L’objectif de cette thèse est d’étudier l’effet d’un entraînement explicite de la conscience phonémique (CP) en anglais L2 et les apports potentiels du tableau blanc interactif (TBI) comme instrument permettant de réaliser cet entraînement avec des apprenants de CE1. A partir des travaux de pédagogues tels que Borel-Maisonny et Caleb Gattegno, nous avons conçu des aides multimodales qui sont à la fois visuelles, sonores et kinesthésiques. Les couleurs de l’approche Gattegno ont été reprises pour créer des cartes de couleur auxquelles nous avons joint une représentation sonore du phonème. La carte sonore est également manipulable sur le TBI. En ce sens, la manipulation sur TBI pourrait aider la manipulation mentale des éléments. Les représentations des phonèmes constituent des représentations externes multimodales intégrées (REMI). Ces REMI ont été intégrées à un dispositif d’apprentissage permettant de valider les hypothèses de recherche. Il s’agissait non seulement d’évaluer l’efficacité de tâches explicites de conscience phonémique dans le cadre de l’apprentissage de l’anglais, mais également d’évaluer l’efficacité de l’utilisation du TBI pour réaliser les tâches de conscience phonémique. Ces hypothèses de recherche ont été testées à l’aide de trois groupes d’apprenants : deux groupes expérimentaux et un groupe contrôle. Un groupe a effectué des tâches explicites de conscience phonémique avec les REMI sur TBI (groupe ConsPhonoTBI), un groupe a effectué ces mêmes tâches de manière classique, c’est-à-dire mentalement sans aide multimodale (groupe ConsPhono), tandis que le groupe contrôle a fait des activités de vocabulaire anglais. La comparaison du groupe contrôle avec le groupe ConsPhono permet de déterminer l’effet d’un entraînement explicite de la conscience phonémique, tandis que la comparaison du groupe ConsPhono avec le groupe ConsPhonoTBI permet de déterminer l’effet des aides multimodales et de leur utilisation sur TBI dans le cadre de cet entraînement explicite. Cette recherche a pour objet une intervention dans le domaine du travail puisque les enseignants et les apprenants sont considérés comme étant en situation de travail. Cette recherche s’inscrit alors dans le cadre de l’ergonomie cognitive. En l’occurrence, la quasi-expérimentation a été menée en 2011-2012 auprès d’apprenants issus de classes de CE1 situées dans l’Isère. Dans la méthodologie de recherche mixte adoptée, les données qualitatives et quantitatives ont été triangulées et permettent d’obtenir des résultats ayant une validité interne. L’étude indique que le travail explicite de la conscience phonémique a un effet sur le niveau atteint dans ce domaine et que l’utilisation des REMI sur TBI permet d’atteindre un meilleur niveau dans le même laps de temps. Par ailleurs, cette étude indique que l’utilisation du TBI pour mener cet entraînement explicite permet à des enseignants non-spécialistes en langue de se décentrer pour réguler l’activité, de proposer une prononciation correcte aux élèves, renforçant ainsi le sentiment d’auto-efficacité au sens de Bandura (2003). En outre, le TBI favorise les échanges entre les apprenants au niveau du groupe classe et permet une découverte collective des phonèmes anglais. / This thesis seeks to study the effect of an explicit training of phonemic awareness (PA) in English L2 and the possible contribution of an Interactive Whiteboard (IWB) as a tool to carry such a training with 7-8 year old learners (in CE1 in France). Based on the work of some educators like Borel-Maisonny and Caleb Gattegno, we created some multimodal materials which are visual, sound and kinesthetic. We used the colors from Gattegno’s approach to create cards to which we attached the sound representation of each phoneme. These cards could also be moved on the IWB. Hence, the manipulation done on the IWB might help the mental manipulation that the learner should normally do mentally. The full representation for each phoneme is an external multimodal integrated representation (EMIR). These EMIR were used among a learning scenario which aimed to test research hypotheses. First of all, the aim was to know whether explicit tasks of phonemic awareness were useful or not. Then, the aim was to check the effect, in any, of the IWB in such a learning scenario concerning phonemic awareness. These research hypotheses have been tested thanks to three groups: two experimental groups and one control group. One group carried out the activities of phonemic awareness with EMIR on an IWB (PA-IWB group), one group carried out the same activities but on a traditional way, that-is-to-say mentally with any multimodal help (PA group) while the control group carried out some activities based on vocabulary. By comparing the control group with the PA group, we found out the effect, if any, of the explicit training of phonemic awareness and, by comparing the PA group with the PA-IWB group, we found out the effect, if any, of the multimodal tools used on the IWB. This research aims to take action in the field of ergonomics since teachers and learners are considered as being at work. This research fits into the field of cognitive ergonomics. Here, the quasi-experimentation was carried out during the school year 2011-2012 with 7-8 year old learners from Isère, France. Using a mixed research method, we triangulated qualitative data with quantitative data in order to get the most accurate results with an internal validity. This study shows that an explicit training of phonemic awareness (PA) has an effect on the level that learners can reach in PA and that the use of EMIR on an IWB allows learners to get an even better level in the same amount of time. Besides, it also appears that the use of the IWB for this kind of training helps the teacher when s/he is not a specialist in the target language. S/he can step aside, regulate the work and provide the correct pronunciation, which helps her/him reinforcing her/his feeling of self-efficacy as defined by Bandura (2003). Finally, the IWB urges the learners on interacting as a whole group and so discovering the English phonemes all together.

This research study consisted of an examination of the role played by the educational psychologist in the emotional and social rehabilitation of the TBI adolescent. A survey of the literature reveals that traumatic brain injury during adolescence negatively impacts on their adaptation, development and functioning after the acute phase of the rehabilitation process. In order to study this phenomenon, a psycho-educational perspective was utilised. An in-depth qualitative study was undertaken by means of a case study design. The two cases being presented offers the reader insight into the cases pre-morbid functioning, the accident and its aftermath, the specific traumatic brain injuries, the emotional and social problems encountered by these adolescents as well as the psychotherapeutic interventions applied by the educational psychologist in the rehabilitation process of the cases under investigation. The conclusions reached from this investigation were that traumatic brain injury during the developmental phase of adolescence, negatively impacts on the emotional and social well being of these adolescents, and that the educational psychologist plays a valuable role in the emotional and social rehabilitation of these adolescents. / Educational Studies / M. Ed. (Guidance and Counselling)

Traumatic brain injury (TBI) is a leading cause of death in all age groups, causing society to be concerned. However, TBI diagnostics and patient outcomes prediction are still lacking in medical science. In this thesis, I used a subset of TBIcare data from Turku University Hospital in Finland to classify the severity, patient outcomes, and CT (computerized tomography) as positive/negative. The dataset was derived from the comprehensive metabolic profiling of serum samples from TBI patients. The study included 96 TBI patients who were diagnosed as 7 severe (sTBI=7), 10 moderate (moTBI=10), and 79 mild (mTBI=79). Among them, there were 85 good recoveries (Good_Recovery=85) and 11 bad recoveries (Bad_Recovery=11), as well as 49 CT positive (CT. Positive=49) and 47 CT negative (CT. Negative=47). There was a total of 455 metabolites (features), excluding three response variables. Feature selection techniques were applied to retain the most important features while discarding the rest. Subsequently, four classifications were used for classification: Ridge regression, Lasso regression, Neural network, and Deep learning. Ridge regression yielded the best results for binary classifications such as patient outcomes and CT positive/negative. The accuracy of CT positive/negative was 74% (AUC of 0.74), while the accuracy of patient outcomes was 91% (AUC of 0.91). For severity classification (multi-class classification), neural networks performed well, with a total accuracy of 90%. Despite the limited number of data points, the overall result was satisfactory.

The current study investigates the effect of strain state, strain rate, and membrane planar area on phospholipid bilayer mechanoporation and failure. Using molecular dynamics, a 1-palmitoyl-2-oleoyl-phosphatidylcholine (POPC) bilayer was deformed biaxially to represent injury-induced neuronal membrane mechanoporation and failure. For all studies, water forming a bridge through both phospholipid bilayer leaflets was used as a failure metric. To examine the effect of strain state, 72 phospholipid structures were subjected to equibiaxial, 2:1 non-equibiaxial, 4:1 non-equibiaxial, strip biaxial, and uniaxial tensile deformations at the von Mises strain rate of 5.45 × 108 s-1. The stress magnitude, failure strain, headgroup clustering, and damage behavior were strain state dependent. The strain state order of detrimentality in descending order was equibiaxial, 2:1 non-equibiaxial, 4:1 non-equibiaxial, strip biaxial, and uniaxial with failure von Mises strains of 0.46, 0.47, 0.53, 0.77, and 1.67, respectively. Additionally, pore nucleation, growth, and failure were used to create a Membrane Failure Limit Diagram (MFLD) to demonstrate safe and unsafe membrane deformation regions. This MFLD allowed representative equations to be derived to predict membrane failure from in-plane strains. To examine the effect of strain rate, the equibiaxial and strip biaxial strain states were repeated at multiple strain rates. Additionally, a 144 phospholipid structure, which was twice the size of the 72 phospholipid structure in the x dimension, was subjected to strip biaxial tensile deformations to examine planar area effect. The applied strain rates, planar area, and cross-sectional area had no effect on the von Mises strains at which pores greater than 0.1 nm2 were detected (0.509 plus/minus 7.8%) or the von Mises strain at failure (0.68 plus/minus 4.8%). Additionally, changes in bilayer planar and cross-sectional areas did not affect the stress response. However, a strain rate increase from 1.4 × 108 to 6.8 × 108 s-1 resulted in a yield stress increase of 44.1 MPa and a yield strain increase of 0.17. Additionally, a stress and mechanoporation behavioral transition was determined to occur at a strain rate of ~1.4 × 108 s-1. These results provide the basis to implement a more accurate mechano-physiological internal state variable continuum model that captures lower-length scale damage.

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L’impulsivité est une séquelle fréquente suite à un traumatisme cranio-cérébral (TCC) à laquelle sont associées de nombreuses conséquences néfastes et qui nécessite un investissement considérable de ressources. En ce sens, une évaluation adéquate de l’impulsivité est de mise dans un contexte de réadaptation. Par contre, malgré son importance, il n’existe pas de définition consensuelle de l’impulsivité post-TCC ni de mesure spécifique permettant de l’évaluer. Il est généralement admis, dans la littérature récente, que l’impulsivité est un construit multidimensionnel. Notamment, le modèle UPPS-P de l’impulsivité gagne un appui significatif et pourrait permettre une compréhension plus spécifique de l’impulsivité post-TCC. Selon ce modèle, il existe quatre dimensions à l’impulsivité soit l’urgence (tendance à agir ses impulsions dans un contexte d’émotions intenses), le manque de persévérance (difficulté au niveau du maintien de l’attention sur une tâche complexe et ennuyante et une susceptibilité à l’ennui), le manque de préméditation (difficulté de prévoir les conséquences d’un comportement avant de le poser) et la recherche de sensations (tendance à préconiser des activités jugées excitantes et l’ouverture à essayer de nouvelles expériences qui peuvent ou non, être dangereuses). Il a été proposé que l’urgence, le manque de persévérance et le manque de préméditation sont associés à des difficultés à inhiber la réponse automatique, à résister à l’interférence proactive et de la prise de décision, respectivement (Bechara et Van der Linden, 2005). Une telle conceptualisation offre une avenue prometteuse quant à l’évaluation de l’impulsivité post-TCC. Le présent projet vise à clarifier le construit de l’impulsivité post-TCC, à déterminer si les mêmes mécanismes cognitifs sont en lien avec les dimensions de l’impulsivité dans un contexte de réadaptation fonctionnelle intensive puis de déterminer quelles tâches de performance prédisent le mieux les comportements impulsifs dans ce milieu. D’abord, une recension des écrits portant sur l’impulsivité post-TCC donne un appui à la conceptualisation multidimensionnelle de l’impulsivité et fait ressortir les obstacles qui nuisent à l’étude de l’impulsivité post-TCC. Ensuite, l’utilisation de diverses tâches de performance permet d’évaluer le lien entre les dimensions de l’UPPS-P et les mécanismes cognitifs. Les résultats indiquent des atteintes sur les mécanismes liés à l’inhibition de la réponse automatique, à la résistance à l’interférence proactive ainsi qu’à la prise de décision. Toutefois, ils ne permettent pas de supporter les propositions de Bechara et Van der Linden quant aux mécanismes sous-jacents aux dimensions de l’impulsivité post-TCC chez les patients en réadaptation intensive. Finalement, les résultats permettent de faire ressortir la pertinence des tâches de performance écologiques dans la prédiction de comportements impulsifs dans la vie quotidienne. Les portées théoriques et cliniques des résultats sont discutées. / Impulsivity is a common sequela following traumatic brain injury (TBI) to which are associated many negative consequences and necessitates important resources. A thorough assessment of impulsivity is therefore necessary in a rehabilitation setting. However, there is no consensual definition of post TBI impulsivity nor is there a specific measure allowing its assessment. It is generally acknowledged, in recent literature, that impulsivity is a multidimensional construct. The UPPS-P model is gaining a significant amount of support and could allow a better understanding of post-TBI impulsivity. According to this model, there are four dimensions to impulsivity, namely urgency (tendency to experience and act on strong impulses frequently under conditions of strong affect), lack of perseverance (inability to remain focused on a task that may be boring or difficult), lack of premeditation (inability to think and reflect on the consequences of an act before engaging in that act) and sensation seeking (tendency to enjoy activities that are exciting and a willingness to try new experiences). It has been suggested that urgency, lack of perseverance and lack of premeditation are linked to impairments on prepotent response inhibition, on resistance to proactive interference and on decision making, respectively (Bechara and Van der Linden, 2005). This conceptualisation offers a promising avenue as to the assessment of post-TBI impulsivity. This project aims to clarify the construct of post-TBI impulsivity, to determine whether the same cognitive mechanisms come into play in the different dimensions of impulsivity in an intensive functional rehabilitation setting and to determine which performance tasks allow the prediction of impulsive behaviors in that setting. Firstly, a literature review among studies on post-TBI impulsivity gives support to a multidimensional conceptualisation of impulsivity and allows to bring out the obstacles which make the study of post-TBI impulsivity more complicated. Secondly, the use of different performance tasks is used to assess the links between UPPS-P dimensions and cognitive mechanisms. Results indicate impairments on the mechanisms linked to prepotent response inhibition, to resistance to proactive interference and to decision making. However, they do not support Bechara and Van der Linden’s (2005) propositions as to the underlying mechanisms to the dimensions of post-TBI impulsivity in an acute rehabilitation setting. Thirdly, the results show the relevance of ecological performance tasks as to the prediction of impulsive behaviors in everyday life. The theoretical and clinical implications of the results are discussed.

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