This study examined the ability of reaction time (RT) and Event-Related Potentials (ERP) to detect malingered neurocognitive deficit (MNCD)in two new tasks compared to the TOMM (N = 47). Honest (HON), malingering (MAL), and traumatic brain injury (TBI) groups were compared on accuracy, RT and ERP measures. Overall, the Test of Memory Malingering (TOMM) accuracy was the most effective at classifying groups (hit rate = 100%). Several non-TOMM accuracy variables and RT variables reached hit rates in the range of 71%-88%. The TOMM RT variable had an unlimited time for participants to respond and was the most successful RT variable compared to the Old/New and Repetition Priming tasks that had a short time limit for participants to respond (approximately 1.5 seconds). The classic old/new effect RT pattern was evident for both the HON and TBI groups with significantly faster RTs for old items compared to new items. A logistic regression was employed to see if a RT and/or ERP variable added any unique prediction power in detecting malingering. The frontal-posterior ERP difference score had unique prediction power to detect malingering when classifying MAL vs. TBI (hit rate = 86%). In the Old/New task, ERP responses of HON produced greater activity in the frontal region compared to the posterior region. The opposite trend was found in TBI (posterior activity andgt; frontal) and MAL showed no significant difference.

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No description available.

Universities have increasingly sought to provide accommodative services to students with learning disorders and Attention-Deficit/Hyperactivity Disorder (ADHD) in recent decades thereby creating a need for diagnostic batteries designed to evaluate cognitive abilities relevant to academic performance. Given that accommodative services (extended time on tests, alternate test forms, etc.) provide incentive to distort impairment steps should be taken to estimate the rate at which students distort impairment and to evaluate the accuracy with which symptom distortion is identified. In order to address these concerns, the Word-Memory Test, Test of Memory Malingering, and Fake Bad Scale (of the MMPI-2) were compared in terms of their clinical utility in a university sample within a two-part study. In the first portion of the study, an analogue design (which included a control group (n = 29) and an experimental group (n = 30) that was asked to simulate an academic disability) was used to calculate the sensitivity and specificity of each measure. In the second portion of this study, scores were collected for 121 consecutively presenting students who were evaluated for academic difficulty at a large private university. Failure rates on measures of malingering placed the base rate of malingering within this population between 10 and 25 percent. The Word-Memory Test (WMT) demonstrated the most robust sensitivity and specificity. The modest sensitivity of the Test of Memory Malingering (TOMM) can be partially explained by the ease with which the measure is completed by university students as well as the format of its presentation. Although the scores on Fake Bad Scale (FBS) are modestly correlated with group membership (between controls and simulators), its use should be discouraged in this context due to poor sensitivity and to high rates of false positives.

Detection of sub-optimal effort is a critical element of all psychological assessment procedures. Failure to consider the validity of the client's performance and symptom reporting may result in inaccurate conclusions about the degree of impairment. Because the American with Disabilities Act requires colleges to provide accommodations for students with documented disabilities, providing resources for students feigning impairment may ultimately drain university resources intended to help those students with disabilities. This study sought to examine the relationship between two different types of measures of effort and variables related to academic ability. De-identified archival data was gathered from the University Accessibility Center (UAC) at Brigham Young University (BYU) which provided psychological assessments for accommodation seeking students (N = 602) for a reduced fee. Measures used to detect sub-optimal effort included the Test of Memory Malingering (TOMM), Word Memory Test (WMT), Validity Indicator Profile (VIP), California Verbal Learning Test-Second Edition (CVLT-II), Reliable Digit Span (RDS), and the Integrated Visual and Auditory Continuous Performance Advanced Edition (IVA-AE). Measures indicating academic ability included select subtests from the Woodcock Johnson Test of Achievement Third Edition (WJ-III). Additionally, Matrix Reasoning of the Wechsler Adult Intelligence Scale Fourth Edition (WAIS-IV) was included as a cognitive measure of nonverbal IQ. Two point biserial correlations were conducted. Results indicated that the nonverbal portion of the VIP had a significant relationship with writing fluency. The TOMM also had a significant relationship with writing fluency. Additionally, results demonstrated that Reliable Digit Span had a significant relationship with Academic Fluency, Writing Fluency, Letter Word Identification, and Math Fluency. Data suggests that university disability service offices may wish to include the RDS, TOMM, and VIP in their considerations of effort.

According to the Americans with Disabilities Act, universities and colleges are required to provide accommodative services for students with disabilities. Many studies have examined the role of malingering mental health symptoms in order to obtain psychotropic medications, but very little research has been done on the role of accommodations as secondary gain in students who may malinger learning disabilities. This study sought to examine both the usefulness of implementing specific malingering detection measures in psychological evaluations with university students and the agreement of those measures within the population. Archival data was gathered from a university accommodation clinic that provided free psychological evaluations for consecutively presenting students (N=121). Four malingering detection measures were used: the Test of Memory and Malingering (TOMM), the Word Memory Test (WMT), the WAIS Digit Span (DS) and two cut scores for the MMPI-2 F Scale (F Scale 80 and F Scale 95). Scores for these four malingering detection measures were compared in terms of their agreement rates, their classification rates (at a 10% malingering base rate recommendation), and their sensitivity, specificity, positive and negative predictive powers using both the TOMM and WMT independently as diagnostic criterion. A qualitative examination of the data revealed that different combinations of measures did classify some of the same respondents as malingering. Results indicated that each of these four measures share the ability to detect malingering in its different forms and have similar classification rates. Although the TOMM and WMT likely provide overlapping information, the pragmatic implementation of one of these measures may assist in the evaluation of suspected malingering with accommodation-seeking students.

No description available.

Bacillus amyloliquefaciens FZB42 ist ein grampositives Bodenbakterium. Es kann in der Rhizosphäre das Wachstum von Pflanzen fördern und durch die Produktion von Sekundärmetaboliten phytopathogene Organismen hemmen. Aus der Genomanalyse und den dazugehörigen Arbeiten war bekannt, dass Bacillus amyloliquefaciens FZB42 nicht-ribosomal je drei antimikrobielle Polyketide und Lipopeptide herstellt, sowie zwei Siderophore und das Dipeptid Bacilysin. Für Bacillus typische Lantibiotika oder große Bacteriocine wurden nicht gefunden. In dieser Arbeit wird erstmalig gezeigt, dass Bacillus amyloliquefaciens FZB42 auf ribosomale Weise antibakterielle Peptide herstellt. Zwei bisher unbekannte Bacteriocine, Amylocyclicin A und Plantazolicin, und deren dazugehörigen Gencluster konnten identifiziert und charakterisiert werden. Amylocyclicin A ist ein unmodifiziertes Peptid, dessen N- und C-Terminus kovalent verbunden sind. Es wurde der Gruppe I der zirkulären Bacteriocine zugeordnet, dessen Mitglieder sich durch schwache Homologie untereinander, aber durch wahrscheinlich ähnliche 3D-Strukturen auszeichnen. Die Masse beträgt 6381 Da und die Substanz ist stark aktiv gegen grampositive Bakterien. Das Biosynthesecluster umfasst sechs Gene für die Synthese, den Export, die Zyklisierung und die Immunität. Plantazolicin ist ein hydrophobes, stark modifiziertes Peptid aus der TOMM-Gruppe, einer Gruppe aus Microcin B17-ähnlichen Peptiden, die nach neueren Erkenntnissen verbreiteter ist, als bisher bekannt. Plantazolicin ist schwach aktiv gegen grampositive Bakterien und besitzt die Masse 1335 Da. Das Biosynthesecluster umfasst zwölf Gene, mit allen nötigen Genen für Synthese, Modifikation, Regulation, Immunität und Export. / Bacillus amyloliquefaciens FZB42 is a Gram-positive, plant-associated bacterium, which stimulates plant growth and produces secondary metabolites that suppress soil-borne plant pathogens. Five gene clusters direct the non-ribosomal synthesis of the cyclic lipopeptides surfactin, bacillomycin, fengycin, an unknown peptide and the iron-siderophore bacillibactin. Three gene clusters direct the non-ribosomal synthesis of the antibacterial acting polyketides macrolactin, bacillaene and difficidin; in addition to the non-ribosomal synthesis of the antibacterial dipeptide bacilysin. Genes involved in ribosome-dependent synthesis of lantibiotics and other peptides are scarce. Only two incomplete gene clusters directing immunity against mersacidin and subtilin were found. In this work two ribosomally synthesized antibacterial peptides, amylocyclicin A and plantazolicin, and their corresponding gene clusters were identified. Amylocyclicin A is a circular peptide with a mass of 6381 Da and strong activity against Gram-positive bacteria. Six genes are responsible for the synthesis, maturation, export and immunity of this peptide belonging to group I of circular bacteriocins. Plantazolicin is a strongly modified hydrophobic peptide bearing a molecular mass of 1,335 Da and displaying antibacterial activity toward closely related Gram-positive bacteria. Essential modification contains the incorporation of azole heterocycles, which derive from Cys, Ser, and Thr residues of the precursor peptide and addition of two methyl groups. Twelve genes are responsible for synthesis, modification, export and immunity of this peptide belonging to the TOMM group of thiazol/oxazol modified microcins.