Orientador: Vera Aparecida Madruga Forti / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Educação Fisica / Made available in DSpace on 2018-08-10T20:00:26Z (GMT). No. of bitstreams: 1 Peres_ClaudiaMaria1966-_M.pdf: 1302254 bytes, checksum: 830a6821ea61927ef7fffe7925c07edd (MD5) Previous issue date: 2008 / Resumo: A literatura relata que, a menopausa tem início entre 38 e 55 anos (dependendo do fator genético). Devido a diminuição na produção do hormônio estrogênio em 75% a 80% das mulheres ocorrerão sintomas tipo: suores noturnos, fogachos (ondas de calor), secura vaginal tornando a relação sexual desagradável, diminuição da libido, do brilho da pele, da memória e da atenção, insônia, irritabilidade, baixa auto-estima, osteoporose em 25% das mulheres (perda de massa óssea em 1% ao ano) e outras doenças ósteo-musculares. Nessa fase também ocorrerá aumento da gordura corporal na região do abdome com elevação da incidência de doenças cardiovasculares. As mulheres menopausadas com sintomas de disfunção temporomandibular (DTM) podem apresentar depressão, ansiedade e stress pela constância da sintomatologia de desconforto e dor. Dessa forma, o objetivo geral desta pesquisa foi de avaliar a qualidade de vida e os sintomas de stress em mulheres menopausadas com DTM que freqüentavam o serviço do Centro de Saúde da Comunidade/ Coordenadoria de Serviços Sociais da Universidade Estadual de Campinas. Foram selecionadas 30 voluntárias, funcionárias e alunas da UNICAMP, com idades entre 38 e 65 anos, diagnosticadas como portadoras da sintomatologia de DTM e com menopausa clinicamente comprovada (12 meses sem menstruações). As voluntárias foram avaliadas através de uma ficha de anamnese, do Questionário de Qualidade de Vida SF-36 e do Inventário de Sintomas de Stress de Lipp (ISSL). Para a análise da ficha de anamnese utilizamos a estatística descritiva e para os dados coletados no Questionário de Qualidade de Vida SF-36 foi utilizado o Software EpiInfo 6® (DEAN et al., 1995). Na análise do ISSL, após a soma dos resultados brutos verificou-se a porcentagem correspondente nas tabelas de correção dos sintomas e das fases de stress. Os resultados obtidos na ficha de anamnese mostraram que as mulheres apresentavam dor crônica sendo: 73,33% de dor nas ATMs, 73% das mulheres apresentaram dores nos músculos masseter e escalenos, 56% nos músculos pterigóideo lateral e pterigóideo medial, 50% no ângulo da mandíbula e nos músculos temporais, 46% no músculos rombóides e 43,33% cefaléia e dor no ouvido. Em relação ao aperto e ao ranger dos dentes as mulheres descreveram respectivamente 73,33% e 66,66%. Já em relação à queixa principal foi relatado: dor nos músculos trapézios 20%, fundo de olho 16,66%, crepitação nas ATMs 13,33%. Quanto à QV os piores escores encontrados foram relacionados com aspectos físicos, dor e vitalidade. Já em relação ao ISSL os resultados mostraram que a fase de stress com maior escore (43,33%) foi à fase de resistência e os sintomas de stress com maior porcentagem foram os psicológicos com 43,33%. As conclusões de nossa pesquisa mostraram que queixas reincidentes constavam nos dados da ficha de anamnese, no SF-36 e no ISSL, sendo interessante a aplicação desse modelo em novas pesquisas por multiprofissionais e em outro tipo de população para consolidação da mesma / Abstract: The literature reports that Menopause begins between 38 to 55 years old (depending on generic factors). Because of the estrogen hormone decreases, in 75% a 80% of the women will have symptoms like: night sweating, flashes, vaginal dryness, uncomfortable coupling and diminishing of sexual desire, diminishing of skin moisture and shine, attention deficit and memory loss, insomnia, irritability, low self-steam, depression, and 25% of them, will develop osteoporosis (bone mass decreases 1% a year) and others osteo-muscular diseases. In this phasis will also have increases of adiposity in abdomen with increases of incidents of cardiovascular diseases. Menopause women with symptoms of temporomandibular joint (TMJ) disorder can have depression, anxiety and stress altered by the constant symptoms of discomfort and pain. The general objective of this search was evaluate the quality of life and the symptoms of the stress in menopause women with TMJ disorder that have been used the ¿Centro de Saúde da Comunidade/Coordenadoria de Serviços Sociais da Universidade Estadual de Campinas¿. 30 volunteers were selected, employees and students of UNICAMP, between 38 and 65 years old, with TMJ disorder and also menopause diagnosis proved (12 months without menstruation). The volunteers were evaluated through a anamnesis chart, Quality of Life Questionary SF-36 and the Lipp Stress Symptom Inventory (ISSL). To analyse the anamnesis chart, we have been used the describing estatistics and for the collected dates in the Quality of Life Questionary SF-36, were used the Software EpiInfo 6® (DEAN et al., 1995). The analysis of ISSL, after the addition of the global results, we verified the corresponding percentage in schedules of the symptoms corrections and the stress phases. The anamnesis chart results showed that the women had chronics pains: 73,33% TMJ pain, 73% of women had masseters and scalenos muscles pain, 56% in lateral pterigoideo pain and medial pterigoideo, 50% in jaw angle and in temporal muscles, 46% in rhomboids muscles and 43,33% of headaches and ears pain. The pressure and screak of the teeth were described by the women 73,33% and 66,66% respecting. In relaction of main complaint were reported: 20% of trapeziums muscles pain, 16,66% in eyes, 13,33% TMJ crackles. In relation of Quality of Life, the worst scores found were in relation with physics aspects, pain and vitality. About ISSL, the results showed that stress phasis with the biggest score (43,33%) was that of resistence and the stress symptoms with greatest percentage were the psycologics with 43,33%. The final conclusion of our search showed that reincidence complaint appeared in anamneses chart, in SF-36 and in ISSL, beind interesting the application of this model in new searches for a several professionals and in other kind of population, to consolidate itself / Mestrado / Atividade Fisica, Adaptação e Saude / Mestre em Educação Física

Inflammatory processes are infamous for their destructive effects on tissues and joints in a variety of diseases. Within the body, inflammation is a highly regulated biological response whose purpose is to promote tissue regeneration following injury. However, in certain settings, inflammation persists and leads to progressive tissue destruction. This thesis focused on modulating inflammatory signaling in both contexts. Part I investigated the effects of a model pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), on the in vitro osteogenic differentiation of mesenchymal stem cells (MSCs). In contrast, Part II describes the development and in vivo evaluation of the first intra-articular controlled release system for the temporomandibular joint (TMJ), which silences inflammatory signaling and thus mitigates the painful joint damage seen in inflammatory TMJ disease. The following specific aims were addressed: (1) to determine the concentration of TNF-α that enhances in vitro osteogenic differentiation of MSCs; (2) to determine the temporal pattern of TNF-α delivery that enhances in vitro osteogenic differentiation of MSCs; (3) to determine the impact of bone-like extracellular matrix (ECM) on the concentration and temporal pattern of TNF-α delivery that enhances in vitro osteogenic differentiation of MSCs; (4) to evaluate the biocompatibility of intra-articular microparticles in the rat TMJ; (5) to develop a microparticle-based formulation for sustained release of a model anti-inflammatory small interfering ribonucleic acid (siRNA); and (6) to evaluate the therapeutic efficacy of intra-articular microparticles delivering siRNA in an animal model of TMJ inflammation. These studies led to the development of powerful strategies to rationally control inflammation to promote bone regeneration and mitigate joint damage in the setting of disease, both of which will ultimately improve the quality and specificity of therapies available in modern medicine. / Only volume 2 has been digitized.