The aim of this study is to discover nonverbal, bodily gesture and contextual cues indicating self-conscious emotions and use these clues to examine personal differences and psychopathological symptoms. Moreover, possible effects of cultural differences on self-conscious emotions&rsquo / recognition and their relation to psychopathology are meant to be discussed. To achieve aforementioned goals, the study is partitioned into three separate but interdependent phases. The aim of the study is scale adaptation for which the State Shame and Guilt Scale, Test of Self-Conscious Affect-3, Guilt- Shame Scale, State-Trait Anxiety Inventory, and Beck Depression Inventory are applied to a group of 250 university students. The second study&rsquo / s objective is to determine the nonverbal expressions used in recognition of self-conscious emotions. To meet this goal, 5 TAT cards, whose compatibility with the research questions is verified, are applied to 45 university students in separate sessions by using close ended questions. In the third part of the study, 9 TAT cards, which include clues about recognition and nonverbal expressions of self-conscious emotions, adapted corresponding scales, and a psychopathological symptoms measuring scale (SCL-90) in self-report format are applied on a group of 250 university students. Factor and correlation analyses done in the first part reveal that adapted scales are reliable and valid, while group comparisons and measurements of the second part indicate differences in emotions. Findings reveal that shame can be recognized by nonverbal expressions whereas for guilt contextual clues are facilitated. In the third part, group comparisons and regression analyses, which are done in order to reveal self-conscious emotions&rsquo / recognition and their significant relationships with psychopathology, display that state self-conscious emotions and shame-proneness have very important roles on psychopathology. All these findings are discussed in the light of cultural effects.

Recently, the American Association of State Highway and Transportation Officials (AASHTO) indicated lack of competition and single-bid contracts in asphalt paving as a major issue facing state transportation departments. Single-bid contracts indicate a lack of competition which increases costs to state and local governments. During the period from 2005-2007 in Kentucky, 42 percent of all bids were awarded with only one firm bidding on the project. Of the asphalt paving jobs, 63 percent of those jobs were awarded to a single bidder. The analysis of this dissertation focuses on detecting tacit collusion in asphalt paving jobs in Kentucky. A focal point enables firms to coordinate bids and engage in a tit-for-tat strategy where they refuse to bid in each other’s counties. In this case the focal point is the county boundaries. Two factors contribute to the ability of firms to use county boundaries to coordinate bids. The first factor is that the political county boundaries form relatively small counties which allow a firm’s service area to cover multiple counties. The firms are able to claim counties and service the projects in those counties. The second factor is that a majority of asphalt projects which the Kentucky Transportation Cabinet puts up for bidding are exclusive to a specific county. This allows firms to know whether a project falls in a county within their bidding territory. Each county and firm in each of the 12 Kentucky Transportation Cabinet geographic districts was analyzed to see if there was evidence of bid coordination. The result is that in 94 out of 120 counties there was evidence of bid coordination or tacit collusion with increases in bid levels. There is evidence that 25 of the 31 Kentucky asphalt paving firms refuse to bid against their rivals in their rival’s territories. This refusal by firms to bid against each other resulted in single-bid contracts that were $70,595,466.09 above the competitive level.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2005. / Härtill 6 uppsatser.

Thesis (Ph.D.)--University of Alabama at Birmingham, 2009. / Title from PDF title page (viewed on July 15, 2010). Includes bibliographical references.

Affibody® molecules are small therapeutic proteins which mimics antibody functionality. This is a report of several methods for increasing productivity and yield in recombinant production of Affibody® molecules. This literature study shows several steps in the production line which can be optimised, several novel methods for cultivating and harvesting cells and purication of proteins. There is also a section about validation of therapeutic protein production according to The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) are presented.

Made available in DSpace on 2015-05-14T16:53:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-08-28Bitstream added on 2015-05-14T16:59:08Z : No. of bitstreams: 1 000822061.pdf: 1227044 bytes, checksum: 7a60f2eeba804ce92e5fefc2788ed59d (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Introdução: Pacientes portadores do vírus da imunodeficiência humana (HIV) apresentam risco aumentado de desenvolverem neoplasias malignas ligadas ao herpesvírus associado ao sarcoma de Kaposi (KSHV), entre elas o sarcoma de Kaposi (SK). Digno de nota, o sarcoma de Kaposi associado a aids (SK-AIDS) apresenta-se mais agressivo que as outras formas de SK, sugerindo a existência de interação sinérgica entre os produtos do KSHV e do HIV-1. O ciclo biológico do KSHV é dividido em fase latente e lítica. As proteínas vFLIP e LANA expressas na fase latente e as proteínas líticas Rta, vGPCR e K1, apresentam propriedades oncogênicas. Graças a habilidade da proteína tat do HIV-1 em estimular a angiogênese e outros fenômenos inflamatórios, é plausível que esta proteína modifique significativamente a expressão gênica do KSHV, proporcionando alterações fenotípicas que contribuem para o desenvolvimento do SK-AIDS. Para melhor entendimento dos efeitos da proteína tat do HIV-1 em células infectadas pelo KSHV, por meio da análise das reações em cadeia da PCR quantitativa acoplada a transcrição reversa (Quantitative real time reverse transcriptase polymerase chain reactions - qRT-PCR), o presente trabalho descreveu as alterações na expressão dos genes codificadores de vFLIP, LANA, Rta, vGPCR e K1 em células endoteliais de veia umbilical humana imortalizada pela telomerase e infectada pelo KSHV a longo prazo (TIVE-LTCs) expostas à proteína tat recombinante do HIV-1 por 12, 24, 48 e 72h. Resultados: Em termos descritivos, a expressões diferencial dos genes latentes na vigência de exposição à proteína tat recombinante do HIV-1 em relação à proteína tat denaturada, aumentou após 12 e 24h para LANA e após 24 e 72h para vFLIP. Para os genes líticos a expressão diferencial aumentou consistentemente até atingir 48h e diminuiu nas próximas 12h para ORF-50. Enquanto que para ... / CNPq: 471524/2011-5 / FAPESP: 09/18403-9

The TAT stories of 38 sexually abused females between the ages of 5 and 18 years and a clinical group of 26 females with no recorded history of abuse were analyzed using the Object Relations and Social Cognitions TAT Scoring System (Westen et al., 1985). Subjects in the sexual abuse group showed significantly lower mean scores on a scale measuring affect-tone of relationship paradigms and on a scale measuring complexity of representations of people. In addition, pathological responses were given significantly more often by sexual abuse victims on the complexity of representations of people scale. Thus, sexually abused children showed more primitive and simple characterizations of people and more negative, punitive affect in their representations. Moreover, these results were independent of age, race, and intelligence. Group differences are discussed in terms of object relations development.

The aim of this paper is better understanding how children think about the world and what they know about how it goes there. The ambition of the research is to find meanings that children attach to the death. One of the prerequisites of research is the assumption that images of death can not be asked directly without causing undesirable reduction of potentially rich answers. For this reason, Thematic Apperception test was elected as a tool and the children told stories to a pre-selected board. Eleven children, at the age from 9 to 10 years collaborated on the research. As a comparative sample was subjected to the same test a group of eleven young adults aged 19 to 20 years. Stories of children and adults were subsequently subjected to thematic analysis, one category was the meaning of death for actors in the story. Results of the analysis were then put into context with Klatt (1991).

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The aim of this paper is better understanding how children think about the world and what they know about how it goes there. The ambition of the research is to find meanings that children attach to the death. One of the prerequisites of research is the assumption that images of death can not be asked directly without causing undesirable reduction of potentially rich answers. For this reason, Thematic Apperception test was elected as a tool and the children told stories to a pre-selected board. Eleven children, at the age from nine to ten collaborated on the research. All of them attended, or just completed 3rd class in Prague's elementary schools. The research showed that in the stories of children who would still not reach the stage of abstract intellectual operations already appear phenomena such as paradox, the cycle of life, psychological causes as the reason of death, or the idea that memories of the deceased man is a "being with him "and can be a relief. So it seems that the time when developmental psychology theory replace the concrete to the abstract for some other, better reflect reality is not so far. KEYWORDS conception of death, childhood, narrative approach, TAT, thematic analysis of the story