triazole avec l'acide aminé comprenant la chaine la plus courte a montré la meilleure mobilité phloémienne et, par ailleurs, une systémie optimisée par rapport aux dérivés acides du fenpiclonil dans la gamme des valeurs de pH de l'apoplasme foliaire. / The purpose of our work is to develop a vectorization strategy to confer phloem mobility to agrochemicals by applying prodrug concept into agrochemical design. Fenpiclonil, a non-systemic fungicide from the phenylpyrrole family, was selected as a model parent compound and modified by associating it with an amino acid or a monosaccharide.The phloem mobility of L and D-glutamic acid and D-glucose fenpiclonil conjugates (D-GFC) was evaluated in Ricinus seedlings. The systemicity test showed that the L-amino acid promoiety was clearly more favorable to phloem mobility than D-amino acid or D-glucose. The results suggested that the transport of the L-amino acid conjugate is governed by a stereospecific amino acid carrier system energized by the proton motive force. Further investigation indicated that D-GFC was a potent and selective inhibitor of sucrose uptake by leaf tissues and sucrose phloem loading. Due to its specific inhibition of sucrose transporters (e.g. AtSUC2), D-GFC can be a candidate as a new tool in phloemology. Finally, we explored structural modifications of the spacer arm to optimize the prodrug strategy. Different structures of the spacer arm were introduced between fenpiclonil and the amino acid function. The conjugate which contains a triazole ring with the shortest amino acid chain showed the best phloem mobility and a better systemicity than fenpiclonil acidic derivatives within the pH range of the foliar apoplast.